Comparative Risk of Ischemic Stroke Among Users of Clopidogrel Together With Individual Proton Pump Inhibitors Clinical Sciences

Conclusions— PPIs of interest did not increase the rate of ischemic stroke among clopidogrel users when compared with pantoprazole, a PPI thought to be devoid of the potential to interact with clopidogrel.
Source: Stroke - Category: Neurology Authors: Tags: Platelet function inhibitors, Acute Cerebral Infarction, Acute Stroke Syndromes, Antiplatelets, Epidemiology Clinical Sciences Source Type: research

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CNS Neurosci Ther. 2021 Dec 3. doi: 10.1111/cns.13763. Online ahead of print.ABSTRACTPostoperative neurological disorders, including postoperative delirium (POD), postoperative cognitive dysfunction (POCD), postoperative covert ischemic stroke, and hemorrhagic stroke, are challenging clinical problems in the emerging aged surgical population. These disorders can deteriorate functional outcomes and long-term quality of life after surgery, resulting in a substantial social and financial burden to the family and society. Understanding predisposing and precipitating factors may promote individualized preventive treatment for e...
Source: CNS Neuroscience and Therapeutics - Category: Neuroscience Authors: Source Type: research
Conclusions: In this study of patients admitted with dengue, neurological complications due to dengue were seen in 2.64%. Encephalopathy, encephalitis and syncope were the commonest manifestations, followed by acute symptomatic seizures, intracranial haemorrhage and GBS. The entire neuroaxis can be involved in dengue infection. To the best of our knowledge, this is the largest reported study of neurological complications of dengue.
Source: Annals of Indian Academy of Neurology - Category: Neurology Authors: Source Type: research
Shalin Shah, Rajsrinivas Parthasarathy, Nishchint Jain, Vipul GuptaAnnals of Indian Academy of Neurology 2021 24(5):794-797
Source: Annals of Indian Academy of Neurology - Category: Neurology Authors: Source Type: research
Jalpan Patel, Ishani Patel, Devangi Desai, Soaham Desai, Himanshu PandyaAnnals of Indian Academy of Neurology 2021 24(5):821-824
Source: Annals of Indian Academy of Neurology - Category: Neurology Authors: Source Type: research
Neural Plast. 2021 Nov 23;2021:6144304. doi: 10.1155/2021/6144304. eCollection 2021.ABSTRACTBACKGROUND: Postinterventional cerebral hyperdensity (PCHD) is commonly seen in acute ischemic patients after mechanical thrombectomy. We propose a new classification of PCHD to investigate its correlation with hemorrhagic transformation (HT). The clinical prognosis of PCHD was further studied.METHODS: Data from 189 acute stroke patients were analyzed retrospectively. According to the European Cooperative Acute Stroke Study criteria (ECASS), HT was classified as hemorrhagic infarction (HI-1 and HI-2) and parenchymal hematoma (pH-1 a...
Source: Neural Plasticity - Category: Neurology Authors: Source Type: research
Vasc Health Risk Manag. 2021 Nov 23;17:739-769. doi: 10.2147/VHRM.S328096. eCollection 2021.ABSTRACTCardiovascular diseases (CVDs) are one of the leading causes of morbidity and mortality in both developed and developing countries, affecting millions of individuals each year. Despite the fact that successful therapeutic drugs for the management and treatment of CVDs are available on the market, nutritional fruits appear to offer the greatest benefits to the heart and have been proved to alleviate CVDs. Experimental studies have also demonstrated that nutritional fruits have potential protective effects against CVDs. The ai...
Source: Atherosclerosis - Category: Cardiology Authors: Source Type: research
Curr Neuropharmacol. 2021 Dec 2. doi: 10.2174/1570159X19666211202123322. Online ahead of print.ABSTRACTMicroglia are the resident immune cells of the brain and play a crucial role in housekeeping and maintaining homeostasis of the brain microenvironment. Upon injury or disease, microglial cells become activated, at least partly, via signals initiated by injured neurons. Activated microglia, thereby, contribute to both neuroprotection and neuroinflammation. However, sustained microglial activation initiates a chronic neuroinflammatory response which can disturb neuronal health and disrupt communications between neurons and ...
Source: Current Neuropharmacology - Category: Drugs & Pharmacology Authors: Source Type: research
J Neurosurg. 2021 Dec 3:1-7. doi: 10.3171/2021.9.JNS211770. Online ahead of print.ABSTRACTOBJECTIVE: On the basis of the characteristics of occluded segments on high-resolution magnetic resonance vessel wall imaging (MR-VWI), the authors evaluated the role of high-resolution MR-VWI-guided endovascular recanalization for patients with symptomatic nonacute intracranial artery occlusion (ICAO).METHODS: Consecutive patients with symptomatic nonacute ICAO that was refractory to aggressive medical treatment were prospectively enrolled and underwent endovascular recanalization. High-resolution MR-VWI was performed before the reca...
Source: Journal of Neurosurgery - Category: Neurosurgery Authors: Source Type: research
CONCLUSIONS: These results indicate that repeated systemic administration of MSCs over 3 weeks resulted in greater functional improvement as compared to single administration and/or vehicle infusion. In addition, administration of MSCs is associated with promotion of interhemispheric connectivity through the CC in the chronic phase of cerebral infarction.PMID:34861644 | DOI:10.3171/2021.8.JNS21687
Source: Journal of Neurosurgery - Category: Neurosurgery Authors: Source Type: research
Mil Med Res. 2021 Dec 3;8(1):62. doi: 10.1186/s40779-021-00356-x.ABSTRACTBACKGROUND: Disruption of the blood-brain barrier (BBB) after a stroke can lead to brain injury and neurological impairment. Previous work confirmed the involvement of the immunoproteasome subunit of low molecular mass peptide 2 (LMP2) in the pathophysiology of ischemia stroke. However, the relationship between the immunoproteasome LMP2 and the BBB remains unclear.METHODS: Adult male Sprague-Dawley rats were subjected to transient middle cerebral artery occlusion/reperfusion (MCAO/R). Three days before MCAO, the rats were treated with lentivirus-media...
Source: Cell Research - Category: Cytology Authors: Source Type: research
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