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Total 229 results found since Jan 2013.

Central Apnea in a COVID19 Pediatric Patient
We report a pediatric patient with COVID 19 associated encephalopathy characterized by focal seizures and central apnea.
Source: Pediatric Neurology - June 3, 2020 Category: Neurology Authors: Stephanie Enner, Sanaya Hormozdyaran, Robin Varughese, Jennifer Milillo, Ivan Pavkovic, Emma Laureta, James Schneider, Sanjeev Kothare Tags: Short Communication Source Type: research

Central Apnea in an Adolescent With COVID-19
We describe a pediatric girl with COVID-19 –associated encephalopathy characterized by focal seizures and central apnea.
Source: Pediatric Neurology - June 3, 2020 Category: Neurology Authors: Stephanie Enner, Sanaya Hormozdyaran, Robin Varughese, Jennifer Milillo, Ivan Pavkovic, Emma Laureta, James Schneider, Sanjeev Kothare Tags: Clinical Letter Source Type: research

Unilateral Cortical Fluid-Attenuated Inversion Recovery –Hyperintense Lesions in Anti-Myelin Oligodendrocyte Glycoprotein–Associated Encephalitis With Seizures (FLAMES): An Under-recognized Entity
We read with interest the article by Tutmaher et  al.1 They report an 11-year-old girl with acute-onset right hemiparesis concerning for stroke. Brain magnetic resonance imaging revealed mild left frontoparietal cortical T2-weighted fluid-attenuated inversion recovery (FLAIR) hyperintensity. She was ultimately diagnosed with myelin oligodendrocyt e glycoprotein-immunoglobulin G (MOG-IgG)–associated disease (MOGAD). MOGAD is a recently recognized subset of central nervous system inflammatory demyelinating diseases, to which children and young adults seem particularly predisposed.
Source: Pediatric Neurology - May 10, 2020 Category: Neurology Authors: Adrian Budhram, Ario Mirian, Eoin P. Flanagan Tags: Correspondence Source Type: research

Unilateral cortical FLAIR-hyperintense Lesions in Anti-MOG Encephalitis with Seizures (FLAMES): An under-recognized entity
We read with interest the article by Tutmaher et al.(1). The authors report an 11-year-old girl with acute-onset right hemiparesis concerning for stroke. Brain magnetic resonance imaging (MRI) revealed mild left fronto-parietal cortical T2-fluid-attenuated inversion recovery (FLAIR) hyperintensity. She was ultimately diagnosed with myelin oligodendrocyte glycoprotein (MOG)-IgG-associated disease (MOGAD). MOGAD is a recently recognized subset of central nervous system inflammatory demyelinating diseases, to which children and young adults seem particularly pre-disposed(2).
Source: Pediatric Neurology - May 10, 2020 Category: Neurology Authors: Adrian Budhram, Ario Mirian, Eoin P. Flanagan Tags: Correspondence Source Type: research

A Stroke Mimic: Anti-MOG Antibody-Associated Disorder Presenting as Acute Hemiparesis
Demyelinating, inflammatory, and autoimmune conditions have been implicated as pediatric stroke mimics.1 Anti-myelin oligodendrocyte glycoprotein-associated disorder (MOG-AD) has not yet been identified as a pediatric stroke mimic. MOG-AD is a distinct entity with varying clinical demyelinating diseases due to anti-MOG antibodies (MOG-ab).2,3 Here we describe a patient who presented with acute-onset hemiparesis and respiratory failure with positive MOG-ab.
Source: Pediatric Neurology - March 10, 2020 Category: Neurology Authors: Michelle S. Tutmaher, Denise F. Chen, Jamika Hallman-Cooper, Philip J. Holt, Bryan Philbrook, Grace Y. Gombolay Tags: Clinical Letter Source Type: research

A Stroke Mimic: anti-MOG antibody associated disorder presenting as acute hemiparesis
Demyelinating, inflammatory, and autoimmune conditions have been implicated as pediatric stroke mimics.1 Anti-myelin oligodendrocyte glycoprotein-Associated Disorders (MOG-AD) has not yet been identified as a pediatric stroke mimic. MOG-AD is a distinct entity with varying clinical demyelinating diseases due to anti-MOG antibodies (MOG-ab).2,3 Here we describe a patient who presented with acute onset hemiparesis and respiratory failure with positive MOG-ab.
Source: Pediatric Neurology - March 10, 2020 Category: Neurology Authors: Michelle S. Tutmaher, Denise F. Chen, Jamika Hallman-Cooper, Philip J. Holt, Bryan Philbrook, Grace Y. Gombolay Tags: Short Communication Source Type: research

Cerebral Vascular Complications of Pediatric Blunt Trauma
Ischemic and hemorrhagic stroke can occur in the setting of pediatric trauma, particularly those with head or neck injuries. The risk of stroke appears highest within the first two weeks after trauma. Stroke diagnosis may be challenging due to lack of awareness or concurrent injuries limiting detailed neurologic assessment. Other injuries may also complicate stroke management, with competing priorities for blood pressure, ventilator management, or antithrombotic timing. Here we review epidemiology, clinical presentation and diagnostic approach to blunt arterial injuries including dissection, cerebral sinovenous thrombosis,...
Source: Pediatric Neurology - January 9, 2020 Category: Neurology Authors: Maria M. Galardi, Jennifer M. Strahle, Alex Skidmore, Akash P. Kansagra, Kristin P. Guilliams Tags: Review Article Source Type: research

Cerebrovascular Complications of Pediatric Blunt Trauma
Ischemic and hemorrhagic stroke can occur in the setting of pediatric trauma, particularly those with head or neck injuries. The risk of stroke appears highest within the first two weeks after trauma. Stroke diagnosis may be challenging due to lack of awareness or concurrent injuries limiting detailed neurological assessment. Other injuries may also complicate stroke management, with competing priorities for blood pressure, ventilator management, or antithrombotic timing. Here we review epidemiology, clinical presentation, and diagnostic approach to blunt arterial injuries including dissection, cerebral sinovenous thrombos...
Source: Pediatric Neurology - January 9, 2020 Category: Neurology Authors: Maria M. Galardi, Jennifer M. Strahle, Alex Skidmore, Akash P. Kansagra, Kristin P. Guilliams Tags: Review Article Source Type: research

Rapid Sequence MRI Protocol in the Evaluation of Pediatric Brain Attacks
The objective of our study was to evaluate the clinical utility of rapid sequence magnetic resonance imaging (MRI) utilizing diffusion weighted imaging (DWI) and fluid attenuated inversion recovery (FLAIR) sequences in children with acute ischemic strokes and non-stroke brain attacks.
Source: Pediatric Neurology - December 26, 2019 Category: Neurology Authors: Gracia De Jong, Nirupama Kannikeswaran, Amy DeLaroche, Ahmad Farooqi, Lalitha Sivaswamy Tags: Research Paper Source Type: research

Outcome Trajectories after Primary Perinatal Hemorrhagic Stroke
We describe 2-month and 2-year neurological outcomes in a prospective cohort.
Source: Pediatric Neurology - December 6, 2019 Category: Neurology Authors: Giulia S. Porcari, Lori C. Jordan, Rebecca N. Ichord, Daniel J. Licht, Sabrina E. Smith, Lauren A. Beslow Tags: Research Paper Source Type: research

Ischaemic Stroke Following Ergotamine Overdose
The use of ergotamine in the treatment of migraine has become disputed due to its significant side effects, such as arterial vasospasm particularly affecting peripheral arteries[1]. However, there is conflicting evidence about the effect of ergotamine on cerebral blood flow[2 –4]. Currently, ergotamine continues to be utilised, albeit off-licence, for the treatment of refractory migraine in paediatric patients[5]. Yet, there is a lack of evidence supporting ergotamine’s utility and safety in migraine treatment[5].
Source: Pediatric Neurology - August 5, 2019 Category: Neurology Authors: Nadja F. Bednarczuk, Ming Lim, Ata Siddiqui, Karine Lascelles Tags: Clinical Letter Source Type: research

Ischemic Stroke Following Ergotamine Overdose
The use of ergotamine in the treatment of migraine has become disputed because of its significant side effects, such as arterial vasospasm particularly affecting the peripheral arteries.1 However, there is conflicting evidence about the effect of ergotamine on cerebral blood flow.2-4 At present, ergotamine continues to be utilized, albeit off-license, for the treatment of refractory migraine in pediatric patients.5 Yet, there is a lack of evidence supporting ergotamine's utility and safety in migraine treatment.
Source: Pediatric Neurology - August 5, 2019 Category: Neurology Authors: Nadja F. Bednarczuk, Ming Lim, Ata Siddiqui, Karine Lascelles Tags: Clinical Letter Source Type: research

Long-term outcome after bilateral perinatal arterial ischemic stroke
To characterize phenotype and outcomes of children with bilateral, large vessel perinatal arterial ischemic stroke.
Source: Pediatric Neurology - August 1, 2019 Category: Neurology Authors: Aleksandra Mineyko, Adam Kirton Tags: Original Articles Source Type: research

MRI Evaluation of Wallerian Degeneration and Association with Motor Outcome in Childhood Stroke
and Purpose: To evaluate the presence of WD and its relationship to sensorimotor deficits following childhood-onset arterial ischemic stroke (AIS).
Source: Pediatric Neurology - July 30, 2019 Category: Neurology Authors: Trish Domi, Gabrielle deVeber, Dr. David Mikulis, Andrea Kassner Tags: Original Articles Source Type: research

Wallerian Degeneration of the Cerebral Peduncle and Association with Motor Outcome in Childhood Stroke
To evaluate the presence of Wallerian degeneration and its relationship with sensorimotor deficits following childhood-onset arterial ischemic stroke (AIS).
Source: Pediatric Neurology - July 30, 2019 Category: Neurology Authors: Trish Domi, Gabrielle deVeber, David Mikulis, Andrea Kassner Tags: Original Article Source Type: research