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Total 126 results found since Jan 2013.

Post-stroke administration of omega-3 polyunsaturated fatty acids promotes neurovascular restoration after ischemic stroke in mice: Efficacy declines with aging.
Abstract Post-stroke treatment with omega-3 polyunsaturated fatty acids (n-3 PUFAs) may be a promising therapy in young animals but this has not been tested in aged subjects, a population at most risk of ischemic stroke. Herein we examined the therapeutic efficacy of n-3 PUFAs after distal middle cerebral artery occlusion (dMCAO) in young (10-12 weeks old) and aged (18 months old) mice. Post-ischemic mice were randomly assigned to 4 groups that received: 1) regular food with low content of n-3 PUFAs, 2) intraperitoneal docosahexaenoic acid (DHA, a major component of n-3 PUFAs) injections, 3) Fish oil (FO, cont...
Source: Neurobiology of Disease - September 12, 2018 Category: Neurology Authors: Jiang X, Suenaga J, Pu H, Wei Z, Smith AD, Hu X, Shi Y, Chen J Tags: Neurobiol Dis Source Type: research

Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease.
CONCLUSIONS: This is the most extensive systematic assessment of effects of omega-3 fats on cardiovascular health to date. Moderate- and high-quality evidence suggests that increasing EPA and DHA has little or no effect on mortality or cardiovascular health (evidence mainly from supplement trials). Previous suggestions of benefits from EPA and DHA supplements appear to spring from trials with higher risk of bias. Low-quality evidence suggests ALA may slightly reduce CVD event risk, CHD mortality and arrhythmia. PMID: 30019766 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - July 18, 2018 Category: General Medicine Authors: Abdelhamid AS, Brown TJ, Brainard JS, Biswas P, Thorpe GC, Moore HJ, Deane KH, AlAbdulghafoor FK, Summerbell CD, Worthington HV, Song F, Hooper L Tags: Cochrane Database Syst Rev Source Type: research

Omega-3 polyunsaturated fatty acids and brain health: Preclinical evidence for the prevention of neurodegenerative diseases.
Conclusions These studies have shown that dietary n-3 PUFA treatments consistently improve cognitive performance in animal models and may also exert disease-modifying actions. N-3 PUFA also provide protection to dopaminergic neurons in animal models of PD and possibly recovery after lesion. Furthermore, some of these effects might depend on specific diet formulations to protect long-chain fatty acids from oxidation or synergies with other nutrients. More generally, this review aims at providing evidence that adjustments in the consumption of dietary lipids alone or combined with other nutrients may be a cost-effective inte...
Source: Trends in Food Science and Technology - September 20, 2017 Category: Food Science Source Type: research

Fish Consumption, Omega-3 Fatty Acids, and Risk of Cardiovascular Disease
Conclusions In this cohort of women without history of cardiovascular disease, intakes of tuna and dark fish, α-linolenic acid, and marine omega-3 fatty acids were not associated with risk of major cardiovascular disease.
Source: American Journal of Preventive Medicine - September 17, 2016 Category: Global & Universal Source Type: research

Delayed Docosahexaenoic Acid Treatment Combined with Dietary Supplementation of Omega-3 Fatty Acids Promotes Long-Term Neurovascular Restoration After Ischemic Stroke
In this study, we investigated the effect of n-3 PUFA supplementation, as well as in combination with docosahexaenoic acid (DHA) injections, on long-term stroke outcomes. Mice were subjected to transient middle cerebral artery occlusion (MCAO) before randomly assigned to four groups to receive the following: (1) low dose of n-3 PUFAs as the vehicle control, (2) intraperitoneal DHA injections, (3) n-3 PUFA dietary supplement, or (4) combined treatment of (2) and (3). Neurological deficits and brain atrophy, neurogenesis, angiogenesis, and glial scar formation were assessed up to 28  days after MCAO. Results revealed that g...
Source: Translational Stroke Research - August 26, 2016 Category: Neurology Source Type: research

Maternal dietary supplementation with omega-3 polyunsaturated fatty acids confers neuroprotection to the newborn against hypoxia-induced dopamine dysfunction
Conclusions Our findings suggest that it may be feasible to confer neuroprotection against hypoxia-induced dopamine dysfunction to newborns likely to experience hypoxic insults. This could significantly improve the outcomes of those 8–11% of newborns who would otherwise experience hypoxia-induced behavioral, motor and cognitive dysfunction.
Source: Sleep Science - June 8, 2016 Category: Sleep Medicine Source Type: research

Alpha-linolenic acid given as enteral or parenteral nutritional intervention against sensorimotor and cognitive deficits in a mouse model of ischemic stroke.
This study evaluated the value of ALA as adjunctive therapy for stroke recovery by comparing whether oral or intravenous supplementation of ALA best support recovery from ischemia. Motor and cognitive deficits were assessed using rotarod, pole and Morris water maze tests. ALA supplementation in diet was better than intravenous treatment in improving motor coordination, but this improvement was not due to a neuroprotective effect since infarct size was not reduced. Both types of ALA supplementation improved spatial learning and memory after stroke. This cognitive improvement correlated with higher survival of hippocampal ne...
Source: Neuropharmacology - April 27, 2016 Category: Drugs & Pharmacology Authors: Bourourou M, Heurteaux C, Blondeau N Tags: Neuropharmacology Source Type: research

n-3 Polyunsaturated Fatty Acids Reduce Neonatal Hypoxic/Ischemic Brain Injury by Promoting Phosphatidylserine Formation and Akt Signaling Basic Sciences
Conclusions— n-3 PUFAs robustly protect against H/I-induced brain damage in neonates by activating Akt prosurvival pathway in compromised neurons. In addition, n-3 PUFAs promote the formation of membrane phosphatidylserine, thereby promoting Akt activity and improving cellular survival.
Source: Stroke - September 28, 2015 Category: Neurology Authors: Zhang, W., Liu, J., Hu, X., Li, P., Leak, R. K., Gao, Y., Chen, J. Tags: Neuroprotectors Basic Sciences Source Type: research

Can Oxygen Therapy Bring Dead Brain Cells Back To Life?
During my Palm Beach Anti-Aging Summit in October, I’m hosting some of the world’s leading authorities on oxygen therapy. The Summit coincides with the grand opening of my 17,000-sq.-ft. Sears Institute for Anti-Aging Medicine, where I’m unveiling a specially-designed room that houses my first hyperbaric oxygen chamber. I hope you’ll be there, as you’ll discover the newest applications and breakthroughs in this growing field. You see, when oxygen is pressurized — like it is when you’re inside the chamber — you can treat more than just chronic disease. Truth is, hyperbaric oxygen can...
Source: Al Sears, MD Natural Remedies - September 14, 2015 Category: Complementary Medicine Authors: Dr. Al Sears Tags: Brain Health brain cells hyperbaric oxygen chamber natural treatment omega-3 fatty acids Palm Beach Anti-Aging Summit Source Type: news

N-3 polyunsaturated fatty acids in animal models with neuroinflammation: An update.
Abstract Neuroinflammation is a characteristic of a multitude of neurological and psychiatric disorders. Modulating inflammatory pathways offers a potential therapeutic target in these disorders. Omega-3 polyunsaturated fatty acids have anti-inflammatory and pro-resolving properties in the periphery, however, their effect on neuroinflammation is less studied. This review summarizes 61 animal studies that tested the effect of omega-3 polyunsaturated fatty acids on neuroinflammatory outcomes in vivo in various models including stroke, spinal cord injury, aging, Alzheimer's disease, Parkinson's disease, lipopolysacch...
Source: European Journal of Pharmacology - May 30, 2015 Category: Drugs & Pharmacology Authors: Trépanier MO, Hopperton KE, Orr SK, Bazinet RP Tags: Eur J Pharmacol Source Type: research

Cytochrome P450 Enzymes in the Bioactivation of Polyunsaturated Fatty Acids and Their Role in Cardiovascular Disease.
Authors: Westphal C, Konkel A, Schunck WH Abstract Various members of the cytochrome P450 (CYP) superfamily have the capacity of metabolizing omega-6 and omega-3 polyunsaturated fatty acids (n-6 and n-3 PUFAs). In most mammalian tissues, CYP2C and CYP2J enzymes are the major PUFA epoxygenases, whereas CYP4A and CYP4F subfamily members function as PUFA hydroxylases. The individual CYP enzymes differ in their substrate specificities as well as regio- and stereoselectivities and thus produce distinct sets of epoxy and/or hydroxy metabolites, collectively termed CYP eicosanoids. Nutrition has a major impact on the endo...
Source: Advances in Experimental Medicine and Biology - May 25, 2015 Category: Research Tags: Adv Exp Med Biol Source Type: research

Intakes of omega-3 polyunsaturated fatty acids and blood pressure change over time: possible interaction with genes involved in 20-HETE and EETs metabolism
Conclusions Our data do not support a major role of ω-6 or ω-3 PUFA intakes on BP change over time, but suggest a possible interaction of ω-3 PUFA with the CYP4F2 V433M.
Source: Prostaglandins and Other Lipid Mediators - May 17, 2015 Category: Lipidology Source Type: research

Low Levels of Plasma Omega 3-Polyunsaturated Fatty Acids are Associated with Cerebral Small Vessel Diseases in Acute Ischemic Stroke Patients
Cerebral small vessel diseases (SVDs) are related to stroke or cognitive dysfunction. n-3-polyunsaturated fatty acids (FAs) such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) represent possible disease modifying factors for cardiovascular disease or dementia. Our hypothesis was that a low proportion of plasma FAs would be associated with cerebral SVDs. We prospectively enrolled 220 patients with a first-episode cerebral infarction within 7 days after symptom onset. The composition of plasma FAs was analyzed by gas chromatography methods.
Source: Nutrition Research - April 16, 2015 Category: Nutrition Authors: Tae-Jin Song, Yoonkyung Chang, Min-Jeong Shin, Ji Hoe Heo, Yong-Jae Kim Tags: Original Research Source Type: research

Dietary supplementation with omega-3 polyunsaturated fatty acids robustly promotes neurovascular restorative dynamics and improves neurological functions after stroke.
Abstract Stroke is a devastating neurological disease with no satisfactory therapies to preserve long-term neurological function, perhaps due to the sole emphasis on neuronal survival in most preclinical studies. Recent studies have revealed the importance of protecting multiple cell types in the injured brain, such as oligodendrocytes and components of the neurovascular unit, before long-lasting recovery of function can be achieved. For example, revascularization in the ischemic penumbra is critical to provide various neurotrophic factors that enhance the survival and activity of neurons and other progenitor cell...
Source: Experimental Neurology - March 12, 2015 Category: Neurology Authors: Zhang W, Wang H, Zhang H, Leak RK, Shi Y, Hu X, Gao Y, Chen J Tags: Exp Neurol Source Type: research

Omega-3 polyunsaturated fatty acids and non-communicable diseases: meta-analysis based systematic review.
In conclusion, n-3 PUFA plays a crucial role in the prevention of NCDs, however, unfavourable effects should be considered in subjects with certain clinical conditions. Cross-cultural studies on the effect of n-3 PUFA on type 2 diabetes are needed to verify why diabetic patients with different ancestries have a different response to n-3 PUFA. PMID: 25740737 [PubMed - in process]
Source: Clinical Genitourinary Cancer - March 1, 2015 Category: Cancer & Oncology Authors: Li D Tags: Asia Pac J Clin Nutr Source Type: research