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Condition: Stroke
Drug: Prozac
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Total 193 results found since Jan 2013.
Measuring Ambulation, Motor, and Behavioral Outcomes with Poststroke Fluoxetine in Tanzania: The Phase II MAMBO Trial
Am J Trop Med Hyg. 2021 Dec 6:tpmd210653. doi: 10.4269/ajtmh.21-0653. Online ahead of print.ABSTRACTWe test the safety of fluoxetine postischemic stroke in sub-Saharan Africa. Adults with acute ischemic stroke, seen <14 days since new-onset motor deficits, were enrolled from November 2019 to October 2020 in a single-arm, open-label phase II trial of daily fluoxetine 20 mg for 90 days at Muhimbili National Hospital, Dar es Salaam, Tanzania. The primary outcome was safety with secondary outcomes of medication adherence and tolerability. About 34 patients were enrolled (11 were female; mean age 52.2 years, 65% < 60 year...
Source: Am J Trop Med Hyg - December 6, 2021 Category: Infectious Diseases Authors: Farrah Mateen Emmanuel Massawe Notburga Mworia Seif Ismail Dylan Rice Andre Vogel Boniface Kapina Novath Mukyanuzi Deus Buma Jef Gluckstein Michael Wasserman Susan Fasoli Faraja Chiwanga Kigocha Okeng'o Source Type: research
Fluoxetine enhances Brain Derived Neurotropic Factor Serum Concentration and Cognition in Patients with Vascular Dementia.
Abstract
Selective serotonin reuptake inhibitors (SSRIs) improve cognition in patients with stroke and increase the expression of brain-derived neurotrophic factor (BDNF) in the rat hippocampus. However, the effects of SSRIs on cognition and BDNF level in vascular dementia (VaD) patients are largely unknown. We performed an open-label study to investigate the effects of fluoxetine, a selective serotonin reuptake inhibitor, on mini-mental state examination (MMSE) score and serum BDNF level in VaD patients. Fifty VaD patients were randomly allocated to receive fluoxetine (20 mg/d; n = 25) or no fluoxetine (control g...
Source: Current Neurovascular Research - August 19, 2013 Category: Neurology Authors: Liu X, Zhang J, Sun D, Fan Y, Zhou H, Fu B Tags: Curr Neurovasc Res Source Type: research
Autism in the Son of a Woman with Mitochondrial Myopathy and Dysautonomia: A Case Report
Conclusion
Given emerging evidence that mitochondrial dysfunction, particularly in the electron transport chain needed for cellular energy production, is an underlying pathophysiological mechanism for some varieties of ASD, clinicians should have a high index of suspicion for mitochondrial disease, especially when they encounter a patient with unusual neurological or constitutional symptoms. The prevalence of mitochondrial disease in ASD patients may be as high as five percent, which means that it is not the “zebra”[27] diagnosis that it might be in a non-ASD patient, where prevalence is about 0.01 percent.10
Reference...
Source: Innovations in Clinical Neuroscience - October 9, 2015 Category: Neuroscience Authors: ICN Online Editor Tags: Anxiety Disorders Asperger's syndrome Autism Behavioral and Cognitive Neurology Case Report Current Issue Intellectual Disability Neurologic Systems and Symptoms Pervasive Developmental Disorders ASD autism spectrum disorder dysauton Source Type: research
Potassium 2-(1-hydroxypentyl)-benzoate improves depressive-like behaviors in rat model
In this study, we demonstrated that PHPB improved depressive-like behaviors induced by chronic unpredictable mild stress (CUMS) in rats. Male SD rats were subjected to the stress for five weeks. PHPB (30 and 100 mg/kg) or fluoxetine (FLX 10 mg/kg, as positive control) was administered orally from the third week in CUMS procedure. The behavioral tests were applied and then the biochemical studies were carried out. PHPB or FLX treatment rescued the behavioral deficiency in CUMS-exposed rats. Meanwhile, PHPB normalized the enhanced level of serum corticosterone, improved hippocampal and serum BDNF levels, as well as...
Source: Acta Pharmaceutica Sinica B - August 21, 2018 Category: Cancer & Oncology Source Type: research
Effect of fluoxetine on HIF-1 α- Netrin/VEGF cascade, angiogenesis and neuroprotection in a rat model of transient middle cerebral artery occlusion.
Effect of fluoxetine on HIF-1α- Netrin/VEGF cascade, angiogenesis and neuroprotection in a rat model of transient middle cerebral artery occlusion.
Exp Neurol. 2020 Apr 12;:113312
Authors: Hu Q, Liu L, Zhou L, Lu H, Wang J, Chen X, Wang Q
Abstract
Fluoxetine is one of the most promising drugs for improving clinical outcome in patients with ischemic stroke. This in vivo study investigated the hypothesis that fluoxetine may affect HIF-1α-Netrin/VEGF cascade, angiogenesis and neuroprotection using a rat model of transient middle cerebral artery occlusion (tMCAO). The rats were given fluoxetine or salin...
Source: Experimental Neurology - April 11, 2020 Category: Neurology Authors: Hu Q, Liu L, Zhou L, Lu H, Wang J, Chen X, Wang Q Tags: Exp Neurol Source Type: research
Pathological Laughing: Brain SPECT Findings
We present the case of a 40-year-old man consulting for uncontrollable episodes of laughing related to emotional lability and not systematically linked to feelings of happiness. Seven months earlier he had presented a pontine ischemic stroke related to an occlusion of the basilar and left vertebral arteries. No epileptic activity or new MRI brain lesions were found. Brain perfusion SPECT performed showed marked hypoperfusion in the right frontal inferior and temporoinsular regions, suggesting a diaschisis phenomenon caused by pontine lesions and highlighted laughing regulation pathways. The patient was successfully treated...
Source: Clinical Nuclear Medicine - August 11, 2015 Category: Nuclear Medicine Tags: Interesting Images Source Type: research
Comparison between herbal medicine and fluoxetine for depression: A systematic review of randomized controlled trials.
CONCLUSIONS: Due to the poor quality of included trials and the potential publication bias of this review, no confirmed conclusion could be draw to evaluate the effectiveness and safety of CHM for depression compared with fluoxetine.
PMID: 26365447 [PubMed - in process]
Source: Complementary Therapies in Medicine - September 16, 2015 Category: Complementary Medicine Authors: Ren Y, Zhu C, Wu J, Zheng R, Cao H Tags: Complement Ther Med Source Type: research
The ms-smart trial in secondary progressive multiple sclerosis: a multi-arm, multi-centre trial of neuroprotection
There is currently no treatment for secondary progressive multiple sclerosis (SPMS) which determines the majority of disability in multiple sclerosis. The MS-SMART trial is a multi-arm, multi-centre, phase 2 randomised trial for patients with SPMS. A total of 440 patients with progressing SPMS will be recruited in England and Scotland and randomised to one of 4 blinded arms: amiloride 5mg bd, riluzole 50mg bd, fluoxetine 20mg bd or placebo. These agents have been chosen after an extensive systematic review which has suggested putative neuroprotective properties. Patients will be followed up for 96 weeks with outcome data c...
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 14, 2015 Category: Neurosurgery Authors: Chataway, J., Chandran, S., Miller, D., Giovannoni, G., Wheeler-Kingshott, C., Pavitt, S., Stallard, N., Hawkins, C., Sharrack, B., for the MS-SMART trialists Tags: Immunology (including allergy), Multiple sclerosis, Stroke, Radiology, Radiology (diagnostics) Thur 21, Parallel session 5: Therapeutics Source Type: research
Holistic Solutions for Anxiety & Depression in Therapy
“It is more important to know what sort of person has a disease than to know what sort of disease a person has.” — Hippocrates (460-377 B.C.E.)
“The art of healing comes from nature and not from the physician. Therefore, the physician must start from nature with an open mind.” — Paracelsus (1493 – 1541)
Treatment options that have long been considered outside the mainstream are becoming commonplace: a survey shows that nearly two in five adults in the United States have tried complementary or alternative therapy in the last year. As clinicians, it is our job to work with the individual t...
Source: Psych Central - December 8, 2015 Category: Psychiatry Authors: Megan Riddle Tags: Anxiety Book Reviews Depression General Happiness Herbs & Supplements Medications Professional Self-Help Stress Treatment anxiety treatment combining natural remedies with conventional care Depression Treatment holistic solutio Source Type: news
Should This Patient With Ischemic Stroke Receive Fluoxetine?
Publication date: December 2015 Source:PM&R, Volume 7, Issue 12 Author(s): Heidi Schambra, Brian Im, Michael W. O'Dell
Source: PMandR - December 18, 2015 Category: Rehabilitation Source Type: research
More Doctors Are Prescribing Exercise Instead Of Medication
BOSTON (AP) — When Dr. Michelle Johnson scribbles out prescriptions, the next stop for many of her patients is the gym, not the pharmacy.
Doctors treating chronic health problems increasingly are prescribing exercise for their patients — and encouraging them to think of physical activity as their new medication.
In one such program run by a health center in Boston’s Roxbury neighborhood, primary care physicians, internists and psychologists prescribe access to a gym for $10 a month, including free child care, classes and kids programs. Providing affordable gym access for patients ensures compliance, said Gibbs Sa...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - March 15, 2016 Category: Consumer Health News Authors: deanreddington Tags: Health Local News Exercise Ken MacLeod Source Type: news
Exercise to Extend Your Life
by Phil Hardesty
Imagine if there was a pill you could take that was free and would virtually eliminate, or at least minimize most disease processes. It would provide you with energy and strength to live your life beyond what you thought was possible. Everyone would want this pill and if it worked as well as it promised, just think of how healthy our population may be.
Of course this "pill" does exist. It's called regular physical activity and exercise.
According to the World Health Organization's Global Health Risks data physical inactivity is the fourth leading cause of death globally only behind high blood pressure, ...
Source: Healthy Living - The Huffington Post - May 9, 2016 Category: Consumer Health News Source Type: news
Modulatory effect of cilostazol on tramadol-induced behavioral and neurochemical alterations in rats challenged across the forced swim despair test
Publication date: Available online 30 May 2016 Source:Beni-Suef University Journal of Basic and Applied Sciences Author(s): Noha M. Gamil, Yousreya A. Maklad, Maha A.E. Ahmed, Shahira Nofal, Amany A.E. Ahmed Pain-associated depression is encountered clinically in some cases such as cancer, chronic neuropathy, and after operations. Tramadol is an opioid analgesic drug that may modulate monoaminergic neurotransmission by inhibition of noradrenaline and serotonin reuptake that may contribute to its antidepressant-like effects. Clinically, tramadol is used either alone or in combination with other NSAIDs in the treatmen...
Source: Beni Suef University Journal of Basic and Applied Sciences - May 30, 2016 Category: Science Source Type: research
Mental Illness Affects Presidents, Too
Perhaps it isn’t surprising, given the intense rhetoric of this year’s presidential election, that politicians have started throwing around accusations of insanity.
In early August, California Rep. Karen Bass, a Democrat, launched the hashtag #DiagnoseTrump and started a change.org petition claiming the Republican nominee, Donald Trump, meets the diagnostic criteria for Narcissistic Personality Disorder. Not long after, Trump called Hillary Clinton “unstable,” and at a rally in New Hampshire said, “She’s got problems.”
The candidates’ verbal volley highlights a p...
Source: Healthy Living - The Huffington Post - August 17, 2016 Category: Consumer Health News Source Type: news
Turmeric: Nature ’s Miracle Root for Disease
My friends Lelir and Westi in Bali don’t like to go to doctors. Nature is their pharmacy.
You see, Lelir is a Balian. That means “herbal healer.”
And Westi’s plantation is bursting with healing plants.
But one plant stands out above all the others. Lelir uses it to make a daily immune-boosting elixir as well as an anti-aging facial scrub. Balians use it as an antibiotic and for liver support. They boil it with milk and sugar to treat the common cold and allergies. Rural doctors make it into a paste with lime to ease sore joints. They make drinks to treat fevers and stomach pain. They mix it wi...
Source: Al Sears, MD Natural Remedies - September 20, 2016 Category: Complementary Medicine Authors: Al Sears Tags: Natural Cures Source Type: news
