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Drug: Proton Pump Inhibitors PPIs

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Total 238 results found since Jan 2013.

Risk of major adverse cardiovascular events for concomitant use of clopidogrel and proton pump inhibitors in patients inheriting CYP2C19 loss-of-function alleles: meta-analysis
Conclusion Patients inheritingCYP2C19 loss-of-function alleles have significantly increased risk of major adverse cardiovascular events when taking clopidogrel and proton pump inhibitors concurrently.
Source: International Journal of Clinical Pharmacy - October 1, 2021 Category: Drugs & Pharmacology Source Type: research

Does the long-term administration of proton pump inhibitors increase the risk of adverse cardiovascular outcomes? A ChatGPT powered umbrella review
CONCLUSION: The findings of this umbrella review suggest that a causal relationship between PPI use and an increased risk of MACE cannot be ruled out. Further research is needed to better understand this relationship, particularly the underlying mechanisms and potential confounding factors. Healthcare professionals should consider the long-term use of PPIs and carefully weigh the risks and benefits for each patient. Finally, ChatGPT was successfully prompted to execute most of the tasks involved in this review. We therefore feel that this tool will be of great assistance in the field of evidence synthesis in the near futur...
Source: Acta Cardiologica - July 11, 2023 Category: Cardiology Authors: Eleftherios Teperikidis Aristi Boulmpou Victoria Potoupni Satyabrata Kundu Balpreet Singh Christodoulos Papadopoulos Source Type: research

Fast Heartburn Relief Without Deadly Drugs
Since gastroesophageal reflux disease (GERD) was first identified in the early 1930s, the number of people experiencing heartburn has increased substantially. In fact, one study shows that in just 10 years, the number of people experiencing:1 Any GERD symptoms increased by 30% Symptoms at least once a week increased by 47% Severe GERD increased by 24% While these numbers are concerning, I’ll admit they’re not surprising considering the typical American diet. Our nutrition-less, grain-based diet of carbohydrates and starches has wrecked our health and made our bodies behave in ways nature never intended. This has led ...
Source: Al Sears, MD Natural Remedies - August 28, 2023 Category: Complementary Medicine Authors: Jacob Tags: Health Heart Health Natural Cures Nutrition Source Type: news

Taking over the counter pain relievers safely
For aching joints or a throbbing head, millions of Americans turn to aspirin, ibuprofen (Advil, Motrin), or other nonsteroidal anti-inflammatory drugs (NSAIDs) every day. They are generally safe, but if not used carefully NSAIDs can have a dark side, according to the September 2013 Harvard Women's Health Watch. NSAIDs are widely used because they perform double duty. “They not only relieve pain, but they reduce inflammation too,” says Dr. Lucy Chen, an assistant professor at Harvard Medical School and attending physician in the anesthesia, critical care, and pain medicine department at Massachusetts General Hos...
Source: New Harvard Health Information - August 23, 2013 Category: Consumer Health News Source Type: news

Electrolyte imbalance triggering relapse of inflammatory neuropathy
We describe a case of a 71 year old female with a fourteen year history of chronic inflammatory demyelinating polyneuropathy (CIDP) and stable monoclonal gammopathy, normally maintained on three–weekly intravenous immunoglobulin (IVIG) therapy. At her best baseline, she has a normal motor examination and reduced vibration sense only to the ankles. She presented with a four week history of progressive numbness and paresthesiae in all four limbs, reduced balance, a decline in mobility with frequent falls and reduced hand function. The deterioration developed after a week of non–bloody diarrhoea with night sweats ...
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 9, 2013 Category: Neurosurgery Authors: Keshavan, A., Gandhi, S., Lunn, M., Reilly, M. Tags: Neurogastroenterology, Immunology (including allergy), Drugs: CNS (not psychiatric), Multiple sclerosis, Neuromuscular disease, Peripheral nerve disease, Stroke, Hypertension Association of British Neurologists (ABN) joint meeting with the Royal College Source Type: research

Prognosis of concomitant users of clopidogrel and proton-pump inhibitors in a high-risk population for upper gastrointestinal bleeding
Conclusion: Among patients at high risk of upper GI bleeding, those with a concomitant use of PPIs and clopidogrel were at a decreased risk of mortality, and possibly also a decreased risk of recurrence of cardiovascular disease.
Source: BMC Clinical Pharmacology - April 15, 2014 Category: Drugs & Pharmacology Authors: Qing WangRickard LjungJesper LagergrenYunxia Lu Source Type: research

Gastroesophageal Reflux in Chronic Cough and Cough Syncope and the Effect of Antireflux Treatment: Case Report and Literature Review.
CONCLUSION: For chronic cough and cough syncope of unknown cause, the GER assessment could be valuable. In treating well-selected GER-related chronic cough and cough syncope, PPI, SRF, and LF can be considered. Moreover, satisfactory restoration of physical and social functions could be achieved after effective antireflux therapy. PMID: 24842868 [PubMed - as supplied by publisher]
Source: The Annals of Otology, Rhinology, and Laryngology - May 19, 2014 Category: ENT & OMF Authors: Hu ZW, Wang ZG, Zhang Y, Tian SR, Wu JM, Zhu GC, Liang WT Tags: Ann Otol Rhinol Laryngol Source Type: research

"Impact of self-reported Gastroesophageal reflux disease in subjects from COPDGene cohort"
Background: The coexistence of gastroesophageal reflux disease (GERD) and COPD has been recognized, but there has been no comprehensive evaluation of the impact of GERD on COPD-related health status and patient-centered outcomes. Methods: Cross-sectional and longitudinal study of 4,483 participants in the COPDGene cohort who met GOLD criteria for COPD. Physician-diagnosed GERD was ascertained by questionnaire. Clinical features, spirometry and imaging were compared between COPD subjects without versus with GERD. We evaluated the relationship between GERD and symptoms, exacerbations and markers of microaspiration in univari...
Source: Respiratory Research - June 3, 2014 Category: Respiratory Medicine Authors: Carlos MartinezYuka OkajimaSusan MurrayGeorge WashkoFernando MartinezEdwin SilvermanJin LeeElizabeth ReganJames CrapoJeffrey CurtisHiroto HatabuMeiLan Han Source Type: research

Impact of self-reported Gastroesophageal reflux disease in subjects from COPDGene cohort
Background: The coexistence of gastroesophageal reflux disease (GERD) and COPD has been recognized, but there has been no comprehensive evaluation of the impact of GERD on COPD-related health status and patient-centered outcomes. Methods: Cross-sectional and longitudinal study of 4,483 participants in the COPDGene cohort who met GOLD criteria for COPD. Physician-diagnosed GERD was ascertained by questionnaire. Clinical features, spirometry and imaging were compared between COPD subjects without versus with GERD. We evaluated the relationship between GERD and symptoms, exacerbations and markers of microaspiration in univari...
Source: Respiratory Research - June 3, 2014 Category: Respiratory Medicine Authors: Carlos MartinezYuka OkajimaSusan MurrayGeorge WashkoFernando MartinezEdwin SilvermanJin LeeElizabeth ReganJames CrapoJeffrey CurtisHiroto HatabuMeiLan Han Source Type: research

Impact of self-reported gastroesophageal reflux disease in subjects from COPDGene cohort.
CONCLUSIONS: In COPD the presence of physician-diagnosed GERD is associated with increased symptoms, poorer QOL and increased frequency of exacerbations at baseline and during follow-up. These associations are maintained after controlling for PPI use. The PPI-exacerbations association could result from confounding-by-indication. PMID: 24894541 [PubMed - indexed for MEDLINE]
Source: Respiratory Care - October 12, 2014 Category: Respiratory Medicine Authors: Martinez CH, Okajima Y, Murray S, Washko GR, Martinez FJ, Silverman EK, Lee JH, Regan EA, Crapo JD, Curtis JL, Hatabu H, Han MK, COPDGene Investigators Tags: Respir Res Source Type: research

Risk of dementia in elderly patients with the use of proton pump inhibitors
Abstract Drugs that modify the risk of dementia in the elderly are of potential interest for dementia prevention. Proton pump inhibitors (PPIs) are widely used to reduce gastric acid production, but information on the risk of dementia is lacking. We assessed association between the use of PPIs and the risk of dementia in elderly people. Data were derived from a longitudinal, multicenter cohort study in elderly primary care patients, the German Study on Aging, Cognition and Dementia in Primary Care Patients (AgeCoDe), including 3,327 community-dwelling persons aged ≥75 years. From follow-up 1 to follow-up 4 (fol...
Source: European Archives of Psychiatry and Clinical Neuroscience - October 24, 2014 Category: Neuroscience Source Type: research