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Source: Pediatric Neurology

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Total 229 results found since Jan 2013.

Acute Ischemic Stroke in a Pediatric Patient due to Osteosarcoma Embolism
We report a six-year-old with an ischemic stroke due to osteosarcoma embolism.
Source: Pediatric Neurology - April 22, 2021 Category: Neurology Authors: Min Ye Shen, Amol Mehta, Rebecca J. Zylber, Alice Lee, Randolph S. Marshall, Arezou Heshmati Tags: Clinical Letter Source Type: research

Distinct Clinical and Radiographic Phenotypes in Pediatric Moyamoya Patients
Moyamoya arteriopathies exhibit different phenotypes based on underlying etiologies. Frequent TIAs is a common phenotype of MMD and symptomatic stroke presentation a common feature of MMD and MMS-SCD, while unilateral disease and low infarct burden is common in MMS-NF1. In addition, absence of ivy sign is a common phenotype in MMS-SCD.
Source: Pediatric Neurology - April 2, 2021 Category: Neurology Authors: Matsanga Leyila Kaseka, Mahmoud Slim, Prakash Muthusami, Peter B. Dirks, Robyn Westmacott, Andrea Kassner, Ishvinder Bhathal, Suzan Williams, Manohar Shroff, William Logan, Mahendranath Moharir, Daune L. MacGregor, Elizabeth Pulcine, Gabrielle A. deVeber, Tags: Research Paper Source Type: research

Acute Fulminant Cerebellitis in Children with COVID-19 Infection: A Rare But Treatable Complication
The past year, coronavirus disease 2019 (COVID-19) has displayed widespread systemic manifestations including neurological features (up to 36%) such as stroke, myelitis, and encephalitis.1,2 We draw attention to two children with COVID-19-associated acute fulminant cerebellitis and discuss the treatment challenges.
Source: Pediatric Neurology - March 24, 2021 Category: Neurology Authors: Sanjiv Sharma, Jigish Ruparelia, Suryanarayanan Bhaskar, Sarbesh Tiwari, Vijaya Lakshmi Nag, Samhita Panda Tags: Clinical Letter Source Type: research

Acute Fulminant Cerebellitis in Paediatric COVID-19 Infection- rare, yet a potentially treatable clinical entity
This past year, coronavirus disease 2019 (COVID-19) has displayed widespread systemic manifestations including neurological features (upto 36%) such as stroke, myelitis and encephalitis.1,2 We would like to draw attention to two cases of paediatric COVID-19-associated acute fulminant cerebellitis and discuss treatment challenges.
Source: Pediatric Neurology - March 24, 2021 Category: Neurology Authors: Sanjiv Sharma, Jigish Ruparelia, Suryanarayanan Bhaskar, Sarbesh Tiwari, Vijaya Lakshmi Nag, Samhita Panda Tags: Short Communication Source Type: research

Longitudinal Stability of Spatial Inattention in Children with Perinatal Stroke
This study is a longitudinal analysis of children with perinatal infarcts, with the goals of determining the pattern of inattention found in children with both left and right hemisphere lesions, and whether or not this pattern shows signs of change over time.
Source: Pediatric Neurology - January 22, 2021 Category: Neurology Authors: Jessica Kriksciun, Caitlin Knight, Doris Trauner Tags: Research Paper Source Type: research

Acute ischemic stroke in a pediatric patient with known exposure to COVID-19 and positive serology
Neurologic manifestations of COVID-19 in pediatrics are not well understood. Recently, Kaur et al. reported a child with transverse myelitis and McAbee et al. described a child with seizures and encephalitis, in the setting of an acute COVID-19 infection.1,2 Acute ischemic stroke (AIS) and focal cerebral arteriopathy have also been reported.3
Source: Pediatric Neurology - December 14, 2020 Category: Neurology Authors: Min Ye Shen, Rachelle Dugue, Angel R. Maldonado-Soto, Kiran T. Thakur, Israel Zyskind, Wendy S. Vargas Tags: Correspondence Source Type: research

Prevent hyperglycemia in MELAS by measuring HbA1c values and by avoiding triggering events
With interest we read the article by Toki et al. about three patients with mitochondrial encephalopathy, lactic acidosis, and stroke-like episode (MELAS), who experienced a fulminant-onset hyperglycemic crisis as first manifestation of mitochondrial diabetes.[1] Hyperglycemic events occurred after surgery, infection, and status epilepticus, respectively.[1] It was concluded that MELAS-patients should routinely undergo measurement for glycated haemoglobin (HbA1c) regardless of age and lack of symptoms.[1] We have the following comments and concerns.
Source: Pediatric Neurology - November 27, 2020 Category: Neurology Authors: Josef Finsterer Tags: Correspondence Source Type: research

Sirolimus Treatment in Sturge-Weber Syndrome
Sturge-Weber syndrome is a rare neurovascular disorder associated with capillary malformation, seizures, cognitive impairments, and stroke-like episodes (SLE), arising from a somatic activating mutation in GNAQ. Studies suggest this mutation may cause hyperactivation of the mTOR pathway. Sirolimus is an mTOR inhibitor studied in other vascular anomalies, and a potentially promising therapy in Sturge-Weber syndrome.
Source: Pediatric Neurology - November 2, 2020 Category: Neurology Authors: Alison J. Sebold, Alyssa M. Day, Joshua Ewen, Jack Adamek, Anna Byars, Bernard Cohen, Eric H. Kossoff, Tomoyuki Mizuno, Matthew Ryan, Jacqueline Sievers, Lindsay Smegal, Stacy J. Suskauer, Cameron Thomas, Alexander Vinks, T. Andrew Zabel, Adrienne M. Hamm Tags: Research Paper Source Type: research

Intracranial and extracranial vascular stenosis as risk factors for stroke in sickle cell disease
Prevalence and contribution of intracranial and extracranial arterial stenosis to stroke risk were assessed prospectively in children and young adults with sickle cell disease (SCD).
Source: Pediatric Neurology - October 22, 2020 Category: Neurology Authors: Alyssa A. Schlotman, Manus J. Donahue, Adetola A. Kassim, Chelsea A. Lee, Spencer L. Waddle, Sumit Pruthi, L Taylor Davis, Mark Rodeghier, Michael R. DeBaun, Lori C. Jordan Tags: Research Paper Source Type: research

Hyperglycemic crisis in patients with mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes (MELAS)
Diabetes mellitus (DM) is the most commonly encountered endocrinopathy in patients with mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes (MELAS), which manifests as multisystemic organ failure. Whether the management of DM in MELAS requires special consideration is not fully clarified.
Source: Pediatric Neurology - September 29, 2020 Category: Neurology Authors: Taira Toki, Yuko Shimizu-Motohashi, Hirofumi Komaki, Eri Takeshita, Akihiko Ishiyama, Takashi Saito, Madoka Mori-Yoshimura, Noriko Sumitomo, Ayaka Hirasawa-Inoue, Eiji Nakagawa, Ichizo Nishino, Yu-ichi Goto, Masayuki Sasaki Tags: Short Communication Source Type: research

Author Response to Budhram, et al.
We would like to thank Budhram et  al. for their interest in our report, “A Stroke Mimic: Anti-MOG Antibody-Associated Disorder Presenting as Acute Hemiparesis.”1 As the authors pointed out,2 our patient resembles other cases that have been termed unilateral cortical FLAMES (FLAIR-hyperintense lesions in anti-MOG-associated enc ephalitis with seizures).3 In the initial description of unilateral cortical FLAMES, two pediatric patients were included in the literature review, one of whom did present with hemiparesis and lethargy.
Source: Pediatric Neurology - September 18, 2020 Category: Neurology Authors: Grace Gombolay, Michelle Tutmaher, Denise Chen, Jamika Hallman-Cooper, Philip Holt, Bryan Philbrook Tags: Correspondence Source Type: research

Neuroimaging perspectives of perinatal arterial ischemic stroke
Perinatal stroke is second only to adult stroke in the overall stroke incidence. It is a major contributor to long term neurologic morbidity which include cognitive dysfunction, cerebral palsy and seizures. Risk factors of stroke in the perinatal period differs from those in children and tend to be multi-factorial. Differences in territorial predilection, response to injury and stroke evolution exist when compared to childhood and adult stroke, and also amongst differing gestation age groups in the perinatal period (i.e.
Source: Pediatric Neurology - August 20, 2020 Category: Neurology Authors: Asthik Biswas, Kshitij Mankad, Manohar Shroff, Prasad Hanagandi, Pradeep Krishnan Tags: Review Article Source Type: research

Defining a Pediatric Stroke Center
Stroke was once recognized so infrequently in children that it was considered a medical curiosity, and until relatively recently, our understanding of the nature of cerebrovascular disorders in children was somewhat rudimentary. But we now know that cerebrovascular disorders are relatively common among children,1 and with the advent of less invasive diagnostic studies and more targeted treatments, stroke is now recognized as a very important clinical condition in children.
Source: Pediatric Neurology - August 11, 2020 Category: Neurology Authors: E. Steve Roach, Timothy Bernard, M.D. Gabrielle deVeber Source Type: research

Developmental remodelling of the motor cortex in hemiparetic children with perinatal stroke
Perinatal stroke often leads to lifelong motor impairment. Two common subtypes differ in timing, location, and mechanism of injury: periventricular venous infarcts (PVI) are fetal white matter lesions while most arterial ischemic strokes (AIS) are cortical injuries acquired near term. Both alter motor system development and primary motor cortex (M1) plasticity, often with retained ipsilateral corticospinal fibers from the non-lesioned motor cortex (M1 ’)
Source: Pediatric Neurology - August 4, 2020 Category: Neurology Authors: Kayla Baker, Helen L. Carlson, Ephrem Zewdie, Adam Kirton Tags: Research Paper Source Type: research

Cancer and Tumor-Associated Childhood Stroke: Results from the International Pediatric Stroke Study
This study sought to evaluate cancer/tumor-associated childhood ischemic stroke in a multinational pediatric stroke registry.
Source: Pediatric Neurology - June 8, 2020 Category: Neurology Authors: Lisa R. Sun, Alexandra Linds, Mukta Sharma, Mubeen Rafay, Sudhakar Vadivelu, Sarah Lee, Leonardo R. Brand ão, Brian Appavu, Jeremie H. Estepp, Juliette Hukin, Sahar M.A. Hassanein, Anthony Chan, Lauren A. Beslow, International Pediatric Stroke Study Grou Tags: Research Paper Source Type: research