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Drug: Proton Pump Inhibitors PPIs
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Total 238 results found since Jan 2013.
Does proton pump inhibitor reduce the antiaggregant efficacy of aspirin in ischemic stroke?
CONCLUSION: The combination of 30 mg lansoprazole and 100 mg aspirin does not cause a decrease in antiaggregant activity in the early period, but chronic use was not evaluated in this study. Patients with AR may benefit from an increase in the dose of aspirin.PMID:36474449
Source: Acta Neurologica Taiwanica - December 7, 2022 Category: Neurology Authors: Tu ğba Özel Ali Ünal Sebahat Özdem Babur Dora Source Type: research
Lack of association between proton pump inhibitors and adverse events in patients taking clopidogrel and aspirin
Commentary on Douglas IJ, Evans SJ, Hingorani AD, et al.. Clopidogrel and interaction with proton pump inhibitors: comparison between cohort and within person study designs. BMJ 2012;345:e4388 Context Clopidogrel inhibits the P2Y12 platelet receptor and is used in patients with acute coronary syndromes or ischaemic stroke to prevent recurrent vascular events. Proton pump inhibitors (PPIs), however, have been shown to reduce the pharmacodynamic effect of clopidogrel upon platelet inhibition, and have been linked in retrospective studies to a higher rate of ischaemic outcomes in patients taking clopidogrel. Methods A total o...
Source: Evidence-Based Medicine - May 15, 2013 Category: Internal Medicine Authors: Waksman, R., Gaglia, M. A. Tags: Smoking and tobacco, Epidemiologic studies, Drugs: cardiovascular system, Stroke, Ischaemic heart disease, Health education, Smoking Aetiology Source Type: research
Intramural hematoma of the esophagus after thrombolysis for ischemic stroke
We report the case of an 88-year-old woman who developed an intramural hematoma of the esophagus after intravenous thrombolysis for an acute ischemic stroke. Before thrombolysis, nasogastric intubation was attempted unsuccessfully. She was kept on nil by mouth, intravenous hydration, proton pump inhibitor, antiemetics, and an antibiotic initiated 2 days before for periodontal disease.
Source: The American Journal of Emergency Medicine - August 29, 2014 Category: Emergency Medicine Authors: Mario Jorge Silva, Joana Saiote, Vera Salvado, Ana Paiva Nunes, Pedro Duarte Tags: Case report Source Type: research
Could Common Heartburn Drugs Up Stroke Risk?
TUESDAY, Nov. 15, 2016 -- A popular category of heartburn medications -- including Nexium, Prevacid, Prilosec and Protonix -- may increase your risk of stroke, a new study suggests.
Known as proton pump inhibitors (PPIs), these drugs increased...
Source: Drugs.com - Daily MedNews - November 15, 2016 Category: Journals (General) Source Type: news
Proton-Pump Inhibitor Use and the Risk of First-Time Ischemic Stroke in the General Population: A Nationwide Population-Based Study
Jiun Wang
Source: The American Journal of Gastroenterology - July 20, 2017 Category: Gastroenterology Authors: Yen-Feng Wang Yung-Tai Chen Jiing-Chyuan Luo Tzeng-Ji Chen Jaw-Ching Wu Shuu-Jiun Wang Source Type: research
Proton-Pump Inhibitor Use and the Risk of First-Time Ischemic Stroke in the General Population
Jiang
Source: The American Journal of Gastroenterology - October 5, 2017 Category: Gastroenterology Authors: Cong Dai Qin Cao Min Jiang Source Type: research
No Significant Association Between Proton Pump Inhibitor Use and Risk of Stroke After Adjustment for Lifestyle Factors and Indication
Proton pump inhibitors (PPI) are among the top 10 most-prescribed medications worldwide. We investigated the association between PPI use and ischemic stroke.
Source: Gastroenterology - December 18, 2017 Category: Gastroenterology Authors: Long H. Nguyen, Paul Lochhead, Amit D. Joshi, Yin Cao, Wenjie Ma, Hamed Khalili, Eric B. Rimm, Kathryn M. Rexrode, Andrew T. Chan Source Type: research
Electrophilic and Drug-Induced Stimulation of NOTCH3 N-terminal Fragment Oligomerization in Cerebrovascular Pathology
AbstractSmall vessel disease is a prevalent age-related condition linked to increased risk of dementia and stroke. We investigate the most commonly inherited form, CADASIL, caused by cysteine-involving mutations inNOTCH3. Recent studies highlight accumulation of NOTCH3 N-terminal fragmentation product (NTF) in disease. In vitro, NTF is capable of both spontaneous and catecholamine-enhanced cysteine-mediated oligomerization. Despite well-characterized genetic influence on CADASIL, environmental effects, including medication usage, on disease remain unclear. We studied effects of assorted electrophilic compounds and drugs on...
Source: Translational Stroke Research - May 3, 2021 Category: Neurology Source Type: research
Regular use of proton-pump inhibitors and risk of stroke: a population-based cohort study and meta-analysis of randomized-controlled trials
Although randomized controlled trials (RCTs) have suggested a non-significant increased risk of stroke among proton pump inhibitor (PPI) users, the association has not been confirmed. We evaluated the associat...
Source: BMC Medicine - December 3, 2021 Category: Internal Medicine Authors: Man Yang, Qiangsheng He, Fang Gao, Krish Nirantharakumar, Tonny Veenith, Xiwen Qin, Amy T. Page, Martin C. S. Wong, Junjie Huang, Zi Chong Kuo, Bin Xia, Changhua Zhang, Yulong He, Wenbo Meng, Jinqiu Yuan and Yihang Pan Tags: Research article Source Type: research
Risk of aspirin-related bleeding is higher in the over-75s
Conclusion
This valuable cohort study helps to quantify the extent of bleeding risk in people taking aspirin for secondary prevention of cardiovascular disease.
Aspirin is well known to carry bleeding risk – particularly in older adults – but this study suggests the risk may be higher than previously thought. The researchers say that for adults under the age of 75, the annual bleeding risk at around 1% is similar to that suggested by previous trials, as is the ratio of bleeds to the number of cardiovascular events. However, this risk increases for older adults, especially for major bleeds of the stomach and upper diges...
Source: NHS News Feed - June 14, 2017 Category: Consumer Health News Tags: Medication Older people Source Type: news
Usefulness of a healthcare database for epidemiological research in atrial fibrillation.
CONCLUSION: The data obtained in this study were comparable with results obtained in prospective cohort studies conducted in Japan.
PMID: 28027833 [PubMed - as supplied by publisher]
Source: Journal of Cardiology - December 23, 2016 Category: Cardiology Authors: Koretsune Y, Yamashita T, Yasaka M, Oda E, Matsubayashi D, Ota K, Kobayashi M, Matsushita Y, Kaburagi J, Ibusuki K, Takita A, Iwashita M, Yamaguchi T Tags: J Cardiol Source Type: research
Real-World Relationship Between Proton Pump Inhibitors and Cerebro-Cardiovascular Outcomes Independent of Clopidogrel.
In this study, we aimed to assess the association between PPIs and cerebro-cardiovascular outcomes independent of clopidogrel.Systematic searches were conducted in the Cochrane Library, PubMed, and Embase databases for all relevant studies up to August 2018. Odds ratios (ORs) with its 95% confidence intervals (CIs) were abstracted and pooled using the random-effects model.A total of 14 observational studies (13 cohort studies and 1 case-control study) were identified. Compared with non-PPI users, PPI users experienced higher risks of stroke (OR: 1.22, 95% CI: 1.08-1.36), myocardial infarction (MI; OR: 1.23, 95% CI: 1.14-1....
Source: International Heart Journal - July 18, 2019 Category: Cardiology Tags: Int Heart J Source Type: research
Proton Pump Inhibitor Use and Risks of Cardiovascular Disease and Mortality in Patients with Type 2 Diabetes
J Clin Endocrinol Metab. 2022 Dec 27:dgac750. doi: 10.1210/clinem/dgac750. Online ahead of print.ABSTRACTBACKGROUND: Proton pump inhibitors (PPIs) are widely used drugs for gastric-acid-related diseases, which may have an impact on the gut microbiome. We aimed to evaluate the associations of PPI use with risks of cardiovascular disease (CVD) and all-cause mortality in patients with type 2 diabetes (T2D).METHODS: We analysed the associations of PPI use with risks of coronary artery disease (CAD), myocardial infarction (MI), heart failure (HF), stroke, and all-cause mortality in 19,229 adults with T2D using data from the UK ...
Source: The Journal of Clinical Endocrinology and Metabolism - December 27, 2022 Category: Endocrinology Authors: Tingting Geng Jun-Xiang Chen Yan-Feng Zhou Qi Lu Zhenzhen Wan Liegang Liu An Pan Gang Liu Source Type: research
