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Total 229 results found since Jan 2013.

Protocols and Guidelines for Stroke in Children: Point and Counterpoint
Cerebrovascular diseases carry a heavy burden of disease in children with consequences that last a lifetime.1 Perinatal stroke causes most hemiparetic cerebral palsy with additional nonmotor consequences affecting diverse aspects of development and quality of life.2 Stroke during childhood is also associated with broad neurodevelopmental disabilities and morbidity. Among a myriad of potential pathophysiologic mechanisms, few are directly treatable and prevention strategies are the exception rather than the rule.
Source: Pediatric Neurology - December 24, 2018 Category: Neurology Authors: Adam Kirton, Michael Dowling Tags: Opinion Paper Source Type: research

Protocols and guidelines for stroke in children: Point, counter point
Cerebrovascular diseases carry a heavy burden of disease in children with consequences that last a lifetime1. Perinatal stroke causes most hemiparetic cerebral palsy with additional non-motor consequences affecting diverse aspects of development and quality of life2. Stroke during childhood is also associated with broad neurodevelopmental disabilities and morbidity. Amongst a myriad of potential pathophysiological mechanisms, few are directly treatable and prevention strategies are the exception rather than the rule3,4.
Source: Pediatric Neurology - December 24, 2018 Category: Neurology Authors: Adam Kirton, Michael Dowling Tags: Opinion Paper Source Type: research

Cerebral infarction in CARS2 mutation
We appreciate the opportunity to respond to Dr. Finsterer's letter.1We want to discuss three issues: alternative treatment(other than conventional antiepileptic medicines) used in the treatment of super refractory status epilepticus in this patient, her cardiac workup, and the possible pathogenesis of stroke in this patient with compound heterozygote pathogenic variants of the CARS2 gene.
Source: Pediatric Neurology - December 24, 2018 Category: Neurology Authors: Debopam Samanta Tags: Correspondence Source Type: research

Reply to Cerebral Infarction in CARS2 Mutation
We appreciate the opportunity to respond to Dr. Finsterer's letter.1 We want to discuss three issues: alternative treatment (other than conventional antiepileptic medicines) used in the treatment of super-refractory status epilepticus in this patient, her cardiac evaluation, and the possible pathogenesis of stroke in this patient with compound heterozygous pathogenic variants of the CARS2 gene.
Source: Pediatric Neurology - December 23, 2018 Category: Neurology Authors: Debopam Samanta Tags: Correspondence Source Type: research

Where to from here?
This festschrift or collection of learned papers will appropriately celebrate and recognize the contributions of Dr Gabrielle deVeber to the field of paediatric stroke. I expect that it will become one of her “few favourite things” currently listed as “Maddy, Nikki, David, Romeo – a horse, and Taylor Swift”. At the same time, for some of us the threat of her retirement has become all too real, all too soon. This perspective piece will seek to track the course of Dr Gabrielle deVeber’s career with the hope that in so doing the answer to the question, ‘Where to from here’ will become clearer.
Source: Pediatric Neurology - December 19, 2018 Category: Neurology Authors: Nomazulu Dlamini Tags: Opinion Paper Source Type: research

Hypothesis: Presymptomatic treatment of Sturge-Weber Syndrome With Aspirin and Antiepileptic Drugs May Delay Seizure Onset
Sturge-Weber Syndrome (SWS) is a neurocutaneous disorder caused by a somatic mosaic mutation in GNAQ.1 SWS brain involvement causes seizures, stroke-like episodes and/or neurological deficits such as hemiparesis and intellectual disability. Seventy-five percent of infants with SWS will develop seizures within the first year of life.2 Those with more severe epilepsy experience greater cognitive deficits and intellectual disability.3 There is ictal single-photon emission computed tomography evidence that, in SWS, the seizures themselves may contribute to the brain injury due to an abnormal hemodynamic response.
Source: Pediatric Neurology - November 24, 2018 Category: Neurology Authors: Alyssa M. Day, Adrienne M. Hammill, Csaba Juh ász, Anna L. Pinto, E. Steve Roach, Charles E. McCulloch, Anne M. Comi, National Institutes of Health Sponsor: Rare Diseases Clinical Research Network (RDCRN) Brain and Vascular Malformation Consortium (BVMC) Tags: Perspectives in Pediatric Neurology Source Type: research

The “Toenail Sign” in MELAS May Be the End Stage of a Stroke-like Lesion
I read with interest the article by Kuwabara et  al. about an 11-year-old boy with mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) due to the variant m.3243A>G who presented with gyral necrosis and cerebral atrophy on cerebral magnetic resonance imaging (MRI) compared with images three years earlier.1
Source: Pediatric Neurology - November 23, 2018 Category: Neurology Authors: Josef Finsterer Tags: Correspondence Source Type: research

The “toenail sign” in MELAS may be the end-stage of a stroke-like lesion
We read with interest the article by Kuwabara et al. about an 11 years-old male with MELAS syndrome due to the variant m.3243A>G who presented on cerebral MRI with gyral necrosis and cerebral atrophy compared to images three years earlier.[1] We have the following comments.
Source: Pediatric Neurology - November 23, 2018 Category: Neurology Authors: Josef Finsterer Tags: Correspondence Source Type: research

Speech and language impairments after childhood arterial ischemic stroke: does hemisphere matter?
and purpose: The association between left hemisphere stroke and acute speech and language impairment is well documented in adults. However little is known about this association in childhood arterial ischemic stroke (AIS). Here we examined potential predictors of acute speech (dysarthria, apraxia) and language impairments after childhood AIS, including site of lesion.
Source: Pediatric Neurology - November 20, 2018 Category: Neurology Authors: Frederique Liegeois, Cristina Mei, Lauren Pigdon, Katherine J. Lee, Belinda Stojanowski, Mark Mackay, Angela Morgan Tags: Clinical Observations Source Type: research

Pediatric Infective Endocarditis and Stroke: A 13-Year Single-Center Review
We explored the relationship between pediatric infective endocarditis and stroke.
Source: Pediatric Neurology - October 17, 2018 Category: Neurology Authors: Gui-fang Cao, Qi Bi Tags: Original Article Source Type: research

Pediatric Infective Endocarditis and Stroke:A 13-Year Single-Center Review
We explored the relationship between pediatric infective endocarditis and stroke.
Source: Pediatric Neurology - October 17, 2018 Category: Neurology Authors: Gui-fang Cao, Qi Bi Tags: Original Article Source Type: research

Pediatric Infective Endocarditis and Stroke:A 13-years Single-center Review
Objective: To explore the relationship between pediatric infective endocarditis and stroke.Patients and Methods: All children with infective endocarditis from January 2002 to December 2015 were included as our sample, and their medical records were comprehensively reviewed.Results: Sixty children with infective endocarditis were identified, including 30 boys and 30 girls aged from 8 months to 18 years (mean ±SD:10.3±5.6), among which 43 (71.6%) had congenital heart diseases. Left-sided endocarditis occurred in 25 of all patients (41.7%), and vegetation was found in 58 of them (96.6%).
Source: Pediatric Neurology - October 17, 2018 Category: Neurology Authors: Gui-fang CAO, Qi BI Tags: Original Article Source Type: research

Childhood Moyamoya: Looking Back to the Future
Moyamoya is a chronic, progressive steno-occlusive arteriopathy that typically affects the anterior circulation arteries of the circle of Willis. A network of deep thalamoperforating and lenticulostriate collaterals develop to by-pass the occlusion giving rise to the characteristic angiographic ‘puff of smoke’ appearance. Moyamoya confers a lifelong risk of stroke and neurological demise, with peak age of presentation in childhood ranging between 5 and 10 years. Moyamoya disease is used to refer to patients who do not have a co-morbid condition, whereas Moyamoya syndrome refers to pati ents in whom moyamoya occurs in a...
Source: Pediatric Neurology - October 15, 2018 Category: Neurology Authors: Nomazulu Dlamini, Prakash Muthusami, Catherine Amlie-Lefond Tags: Review Article Source Type: research

Short Takes
Regional oxygen extraction predicts border zone vulnerability to stroke in sickle cell disease. Neurology 2018;90:e1134-e1142. doi:10.1212/WNL.0000000000005194 Fields ME, Guilliams KP, Ragan DK, et al.
Source: Pediatric Neurology - October 11, 2018 Category: Neurology Authors: Steven G. Pavlakis Source Type: research

Stroke in pediatric bacterial meningitis: Population-based epidemiology
Bacterial meningitis is a severe infection of the nervous system with a high complication rate including stroke. The purpose of this study is to assess the incidence, risk factors, patterns and outcomes in pediatric meningitis complicated by stroke.
Source: Pediatric Neurology - September 21, 2018 Category: Neurology Authors: Mary Dunbar, Hely Shah, Siddharth Shinde, Joseph Vayalumkal, Otto G. Vanderkooi, Xing-Chang Wei, Adam Kirton Tags: Original Articles Source Type: research