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Source: Pediatric Neurology
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Total 229 results found since Jan 2013.
Modeling Developmental Plasticity After Perinatal Stroke: Defining Central Therapeutic Targets in Cerebral Palsy
Abstract: Perinatal stroke is presented as the ideal human model of developmental neuroplasticity. The precise timing, mechanisms, and locations of specific perinatal stroke diseases provide common examples of well defined, focal, perinatal brain injuries. Motor disability (hemiparetic cerebral palsy) constitutes the primary adverse outcome and the focus of models explaining how motor systems develop in health and after early injury. Combining basic science animal work with human applied technology (functional magnetic resonance imaging, diffusion tensor imaging, and transcranial magnetic stimulation), a model of plastic m...
Source: Pediatric Neurology - January 21, 2013 Category: Neurology Authors: Adam Kirton Tags: Review Articles Source Type: research
Introduction of the New Editor-in-Chief of Pediatric Neurology
Dr. E. Steve Roach has accepted the offer to be the new Editor-in-Chief of Pediatric Neurology. Dr. Roach is currently the Chief, Division of Pediatric Neurology at The Ohio State University College of Medicine; he is also the current President of the Child Neurology Society. Dr. Roach brings a broad background of interest, experience, and expertise to his new position. He has been an astute and conscientious member of the editorial board of Pediatric Neurology for many years. Childhood stroke and tuberous sclerosis are among his primary interests. He has published extensively, and his skills will hold him in good stead as...
Source: Pediatric Neurology - January 1, 2013 Category: Neurology Authors: Kenneth F. Swaiman Tags: Editorials Source Type: research
Mechanisms of Pediatric Cerebral Arteriopathy: An Inflammatory Debate
Abstract: Arteriopathy is the leading cause of childhood arterial ischemic stroke, but its mechanisms are poorly understood. This review explores the possible role of inflammatory mechanisms and evidence for inflammatory pathophysiology in specific pediatric cerebral arteriopathies. Pathologically proven small-vessel central nervous system vasculitis provides a definitive inflammatory model where available treatments are likely improving outcomes. In contrast, a common large-vessel arteriopathy presents many features suggestive of inflammation, but definitive proof remains elusive. Recent advances and future research direc...
Source: Pediatric Neurology - January 1, 2013 Category: Neurology Authors: Aleksandra Mineyko, Adam Kirton Tags: Review Articles Source Type: research
Genetic Risk Factors for Perinatal Arterial Ischemic Stroke
Abstract: The cause of perinatal arterial ischemic stroke is unknown in most cases. We explored whether genetic polymorphisms modify the risk of perinatal arterial ischemic stroke. In a population-based case-control study of 1997-2002 births at Kaiser Permanente Northern California, we identified 13 white infants with perinatal arterial ischemic stroke. Control subjects included 86 randomly selected white infants. We genotyped polymorphisms in nine genes involved in inflammation, thrombosis, or lipid metabolism previously linked with stroke, and compared genotype frequencies in case and control individuals. We tested sever...
Source: Pediatric Neurology - January 1, 2013 Category: Neurology Authors: Amy A. Gelfand, Lisa A. Croen, Anthony R. Torres, Yvonne W. Wu Tags: Original Articles Source Type: research
