Filtered By:
Drug: Minocycline

This page shows you your search results in order of date. This is page number 4.

Order by Relevance | Date

Total 88 results found since Jan 2013.

Sex differences in stroke therapies.
Abstract Stroke is the fifth leading cause of death and acquired disability in aged populations. Women are disproportionally affected by stroke, having a higher incidence and worse outcomes than men. Numerous preclinical studies have discovered novel therapies for the treatment of stroke, but almost all of these have been shown to be unsuccessful in clinical trials. Despite known sex differences in occurrence and severity of stroke, few preclinical or clinical therapeutics take into account possible sex differences in treatment. Reanalysis of data from studies of tissue plasminogen activator (tPA), the only curren...
Source: Cell Research - November 23, 2016 Category: Cytology Authors: Sohrabji F, Park MJ, Mahnke AH Tags: J Neurosci Res Source Type: research

Minocycline Suppresses NLRP3 Inflammasome Activation in Experimental Ischemic Stroke
Conclusion: We demonstrated that minocycline can ameliorate ischemia-induced brain damage via inhibiting NLRP3 inflammasome activation.Neuroimmunomodulation
Source: Neuroimmunomodulation - November 15, 2016 Category: Allergy & Immunology Source Type: research

The effect of minocycline on neuroinflammation after brain trauma
Conclusion Progressive volume loss in white matter with high microglial activation indicates on-going neurodegeneration. Minocycline reduced [11C]PBR28 binding, suggesting a treatment effect on microglial activation. These findings support the case for further clinical evaluation of minocycline as a treatment for neurodegeneration after TBI.
Source: Journal of Neurology, Neurosurgery and Psychiatry - November 14, 2016 Category: Neurosurgery Authors: Scott, G., Jolly, A., Jenkins, P. O., Lingford-Hughes, A., Patel, M., Goldstone, A., Matthews, P., Sharp, D. Tags: Drugs: CNS (not psychiatric), Neurological injury, Stroke, Trauma CNS / PNS, Radiology, Radiology (diagnostics), Trauma, Injury ABN Annual Meeting, 17-19 May 2016, The Brighton Centre, Brighton Source Type: research

Sex differences in stroke therapies
Stroke is the fifth leading cause of death and acquired disability in aged populations. Women are disproportionally affected by stroke, having a higher incidence and worse outcomes than men. Numerous preclinical studies have discovered novel therapies for the treatment of stroke, but almost all of these have been shown to be unsuccessful in clinical trials. Despite known sex differences in occurrence and severity of stroke, few preclinical or clinical therapeutics take into account possible sex differences in treatment. Reanalysis of data from studies of tissue plasminogen activator (tPA), the only currently FDA‐approved...
Source: Journal of Neuroscience Research - November 6, 2016 Category: Neuroscience Authors: Farida Sohrabji, Min Jung Park, Amanda H. Mahnke Tags: Review Source Type: research

Neuroprotection in acute stroke: targeting excitotoxicity, oxidative and nitrosative stress, and inflammation
Publication date: Available online 11 May 2016 Source:The Lancet Neurology Author(s): Ángel Chamorro, Ulrich Dirnagl, Xabier Urra, Anna M Planas Treatments for acute ischaemic stroke continue to evolve after the superior value of endovascular thrombectomy was confirmed over systemic thrombolysis. Unfortunately, numerous neuroprotective drugs have failed to show benefit in the treatment of acute ischaemic stroke, making the search for new treatments imperative. Increased awareness of the relevance of rigorous preclinical testing, and appropriate selection of study participants, might overcome the barriers to progress...
Source: The Lancet Neurology - May 11, 2016 Category: Neurology Source Type: research

Hypothermia followed by rapid rewarming exacerbates ischemia-induced brain injury and augments inflammatory response in rats.
Abstract Hypothermia followed by slow rewarming is neuroprotective for ischemic stroke. However, slow rewarming causes patients' longer stay in intensive care unit and increases the risk of hypothermic complications. Hypothermia followed by rapid rewarming (HTRR) is more convenient; but it exacerbates intracranial hypertension for patients with massive hemispheric infarcts. The present study aims to investigate in detail how HTRR exacerbates ischemic brain injury and what are underlying mechanisms. Rats subjected to transient focal ischemia by middle cerebral artery occlusion were treated with normothermia or hypo...
Source: Biochemical and Biophysical Research communications - April 19, 2016 Category: Biochemistry Authors: Zhu SZ, Gu Y, Wu Z, Hu YF, Pan SY Tags: Biochem Biophys Res Commun Source Type: research

Activation of microglia within paraventricular nucleus of hypothalamus is NOT involved in maintenance of established hypertension.
CONCLUSIONS: Activated microglia with morphological alteration within PVN are not involved in the maintenance of established severe hypertension, and inflammation within PVN could not be the therapeutic target of established hypertension. PMID: 26874752 [PubMed - as supplied by publisher]
Source: Journal of Cardiology - February 10, 2016 Category: Cardiology Authors: Takesue K, Kishi T, Hirooka Y, Sunagawa K Tags: J Cardiol Source Type: research

Drug repurposing for immune modulation in acute ischemic stroke.
Abstract Innate immune cells play a dualistic role in the evolution of ischemic brain damage, with classic phenotypes promoting injury, and alternatively activated M2 microglia/macrophages or N2 neutrophils providing tissue remodelling and repair. Recently, a number of drugs commonly used for other indications (i.e., azithromycin, minocycline, bexarotene, rosiglitazone, metformin) was reported to provide neuroprotection in preclinical stroke models by promoting immune polarization towards non-inflammatory, protective phenotypes. Repurposing drugs with a well-established safety profile should allow a reduction in t...
Source: Current Opinion in Pharmacology - December 1, 2015 Category: Drugs & Pharmacology Authors: Amantea D, Bagetta G Tags: Curr Opin Pharmacol Source Type: research

Vasculitic neuropathy following exposure to minocycline
Conclusions: Our findings suggest that the typical neuropathy associated with minocycline use is painful single or multiple mononeuropathy due to peripheral nerve vasculitis, which may also be accompanied by presumed CNS vasculitis (presenting as stroke).
Source: Neurology Neuroimmunology and Neuroinflammation - November 12, 2015 Category: Neurology Authors: Baratta, J. M., Dyck, P. J. B., Brand, P., Thaisetthawatkul, P., Dyck, P. J., Engelstad, J. K., Goodman, B., Karam, C. Tags: All Cerebrovascular disease/Stroke, Other cerebrovascular disease/ Stroke, All Immunology, Autoimmune diseases, Vasculitis Article Source Type: research

Pharmacological Preventions of Brain Injury Following Experimental Germinal Matrix Hemorrhage: an Up-to-Date Review
Abstract Germinal matrix hemorrhage (GMH) is defined as the rupture of immature blood vessels in the subependymal zone of premature infants with significant mortality and morbidity. Considering the notable social and ecological stress brought by GMH-induced brain injury and sequelae, safe and efficient pharmacological preventions are badly needed. Currently, several appropriate animal models are available to mimic the clinical outcomes of GMH in human patients. In the long run, hemorrhagic strokes are the research target. Previously, we found that minocycline was efficient to alleviate GMH-induced brain edema and ...
Source: Translational Stroke Research - November 11, 2015 Category: Neurology Source Type: research

Minocycline mitigates the gliogenic effects of proinflammatory cytokines on neural stem cells
Mobilizing endogenous neural stem cells (NSCs) in the adult brain is designed to enhance the brain's regenerative capacity after cerebral lesions, e.g., as a result of stroke. Cerebral ischemia elicits neuroinflammatory processes affecting NSCs in multiple ways, the precise mechanisms of which currently remain elusive. An inhibitory effect of minocycline on microglia activation, a hallmark of postischemic neuroinflammation, has already been demonstrated in clinical trials, showing minocycline to be safe and potentially effective in ischemic stroke. Here we investigate the direct effects of minocycline and of proinflammator...
Source: Journal of Neuroscience Research - November 3, 2015 Category: Neuroscience Authors: Sabine Ulrike Vay, Stefan Blaschke, Rebecca Klein, Gereon Rudolf Fink, Michael Schroeter, Maria Adele Rueger Tags: Research Article Source Type: research

Minocycline-induced pigmentation of the skin and nails
Introduction Minocycline is an effective treatment for inflammatory cutaneous conditions, such as acne vulgaris and rosacea, infectious conditions and has recently been investigated for its neuroprotective properties. However, treatment with minocycline can induce iatrogenic pigmentation, affecting both the skin and other organs. Recognition of these changes may avoid unnecessary investigations. This image case report aims to remind clinicians of this often-persistent side effect of minocycline. Case A 73-year-old man attended the dermatology outpatient clinic with a 20-year history of progressive swelling of the nose, ass...
Source: Postgraduate Medical Journal - October 23, 2015 Category: Journals (General) Authors: Ali, F. R., Yiu, Z. Z., Ogden, S. Tags: Liver disease, Urology, Genetics, Immunology (including allergy), Drugs: infectious diseases, Movement disorders (other than Parkinsons), Stroke, Hypertension, Psychotic disorders (incl schizophrenia), Pneumonia (respiratory medicine), Connective tissue d Source Type: research

Minocycline ameliorates hypoxia-induced blood–brain barrier damage by inhibition of HIF-1α through SIRT-3/PHD-2 degradation pathway
Conclusions: Minocycline inhibits HIF-1α-mediated cellular responses and protects BBB integrity through SIRT-3/PHD-2 pathway, proving to be a potential drug for the prevention and treatment of hypoxic brain injuries.
Source: Neuroscience - August 7, 2015 Category: Neuroscience Source Type: research

Sequential Therapy with Minocycline and Candesartan Improves Long-Term Recovery After Experimental Stroke
In this study, we hypothesize that opposing actions of minocycline and candesartan on angiogenesis, when administered simultaneously, will reduce the benefit of candesartan treatment. Therefore, we propose a sequential combination treatment regimen to yield a better outcome and preserve the proangiogenic potential of candesartan. In vitro angiogenesis was assessed using human brain endothelial cells. In vivo, Wistar rats subjected to 90-min middle cerebral artery occlusion (MCAO) were randomized into four groups: saline, candesartan, minocycline, and sequential combination of minocycline and candesartan. Neurobehavioral te...
Source: Translational Stroke Research - May 26, 2015 Category: Neurology Source Type: research

Minocycline Reduces Spontaneous Hemorrhage in Mouse Models of Cerebral Amyloid Angiopathy Basic Sciences
Conclusions— Minocycline reduced gliosis, inflammatory gene expression, gelatinase activity, and spontaneous hemorrhage in 2 different mouse models of CAA, supporting the importance of matrix metalloproteinase–related and inflammatory pathways in intracerebral hemorrhage pathogenesis. As a Food and Drug Administration–approved drug, minocycline might be considered for clinical trials to test efficacy in preventing CAA-related intracerebral hemorrhage.
Source: Stroke - May 22, 2015 Category: Neurology Authors: Yan, P., Zhu, A., Liao, F., Xiao, Q., Kraft, A. W., Gonzales, E., Perez, R., Greenberg, S. M., Holtzman, D. M., Lee, J.-M. Tags: Animal models of human disease, Intracerebral Hemorrhage, Neuroprotectors Basic Sciences Source Type: research