Donor risk factors in orthotopic liver transplant: analysis of the OPTN/UNOS registry.
This study of the United Network for Organ Sharing registry data analyzed reputed donor factors using the post-MELD data and evaluated them further in HCV positive and HCV negative recipients with hepatic cirrhosis to develop a modified DRI (mDRI). We found that HCV negative cirrhotic recipients have generally higher tolerance against inferior qualities of donors than HCV positive cirrhotic patients. In addition, the results revealed the post-MELD prognostic factors that should be considered in the donor procurement processes. The group of "all recipients" and the subset of HCV positive cirrhotic recipients showed a similar set of donor risk factors found to significantly decrease graft survival. For these two groups, an mDRI included death by cerebrovascular accident or stroke, donor age>or=65 years, and donor history of diabetes. Using the mDRI for "all recipients", the 1-year graft survival decreased by 3-4% per additional donor factor present. In HCV positive cirrhotic recipients, the 1-year graft survival decreased by 2-6% per additional donor factor present. In addition, we developed an mDRI for HCV negative cirrhotic recipients comprised of only two donor factors, cytomegalovirus positive donor serostatus and donor age>or=65 years, resulting in a 1-year graft survival of 87.7% for no factors and 83.2% for 2 donor factors. Overall, our findings suggest that by having more refined, thus fewer, donor risk factors, the newly proposed DRI could pot...
Is the seated saline infusion test an accurate means of determining primary aldosteronism subtypes? How does it compare with other tests?Clinical Endocrinology
Researchers from Case Western Reserve University in Ohio found those who lived in areas with high pollution levels were 26 per cent more likely to die within 4.8 years of the operation.
In only the third documented such procedure, an international team of surgeons met in Belgrade, Serbia, to transplant a testicle from one twin to the other, restoring testosterone.
TYPE 2 diabetes is a chronic condition that requires a person to overhaul aspects of their lifestyle to keep rising blood sugar levels in check. Diet plays a decisive role in regulating blood sugar and warding off the threat of developing serious conditions and evidence is increasingly singling out certain items for their blood sugar-lowering benefits, including a certain fruit.
Background Diabetes mellitus predicts poorer outcomes in patients with acute coronary syndrome (ACS), but the magnitude of this association in patients at older ages remains controversial. Methods Data were extracted from the Codi Infart database. All consecutive patients with diagnosis of ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI) between 2010 and 2015 were included. We assessed the impact of diabetes mellitus on 30-day and one-year mortality in patients aged less than and at least 75 years. Results A total of 12 792 cases were registered, of whom...
Conclusion: Sirolimus-eluting Stentys stent may represent a potential solution for specific coronary anatomies such as bifurcation, ectasic, or tapered vessels. Risk of stent thrombosis appears related to clinical presentation with STEMI and to anatomic features, stressing the importance of the use of intracoronary imaging for self-expandable stents implantation.
Background We hypothesized that the transition from bare-metal stents (BMS) to newer generation drug-eluting stents (n-DES) in clinical practice may have reduced the risk also in patients with kidney dysfunction. Methods: Observational study in the national SWEDEHEART registry, that compared the 1-year risk of in-stent restenosis (RS) and stent thrombosis (ST) in all percutaneous coronary intervention treated patients(n = 92 994) during 2007–2013. Results: N-DES patients were younger than BMS, but had more often diabetes, previous myocardial infarction, previous revascularization and were more often treated w...
No abstract available
A subanalysis of CREDENCE suggests that SGLT2 inhibitor use should be based on clinical benefit, not solely glycemic control, say researchers. Another study hints that these drugs up EPO levels.Medscape Medical News
Psychiatric Services, Ahead of Print.