HIV/HCV Co ‐infection and the risk of Cardiovascular Disease: A Meta‐analysis

In conclusion, individuals with HIV/HCV coinfection had an increased risk compared to those with HIV monoinfection. More research is needed to further examine the nature of this association, and response to traditional risk reductive therapies. This article is protected by copyright. All rights reserved.
Source: Journal of Viral Hepatitis - Category: Infectious Diseases Authors: Tags: Original Paper Source Type: research

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AbstractMyocardial infarction is a frequent complication of cardiovascular disease leading to high morbidity and mortality worldwide. Elevated C-reactive protein (CRP) levels after myocardial infarction are associated with heart failure and poor prognosis. Cardiomyocyte microvesicles (CMV) are released during hypoxic conditions and can act as mediators of intercellular communication. MicroRNA (miRNA) are short non-coding RNA which can alter cellular mRNA-translation. Microvesicles (MV) have been shown to contain distinct patterns of miRNA from their parent cells which can affect protein expression in target cells. We hypot...
Source: Journal of Thrombosis and Thrombolysis - Category: Hematology Source Type: research
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Source: The Lancet Diabetes and Endocrinology - Category: Endocrinology Source Type: research
In clinical trials of treatments for chronic pain, the percentage of participants who withdraw early can be as high as 50%. Major reasons for early withdrawal in these studies include perceived lack of efficacy and adverse events. Commonly used strategies for accommodating missing data include last observation carried forward, baseline observation carried forward, and more principled methods such as mixed-model repeated-measures and multiple imputation. All these methods require strong and untestable assumptions concerning the conditional distribution of outcomes after dropout, given the observed data. We review recent dev...
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Source: Pain - Category: Anesthesiology Tags: Research Paper Source Type: research
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Cardiac murmurs are initially classified into systolic, diastolic and continuous. They can be timed in relation to the carotid pulse. A systolic murmur starts with or after the first heart sound and ends at or before the second heart sound. Clinically, systole can be timed with the onset of carotid pulse. Diastolic murmurs start with or after the second heart sound. By definition, a continuous murmur starts in systole, persists through the second heart sound, into the diastole. When the pressure gradient is high between the two chambers across which the murmur is generated is high, the murmur is high pitched. Levine&rsquo...
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In conclusion, individuals with HIV/HCV coinfection had an increased CVD risk compared to those with HIV monoinfection. More research is needed to further examine the nature of this association, and response to traditional risk‐reduction therapies.
Source: Journal of Viral Hepatitis - Category: Infectious Diseases Authors: Tags: ORIGINAL ARTICLE Source Type: research
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