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Source: Pediatric Neurology

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Total 229 results found since Jan 2013.

Monogenic Causes of Cerebrovascular Disease in Childhood: A Case Series
Despite an increase in the number of genes associated with pediatric stroke, imaging phenotypes in children have not been well reported. Guidelines are needed to facilitate identification and treatment of patients with monogenic causes of cerebrovascular disorders.
Source: Pediatric Neurology - September 6, 2023 Category: Neurology Authors: Bridget E.L. Ostrem, Deena Godfrey, Paul Caruso, Patricia Musolino Tags: Research Paper Source Type: research

Perinatal Stroke in a Chinese Neonatal Center: Clinical Characteristics, Long-Term Outcomes, and Prognostic Factors
To assess the clinical characteristics, long-term outcomes, and prognostic factors of perinatal stroke.
Source: Pediatric Neurology - August 21, 2023 Category: Neurology Authors: Qianqian Xia, Fa Guo, Xinlin Hou, Zezhong Tang, Lili Liu Tags: Research Paper Source Type: research

Stroke in the Developing Brain: Neurophysiological Implications of Stroke Timing, Location, and Comorbid Factors
Pediatric stroke, which is unique in that it represents a static insult to a developing brain, often leads to long-term neurological disability. Neuroplasticity in infants and children influences neurophysiologic recovery patterns after stroke therefore outcomes depend on several factors including timing and location of stroke and the presence of comorbid conditions.
Source: Pediatric Neurology - August 11, 2023 Category: Neurology Authors: Nayo M. Hill, Laura A. Malone, Lisa R. Sun Source Type: research

Inherited thrombophilia associated with ischemic pediatric stroke in parents-child pairs
We aimed to examine inherited thrombophilia frequencies by extending genetic profile to previously rarely or not-investigated polymorphisms, in children with ischemic pediatric stroke (IPS) and their parents.The study included 33 children: 23 with perinatal (PAIS), 8 with childhood arterial ischemic stroke (CAIS) and 2 with sinovenous thrombosis (SVT) and their parents (33 mother-child, 12 father-child and 12 mother-father-child pairs). Genotyping of FV-Leiden, FV-H1299R, FII-G20210A, β-fibrinogen-455G>A, FXIII-A-Val34Leu, PAI-1(4G/5G), HPA-1, MTHFR-C677T, MTHFR-A1298C, ACE(I/D) and APOE( ε2-4) was performed using CVD St...
Source: Pediatric Neurology - June 27, 2023 Category: Neurology Authors: Jasna Lenicek Krleza, Desiree Coen Herak, Ivana Đakovic, Katarina Vulin, Goran Roic, Ana Tripalo Batoš, Andrea Čeri, Renata Zadro, Vlasta Đuranovic Tags: Research Paper Source Type: research

Inherited Thrombophilia Associated With Ischemic Pediatric Stroke in Parent-Child Pairs
We aimed to examine inherited thrombophilia frequencies by extending genetic profile to previously rarely or not investigated polymorphisms in children with ischemic pediatric stroke (IPS) and their parents.
Source: Pediatric Neurology - June 27, 2023 Category: Neurology Authors: Jasna Lenicek Krleza, Desiree Coen Herak, Ivana Đakovic, Katarina Vulin, Goran Roic, Ana Tripalo Batoš, Andrea Čeri, Renata Zadro, Vlasta Đuranovic Tags: Research Paper Source Type: research

Seizures in Pediatric Moyamoya: Risk Factors and Functional Outcomes
Children with moyamoya arteriopathy are at high risk for stroke and seizures. Risk factors for seizures and the impact of seizures on neurologic outcomes in children with moyamoya are unknown.
Source: Pediatric Neurology - May 8, 2023 Category: Neurology Authors: John R. Gatti, Rachel Penn, Syed Ameen Ahmad, Lisa R. Sun Tags: Research Paper Source Type: research

Mineralizing Lenticulostriate Vasculopathy: An Emerging Risk Factor for Basal Ganglia Stroke after Minor Head Trauma in Young Children
Mineralizing lenticulostriate vasculopathy is a well-recognized risk factor for basal ganglia stroke after minor head trauma in infants and young children. It is diagnosed on head computed tomography by the presence of basal ganglia calcification, seen as punctate hyperdensities on axial and linear hyperdensities on reconstructed coronal and sagittal images. In children with anterior fontanel window, its presence is suggested by branching hyperechogenic stripes in the basal ganglia region on cranial ultrasound.
Source: Pediatric Neurology - May 8, 2023 Category: Neurology Authors: Jatinder Singh Goraya Tags: Review Article Source Type: research

Sexual and Gender Diversity in Pediatric Neurology: Why We Care
Sexual and gender diversity (SGD) – an inclusive term describing people who identify outside of heteronormative binary concepts of gender and sexuality – directly affects us in the pediatric neurology clinic. SGD identity can impact various neurological conditions, including headache, epilepsy, and functional neurological disord ers, all of which have been observed at higher rates in the SGD community.1-4 Gender-affirming hormone therapy can interact with medications commonly used to treat neurological conditions1,5,6 and may increase the risk for idiopathic intracranial hypertension7 and stroke.
Source: Pediatric Neurology - April 19, 2023 Category: Neurology Authors: Alison Christy, Jaclyn Martindale, Jennifer Hranilovich, Casey Orozco-Poore, Finley Kernan-Schloss, Chase T.M. Anderson, Jonathan Strober, Wendy Mitchell, Mackenzie P. Lerario Tags: Editorial Source Type: research

Massive Neonatal Arterial Ischemic Stroke
Massive infarction in adults is a devastating entity characterized by signs of extreme swelling of the brain ’s parenchyma. We explored whether a similar entity exists in neonates, which we call Massive Neonatal Arterial Ischemic Stroke (M-NAIS), and assess its potential clinical implications.
Source: Pediatric Neurology - March 23, 2023 Category: Neurology Authors: Gemma Arca, Christian N úñez, Christian Stephan-Otto, Juan Arnaez, Thais Agut, Malaika Cordeiro, Nuria Boronat, Simón Lubián-López, Isabel Benavente-Fernández, Eva Valverde, Alfredo Garcia-Alix Tags: Research Paper Source Type: research

Diffusion-Weighted Magnetic Resonance Imaging Demonstrates White Matter Alterations in Watershed Regions in Children With Moyamoya Without Stroke or Silent Infarct
Moyamoya is a disease with progressive cerebral arterial stenosis leading to stroke and silent infarct. Diffusion-weighted magnetic resonance imaging (dMRI) studies show that adults with moyamoya have significantly lower fractional anisotropy (FA) and higher mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) compared with controls, which raises concern for unrecognized white matter injury. Children with moyamoya have significantly lower FA and higher MD in their white matter compared with controls.
Source: Pediatric Neurology - March 15, 2023 Category: Neurology Authors: Banu Ahtam, Marina Solti, Justin M. Doo, Henry A. Feldman, Rutvi Vyas, Fan Zhang, Lauren J. O'Donnell, Yogesh Rathi, Edward R. Smith, Darren Orbach, Alfred P. See, P. Ellen Grant, Laura L. Lehman Tags: Research Paper Source Type: research

Diffusion Magnetic Resonance Imaging Demonstrates White Matter Alterations in Watershed Regions in Children with Moyamoya without Stroke or Silent Infarct
Moyamoya is a disease with progressive cerebral arterial stenosis leading to stroke and silent infarct. Diffusion magnetic resonance imaging (dMRI) studies show that adults with moyamoya have significantly lower fractional anisotropy (FA) and higher mean diffusivity (MD), axial diffusivity (AD) and radial diffusivity (RD) compared to controls. This raises concern for unrecognized white matter injury. Children with moyamoya have significantly lower FA and higher MD in their white matter compared to controls.
Source: Pediatric Neurology - March 15, 2023 Category: Neurology Authors: Banu Ahtam, Marina Solti, Justin M. Doo, Henry A. Feldman, Rutvi Vyas, Fan Zhang, Lauren J. O ’Donnell, Yogesh Rathi, Edward R. Smith, Darren Orbach, Alfred P. See, P. Ellen Grant, Laura L. Lehman Tags: Research Paper Source Type: research

Before blaming SARS-CoV-2 for cerebrovascular disease in children, all differentials need to be ruled out
We read with interest the article by Spanelova et al. about four pediatric patients with cerebrovascular complications after a putative SARS-CoV-2 infection [1]. Patient-1 was diagnosed with subdural hematoma (SDH) and meningitis, patient-2 with cerebral vasculitis, patient-3 with lacunar stroke, and patient-4 with venous sinus thrombosis (VST) with haemorrhage [1]. It was concluded that SARS-CoV-2 infections in children can be complicated by cerebro-vascular disease [1]. The study is promising but raises concerns that should be discussed.
Source: Pediatric Neurology - February 14, 2023 Category: Neurology Authors: Josef Finsterer Tags: Correspondence Source Type: research

Case Report: Successful Anterior Circulation Thrombectomy After 24  Hours in an Adolescent
Arterial ischemic  stroke in children comes with the potential for morbidity and mortality and can result in high cost of care and decreased quality of life among survivors. Children with arterial ischemic stroke are increasingly being treated with mechanical thrombectomy, but little is known about the risks an d benefits 24 hours after a patient’s last known well (LKW) time.
Source: Pediatric Neurology - January 27, 2023 Category: Neurology Authors: Victoria Vinarsky, Lisa R. Sun, Vivek S. Yedavalli, Lindsay Schleifer, Karissa Arthur, Ferdinand Hui, Dana B. Harrar Tags: Research Paper Source Type: research

Case Report: Successful Anterior Circulation Thrombectomy After 24 Hours in An Adolescent
Arterial ischemic stroke (AIS) in children comes with the potential for morbidity and mortality and can result in a high cost of care and decreased quality of life among survivors.Children with AIS are increasingly being treated with mechanical thrombectomy (MT), but little is known about the risks and benefits 24 hours after a patient ’s last known well (LKW) time. A 16-year-old female presented with acute onset of dysarthria and right hemiparesis with LKW time 22 hours prior. Pediatric National Institutes of Health Stroke Scale (PedNIHSS) was 12.
Source: Pediatric Neurology - January 27, 2023 Category: Neurology Authors: Victoria Vinarsky, Lisa R. Sun, Vivek S. Yedavalli, Lindsay Schleifer, Karissa Arthur, Ferdinand Hui, Dana B. Harrar Tags: Research Paper Source Type: research

Roadmap for the Assessment and Management of Outcomes in Pediatric Stroke
Neurologic morbidity is common after pediatric stroke, with moderate to severe deficits that can significantly impact education and social function. Care and recovery occur in phases distinguished by the time interval after stroke onset. These phases include the hyperacute and acute periods in which the focus is on cerebral reperfusion and prevention of neurologic deterioration, followed by the subacute and chronic phases in which the focus is on secondary stroke prevention and mitigation of disability through rehabilitation, adaptation, and reintegration into the community.
Source: Pediatric Neurology - January 19, 2023 Category: Neurology Authors: Ryan J. Felling, Lori C. Jordan, Christine Mrakotsky, Gabrielle deVeber, Rachel K. Peterson, Aleksandra Mineyko, Samantha J. Feldman, Kevin Shapiro, Warren Lo, Lauren A. Beslow Tags: Review Article Source Type: research