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Total 13528 results found since Jan 2013.

Management of Acute Cerebral Infarction by Intravenous Thrombolysis with Recombinant T Cell Receptor and Plasminogen Activator and Association of Emergency Nursing Route in the Prognosis
In this study, 100 patients were randomly selected that were equally divided into experimental and control groups. The period of hospital admission, the results of the Montreal Cognitive Assessment (MoCA) and the Mini-mental State Examination (MMSE), the results of the Glasgow Outcome Scale (GOS), and the results of the Activities of Daily Living were all analysed before and after the intervention.. Both the amount of time it took to get a diagnosis after being admitted and the amount of time it took to receive specialised therapy after receiving a diagnosis were significantly reduced in the observation group (both P value...
Source: Cellular and Molecular Biology - September 16, 2023 Category: Molecular Biology Authors: None Yuqi Liu None Chengyong Wang None Yuanpeng Han Source Type: research

The cell-specific roles of Nrf2 in acute and chronic phases of ischemic stroke
CNS Neurosci Ther. 2023 Sep 16. doi: 10.1111/cns.14462. Online ahead of print.ABSTRACTIschemic stroke refers to the sudden loss of blood flow in a specific area of the brain. It is the fifth leading cause of mortality and the leading cause of permanent disability. The transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) controls the production of several antioxidants and protective proteins and it has been investigated as a possible pharmaceutical target for reducing harmful oxidative events in brain ischemia. Each cell type exhibits different roles and behaviors in different phases post-stroke, which is...
Source: CNS Neuroscience and Therapeutics - September 16, 2023 Category: Neuroscience Authors: George Fadoul Milos Ikonomovic Feng Zhang Tuo Yang Source Type: research

Brain Pathology in COVID-19: Clinical Manifestations and Potential Mechanisms
AbstractNeurological manifestations of coronavirus disease 2019 (COVID-19) are less noticeable than the respiratory symptoms, but they may be associated with disability and mortality in COVID-19. Even though Omicron caused less severe disease than Delta, the incidence of neurological manifestations is similar. More than 30% of patients experienced “brain fog”, delirium, stroke, and cognitive impairment, and over half of these patients presented abnormal neuroimaging outcomes. In this review, we summarize current advances in the clinical findings of neurological manifestations in COVID-19 patients and compare them with ...
Source: Neuroscience Bulletin - September 16, 2023 Category: Neuroscience Source Type: research

Stroke Doesn't Have to Lead to Death or Disability
(MedPage Today) -- Imagine having a severe, life-threatening stroke at 5 p.m., being rushed by ambulance to undergo minimally invasive surgery to remove the blood clot from your brain, then walking out of the hospital, symptom-free, the very next...
Source: MedPage Today Cardiovascular - September 15, 2023 Category: Cardiology Source Type: news

Rhein attenuates cerebral ischemia-reperfusion injury via inhibition of ferroptosis through NRF2/SLC7A11/GPX4 pathway
CONCLUSION: Rhein attenuates cerebral I/R injury by inhibiting ferroptosis via the NRF2/SLC7A11/GPX4 axis, highlighting its potential as a therapeutic agent for ischemic stroke.PMID:37714424 | DOI:10.1016/j.expneurol.2023.114541
Source: Experimental Neurology - September 15, 2023 Category: Neurology Authors: Hua Liu Tian-Ai Zhang Wen-Yue Zhang Si-Rui Huang Yue Hu Jia Sun Source Type: research

A rehabilitative approach beyond the acute stroke event: a scoping review about functional recovery perspectives in the chronic hemiplegic patient
ConclusionThe literature analyzed invites us to reflect respect to neurorehabilitation approach to the patient with chronic stroke sequelae often considered to have as its objective the maintenance of the present motor function and contain disability: instead, the review reports how, even in chronicity, the patient always reports margins of statistically and clinically significant improvement. The chronic stroke rehabilitation over 6 months has been proved effective in obtaining recovery in different settings.
Source: Frontiers in Neurology - September 15, 2023 Category: Neurology Source Type: research

Predicting The Onset Of Diabetes-Related Complications After A Diabetes Diagnosis With Machine Learning Algorithms
The burden of Diabetes has been ranked as the eighth cause in the ranking of causes of disability-adjusted life years (DALYs) all over the world [1,2], accounting for 2.8% of total DALYs and with an increase of more than 148% in 2019 as compared with the data obtained in 1990 [2]. Diabetes is one of the most significant factors increasing the risk of mortality, morbidity, and disability worldwide, and its economic burden demands new ways to curb diabetes healthcare expenditure [3]. Furthermore, people with diabetes are at greater risk of additionally suffering from cardiovascular diseases, such as heart attack or stroke [4...
Source: Diabetes Research and Clinical Practice - September 15, 2023 Category: Endocrinology Authors: Toni Mora, David Roche, Beatriz Rodr íguez-Sánchez Source Type: research

Functional effects of haemoglobin can be rescued by haptoglobin in an in vitro model of subarachnoid haemorrhage
Subarachnoid haemorrhage causes significant cognitive and functional disability in survivors, and one contributing factor is exposure of neurons to haemoglobin causing cell loss and dysfunction. In this in vitro subarachnoid haemorrhage model, haemolysate application to cultured neurons impairs cytoskeletal integrity. Furthermore, amplitude of AMPA receptor-mediated synaptic currents is reduced by haemolysate, driven by reduction in GluA1 expression. These deficits can be prevented with application of exogenous haptoglobin without off-target effects. These results provide new insight into neuronal dysfunction in haemorrhag...
Source: Journal of Neurochemistry - September 14, 2023 Category: Neuroscience Authors: Hannah Warming, Katrin Deinhardt, Patrick Garland, John More, Diederik Bulters, Ian Galea, Mariana Vargas ‐Caballero Tags: ORIGINAL ARTICLE Source Type: research

Endovascular treatment for large-core ischaemic stroke: a meta-analysis of randomised controlled clinical trials
Conclusion EVT appears to be effective and safe and may be considered for the treatment of large-core AIS, as assessed by ASPECTS of 2–5 or volumetric methods. PROSPERO registration number CRD42022334417.
Source: Journal of Neurology, Neurosurgery and Psychiatry - September 14, 2023 Category: Neurosurgery Authors: Palaiodimou, L., Sarraj, A., Safouris, A., Magoufis, G., Lemmens, R., Sandset, E. C., Turc, G., Psychogios, M., Tsivgoulis, G. Tags: Editor's choice Cerebrovascular disease Source Type: research

Cardiovascular disease and risk factors in adults with diabetes mellitus in Hungary: a population-based study
The objective of this study was to estimate the prevalence of CVD in individuals with DM and to investigate the association between potential risk factors and the presence of CVD among individuals with DM in a population-based sample.MethodsThe study was based on data from three waves of the European Health Interview Surveys (EHIS) conducted in Hungary in 2009, 2014, and 2019.ResultsThe prevalence of CVD among patients with DM decreased during the study period and that socioeconomic factors, cardiometabolic risk factors including high blood pressure and high cholesterol, and depression are major contributors to CVD burden ...
Source: Frontiers in Endocrinology - September 14, 2023 Category: Endocrinology Source Type: research

Astrocytes in functional recovery following central nervous system injuries
J Physiol. 2023 Sep 13. doi: 10.1113/JP284197. Online ahead of print.ABSTRACTAstrocytes are increasingly recognised as partaking in complex homeostatic mechanisms critical for regulating neuronal plasticity following central nervous system (CNS) insults. Ischaemic stroke and traumatic brain injury are associated with high rates of disability and mortality. Depending on the context and type of injury, reactive astrocytes respond with diverse morphological, proliferative and functional changes collectively known as astrogliosis, which results in both pathogenic and protective effects. There is a large body of research on the...
Source: The Journal of Physiology - September 13, 2023 Category: Physiology Authors: Qasim M Alhadidi Ghaith A Bahader Oiva Arvola Philip Kitchen Zahoor A Shah Mootaz M Salman Source Type: research