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Drug: Minocycline

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Total 88 results found since Jan 2013.

Minocycline attenuates brain injury and iron overload after intracerebral hemorrhage in aged female rats.
Abstract Brain iron overload is involved in brain injury after intracerebral hemorrhage (ICH). There is evidence that systemic administration of minocycline reduces brain iron level and improves neurological outcome in experimental models of hemorrhagic and ischemic stroke. However, there is evidence in cerebral ischemia that minocycline is not protective in aged female animals. Since most ICH research has used male models, this study was designed to provide an overall view of ICH-induced iron deposits at different time points (1 to 28 days) in aged (18-month old) female Fischer 344 rat ICH model and to investig...
Source: Neurobiology of Disease - June 4, 2018 Category: Neurology Authors: Dai S, Hua Y, Keep RF, Novakovic N, Fei Z, Xi G Tags: Neurobiol Dis Source Type: research

Minocycline Effects on Intracerebral Hemorrhage-Induced Iron Overload in Aged Rats Basic Sciences
This study quantified brain iron levels after ICH with magnetic resonance imaging R2* mapping. The effect of minocycline on iron overload and ICH-induced brain injury in aged rats was also determined.Methods—Aged (18 months old) male Fischer 344 rats had an intracerebral injection of autologous blood or saline, and brain iron levels were measured by magnetic resonance imaging R2* mapping. Some ICH rats were treated with minocycline or vehicle. The rats were euthanized at days 7 and 28 after ICH, and brains were used for immunohistochemistry and Western blot analyses. Magnetic resonance imaging (T2-weighted, T2* gradient-...
Source: Stroke - March 26, 2018 Category: Neurology Authors: Shenglong Cao, Ya Hua, Richard F. Keep, Neeraj Chaudhary, Guohua Xi Tags: Basic Science Research, Intracranial Hemorrhage Original Contributions Source Type: research

Vascular tight junction disruption and angiogenesis in spontaneously hypertensive rat with neuroinflammatory white matter injury.
Abstract Vascular cognitive impairment is a major cause of dementia caused by chronic hypoxia, producing progressive damage to white matter (WM) secondary to blood-brain barrier (BBB) opening and vascular dysfunction. Tight junction proteins (TJPs), which maintain BBB integrity, are lost in acute ischemia. Although angiogenesis is critical for neurovascular remodeling, less is known about its role in chronic hypoxia. To study the impact of TJP degradation and angiogenesis during pathological progression of WM damage, we used the spontaneously hypertensive/stroke prone rats with unilateral carotid artery occlusion ...
Source: Neurobiology of Disease - February 24, 2018 Category: Neurology Authors: Yang Y, Kimura-Ohba S, Thompson JF, Salayandia VM, Cosse M, Raz L, Jalal FY, Rosenberg GA Tags: Neurobiol Dis Source Type: research

Progression of vasogenic edema induced by activated microglia under permanent middle cerebral artery occlusion.
In this study, we examined the role of microglia in the progression of ischemic brain edema using mice with permanent middle cerebral artery occlusion. The intensity of T2-weighted imaging (T2WI) in the cerebral cortex and the striatum was elevated 3 h after occlusion and spread to peripheral regions of the ischemic hemisphere. Merged images of 2,3,5-triphenyl tetrazolium chloride staining and T2WI revealed the exact vasogenic edema region, which spread from the ischemic core to outside the ischemic region. Microglia were strongly activated in the ischemic region 3 h after occlusion and, notably, activated microglia we...
Source: Biochemical and Biophysical Research communications - January 15, 2018 Category: Biochemistry Authors: Tanaka M, Ishihara Y, Mizuno S, Ishida A, Vogel CF, Tsuji M, Yamazaki T, Itoh K Tags: Biochem Biophys Res Commun Source Type: research

Letter by Chang et al Regarding Article, “Minocycline in Acute Cerebral Hemorrhage: An Early Phase Randomized Trial” Letter to the Editor
Source: Stroke - December 22, 2017 Category: Neurology Authors: Jason J. Chang, Nerses Sanossian, Georgios Tsivgoulis Tags: Biomarkers, Intracranial Hemorrhage, Neuroprotectants Letters to the Editor Source Type: research

Response by Fouda and Switzer to Letter Regarding Article, “Minocycline in Acute Cerebral Hemorrhage: An Early Phase Randomized Trial” Letter to the Editor
Source: Stroke - December 22, 2017 Category: Neurology Authors: Abdelrahman Y. Fouda, Jeffrey A. Switzer, MACH Investigators Tags: Intracranial Hemorrhage, Neuroprotectants Letters to the Editor Source Type: research

Depression in the Context of Medical Disorders: New Pharmacological Pathways Revisited
In conclusion a hypothetic model for the implication of actual findings in everyday clinical practice is proposed. In this context personalized treatment could be used to tailor treatment to specific individuals according to their clinical endophenotypes. Moreover a potential target for the development of novel intervention strategies might be used.Neurosignals 2017;25:54 –73
Source: Neurosignals - October 25, 2017 Category: Neurology Source Type: research

Depression in the Context of Medical Disorders: New Pharmacological Pathways Revisited.
In conclusion a hypothetic model for the implication of actual findings in everyday clinical practice is proposed. In this context personalized treatment could be used to tailor treatment to specific individuals according to their clinical endophenotypes. Moreover a potential target for the development of novel intervention strategies might be used. PMID: 29041003 [PubMed - as supplied by publisher]
Source: Neuro-Signals - October 17, 2017 Category: Neurology Authors: Lang UE, Walter M Tags: Neurosignals Source Type: research

Minocycline in Acute Cerebral Hemorrhage Brief Report
Conclusions—In intracerebral hemorrhage, a 400 mg dose of minocycline was safe and achieved neuroprotective serum concentrations. However, oral administration led to delayed absorption in these critically ill patients and should not be used when rapid, high concentrations are desired. Given the safety and pharmacokinetic profile of minocycline in intracerebral hemorrhage and promising data in the treatment of ischemic stroke, intravenous minocycline is an excellent candidate for a prehospital treatment trial.Clinical Trial Registration—URL: http://www.clinicaltrials.gov. Unique identifier: NCT01805895.
Source: Stroke - September 25, 2017 Category: Neurology Authors: Abdelrahman Y. Fouda, Andrea S. Newsome, Samantha Spellicy, Jennifer L. Waller, Wenbo Zhi, David C. Hess, Adviye Ergul, David J. Edwards, Susan C. Fagan, Jeffrey A. Switzer Tags: Intracranial Hemorrhage, Neuroprotectants Brief Reports Source Type: research

Minocycline and matrix metalloproteinase inhibition in acute intracerebral hemorrhage: a pilot study
ConclusionsHigh‐dose intravenous minocycline can be safely administered to patients with ICH. Larger randomized clinical trials evaluating the efficacy of minocycline and MMP‐9 inhibition in ICH patients are required.
Source: European Journal of Neurology - September 20, 2017 Category: Neurology Authors: J. J. Chang, M. Kim ‐Tenser, B. A. Emanuel, G. M. Jones, K. Chapple, A. Alikhani, N. Sanossian, W. J. Mack, G. Tsivgoulis, A. V. Alexandrov, T. Pourmotabbed Tags: Original Article Source Type: research

Cell-based and pharmacological neurorestorative therapies for ischemic stroke.
Abstract Ischemic stroke remains one of most common causes of death and disability worldwide. Stroke triggers a cascade of events leading to rapid neuronal damage and death. Neuroprotective agents that showed promise in preclinical experiments have failed to translate to the clinic. Even after decades of research, tPA remains the only FDA approved drug for stroke treatment. However, tPA is effective when administered 3-4.5 h after stroke onset and the vast majority of stroke patients do not receive tPA therapy. Therefore, there is a pressing need for novel therapies for ischemic stroke. Since stroke induces rapid...
Source: Neuropharmacology - August 31, 2017 Category: Drugs & Pharmacology Authors: Venkat P, Shen Y, Chopp M, Chen J Tags: Neuropharmacology Source Type: research

Antineuroinflammation of Minocycline in Stroke
Accumulating research substantiates the statement that inflammation plays an important role in the development of stroke. Both proinflammatory and anti-inflammatory mediators are involved in the pathogenesis of stroke, an imbalance of which leads to inflammation. Anti-inflammation is a kind of hopeful strategy for the prevention and treatment of stroke. Substantial studies have demonstrated that minocycline, a second-generation semisynthetic antibiotic belonging to the tetracycline family, can inhibit neuroinflammation, inflammatory mediators and microglia activation, and improve neurological outcome. Experimental and clin...
Source: The Neurologist - June 24, 2017 Category: Neurology Tags: Review Article Source Type: research

A Combination of Three Repurposed Drugs Administered at Reperfusion as a Promising Therapy for Postischemic Brain Injury
This study evaluated efficacy of the combination of three clinically approved drugs: lamotrigine, minocycline, and lovastatin, using two mouse models: global and focal cerebral ischemia induced by transient occlusion of the common carotid arteries or the middle cerebral artery, respectively. In vitro, the combination drug, but not single drug, protected neurons against oxygen-glucose deprivation (OGD)-induced cell death. The combination drug simultaneously targeted cell apoptosis and DNA damage induced by ischemia. Besides acting on neurons, the combination drug suppressed inflammatory processes in microglia and brain endo...
Source: Translational Stroke Research - June 17, 2017 Category: Neurology Source Type: research

Inhibition of Gelatinases (MMP-2 and MMP-9) by Withania somnifera Phytochemicals Confers Neuroprotection in Stroke: An In Silico Analysis
AbstractA stroke or cerebrovascular accident is a serious, life-threatening medical condition that occurs when the blood supply to part of the brain is severely reduced or cut off, depriving brain tissue of oxygen and nutrients. Studies suggested that level of gelatinases (MMP-2 and MMP-9) usually increases in the brain after stroke. The elevated activity of gelatinases plays the deleterious role in ischemic stroke, hemorrhagic stroke and perinatal hypoxic –ischemic brain injury. Therefore, matrix metalloproteinase (MMP)-2 and MMP-9 inhibition have therapeutic importance in stroke condition. Present in silico study inves...
Source: Interdisciplinary Sciences, Computational Life Sciences - May 9, 2017 Category: Bioinformatics Source Type: research