Prevent hyperglycemia in MELAS by measuring HbA1c values and by avoiding triggering events

With interest we read the article by Toki et al. about three patients with mitochondrial encephalopathy, lactic acidosis, and stroke-like episode (MELAS), who experienced a fulminant-onset hyperglycemic crisis as first manifestation of mitochondrial diabetes.[1] Hyperglycemic events occurred after surgery, infection, and status epilepticus, respectively.[1] It was concluded that MELAS-patients should routinely undergo measurement for glycated haemoglobin (HbA1c) regardless of age and lack of symptoms.[1] We have the following comments and concerns.

Source: Pediatric Neurology - November 27, 2020 Category: Neurology Authors: Josef Finsterer Tags: Correspondence Source Type: research