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Specialty: Cardiology
Drug: Insulin

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Total 191 results found since Jan 2013.

Triglyceride-Glucose Index as a Surrogate Marker of Insulin Resistance for Predicting Cardiovascular Outcomes in Nondiabetic Patients with Non-ST-Segment Elevation Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention.
CONCLUSIONS: The TyG index is an independent risk predictor for adverse cardiovascular events in nondiabetic subjects diagnosed with NSTE-ACS and who received elective PCI. Further prospective studies are needed to verify these findings. PMID: 33191314 [PubMed - as supplied by publisher]
Source: Journal of Atherosclerosis and Thrombosis - November 17, 2020 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

HIIT for post-COVID patients within cardiac rehabilitation: Response to letter to the editor
We thank Li and colleagues for their comments regarding our recent research into the benefits of incorporating high-intensity interval training (HIIT) into cardiac rehabilitation for patients with coronary artery disease (CAD) [1]. In recent years, HIIT has proven popular in the general community and has been studied across a wide array of cardiovascular (CV)-related disorders, such as hypertension [2,3], stroke [4,5], type II diabetes [6] and non-alcoholic fatty liver disease [7]. This is due to compounding, compelling evidence of the efficacy of HIIT on CV outcomes such as reduced blood pressure, lowered body fat, improv...
Source: International Journal of Cardiology - August 29, 2020 Category: Cardiology Authors: Andrew Keech, Kimberley Way, Katie Holgate, Jennifer Fildes, Praveen Indraratna, Jennifer Yu Tags: Letter to the Editor Source Type: research

Cardiovascular effects of preeclampsia
This study reviews the evidence of increase cardiovascular risk in these women. Recent findings Women with preeclampsia are at two-fold higher risk for development of coronary artery disease, stroke and death, and four-fold increased risk of heart failure. Preeclampsia developed in early part of pregnancy confers greater risk than later in pregnancy. Common factors that predispose women to preeclampsia also confer high risk for developing cardiovascular disease include obesity, metabolic abnormalities, dyslipidaemia, insulin resistance, heightened inflammatory responses, hypercoagulable states and endothelia dysfunction...
Source: Current Opinion in Cardiology - June 6, 2020 Category: Cardiology Tags: HYPERTENSION: Edited by Hector O. Ventura and Carl J. Lavie Source Type: research

Obstructive sleep apnoea and cardiovascular consequences: Pathophysiological mechanisms.
Abstract Obstructive sleep apnoea syndrome is a growing health concern, affecting nearly one billion people worldwide; it is an independent cardiovascular risk factor, associated with incident obesity, insulin resistance, hypertension, arrhythmias, stroke, coronary artery disease and heart failure. Obstructive sleep apnoea-related cardiovascular and metabolic co-morbidities are a major concern for prognosis and the complexity of obstructive sleep apnoea integrated care. Continuous positive airway pressure, the first-line therapy for the treatment of obstructive sleep apnoea, is highly effective at improving sympto...
Source: Archives of Cardiovascular Diseases - March 25, 2020 Category: Cardiology Authors: Arnaud C, Bochaton T, Pépin JL, Belaidi E Tags: Arch Cardiovasc Dis Source Type: research

Dietary Glycemic Index and Glycemic Load in Relation to Atherosclerotic Stenosis of Carotid and Cardiovascular Risk Factors in Ischemic Stroke Patients.
CONCLUSION: Higher GI and GL were positively associated with a higher degree of carotid stenosis in these Chinese cerebral infarction patients, especially in younger patients and women. PMID: 32147606 [PubMed - as supplied by publisher]
Source: Journal of Atherosclerosis and Thrombosis - March 11, 2020 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Exploring the Possible Impact of Unbalanced Open-Label Drop-In of Glucose-Lowering Medications on EXSCEL Outcomes.
Conclusions: EXSCEL-observed HRs for MACE and ACM remained robust after right censoring or application of literature-derived risk reductions, but the exenatide versus placebo MACE effect size and statistical significance were increased by IPTW. Effects of open-label drop-in cardioprotective medications need to be considered carefully when designing, conducting, and analyzing cardiovascular outcome trials of glucose-lowering agents under the premise of glycemic equipoise. Clinical Trial Registration: URL: https://clinicaltrials.gov Unique Identifier: NCT01144338. PMID: 32098501 [PubMed - as supplied by publisher]
Source: Circulation - February 25, 2020 Category: Cardiology Authors: Bethel MA, Stevens SR, Buse JB, Choi J, Gustavson SM, Iqbal N, Lokhnygina Y, Mentz RJ, Patel RA, Öhman P, Schernthaner G, Lecube A, Hernandez AF, Holman RR Tags: Circulation Source Type: research

A comprehensive contribution of genetic variations of the insulin-like growth factor 1 signalling pathway to stroke susceptibility
The insulin-like growth factor (IGF)-1 signalling pathway has been implicated in the pathogenesis of atherosclerosis; however, the mechanism underlying its role in stroke remains unexplained. Herein, we aimed to explore the effects of genetic polymorphisms in the IGF1 pathway on stroke in the Chinese Han population.
Source: Atherosclerosis - January 17, 2020 Category: Cardiology Authors: Yingshui Yao, Hui Zhu, Lijun Zhu, Zhengmei Fang, Yao Fan, Chunlan Liu, Yuanrui Tian, Yan Chen, Wuzhuang Tang, Zhanyun Ren, Jie Li, Song Yang, Yanchun Chen, Xianghai Zhao, Chong Shen Source Type: research

A randomised, double ‐blind, placebo‐controlled trial of metformin on myocardial efficiency in insulin‐resistant chronic heart failure patients without diabetes
ConclusionMetformin treatment in non ‐diabetic HFrEF patients improved myocardial efficiency by reducing myocardial oxygen consumption. Measurement of circulating metformin levels differentiated responders from non‐responders. These energy‐sparing effects of metformin encourage further large‐scale investigations in heart failur e patients without diabetes.
Source: European Journal of Heart Failure - December 20, 2019 Category: Cardiology Authors: Anders Hostrup Larsen, Niels Jessen, Helene N ørrelund, Lars Poulsen Tolbod, Hendrik Johannes Harms, Søren Feddersen, Flemming Nielsen, Kim Brøsen, Nils Henrik Hansson, Jørgen Frøkiær, Steen Hvitfeldt Poulsen, Jens Sörensen, Henrik Wigg Tags: Research Article Source Type: research

ENGAGE AF-TIMI: Insulin Linked to Greater Risk for Stroke, CV Death, Bleeding ENGAGE AF-TIMI: Insulin Linked to Greater Risk for Stroke, CV Death, Bleeding
In a subanalysis, patients with diabetes treated with insulin were at higher risk for these outcomes compared with those not treated with insulin.Medscape Medical News
Source: Medscape Cardiology Headlines - December 20, 2019 Category: Cardiology Tags: Diabetes & Endocrinology News Source Type: news

Association of obesity with cardiovascular outcomes in patients with type 2 diabetes and cardiovascular disease: Insights from TECOS
ConclusionsThe majority of TECOS participants with ASCVD and T2D were overweight or obese, yet overweight or obese class I individuals had lower CV risk than those who were under/normal weight. These results suggest the presence of an obesity paradox, but this paradox may reflect an epidemiological artifact rather than a true negative association between normal weight and clinical outcomes.
Source: American Heart Journal - October 21, 2019 Category: Cardiology Source Type: research

Force Sensing by Piezo Channels in Cardiovascular Health and Disease.
Abstract Mechanical forces are fundamental in cardiovascular biology, and deciphering the mechanisms by which they act remains a testing frontier in cardiovascular research. Here, we raise awareness of 2 recently discovered proteins, Piezo1 and Piezo2, which assemble as transmembrane triskelions to combine exquisite force sensing with regulated calcium influx. There is emerging evidence for their importance in endothelial shear stress sensing and secretion, NO generation, vascular tone, angiogenesis, atherosclerosis, vascular permeability and remodeling, blood pressure regulation, insulin sensitivity, exercise per...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - September 18, 2019 Category: Cardiology Authors: Beech DJ, Kalli AC Tags: Arterioscler Thromb Vasc Biol Source Type: research

Carotid plaque is a predictor of major adverse cardiac and cerebrovascular events in patients undergoing coronary angiography.
Conclusions: CP is an independent predictor of MACCE in patients undergoing coronary angiography. PMID: 31448766 [PubMed - in process]
Source: Archivos de Cardiologia de Mexico - August 27, 2019 Category: Cardiology Authors: Franco-Gutiérrez R, Pérez-Pérez AJ, Franco-Gutiérrez V, Ocaranza-Sánchez R, Testa-Fernández A, López-Reboiro ML, López-López A, Santás-Álvarez M, Crespo-Leiro MG, González-Juanatey C Tags: Arch Cardiol Mex Source Type: research

Mir-206 Deficiency Results In A Favorable Phenotype: Relevance For Type-2 Diabetes Mellitus And Metabolic Syndrome
Background and Aims: Type-2 diabetes mellitus (T2DM) and metabolic syndrome (MS) are multifactorial and multigenic diseases and hallmarks for atherosclerosis and stroke. Characteristics of these diseases include glucose intolerance, insulin resistance, hypertension, and disorders in triglyceride and cholesterol metabolism. Despite intensive research in this area, major factors liable for T2DM and MS and in turn for treatment are still elusive.
Source: Atherosclerosis - August 4, 2019 Category: Cardiology Authors: G. Kostner, N. Vujic, D. Kratky Tags: Posters 26 - 29 May, 2019 Source Type: research

Serum Insulin Levels Are Associated With Plaque Composition In The Carotid Artery: The Rotterdam Study
Background and Aims: Insulin resistance and high levels of glucose are implicated in the etiology of cardiovascular disease, including stroke. However, their direct influence on the formation and composition of atherosclerotic plaque, the single most important risk factor for cardiovascular disease, remains unclear.
Source: Atherosclerosis - August 2, 2019 Category: Cardiology Authors: B. Mujaj, D. Bos, M. Vernooij, A. van der Lugt, T. Muka, M. Kavousi, J. Staessen, O. Franco Tags: E-poster session Source Type: research