Filtered By:
Condition: Stroke
Drug: Prozac

This page shows you your search results in order of relevance. This is page number 8.

Order by Relevance | Date

Total 193 results found since Jan 2013.

The effect of fluoxetine on morning blood pressure surge in patients with ischemic stroke: a prospective preliminary clinical study
Conclusion Fluoxetine might improve MBPS in patients with ischemic stroke.
Source: Blood Pressure Monitoring - July 16, 2021 Category: Cardiology Tags: Clinical Methods and Pathophisiology Source Type: research

Protein-Drug Interactome Analysis of SSRI-mediated Neurorecovery following Stroke.
Abstract Serotonin selective reuptake inhibitors (SSRIs) have been widely used as first-line drugs in the treatment of a range of depressive and anxiety disorders. Recently, clinical studies found that this class of agents also shows significant efficacy in promoting neurogenesis, neuroplasticity and neurorecovery following stroke. Here, we attempt to elucidate molecular mechanism and biological implication underlying the SSRI-mediated neurorecovery. In the procedure, a comprehensive protein-drug interactome (PDI) was constructed for various SSRIs and their major metabolites as well as a group of control drugs acr...
Source: Biosystems - April 3, 2014 Category: Biotechnology Authors: Chen HF, Pan XL, Wang JW, Kong HM, Fu YM Tags: Biosystems Source Type: research

Clinical effects and safety of electroacupuncture for the treatment of post-stroke depression: a systematic review and meta-analysis of randomised controlled trials.
CONCLUSION: There was no significant difference between EA and antidepressants in the severity of depression, however EA caused fewer adverse events than antidepressants. Additional larger scale RCTs with rigorous study design are required. PMID: 29776950 [PubMed - as supplied by publisher]
Source: Acupuncture in Medicine - May 18, 2018 Category: Complementary Medicine Authors: Li XB, Wang J, Xu AD, Huang JM, Meng LQ, Huang RY, Xu J Tags: Acupunct Med Source Type: research

Ameliorative effect of Xiaoyao - jieyu - san on post-stroke depression and its potential mechanisms
AbstractA stroke is a severe life-threatening disease with high fatality and disability rate. This investigation aimed to study the effect ofXiaoyao-jieyu-san (XYJY) on post-stroke depression (PSD) and its potential mechanisms. PSD rats were prepared using middle cerebral artery embolization (MCAO) and chronic unpredictable mild stress (CUMS), and divided into six groups (n = 10)—sham; MCAO; MCAO + CUMS (PSD); PSD + fluoxetine (1.84 mg/kg/day, 4 weeks); and PSD + XYJY (450 mg/kg/day and 900 mg/kg/day, 4 weeks). Body weight recording, despair swimming test, and sucrose preference test were performed a...
Source: Journal of Natural Medicines - September 7, 2018 Category: Drugs & Pharmacology Source Type: research

Stable isotope labeling derivatization and magnetic dispersive solid phase extraction coupled with UHPLC-MS/MS for the measurement of brain neurotransmitters in post-stroke depression rats administrated with gastrodin.
Abstract Synchronous measurement of brain neurotransmitters and blood drug metabolism by dual sites in vivo microdialysis can provide very important information for several neurological disorders such as post-stroke depression (PSD). In this work, d0/d3-6-N-methyl-rhodamine 6G-N-hydroxysuccinimidyl formate (d0/d3-MRSF) were firstly designed, synthesized and used as stable isotope labeling derivatization reagents for the determination of multiple neurotransmitters by ultra-high performance liquid chromatography-tandem mass spectrometry. The light d0-MRSF was used to label neurotransmitters in real samples and the ...
Source: Analytica Chimica Acta - January 23, 2019 Category: Chemistry Authors: Zhao XE, He Y, Zhu S, Xu Y, You J, Bai Y, Liu H Tags: Anal Chim Acta Source Type: research

Effect of Electroacupuncture on Relieving Central Post-Stroke Pain by Inhibiting Autophagy in the Hippocampus.
CONCLUSION: EA may inhibit autophagy in the hippocampus by reducing β-catenin/COX-2 protein expression and effectively alleviating CPSP. SIGNIFICANCE: Statement Previous studies have found that EA can reduce the expression of NK-1R in damaged rats by inhibition of COX-2 and β-catenin loops, which controls the activation of glial cells in the damaged area and the apoptosis of neuronal cells, and alleviated pain. In the male SD rat model, we evaluated this effect that EA inhibits autophagy in the hippocampus by reducing β-catenin/COX-2 protein expression in the brain tissue. In addition, we assessed expression levels...
Source: Brain Research - January 23, 2020 Category: Neurology Authors: Zheng L, Li XY, Huang FZ, Zhang XT, Tang HB, Li YS, Kevin Zhang W, Li XJ, Tian GH Tags: Brain Res Source Type: research

Update on the EFFECTS study of fluoxetine for stroke recovery: a randomised controlled trial in Sweden
Studies have suggested that fluoxetine might improve neurological recovery after stroke, but the results remain inconclusive. The EFFECTS (Efficacy oF Fluoxetine – a randomisEd Controlled Trial in Stroke) reac...
Source: Trials - February 28, 2020 Category: General Medicine Authors: Erik Lundstr öm, Eva Isaksson, Per Näsman, Per Wester, Björn Mårtensson, Bo Norrving, Håkan Wallén, Jörgen Borg, Martin Dennis, Gillian Mead, Graeme J. Hankey, Maree L. Hackett and Katharina S. Sunnerhagen Tags: Update Source Type: research

Fluoxetine Disappoints in Two New Stroke Trials Fluoxetine Disappoints in Two New Stroke Trials
The antidepressant failed to yield improvements in stroke recovery and was associated with an increase in fracture rates in the EFFECTS and AFFINITY studies.Medscape Medical News
Source: Medscape Psychiatry Headlines - May 14, 2020 Category: Psychiatry Tags: Neurology & Neurosurgery News Source Type: news

Update to the FOCUS, AFFINITY and EFFECTS trials studying the effect(s) of fluoxetine in patients with a recent stroke: statistical analysis plan for the trials and for the individual patient data meta-analysis
Three large trials of fluoxetine for stroke recovery (FOCUS (fluoxetine or control under supervision), AFFINITY (the Assessment oF FluoxetINe In sTroke recovery) and EFFECTS (Efficacy oF Fluoxetine —a randomisE...
Source: Trials - November 25, 2020 Category: General Medicine Authors: Gillian Elizabeth Mead, Catriona Graham, Laurent Billot, Per N äsman, Erik Lundström, Steff Lewis, Graeme J. Hankey, Maree L. Hackett, John Forbes and Martin Dennis Tags: Update Source Type: research

Final Word on SSRI for Post-Stroke Depression? Final Word on SSRI for Post-Stroke Depression?
The antidepressant fluoxetine does not prevent or alleviate post-stroke depression, new findings from a randomized, placebo-controlled trial confirm.Medscape Medical News
Source: Medscape Neurology and Neurosurgery Headlines - August 12, 2021 Category: Neurology Tags: Neurology & Neurosurgery News Source Type: news

The Efficacy and Tolerability of Selective Serotonin Reuptake Inhibitors for Motor Recovery in Non-depressed Patients After Acute Stroke: A Meta-Analysis
Conclusions: Fluoxetine and citalopram can promote motor recovery in non-depressed patients with acute stroke, but it is necessary to pay attention to the possible AEs of fluoxetine, such as hyponatremia, seizure and fracture.Systematic Review Registration: PROSPERO, identifier [CRD42021227452].
Source: Frontiers in Neurology - October 20, 2021 Category: Neurology Source Type: research

Cognitive Impairment After Stroke and Treatment with Fluoxetine: A Planned Analysis of the AFFINITY Randomised Controlled Trial
Strokes increase the risk of cognitive impairment and dementia, and the risk of post-stroke cognitive decline does not subside with time.1 Selective serotonin reuptake inhibitors (SSRIs), such as fluoxetine, display neuroprotective and neuro-regenerative properties in animal models of brain ischaemia,2 raising hope that their use could lessen the detrimental effects of stroke on cognition.
Source: The American Journal of Geriatric Psychiatry - August 19, 2022 Category: Geriatrics Authors: Osvaldo P. Almeida, Graeme J. Hankey, Andrew Ford, Christopher Etherton-Beer, Leon Flicker, Maree L. Hackett, AFFINITY Trial Collaboration Tags: Letter to the Editor Source Type: research

In-hospital predictors of post-stroke depression for targeted initiation of Selective Serotonin Reuptake Inhibitors (SSRIs)
Although SSRIs are no longer widely prescribed for post-stroke motor recovery, fluoxetine demonstrated beneficial effects on post-stroke depression (PSD). Given the potential side effects of SSRIs, targeted in...
Source: BMC Psychiatry - November 19, 2022 Category: Psychiatry Authors: Julie Yi, Justin Lu, Annie Yang and Elisabeth Breese Marsh Tags: Research article Source Type: research

Xingnao Jieyu capsules are similar to fluoxetine for post-stroke depression
(Neural Regeneration Research) Xingnao Jieyu capsules are similar to fluoxetine for post- stroke depression.
Source: EurekAlert! - Medicine and Health - August 14, 2013 Category: Global & Universal Source Type: news