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Condition: Ischemic Stroke
Countries: USA Health

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Total 575 results found since Jan 2013.

Warfarin Use And the Risk Of Stroke, Bleeding, And Mortality In Older Adults On Dialysis With Incident Atrial Fibrillation
ConclusionOlder ESRD patients with AF who were treated with warfarin had a no difference in stroke risk, lower mortality risk, but increased major bleeding risk. The bleeding risk associated with warfarin was greater among women than men. The risk/benefit ratio of warfarin may be less favorable among older women.
Source: Nephrology - December 1, 2017 Category: Urology & Nephrology Authors: Jingwen Tan, Sunjae Bae, Jodi B. Segal, Junya Zhu, G. Caleb Alexander, Dorry L. Segev, Mara McAdams ‐DeMarco Tags: Original Article Source Type: research

Ischemic Stroke: Management by the Nurse Practitioner
This article addresses preischemic stroke, acute, and postischemic stroke care by the NP with a focus on the American Heart Association 8 D ’s of stroke chain of survival.
Source: The Journal for Nurse Practitioners - November 10, 2018 Category: Nursing Authors: Susan E. Wilson, Susan Ashcraft Tags: Featured Article Source Type: research

Occupational and leisure-time physical activity differentially predict 6-year incidence of stroke and transient ischemic attack in women.
Conclusions Higher intensity levels of OPA increased stroke and TIA risks, while LTPA decreased risks; results corroborate the physical activity health paradox for women and cerebrovascular disease. More standing at work increased cerebrovascular disease risks, especially for women with CVD. PMID: 30448859 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Work, Environment and Health - November 19, 2018 Category: Occupational Health Authors: Hall C, Heck JE, Sandler DP, Ritz B, Chen H, Krause N Tags: Scand J Work Environ Health Source Type: research

Prolyl hydroxylase domain inhibitors: can multiple mechanisms be an opportunity for ischemic stroke?
Abstract Stroke and cerebrovascular disease are now the fifth most common cause of death behind other diseases such as heart, cancer and respiratory disease and accounts for approximately 40-50 fatalities per 100,000 people each year in the United States. Currently the only therapy for acute stroke, is intravenous administration of tissue plasminogen activator which was approved in 1996 by the FDA. Surprisingly no new treatments have come on the market since, although endovascular mechanical thrombectomy is showing promising results in trials. Recently focus has shifted towards a preventative therapy rather than t...
Source: Neuropharmacology - December 19, 2018 Category: Drugs & Pharmacology Authors: Lanigan SM, O'Connor JJ Tags: Neuropharmacology Source Type: research

Racial Differences in Mechanical Thrombectomy Utilization for Ischemic Stroke in the United States.
Conclusion: We found a significant disparity in MT utilization for AA compared with NHW and Hispanics. More work is needed to understand the drivers of this racial disparity in stroke treatment. PMID: 31969788 [PubMed - in process]
Source: Ethnicity and Disease - January 25, 2020 Category: International Medicine & Public Health Tags: Ethn Dis Source Type: research

let-7g counteracts endothelial dysfunction and ameliorating neurological functions in mouse ischemia/reperfusion stroke model
Publication date: Available online 1 February 2020Source: Brain, Behavior, and ImmunityAuthor(s): David L. Bernstein, Sachin Gajghate, Nancy L. Reichenbach, Malika Winfield, Yuri Persidsky, Nathan A. Heldt, Slava RomAbstractStroke is a debilitating disease, accounting for almost 20% of all hospital visits, and 8% of all fatalities in the United States in 2017. Following an ischemic attack, inflammatory processes originating from endothelial cells within the brain microvasculature can induce many toxic effects into the impacted area, from both sides of the blood brain barrier (BBB). In addition to increased BBB permeability...
Source: Brain, Behavior, and Immunity - February 1, 2020 Category: Neurology Source Type: research

The Advanced Practice Nurse Will See You Now: Impact of a Transitional Care Clinic on Hospital Readmissions in Stroke Survivors
Conclusions: The results suggest the APRN-led clinic may impact 30-day hospital readmissions in stroke/transient ischemic attack survivors.
Source: Journal of Nursing Care Quality - February 19, 2020 Category: Nursing Tags: Articles Source Type: research

Expansion of the dimensions in the current management of acute ischemic stroke
AbstractStroke is the fifth leading cause of death in the United States with a huge burden on health care. Acute ischemic stroke (AIS) accounts for 87% of all stroke. The use of thrombolytic agents in AIS treatment is well known since 1950 but no FDA approval until 1996, due to lack of strong evidence showing benefits outweigh the risk of intracranial hemorrhage. The NINDS trial led to the approval of intravenous tissue plasminogen activator treatment (IV recombinant tPA) within 3  h of stroke. Due to this limitation of 3–4.5 h. window, evolution began in the development of effective endovascular therapy (EVT). Multipl...
Source: Journal of Neurology - May 19, 2020 Category: Neurology Source Type: research

Sex Differences in Prehospital Delay in Patients With Acute Stroke: A Systematic Review.
CONCLUSIONS: Most study authors found no differences in prehospital delay between women and men; however, women delayed longer in some Asian-Pacific and American studies. Findings of sex differences were inconclusive. PMID: 32649376 [PubMed - as supplied by publisher]
Source: The Journal of Cardiovascular Nursing - July 2, 2020 Category: Nursing Authors: Potisopha W, Vuckovic KM, DeVon HA, Park CG, Hershberger PE Tags: J Cardiovasc Nurs Source Type: research

Network Mapping of Time to Antithrombotic Therapy Among Patients With Ischemic Stroke and Transient Ischemic Attack (TIA)
Conclusion: The proportion of patients receiving antithrombotics within 48 h was higher than previously reported in Australia but remained lower than the standard achieved in North American hospitals. Our process map and network analysis show avenues to shorten the time to antithrombotic.
Source: Frontiers in Neurology - June 7, 2021 Category: Neurology Source Type: research

E-096 COVID status is related to clot burden during thrombectomy in acute stroke patients
ConclusionOf 230 patients included in this interim analysis across 24 centers in the United States, between 02/2021 and 01/2022, 16 patients had a history of COVID. Comparing COVID-positive to non-positive, patients with COVID were younger (median 66.5 years vs 71.5 years, p 0.042), and had more intracranial clot by weight (median 101.0 mg vs 42.0 mg, p 0.047). There was a trend toward COVID positive patients to have more clot volume (median 180 cc vs 77.5 cc p 0.08), suggesting the difference was a higher clot burden instead of more density to the thrombus. These results suggest different histopathological characteristics...
Source: Journal of NeuroInterventional Surgery - July 23, 2022 Category: Neurosurgery Authors: Fraser, J., Dabney, A., Vicari, J., Rivet, D., Woodward, B., Nanda, A., Fiorella, D., Baltan, S., Sohrabji, F., Pennypacker, K., Kellner, C. Tags: SNIS 19th annual meeting electronic poster abstracts Source Type: research

Broadening Our SCOPE of Understanding Patent Foramen Ovale High-risk Features and Stroke
Paradoxical embolization of a blood clot of presumed venous origin through a patent foramen ovale (PFO) is increasingly recognized as a legitimate cause of otherwise cryptogenic ischemic stroke (CIS). The term PFO-associated stroke has been proposed, as has where and how to classify this entity in the nomenclature of various ischemic stroke subtyping systems. PFOs are common, with prevalence as high as 25% in the general population. The prevalence of PFO is further increased in patients with CIS (overall 2.9 times higher), and especially so in the subset of younger patients (<55 years, 5.1 times higher). One estimate of...
Source: JAMA Neurology - October 10, 2022 Category: Neurology Source Type: research

EMAGINE –Study protocol of a randomized controlled trial for determining the efficacy of a frequency tuned electromagnetic field treatment in facilitating recovery within the subacute phase following ischemic stroke
Stroke is a leading cause of disability with limited effective interventions that improve recovery in the subacute phase. This protocol aims to evaluate the safety and efficacy of a non-invasive, extremely low-frequency, low-intensity, frequency-tuned electromagnetic field treatment [Electromagnetic Network Targeting Field (ENTF) therapy] in reducing disability and promoting recovery in people with subacute ischemic stroke (IS) with moderate-severe disability and upper extremity (UE) motor impairment. Following a sample-size adaptive design with a single interim analysis, at least 150 and up to 344 participants will be rec...
Source: Frontiers in Neurology - May 5, 2023 Category: Neurology Source Type: research

A study of the correlation between stroke and gut microbiota over the last 20years: a bibliometric analysis
ConclusionFindings suggest that in the next 10 years, the number of publications produced annually may increase significantly. Future research trends tend to concentrate on the mechanisms of stroke and gut microbiota, with the inflammation and immunological mechanisms, TMAO, and fecal transplantation as hotspots. And the relationship between these mechanisms and a particular cardiovascular illness may also be a future research trend.
Source: Frontiers in Microbiology - June 7, 2023 Category: Microbiology Source Type: research

CO142 Evaluating the Impact of the COVID-19 Pandemic on Acute Ischemic Stroke Outcomes in the Stroke Belt
This study sought to compare specific key outcomes related to ischemic stroke that occurred before and during the COVID-19 pandemic. We assessed mortality rates, morbidity rates, and the administration of thrombolytics in patients with ischemic stroke admitted to emergency departments (ED) in the Stroke Belt, a region of the United States with historically worse stroke outcomes.
Source: Value in Health - June 1, 2023 Category: International Medicine & Public Health Authors: E. Stitzlein, F. Pathan, I. Weimer, K. Lodaya, F. D'Souza, A. Shenoy Source Type: research