The effect of minocycline on neuroinflammation after brain trauma

Conclusion Progressive volume loss in white matter with high microglial activation indicates on-going neurodegeneration. Minocycline reduced [11C]PBR28 binding, suggesting a treatment effect on microglial activation. These findings support the case for further clinical evaluation of minocycline as a treatment for neurodegeneration after TBI.

http://jnnp.bmj.com/cgi/content/short/87/12/e1-fg?rss=1

Source: Journal of Neurology, Neurosurgery and Psychiatry - November 14, 2016 Category: Neurosurgery Authors: Scott, G., Jolly, A., Jenkins, P. O., Lingford-Hughes, A., Patel, M., Goldstone, A., Matthews, P., Sharp, D. Tags: Drugs: CNS (not psychiatric), Neurological injury, Stroke, Trauma CNS / PNS, Radiology, Radiology (diagnostics), Trauma, Injury ABN Annual Meeting, 17-19 May 2016, The Brighton Centre, Brighton Source Type: research