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Specialty: Cardiology
Drug: Insulin

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Total 191 results found since Jan 2013.

How dysregulation of the immune system promotes diabetes mellitus and cardiovascular risk complications
Front Cardiovasc Med. 2022 Sep 29;9:991716. doi: 10.3389/fcvm.2022.991716. eCollection 2022.ABSTRACTDiabetes mellitus (DM) is a chronic metabolic disorder characterized by persistent hyperglycemia due to insulin resistance or failure to produce insulin. Patients with DM develop microvascular complications that include chronic kidney disease and retinopathy, and macrovascular complications that mainly consist in an accelerated and more severe atherosclerosis compared to the general population, increasing the risk of cardiovascular (CV) events, such as stroke or myocardial infarction by 2- to 4-fold. DM is commonly associate...
Source: Atherosclerosis - October 17, 2022 Category: Cardiology Authors: Diane Girard Claire Vandiedonck Source Type: research

Identification of immune cell infiltration and diagnostic biomarkers in unstable atherosclerotic plaques by integrated bioinformatics analysis and machine learning
CONCLUSION: M1 macrophages is an important cause of unstable plaque formation, and CD68, PAM, and IGFBP6 could be used as diagnostic markers to identify unstable plaques effectively.PMID:36211422 | PMC:PMC9537477 | DOI:10.3389/fimmu.2022.956078
Source: Atherosclerosis - October 10, 2022 Category: Cardiology Authors: Jing Wang Zijian Kang Yandong Liu Zifu Li Yang Liu Jianmin Liu Source Type: research

Well-posedness of a mathematical model of diabetic atherosclerosis with advanced glycation end-products
Appl Anal. 2022;101(11):3989-4013. doi: 10.1080/00036811.2022.2060210. Epub 2022 Apr 6.ABSTRACTAtherosclerosis is a leading cause of death worldwide; it emerges as a result of multiple dynamical cell processes including hemodynamics, endothelial damage, innate immunity and sterol biochemistry. Making matters worse, nearly 463 million people have diabetes, which increases atherosclerosis-related inflammation, diabetic patients are twice as likely to have a heart attack or stroke. The pathophysiology of diabetic vascular disease is generally understood. Dyslipidemia with increased levels of atherogenic LDL, hyperglycemia, ox...
Source: Atherosclerosis - October 3, 2022 Category: Cardiology Authors: Xuming Xie Source Type: research

Crosstalk between neurological, cardiovascular, and lifestyle disorders: insulin and lipoproteins in the lead role
Pharmacol Rep. 2022 Sep 23. doi: 10.1007/s43440-022-00417-5. Online ahead of print.ABSTRACTInsulin resistance and impaired lipoprotein metabolism contribute to a plethora of metabolic and cardiovascular disorders. These alterations have been extensively linked with poor lifestyle choices, such as consumption of a high-fat diet, smoking, stress, and a redundant lifestyle. Moreover, these are also known to increase the co-morbidity of diseases like Type 2 diabetes mellitus and atherosclerosis. Under normal physiological conditions, insulin and lipoproteins exert a neuroprotective role in the central nervous system. However, ...
Source: Atherosclerosis - September 23, 2022 Category: Cardiology Authors: Richa Tyagi Bhupesh Vaidya Shyam Sunder Sharma Source Type: research

Heterogeneity of outcomes within diabetic patients with atrial fibrillation on edoxaban: a sub-analysis from the ETNA-AF Europe registry
ConclusionsIn a real-world cohort of AF patients on edoxaban, diabetes requiring insulin therapy, rather than the presence of diabetes per se, appears to be an independent factor affecting the occurrence of thromboembolic events during follow-up. Regardless of the diabetes type, diabetic patients had a lower survival compared with those without diabetes.Graphical abstract
Source: Clinical Research in Cardiology - August 17, 2022 Category: Cardiology Source Type: research

Association of the triglyceride-glucose index and vascular target organ damage in a Beijing community-based population
CONCLUSIONS: The TyG index was positively associated with artery stiffness and nephric microvascular damage in a Beijing community-based population in China. This result provides evidence that the TyG index may serve as a simple and effective indicator to reflect vascular TOD.PMID:35966556 | PMC:PMC9366355 | DOI:10.3389/fcvm.2022.948402
Source: Atherosclerosis - August 15, 2022 Category: Cardiology Authors: Wenjun Ji Lan Gao Pengfei Sun Jia Jia Jianping Li Xingang Wang Fangfang Fan Yan Zhang Source Type: research

Dietary Meat, Trimethylamine N-Oxide-Related Metabolites, and Incident Cardiovascular Disease Among Older Adults: The Cardiovascular Health Study
CONCLUSIONS: In this large, community-based cohort, higher meat intake associated with incident ASCVD, partly mediated by microbiota-derived metabolites of L-carnitine, abundant in red meat. These novel findings support biochemical links between dietary meat, gut microbiome pathways, and ASCVD.PMID:35912635 | DOI:10.1161/ATVBAHA.121.316533
Source: Arteriosclerosis, Thrombosis and Vascular Biology - August 1, 2022 Category: Cardiology Authors: Meng Wang Zeneng Wang Yujin Lee Heidi T M Lai Marcia C de Oliveira Otto Rozenn N Lemaitre Amanda Fretts Nona Sotoodehnia Matthew Budoff Joseph A DiDonato Barbara McKnight W H Wilson Tang Bruce M Psaty David S Siscovick Stanley L Hazen Dariush Mozaffarian Source Type: research

Triglyceride-glucose index trajectory and stroke incidence in patients with hypertension: a prospective cohort study
It has been suggested that the baseline triglyceride-glucose (TyG) index, a simple surrogate measure for insulin resistance, is significantly associated with the occurrence of stroke. Nevertheless, the impact ...
Source: Cardiovascular Diabetology - July 27, 2022 Category: Cardiology Authors: Zegui Huang, Xiong Ding, Qing Yue, Xianxuan Wang, Zekai Chen, Zefeng Cai, Weijian Li, Zhiwei Cai, Guanzhi Chen, Yulong Lan, Weiqiang Wu, Shouling Wu and Youren Chen Tags: Research Source Type: research

Fibronectin containing alternatively spliced extra domain A interacts at the central and c-terminal domain of Toll-like receptor-4
In conclusion, FN-EDA interacts and forms a stable complex through its "SPEDGIRELF" sequence at the central and C-terminal domain region of TLR4. The revelation of FN-EDA and TLR4 interacting sites may help design novel therapeutics for drug discovery research.PMID:35690624 | DOI:10.1038/s41598-022-13622-2
Source: Atherosclerosis - June 11, 2022 Category: Cardiology Authors: Shubhangi Gupta Azeem Ali Saurabh Pandey Imran A Khan Prem Prakash Source Type: research