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Total 25 results found since Jan 2013.

P158/212 The first pass effect: the initial real-life experience of the University Clinical centre of Serbia
ConclusionDespite shorter time intervals and higher frequency of recanalization rate of the FPE group, no difference was observed in relation to clinical and safety outcomes after 90 days of AIS. In order to better understand the FPE and its predictors, further studies are needed in form of randomized controlled clinical studies.Disclosure of InterestNothing to disclose
Source: Journal of NeuroInterventional Surgery - August 21, 2023 Category: Neurosurgery Authors: Mircic, U., Vukasinovic, I., Nedeljkovic, Z., Pirkovic, I., Nestorovic, D., Cvetic, V., Ercegovac, M., Jovanovic, D., Berisavac, I., Stanarcevic, P. Tags: 2.3 ISCHEMIC - Treatment Source Type: research

P022/217 Hemorrhagic complications during mechanical thrombectomy
ConclusionProcedure-induced hemorrhage complications are rare and potentially disastrous events of which interventionalists need to be aware and be prepared for adequate endovascular solutions.Disclosure of InterestNothing to disclose
Source: Journal of NeuroInterventional Surgery - August 21, 2023 Category: Neurosurgery Authors: Mircic, U., Vukasinovic, I., Nestorovic, D., Petrovic, M. Tags: 4.4 CASE PROPOSAL - Complications Source Type: research

Association of MMP1 and MMP3 haplotypes with myocardial infarction and echocardiographic parameters of the left ventricle
ConclusionMMP1 andMMP3 haplotypes are strongly associated with MI. Further studies are needed to validate this result and to examine their association with echocardiographic parameters of LV structure and function after MI.
Source: Molecular Genetics & Genomic Medicine - August 1, 2022 Category: Genetics & Stem Cells Authors: Tamara Djuric, Jovana Kuveljic, Ana Djordjevic, Milica Dekleva, Goran Stankovic, Aleksandra Stankovic, Maja Zivkovic Tags: ORIGINAL ARTICLE Source Type: research

Cost-effectiveness of a photopethysmographic procedure for screening for atrial fibrillation in 6 European countries
ConclusionThe model results showed a strong dependence of the results on the country-specific costs for stroke treatment. The use of the investigated screening method is close to cost-neutral or cost-reducing in the Western European countries and Greece. In countries with low price levels, higher cost increases due to AF screening are to be expected. Lower costs of anticoagulation, which are expected due to the upcoming patent expiry of direct anticoagulants, have a positive effect on the cost result.
Source: Health Economics Review - February 26, 2022 Category: International Medicine & Public Health Source Type: research

Reliability and validity of the Stroke and Aphasia Quality of Life Scale-39 (SAQOL-39) for a Serbian population
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Source: International Journal of Speech-Language Pathology - September 20, 2021 Category: Speech-Language Pathology Authors: Mile Vukovi Ć Željana Sukur Irena Vukovi Ć Christos Salis Chris Code Source Type: research

Cerebral venous thrombosis: a retrospective unicentric analysis of clinical and neuroimaging characteristics
AbstractThrombosis of dural sinuses and/or cerebral veins (CVT) is an uncommon form of stroke, usually affecting young individuals. It has a variable clinical presentation ranging from mild cases presenting only headaches, to severe cases featuring encephalopathy, coma or status epilepticus. A retrospective cross-sectional study of patients treated in the outpatient department and in-hospital during the period from 2014 to 2020 at the Neurology Clinic —University Clinical Centre of Serbia was conducted. Forty-nine patients (24 men; 25 women) were included in the study. Twenty-three patients (46.9%) suffered a subacute fo...
Source: Neurological Sciences - August 4, 2021 Category: Neurology Source Type: research

Health-Related Quality of Life in Stroke Survivors in Relation to the Type of Inpatient Rehabilitation in Serbia: A Prospective Cohort Study.
Conclusions: There was a significant difference in health-related quality of life perceived by stroke survivors who underwent additional hospital rehabilitation in relation to those who underwent only inpatient rehabilitation. PMID: 33266160 [PubMed - in process]
Source: Medicina (Kaunas) - November 30, 2020 Category: Universities & Medical Training Authors: Rancic NK, Mandic MN, Kocic BN, Veljkovic DR, Kocic ID, Otasevic SA Tags: Medicina (Kaunas) Source Type: research

Age at death in elderly cohorts of four European countries of the Seven Countries Study: the role of comorbidities.
CONCLUSION: AD seems a valuable indicator of all-cause mortality when the study population has reached or approached the extinction. PMID: 32410168 [PubMed - as supplied by publisher]
Source: Aging Clinical and Experimental Research - May 13, 2020 Category: Geriatrics Authors: Menotti A, Puddu PE, Tolonen H Tags: Aging Clin Exp Res Source Type: research

Possible synergistic effect of apoE and LRP1 genotypes on metabolic syndrome development in Serbian patients.
Abstract The modern way of life contributes to the higher frequency of a complex state medically called metabolic syndrome (MetS), which is an inevitable consequence of several most common diseases of modern civilization. Patients with MetS have three times higher risk of experiencing a heart attack or a stroke and twice higher possibility to die from them. Serbia holds the infamous third place in Europe in mortality from heart disease, just behind Russia and Ukraine. The study explores the correlation of every combination of genotypes of apoE (apolipoprotein E) and LRP1 (low density receptor- related protein 1) g...
Source: Molecular Biology Reports - September 19, 2019 Category: Molecular Biology Authors: Vučinić N, Stankov K, Đan M, Barjaktarović I, Stokić E, Strajnić LJ, Obreht D, Đan I Tags: Mol Biol Rep Source Type: research

Genotype phenotype correlation in a pediatric population with antithrombin deficiency
Conclusion: Type II HBS (AT Budapest 3) in the homozygous form is a strong risk factor for arterial and venous thrombosis in pediatric patients.What is Known:•Inherited AT deficiency is a rare autosomal dominant disorder, caused by mutations in the SERPINC1gene.•The genotype phenotype correlation in AT deficiency patients remains unclear, especially in pediatric patients.What is New:•The genetic results for our paediatric population predominantly showed the presence of a single specific mutation in exon 2, that causes type II HBS deficiency (AT Budapest 3).•In this group thrombosis mostly occurred as unprovoked, in...
Source: European Journal of Pediatrics - July 28, 2019 Category: Pediatrics Source Type: research

A Post-hoc Study of D-Amino Acid Oxidase in Blood as an Indicator of Post-stroke Dementia
In conclusion, our data support that plasma DAO levels were increased in PSD patients and correlated with brain WMH, independent of age, gender, hypertension, and renal function. Plasma DAO levels may therefore aid in PSD diagnosis. Introduction Stroke is a risk factor for both vascular dementia and Alzheimer's disease (1, 2). Functional recovery develops over the course of 26 weeks after a stroke (3), but the survivors are often left with disabilities. In addition to the sequelae of acute neuronal damage, the 1-year post-stroke dementia (PSD) rates after first-ever and recurrent stroke are ~10 and 30...
Source: Frontiers in Neurology - April 25, 2019 Category: Neurology Source Type: research

Harnessing the Four Elements for Mental Health
DiscussionAs detailed above, the “elements” in both a classical and a contemporary sense have effects on our mental health and are potentially modifiable aspects that can be harnessed as therapeutic interventions. The most robust interventional evidence currently available shows tentative support for several use of the elements via horticultural and nature-exposure therapy, green exercise/physical activity, sauna and heat therapy, balneotherapy, and breathing exercises. It should be noted that, in many cases, these interventions were not studied in definitive diagnosed psychiatric disorders and thus it is pre...
Source: Frontiers in Psychiatry - April 23, 2019 Category: Psychiatry Source Type: research

Orexin-A Prevents Lipopolysaccharide-Induced Neuroinflammation at the Level of the Intestinal Barrier
We examined a possible protective effect of OX-A against LPS-induced ROS formation and microglia activation. To mimic in vitro the connection between gut and brain and to study the putative effect on the cortical microglia, we used a co-culture of Caco-2 cells and primary cortical microglia with Caco-2 cells placed at the apical side of a transwell and primary cortical microglia at the basolateral side. All treatments used to study the apical vs. basal connection were applied to the apical compartment. We used DHR (10 μM, 20 min), a cell-permeable fluorogenic probe useful for the detection of ROS formation, to dete...
Source: Frontiers in Endocrinology - April 9, 2019 Category: Endocrinology Source Type: research

The association of clopidogrel and 2-oxo-clopidogrel plasma levels and the 40  months clinical outcome after primary PCI
Conclusion Clopidogrel dose-adjusted plasma concentration in STEMI patients, as well as multivessel coronary artery disease, showed significance in predicting an unfavorable composite clinical outcome after 40-month follow-up.
Source: International Journal of Clinical Pharmacy - October 26, 2018 Category: Drugs & Pharmacology Source Type: research