Filtered By:
Drug: Proton Pump Inhibitors PPIs

This page shows you your search results in order of relevance.

Order by Relevance | Date

Total 238 results found since Jan 2013.

Comparative Risk of Ischemic Stroke Among Users of Clopidogrel Together With Individual Proton Pump Inhibitors Clinical Sciences
Conclusions— PPIs of interest did not increase the rate of ischemic stroke among clopidogrel users when compared with pantoprazole, a PPI thought to be devoid of the potential to interact with clopidogrel.
Source: Stroke - February 23, 2015 Category: Neurology Authors: Leonard, C. E., Bilker, W. B., Brensinger, C. M., Flockhart, D. A., Freeman, C. P., Kasner, S. E., Kimmel, S. E., Hennessy, S. Tags: Platelet function inhibitors, Acute Cerebral Infarction, Acute Stroke Syndromes, Antiplatelets, Epidemiology Clinical Sciences Source Type: research

Does the Stenting Versus Aggressive Medical Therapy Trial Support Stenting for Subgroups With Intracranial Stenosis? Brief Reports
Conclusions— The SAMMPRIS results do not provide evidence to support the use of PTAS using the Wingspan stent system compared with medical treatment in any examined subpopulation of patients with symptomatic intracranial stenosis, including those with qualifying event hypoperfusion symptoms. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT00576693.
Source: Stroke - October 26, 2015 Category: Neurology Authors: Lutsep, H. L., Lynn, M. J., Cotsonis, G. A., Derdeyn, C. P., Turan, T. N., Fiorella, D., Janis, L. S., Lane, B. F., Montgomery, J., Chimowitz, M. I., for the SAMMPRIS Investigators Tags: Other Stroke Treatment - Medical, Angioplasty and Stenting Brief Reports Source Type: research

Concomitant Use of Proton Pump Inhibitors and Clopidogrel Is Not Associated with Adverse Outcomes after Ischemic Stroke in Chinese Population
Conflicting data exist as to whether proton pump inhibitors (PPIs) diminish the efficacy of clopidogrel. We, therefore, assessed the effect of concomitant PPI use in ischemic stroke (IS) patients receiving clopidogrel.
Source: Journal of Stroke and Cerebrovascular Diseases - August 17, 2016 Category: Neurology Authors: Xingyang Yi, Qiang Zhou, Chun Wang, Jing Lin, Wen Cheng, Lifen Chi Source Type: research

This Popular Kind Of Heartburn Medicine Can Increase Stroke Risk
This study further questions the cardiovascular safety of these drugs,” Sehested said. Although the study found an association between PPIs and stroke risk, it does not prove cause and effect. More studies are needed, and doctors should consider if and for how long patients should take these drugs, the researchers said. [7 Bizarre Drug Side Effects] PPIs are not the only medicines available to treat heartburn. The researchers noted that another type of heartburn medication, called a histamine H2 antagonist, was found to have no association with stroke risk in the study. Histamine H2 antagonists include famotidine (Pe...
Source: Science - The Huffington Post - November 21, 2016 Category: Science Source Type: news

Cost-Effectiveness of Proton Pump Inhibitor Co-Therapy in Patients Taking Aspirin for Secondary Prevention of Ischemic Stroke
Conclusions Co-therapy with ASA plus PPI appears to be cost-effective compared with ASA monotherapy. The addition of PPI also appeared to prolong the duration of ASA therapy, thereby reducing the risk of ischemic stroke.
Source: PharmacoEconomics - May 20, 2015 Category: Health Management Source Type: research

Long ‐term use of Proton Pump Inhibitors, Dose‐response Relationship, and Associated Risk of Ischemic Stroke and Myocardial Infarction
ConclusionUse of PPIs was associated with increased risks of first‐time ischemic stroke and MI, particularly among long‐term users and at high doses.This article is protected by copyright. All rights reserved.
Source: Journal of Internal Medicine - October 1, 2017 Category: Internal Medicine Authors: Thomas S. G. Sehested, Thomas A. Gerds, Emil L. Fosb øl, Peter W. Hansen, Mette G. Charlot, Nicholas Carlson, Mark A. Hlatky, Christian Torp‐Pedersen, Gunnar H. Gislason Tags: Original Source Type: research

Long ‐term use of proton pump inhibitors, dose–response relationship and associated risk of ischemic stroke and myocardial infarction
ConclusionUse of PPIs was associated with increased risks of first‐time ischemic stroke and MI, particularly amongst long‐term users and at high doses.
Source: Journal of Internal Medicine - November 7, 2017 Category: Internal Medicine Authors: T. S. G. Sehested, T. A. Gerds, E. L. Fosb øl, P. W. Hansen, M. G. Charlot, N. Carlson, M. A. Hlatky, C. Torp‐Pedersen, G. H. Gislason Tags: Original Article Source Type: research

CYP2C19 Loss-of-Function Variants Associated with Long-term Ischemic Stroke Events During Clopidogrel Treatment in the Chinese Population
This study aims to determine whether CYP2C19 loss-of-function (LoF) variants were associated with long-term ischemic stroke risk in Chinese primary care patients treated with clopidogrel. Patients treated with clopidogrel were ascertained from a Chinese Electronic Medical Record linked with biobank for a retrospective cohort study. Their medical information was examined for the period from January 2018 to December 2021. Two CYP2C19 major loss of function variants (*2:rs4244285, *3: rs4986893) were genotyped. The clinical outcome was ischemic stroke event. Cox regression analysis was used to evaluate the association between...
Source: Clinical Pharmacology and Therapeutics - August 22, 2023 Category: Drugs & Pharmacology Authors: Peng Wu Ziqing Liu Zijian Tian Benrui Wu Jian Shao Qian Li Zhaoxu Geng Ying Pan Ke Lu Qiang Wang Tao Xu Kaixin Zhou Source Type: research

Risk of Stroke-Associated Pneumonia With Acid-Suppressive Drugs: A Population-Based Cohort Study
Abstract: Acid-suppressive drugs, including histamine-2 receptor antagonists (H2RAs) and proton pump inhibitors (PPIs), are common medications used for treating upper gastrointestinal tract disorders. However, acid-suppressive drugs have been reported to increase the risk of pneumonia in numerous disease populations. However, the relationship between acid-suppressive drugs and stroke-associated pneumonia (SAP) remains controversial. The purpose of this study was to investigate the association between acid-suppressive drug usage and pneumonia among patients with stroke by using a nationwide data set. A population-based coho...
Source: Medicine - July 1, 2015 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

Antidepressants and the Risk of Ischemic Stroke in Older Adults According to the Degree of Serotonin Reuptake Inhibition: A Retrospective Cohort Study
CONCLUSION: The use of strong and intermediate SRIs should be considered carefully in older adult patients, especially when high-dose antidepressants are prescribed even for a short duration.PMID:37562992 | DOI:10.1016/j.jagp.2023.07.013
Source: The American Journal of Geriatric Psychiatry - August 10, 2023 Category: Psychiatry Authors: Kyoung-Eun Kwon Bo Ram Yang Mi-Sook Kim Byung-Joo Park Joongyub Lee Sun-Young Jung Source Type: research