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Source: Pediatric Neurology
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Total 229 results found since Jan 2013.
“Black Toenail” sign
A 11-year-old boy with genetically confirmed MELAS (mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes syndrome with mutation at mt.3243A>G) presented with extreme fatigue. He had elevated lactic acid of 5.2 mmol/L upon presentation. His magnetic resonance imaging (MRI) scan of the brain showed progression of multifocal gyral necrosis and cerebral atrophy compared to the images done 3 years prior to presentation (Fig. 1). He was discharged soon after his fatigue resolved in response to supportive therapy.
Source: Pediatric Neurology - September 20, 2018 Category: Neurology Authors: Norimitsu Kuwabara, Namrata Shah Source Type: research
Incidence of and Associated Factors Related to Epilepsy in Perinatal Arterial Ischemic Stroke Survivors
We examined studies on perinatal or neonatal patients ( ≤ 28 days of life) with arterial ischemic strokes in which the development of epilepsy was reported.
Source: Pediatric Neurology - September 20, 2018 Category: Neurology Authors: Abbas Rattani, Jaims Lim, Akshitkumar M Mistry, Marc A Prablek, Steven G Roth, Lori C Jordan, Chevis N Shannon, Robert P Naftel Source Type: research
Incidence of Epilepsy and Associated Risk Factors in Perinatal Ischemic Stroke Survivors
Epilepsy is a serious and often lifelong consequence of perinatal arterial ischemic stroke (PAIS). Variable incidences and risk factors for long-term epilepsy in PAIS have been reported. To determine the incidence of epilepsy in PAIS survivors and report factors associated with the risk of developing epilepsy, a meta-analysis and systematic review of prior publications was performed.
Source: Pediatric Neurology - September 20, 2018 Category: Neurology Authors: Abbas Rattani, Jaims Lim, Akshitkumar M. Mistry, Marc A. Prablek, Steven G. Roth, Lori C. Jordan, Chevis N. Shannon, Robert P. Naftel Tags: Original Article Source Type: research
In-Hospital Pediatric Stroke Alert Activation
Pediatric stroke alerts or “code strokes” allow for rapid evaluation, imaging and treatment of children presenting with stroke-like symptoms. In a previous study of emergency department-initiated pediatric stroke alerts, 24% of children had confirmed strokes. The purpose of this study was to characterize in-hospital pedia tric stroke alerts.
Source: Pediatric Neurology - August 10, 2018 Category: Neurology Authors: Megan Barry, Truc M. Le, Melissa C. Gindville, Lori C. Jordan Tags: Original Articles Source Type: research
Pediatric Stroke Imaging
Pediatric stroke is a distinct clinical entity as compared to that in adults due to its unique and diverse set of etiologies. Furthermore, the role and application of diagnostic imaging has specific constraints and considerations. The intention of this article is to review these concepts in a thorough manner to offer a pediatric stroke imaging framework that providers can employ when taking care of these patients.
Source: Pediatric Neurology - July 9, 2018 Category: Neurology Authors: Alexander Khalaf, Michael Iv, Heather Fullerton, Max Wintermark Tags: Review Article Source Type: research
Bizarre Arterial Beading in a Child With Stroke
This 11-year-old girl with thalassemia major who received regular blood transfusions and oral deferiprone presented with a two year history of intermittent dizziness. Examination revealed cerebellar signs.
Source: Pediatric Neurology - July 3, 2018 Category: Neurology Authors: Nupur Parakh, Vinit Baliyan, Puneet Jain, Suvasini Sharma, Atin Kumar Tags: Visual Diagnosis Source Type: research
Bizarre beading in a child with stroke
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Source: Pediatric Neurology - July 3, 2018 Category: Neurology Authors: Nupur Parakh, Vinit Baliyan, Puneet Jain, Suvasini Sharma, Atin Kumar Tags: Visual Diagnosis Source Type: research
Cockayne Syndrome Complicated by Moyamoya Vasculopathy and Stroke
A 17-year-old male with Cockayne syndrome type B (heterozygous c.3536delA variation resulting in frame shift pathogenic variant and a compound heterozygous c.2830-2A->G variation resulting in a splicing probable pathogenic variant of the ERCC6 gene) and progressive sensorineural hearing loss requiring cochlear implantation one year prior presented after a one hour episode of transient right-sided weakness with decreased responsiveness. He had a similar episode one week prior. His examination was consistent with the stigmata of Cockayne syndrome —progeroid facies, microcephaly, cachectic dwarfism weighing 9.8kg, diffuse h...
Source: Pediatric Neurology - May 18, 2018 Category: Neurology Authors: Robert C. Stowe, Andres Jimenez-Gomez, Alfred Balasa, Gary D. Clark Tags: Clinical Letter Source Type: research
Quantitative Apparent Diffusion Coefficient Mapping May Predict Seizure Onset in Children with Sturge-Weber Syndrome
This study aims to identify early pathophysiological changes that exist prior to the development of clinical symptoms and evaluate if the Apparent Diffusion Coefficient (ADC) map is a candidate early biomarker of seizure risk in patients with SWS.
Source: Pediatric Neurology - April 12, 2018 Category: Neurology Authors: Anna L.R. Pinto, Yangming Ou, Mustafa Sahin, P. Ellen Grant Tags: Short Communication Source Type: research
Neuroplasticity: The Other Side of the Coin
Neuroplasticity has gained notoriety as a term used to describe the brain's ability to develop new connections following injury, with an implication for functional recovery. From the neonatal brain to an adult stroke survivor, the central nervous system has the remarkable ability to change through experience-dependent plasticity. But what happens when those experiences are negative life experiences rather than positive? Instead of a brain focused on stimulation and rehabilitation, what happens when the developing nervous system is exposed to the neural, biochemical, and hormonal effects of overwhelming stress such as negle...
Source: Pediatric Neurology - March 26, 2018 Category: Neurology Authors: Ria Pal, Jorina Elbers Tags: Perspectives in Pediatric Neurology Source Type: research
Neuroplasticity: the Other Side of the Coin
In neuroscience, neuroplasticity has gained notoriety as a term used to describe the brain's ability to develop new connections following injury, with an implication for functional recovery. From the neonatal brain to an adult stroke survivor, the central nervous system has the remarkable ability to change through experience-dependent plasticity. But what happens when those experiences are negative life experiences, rather that positive? Instead of a brain focused on stimulation and rehabilitation, what happens to the developing nervous system when it is exposed to the neural, biochemical and hormonal effects of overwhelmi...
Source: Pediatric Neurology - March 26, 2018 Category: Neurology Authors: Ria Pal, Jorina Elbers Tags: Perspectives in Pediatric Neurology Source Type: research
Mechanical Thrombectomy in an Infant With Acute Embolic Stroke
This 9-month-old previously healthy male infant was admitted with acute respiratory failure because of parainfluenza infection, requiring intubation. On the day after admission, an acute pulmonary hypertension crisis caused cardiovascular collapse and led to initiation of venoarterial extracorporeal membrane oxygenation (ECMO) with standard therapeutic anticoagulation. The following day, on routine neurological assessment, the patient was noted to have bilateral fixed and dilated pupils. With decreased rates of sedative and paralytic infusions, he was noted to only move the left side of his body with preserved lower brainstem activity.
Source: Pediatric Neurology - February 15, 2018 Category: Neurology Authors: Lisa R. Sun, Monica Pearl, Mona N. Bahouth, Melisa Carrasco, Katherine Hoops, Jennifer Schuette, Ryan J. Felling Tags: Clinical Letter Source Type: research
Mechanical Thrombectomy in an Infant with Acute Embolic Stroke
A 9-month-old previously healthy male infant was admitted with acute respiratory failure due to parainfluenza infection requiring intubation. On the day after admission, an acute pulmonary hypertension crisis causing cardiovascular collapse led to initiation of venoarterial extracorporeal membrane oxygenation (ECMO) with standard therapeutic anticoagulation. The following day, on routine neurologic assessment, the patient was noted to have bilateral fixed and dilated pupils. With decreased rates of sedative and paralytic infusions, he was noted to only move the left side of his body with preserved lower brainstem activity.
Source: Pediatric Neurology - February 15, 2018 Category: Neurology Authors: Lisa R. Sun, Monica Pearl, Mona N. Bahouth, Melisa Carrasco, Katherine Hoops, Jennifer Schuette, Ryan J. Felling Tags: Clinical Letter Source Type: research
Post Varicella Arterial Ischaemic Stroke in Denmark 2010-2016
Background: Varicella, most often a benign disease of childhood, is associated with an increased risk of arterial ischaemic stroke (AIS) in children. The aim of the present study was to estimate the incidence of post varicella AIS in the Danish child population and describe clinical characteristics of children admitted with post varicella AIS. Methods: In the Danish National Patient Register, we identified inpatients 28 days-16 years of age with a discharge diagnosis of stroke and/or cerebrovascular disease from 2010-2016.
Source: Pediatric Neurology - December 1, 2017 Category: Neurology Authors: Ida Glode Helmuth, K åre Mølbak, Peter Vilhelm Uldall, Anja Poulsen Tags: Original Articles Source Type: research
