Cognitive Impairment After Stroke and Treatment with Fluoxetine: A Planned Analysis of the AFFINITY Randomised Controlled Trial

Strokes increase the risk of cognitive impairment and dementia, and the risk of post-stroke cognitive decline does not subside with time.1 Selective serotonin reuptake inhibitors (SSRIs), such as fluoxetine, display neuroprotective and neuro-regenerative properties in animal models of brain ischaemia,2 raising hope that their use could lessen the detrimental effects of stroke on cognition.

https://www.ajgponline.org/article/S1064-7481(22)00494-8/fulltext?rss=yes

Source: The American Journal of Geriatric Psychiatry - August 19, 2022 Category: Geriatrics Authors: Osvaldo P. Almeida, Graeme J. Hankey, Andrew Ford, Christopher Etherton-Beer, Leon Flicker, Maree L. Hackett, AFFINITY Trial Collaboration Tags: Letter to the Editor Source Type: research