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Source: Pediatric Neurology

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Total 229 results found since Jan 2013.

Association between the 20210G > A prothrombin gene polymorphism and arterial ischemic stroke in children and young adults – two meta-analyses of 3586 cases and 6440 controls in total
Previous data have shown that the 20210G>A polymorphism of the Factor II gene is related to an elevated prothrombin level, which may in turn lead to a procoagulant state. The heterogeneous and multifactorial character of arterial ischemic stroke (AIS) often results in contradictory reports describing the association between the 20210G>A polymorphism and AIS in different populations. We performed a meta-analysis of available data addressing the relation between the FII 20210G>A polymorphism and AIS, both in young adults and children.
Source: Pediatric Neurology - January 3, 2017 Category: Neurology Authors: Beata Sarecka-Hujar, Ilona Kopyta, Michal Skrzypek, Joanna Sordyl Source Type: research

Large-Vessel Vasculopathy in Children With Sickle Cell Disease: A Magnetic Resonance Imaging Study of Infarct Topography and Focal Atrophy
Large-vessel vasculopathy (LVV) increases stroke risk in pediatric sickle cell disease beyond the baseline elevated stroke risk in this vulnerable population. The mechanisms underlying this added risk and its unique impact on the developing brain are not established.
Source: Pediatric Neurology - December 6, 2016 Category: Neurology Authors: Kristin P. Guilliams, Melanie E. Fields, Dustin K. Ragan, Yasheng Chen, Cihat Eldeniz, Monica L. Hulbert, Michael M. Binkley, James N. Rhodes, Joshua S. Shimony, Robert C. McKinstry, Katie D. Vo, Hongyu An, Jin-Moo Lee, Andria L. Ford Tags: Original Article Source Type: research

Large Vessel Vasculopathy in Children with Sickle Cell Disease: an MRI study of Infarct Topography and Focal Atrophy
Large-vessel vasculopathy (LVV) increases stroke risk in pediatric sickle cell disease (SCD) beyond the baseline elevated stroke risk in this vulnerable population. The mechanisms underlying this added risk and its unique impact on the developing brain are not established.
Source: Pediatric Neurology - December 6, 2016 Category: Neurology Authors: Kristin P. Guilliams, Melanie E. Fields, Dustin K. Ragan, Yasheng Chen, Cihat Eldeniz, Monica L. Hulbert, Michael M. Binkley, James N. Rhodes, Joshua S. Shimony, Robert C. McKinstry, Katie Vo, Hongyu An, Jin-Moo Lee, Andria L. Ford Tags: Original Articles Source Type: research

Risks and benefits of rituximab in the treatment of Hashimoto ’s encephalopathy in children: Two case reports and a mini-review
Hashimoto ’s encephalopathy was first described in adults by Lord Brain in 1966. 1 This rare syndrome denotes an association of encephalopathy with Hashimoto thyroiditis.2 The disease is characterized by a subacute onset of confusion with altered level of consciousness, seizures and myoclonus. It’s manife stations, however vary widely and coma, hallucinations, psychosis, headache, stroke like episodes, subacute cognitive decline and tremor have all been reported.3
Source: Pediatric Neurology - September 19, 2016 Category: Neurology Authors: A. Maas, K.P.J. Braun, K. Geleijns, F.E. Jansen, A. van Royen-Kerkof Tags: Review Article Source Type: research

Ischemic Stroke Due to a Cardiac Myxoma
An 11-year old boy was admitted for lameness of the right leg evolving for 3 days and aphasia evolving for few hours. He was carrying a mutation in the gene PRKAR1A involved in the Carney complex (CNC). Family history revealed that his mother, also CNC carrier, was already operated of a cardiac myxoma three times. Physical examination found normal blood pressure and heart rate, spotty skin pigmentation all over the body, no sign of cardiac insufficiency, right flask hemiplegia, aphasia and beginning consciousness disorder.
Source: Pediatric Neurology - September 14, 2016 Category: Neurology Authors: Olivia Domanski, Romain Dubois, Bruno Jegou Tags: Visual Diagnosis Source Type: research

Thrombectomy for acute stroke in childhood: a case report, literature review, and recommendations
AHA/ASA updated guidelines include recommendation for thrombectomy in certain adult stroke cases. The safety and efficacy of thrombectomy in children is unknown.An 8-year-old girl experienced acute stroke symptoms on two occasions while therapeutically anticoagulated on NovalungR. CTs showed proximal vessel thrombi, which were retrieved using a Trevo device without hemorrhagic complications. Post-procedural assessment found respective decreases in the NIHSS score from 10 to 4 and 12 to 7. The indications for treatment and early benefits observed in our case are consistent with other paediatric thrombectomy cases reported.
Source: Pediatric Neurology - September 13, 2016 Category: Neurology Authors: Maria Celeste Buompadre, Kathleen Andres, Lee-Anne Slater, Hadi Mohseni-Bod, Anne-Marie Guerguerian, Helen Branson, Suzanne Laughlin, Derek Armstrong, Mahendranath Moharir, Gabrielle deVeber, Tilman Humpl, Osami Honjo, Shaf Keshavjee, Rebecca Ichord, Vito Tags: Review Article Source Type: research

Pediatric Stroke Clinical Pathway Improves the Time to Diagnosis in an Emergency Department
Identified barriers to the diagnosis of pediatric stroke include delays in provider recognition and definitive neuroimaging [magnetic resonance imaging (MRI)]. Clinical pathways are recommended to address these barriers; yet, few studies have evaluated their impact. Aim: Describe the impact of a pediatric stroke clinical pathway (PSCP) on the diagnosis of stroke in patients presenting with focal neurologic dysfunction to a pediatric emergency department.
Source: Pediatric Neurology - September 12, 2016 Category: Neurology Authors: Amy M. DeLaroche, Lalitha Sivaswamy, Ahmad Farooqi, Nirupama Kannikeswaran Source Type: research

Corrigendum to ‘Guidelines for Urgent Management of Stroke in Children’ Pediatric Neurology 56 (2016) 8–17
The Stroke Stat algorithm instituted at Boston Children's Hospital in 2014 was adapted from a pre-existing protocol for acute stroke evaluation and management at the The Hospital for Sick Children and was kindly provided to Dr. Rivkin by Dr. Gabrielle DeVeber in  2008.
Source: Pediatric Neurology - August 31, 2016 Category: Neurology Authors: Michael J. Rivkin, Timothy J. Bernard, Michael M. Dowling, Catherine Amlie-Lefond Tags: Corrigendum Source Type: research

Association Between Prolonged Seizures and Malignant Middle Cerebral Artery Infarction in Children With Acute Ischemic Stroke
Malignant middle cerebral artery infarct syndrome is a potentially fatal complication of stroke that is poorly understood in children. We studied the frequency, associated characteristics, and outcomes of this condition in children.
Source: Pediatric Neurology - August 26, 2016 Category: Neurology Authors: Andrea Andrade, Sandra Bigi, Suzanne Laughlin, Sujatha Parthasarathy, Adriane Sinclair, Peter Dirks, Ann Marie Pontigon, Mahendranath Moharir, Rand Askalan, Daune MacGregor, Gabrielle deVeber Tags: Original Article Source Type: research

The association between prolonged seizures and malignant middle cerebral artery infarction in children with acute ischemic stroke
Malignant middle cerebral artery infarct syndrome is a potentially fatal complication of stroke that is poorly understood in children. We studied the frequency, associated characteristics and outcomes of this condition in children.
Source: Pediatric Neurology - August 26, 2016 Category: Neurology Authors: Andrea Andrade, Sandra Bigi, Suzanne Laughlin, Sujatha Parthasarathy, Adriane Sinclair, Peter Dirks, Ann Marie Pontigon, Mahendranath Moharir, Rand Askalan, Daune MacGregor, Gabrielle deVeber Source Type: research

Epilepsy characteristics and clinical outcome in patients with mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) due to mtDNA A3243G mutation
Epileptic seizures in patients with mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) are reportedly known for heterogeneity with no pathognomic features. We reviewed epilepsy characteristics and clinical outcome exclusively in a pediatric population.
Source: Pediatric Neurology - August 24, 2016 Category: Neurology Authors: Ha Neul Lee, Soyong Eom, Se Hoon Kim, Hoon-Chul Kang, Joon Soo Lee, Heung Dong Kim, Young-Mock Lee Source Type: research

Fabry Disease: A Disorder of Childhood Onset
Fabry disease, an X-linked disorder of glycosphingolipids, markedly increases the risk of systemic vasculopathy, ischemic stroke, small-fiber peripheral neuropathy, cardiac dysfunction and chronic kidney disease.
Source: Pediatric Neurology - July 28, 2016 Category: Neurology Authors: Raphael Schiffmann, Markus Ries Tags: Review Article Source Type: research

Quality of Life in Pediatric Moyamoya Disease
Moyamoya Disease (MMD) is a progressive intracranial arteriopathy with high risk of stroke. Its impact on quality of life is unstudied. We surveyed children with MMD and compared their quality of life to chronically-ill children and children with stroke to better understand the impact of this diagnosis.
Source: Pediatric Neurology - June 26, 2016 Category: Neurology Authors: Alexander Ball, Gary Steinberg, Jorina Elbers Source Type: research

Vascular imaging outcomes of childhood primary angiitis of the central nervous system
Inflammation affecting cerebral blood vessels is a common cause of stroke in children. Arterial abnormalities on vascular imaging are an important risk factor for stroke recurrence. We aimed to describe the vascular imaging outcomes in children with primary angiitis of the central nervous system (cPACNS) after 12-months, and identify factors associated with vascular progression and stroke recurrence.
Source: Pediatric Neurology - June 16, 2016 Category: Neurology Authors: Jorina Elbers, Derek Armstrong, Ivanna Yau, Susanne Benseler Source Type: research