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Condition: Dementia
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Total 103 results found since Jan 2013.

A Study to Decipher the Potential Effects of Butylphthalide against Central Nervous System Diseases Based on Network Pharmacology and Molecular Docking Integration Strategy
CONCLUSIONS: Our study proposed a drug-target-disease integrated method to predict the drug repurposing potentials to associated diseases by application of NP and MD, which could be an attractive alternative to facilitate the development of CNS disease therapies. NBP may be promising and showed potentials to be repurposed for treatments for AD, epilepsy, ALS, and depression, and further investigations are warranted to be carefully designed and conducted.PMID:34035826 | PMC:PMC8116153 | DOI:10.1155/2021/6694698
Source: Molecular Medicine - May 26, 2021 Category: Molecular Biology Authors: Qinqin Zhao Bei Zheng Pinpin Feng Xiang Li Source Type: research

Efficacy of phenobarbital in treating elderly epilepsy patients in rural northeast China: a community-based intervention trial
In the latest study, there were approximately 45.9 million individuals with active epilepsy (at least one breakthrough seizure in the past 5 years) globally and approximately 3.26 million patients with epilepsy (PWE) in China [1]. Epilepsy is the third most common neurological disorder in the elderly population after stroke and dementia [2] and is comparatively more frequent in this population than in the young population [3]. The number of patients with late-onset epilepsy (LOE; recurrent unprovoked seizures starting at 60 years or older [4]) has increased significantly, representing up to 25% of new-onset epilepsies [5].
Source: Seizure: European Journal of Epilepsy - May 11, 2021 Category: Neurology Authors: Nan Li, Jing Li, Danyang Zhao, Weihong Lin Source Type: research

Screening for Cognitive Impairment After Stroke: Validation of the Chinese Version of the Quick Mild Cognitive Impairment Screen
Conclusion: The Qmci-CN is accurate in identifying PSD and separating PSD from PSCIND in patients post-stroke following rehabilitation and is comparable to the widely-used MoCA-CN, albeit with a significantly shorter administration time. The Qmci-CN had relatively poor accuracy in identifying PSCIND from NC and hence may lack accuracy for certain subgroups. However, given the small sample size, the study is under-powered to show superiority of one instrument over another. Further study is needed to confirm these findings in a larger sample size and in other settings (countries and languages).
Source: Frontiers in Neurology - March 5, 2021 Category: Neurology Source Type: research

Clinical features of neurological patients with coronavirus 2019: an observational study of one centre.
CONCLUSIONS: We studied a select group of patients (elderly, with comorbidities, and moderate or severe COVID-19 course). Pre-existing neurological disorders were additionally associated with a poorer prognosis and a high fatality rate (30%). Dementia and CNS vascular disorder were the most frequent pre-existing neurological conditions. The neurological symptoms of COVID-19 were various. We observed impaired consciousness, dizziness, headache, nausea, myalgia, psychomotor agitation and slowness, delirium, and psychoses. Further analysis is needed to elucidate the incidence of COVID-19 neurological complications. PMID:...
Source: Neurologia i Neurochirurgia Polska - February 2, 2021 Category: Neurology Authors: Zielińska-Turek J, Jasińska A, Kołakowska J, Szadurska J, Kosior DA, Dorobek M Tags: Neurol Neurochir Pol Source Type: research

Effect of acupuncture treatment on post-stroke cognitive impairment: A randomized controlled trial
Introduction: Post-stroke cognitive impairment (PSCI), which has a high morbidity, is closely associated with the recurrence and rehabilitation of ischemic stroke. There are 2 different stages of PSCI, including post-stroke cognitive impairment with no dementia (PSCIND) and post-stroke dementia (PSD). The latter has a significantly higher mortality rate than the previous one. Therefore, preventing the onset of PSD is of vital importance. However, there is no unequivocally effective prevention or treatment for PSCI, except intensive secondary prevention of stroke. The primary aim of this protocol is to explore whether a...
Source: Medicine - December 18, 2020 Category: Internal Medicine Tags: Research Article: Study Protocol Clinical Trial Source Type: research

Shenmayizhi Formula Combined with Ginkgo Extract Tablets for the Treatment of Vascular Dementia: A Randomized, Double-Blind, Controlled Trial.
Authors: Zhang H, Cao Y, Pei H, Wang H, Ma L, Wang Z, Diao X, Yang Y, Liu N, Wei Y, Li H Abstract Shenmayizhi formula (SMYZF) has been shown to have an effect on vascular dementia (VaD) in previous studies. The aim of this study was to evaluate whether a combination of SMYZF with Ginkgo extract tablets improves mild-to-moderate VaD. In this 12-week, randomized, double-blind, controlled study, we randomly assigned 196 patients with VaD (aged 50-85 years) to either the SMYZF group (n = 98) or the Ginkgo group (n = 98). All patients received Ginkgo extract tablets as a basic treatment, while the SMYZF group al...
Source: Evidence-based Complementary and Alternative Medicine - August 14, 2020 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Cholesterol profiles and incident cognitive decline among older adults: the Shanghai Aging Study
Conclusionseffect of cholesterol on cognitive decline may be modified by VRFs.
Source: Age and Ageing - August 6, 2020 Category: Geriatrics Source Type: research

Burden of cause-specific mortality attributable to heat and cold: A multicity time-series study in Jiangsu Province, China.
Abstract Previous epidemiological studies primarily examined the temperature-related mortality burden of all-cause or cardiovascular diseases (CVD) and respiratory diseases. However, evidence on the heat- and cold-attributable mortality burden from other specific causes is limited. This paper aimed to systematically examine the association of heat and cold with a comprehensive spectrum of plausible temperature-related diseases, and to estimate the mortality burdens attributable to heat and cold. In the time-series study of 11 cities in Jiangsu, China, distributed lag non-linear models were applied to estimate city...
Source: Environment International - July 30, 2020 Category: Environmental Health Authors: Ma Y, Zhou L, Chen K Tags: Environ Int Source Type: research

Relationship between Urinary Alzheimer-Associated Neuronal Thread Protein and Apolipoprotein Epsilon 4 Allele in the Cognitively Normal Population.
Abstract We investigated the relationship between urinary Alzheimer-associated neuronal thread protein (AD7c-NTP) levels and apolipoprotein epsilon 4 (ApoE ɛ4) alleles, as well as other factors that cause cognitive decline, in the cognitively normal population. We recruited 329 cognitively normal right-handed Han Chinese subjects who completed ApoE gene testing and urinary AD7c-NTP testing. There was no significant difference in urinary AD7c-NTP levels between the normal control and subjective cognitive decline groups. Urinary AD7c-NTP levels were significantly higher in subjects with ApoE ɛ3/4 and 4/4 [0.6074 (...
Source: Neural Plasticity - June 27, 2020 Category: Neurology Authors: Li Y, Kang M, Sheng C, Chen G, Li T, Wang J, Cai Y, Wang R, Han Y Tags: Neural Plast Source Type: research

Understanding Cognitive Impairment after Stroke: Stories from a Middle-Income Country
This study presents findings from a community of Malaysian-Chinese stroke survivors living in Malaysia on their understandings of cognitive deficits after stroke. The way stroke survivors thought about CI was also mediated by the cultural and social context that surrounded them. Of interest was the primacy of physical health over the cognitive which resulted in the invisibility of CI within this community, regardless of whether the deficits were mild or severe. Based on these findings, there is a need to rethink how cognitive decline should be observed in realistic community settings.
Source: Journal of Population Ageing - June 10, 2020 Category: International Medicine & Public Health Source Type: research

Severe acute respiratory syndrome coronavirus 2 is penetrating to dementia research.
Abstract 1. Introduction Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus infectious disease 2019 (COVID-19), which was first reported in Wuhan, China, in late December, 2019. Despite the tremendous efforts to control the disease, SARS-CoV-2 has infected 1,5 million people and caused the death of more than a hundred thousand people across the globe as of writing. Recently, Mao et al. [1] investigated the penetration potential of SARS-CoV-2 into the central nervous system in 214 patients. They reported that 36.4% of the patients had some neurologic findings which are ranged from nonsp...
Source: Current Neurovascular Research - May 21, 2020 Category: Neurology Authors: Bostanciklioglu M, Temiz E Tags: Curr Neurovasc Res Source Type: research

2019-NCoV: What Every Neurologist Should Know ?
Nitika Mahajan, Monika Singla, Balveen Singh, Venkatesh Sajja, Parth Bansal, Birinder Paul, Parveen Goel, Rahul Midha, Rajinder Bansal, Gagandeep SinghAnnals of Indian Academy of Neurology 2020 23(7):28-32The 2019 novel Corona Virus pandemic beginning from Wuhan, China primarily affects the respiratory tract but its has impacted clinical practice across a range of specialities including neurology. We review the bearing of the 2019 NCoV infection on neurological practice. Neurological manifestations are less common than respiratory manifestations, yet conspicuous, affecting nearly over a third of hospitalized individuals. T...
Source: Annals of Indian Academy of Neurology - April 23, 2020 Category: Neurology Authors: Nitika Mahajan Monika Singla Balveen Singh Venkatesh Sajja Parth Bansal Birinder Paul Parveen Goel Rahul Midha Rajinder Bansal Gagandeep Singh Source Type: research

Establishment of a Risk Prediction Model for Mild Cognitive Impairment Among Elderly Chinese
ConclusionsThis model performs an effective prediction that may be applied to the primary prevention for patients with MCI, helping to reduce the risk of MCI.
Source: The Journal of Nutrition, Health and Aging - February 11, 2020 Category: Nutrition Source Type: research