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Total 1466 results found since Jan 2013.

Hydroxyurea treatment for sickle cell anemia during pregnancy and lactation: current evidence and knowledge gaps
AbstractSickle cell anemia (SCA) is a life-threatening genetic condition contributing to high-risk pregnancies affecting both the mother and fetus. With improved management of children with SCA, this life-threatening hematological disorder has evolved into a chronic disease of adults, and consequently parenthood has now become a possible and important life goal for many patients. Providing continuous management with healthy red blood cell function and avoiding SCA-associated complications, such as pain crises, acute chest syndrome, and stroke, are crucial for a healthy pregnancy. Despite its excellent safety profile in non...
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - March 17, 2023 Category: Drugs & Pharmacology Authors: Min Dong, Russell E. Ware, Andr é Dallmann, Alexander A. Vinks Tags: REVIEW Source Type: research

Impact of hypertensive disorders of pregnancy on short- and long-term outcomes of pregnancy-associated hemorrhagic stroke
ConclusionsIn this retrospective study, women with hypertension disorders of pregnancy did not show worse short-term outcomes of pregnancy-associated hemorrhagic stroke compared to those without but had poorer long-term functional outcomes. This underlines the importance of prevention, recognition, and treatment of hypertension disorders in these women.
Source: Frontiers in Neurology - March 16, 2023 Category: Neurology Source Type: research

Endovascular coiling versus neurosurgical clipping for treatment of ruptured and unruptured intracranial aneurysms during pregnancy and postpartum period
Conclusions Most pregnant and postpartum patients are treated with EC for both ruptured and unruptured IA. For treatment of ruptured IA, EC is independently associated with a lower risk of perioperative ischemic stroke, but other in-hospital complications and mortality are comparable between EC and NC.
Source: Journal of NeuroInterventional Surgery - March 14, 2023 Category: Neurosurgery Authors: Garg, A., Elmashala, A., Roeder, H., Ortega-Gutierrez, S. Tags: Editor''s choice, Hemorrhagic stroke Source Type: research

In Reply to the Letter to the Editor Regarding "A neonatal case of cerebral venous sinus thrombosis with intrauterine onset after COVID-19 infection during pregnancy: Cause or coincidence?"
We are grateful to Josef Finsterer for his comments on our recent case regarding the possible association of maternal COVID-19 infection during pregnancy with a neonatal case of intrauterine cerebral sinus venous thrombosis (CSVT). In the letter to editor, he had raised several arguments against a causal relationship, however our case report focused on the plausability of maternal COVID-19 infection as a triggering factor for in utero onset of CVST.
Source: Journal of Stroke and Cerebrovascular Diseases - March 6, 2023 Category: Neurology Authors: Dr Mine Ozdil, Dr İpek Dokurel Cetin Tags: Letter to the Editor Source Type: research

Did You Know: These Medications Can Cause or Worsen Hypertension and Are Sometime Overlooked?
Hypertension (HTN) is a leading risk factor for cardiovascular conditions (eg, stroke, myocardial infarction, sudden death, heart failure) and kidney disease.1,2 However, the exact etiology of HTN is unknown. Primary HTN accounts for ∼90% of cases. The remaining 10% of cases have a secondary cause, which can vary with age and include multiple etiologies, some reversible. For example, common secondary causes of HTN include kidney disease, primary hyperaldosteronism, obstructive sleep apnea, atherosclerotic renal artery stenosis , pregnancy, and/or drug and substance use.
Source: The Journal for Nurse Practitioners - March 6, 2023 Category: Nursing Authors: Timothy Nguyen Tags: Prescription Pad Source Type: research

New VOYAGER PAD Analysis Confirms Consistent Benefit of XARELTO ® (rivaroxaban) Plus Aspirin Following Lower Extremity Revascularization (LER)
TITUSVILLE, NJ, March 5, 2023 – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced data from a new prespecified analysis from the Phase 3 VOYAGER PAD clinical trial reinforcing the benefits of the XARELTO® (rivaroxaban) vascular dose (2.5 mg twice daily plus aspirin 100 mg once daily) over standard of care (aspirin alone), demonstrating consistent benefit at 30 days, 90 days and up to three years following LER in patients with PAD. Lower extremity revascularization, also called peripheral revascularization, is a procedure that restores blood flow in blocked arteries or veins. This analysis of ...
Source: Johnson and Johnson - March 5, 2023 Category: Pharmaceuticals Tags: Latest News Source Type: news

High Blood Pressure in Pregnancy Tied to Thinking Problems Later
THURSDAY, March 2, 2023 -- A new study links high blood pressure during pregnancy with cognitive issues later in life, adding to known risks such as stroke and heart disease. Women with preeclampsia -- high blood pressure during pregnancy that may...
Source: Drugs.com - Daily MedNews - March 2, 2023 Category: General Medicine Source Type: news

Hypertensive Disorders of Pregnancy Linked to Risk for CVD
FRIDAY, Feb. 24, 2023 -- Genetic evidence indicates that hypertensive disorders of pregnancy (HDPs) are associated with an increased risk for atherosclerotic cardiovascular disease, specifically coronary artery disease and ischemic stroke, according...
Source: Drugs.com - Pharma News - February 24, 2023 Category: Pharmaceuticals Source Type: news

APRIL: A double-blind, placebo-controlled, randomized, Phase Ib/IIa clinical study of ApTOLL for the treatment of acute ischemic stroke
In the reperfusion era, a new paradigm of treating patients with endovascular treatment (EVT) and neuroprotective drugs is emerging as a promising therapeutic option for patients with acute ischemic stroke (AIS). In this context, ApTOLL, a Toll-like receptor 4 (TLR4) antagonist with proven neuroprotective effect in preclinical models of stroke and a very good pharmacokinetic and safety profile in healthy volunteers, is a promising first-in-class aptamer with the potential to address this huge unmet need. This protocol establishes the clinical trial procedures to conduct a Phase Ib/IIa clinical study (APRIL) to assess ApTOL...
Source: Frontiers in Neurology - February 24, 2023 Category: Neurology Source Type: research

Stroke in Pregnancy
This article will review current information about the epidemiology, risk factors, pathophysiology, management, and outcomes of conditions associated with maternal stroke.Recent FindingsPregnancy confers a substantially increased risk of stroke in women. The period of highest risk of stroke is the peripartum and 6-week post-partum period, coinciding with the highest risk for hypertensive disorders of pregnancy and peak gestational hypercoagulability. Physiological changes of pregnancy, including hypercoagulable states, venous stasis, and hemodynamic changes, are significant contributors to maternal stroke. However, hyperte...
Source: Current Obstetrics and Gynecology Reports - February 22, 2023 Category: OBGYN Source Type: research

The 3rd Beijing Forum of Evidence-Based Medicine and 2023 Cochrane China Network Symposium successfully held
Cochrane China recently hosted a virtual event for the evidence-based medicine community that brought together many of its partners, local expertise, and international speakers. Here the team provides an overview of who was involved and what was covered at the event.  The3rd Beijing forum of evidence-based medicine and Cochrane China Network  Symposium was successfully held virtually on January 15th, 2023. The host of this conference wereCochrane China Network and Beijing GRADE Center. The organizers are Centre for Evidence-based Chinese Medicine, Beijing University of Chinese Medicine, affiliate of the Cochrane China Ne...
Source: Cochrane News and Events - February 17, 2023 Category: Information Technology Authors: Muriah Umoquit Source Type: news

Janssen Data at ASCO GU Support Ambition to Transform Treatment of Prostate and Bladder Cancer Through Precision Medicine and Early Intervention
RARITAN, N.J., February 13, 2023 – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced plans to present more than 20 abstracts featuring seven oncology therapies from its robust portfolio and pipeline at the annual American Society of Clinical Oncology (ASCO) Genitourinary (GU) Cancers Symposium, taking place in San Francisco on February 16-18. Building on more than a decade of leadership in the development of medicines for people diagnosed with GU cancers, Janssen will present data demonstrating its ambition to advance patient-centered treatment through precision medicine, real-world evidence a...
Source: Johnson and Johnson - February 13, 2023 Category: Pharmaceuticals Tags: Latest News Source Type: news

Recurrent thrombotic events after disappearance of antiphospholipid autoantibodies: A long-term longitudinal study in patients with antiphospholipid syndrome
Antiphospholipid syndrome (APS) is an autoimmune disease characterized by the occurrence of thrombosis and/or pregnancy morbidity related to the presence of persistent antiphospholipid autoantibodies (aPL) [1]. The most frequent clinical manifestations of APS are thrombotic events and death may be caused by stroke, myocardial infarction, pulmonary embolism or catastrophic APS [2]. APS treatment is based on long term anticoagulation [3].
Source: Thrombosis Research - February 9, 2023 Category: Hematology Authors: Thomas Ballul, Arthur Mageau, Pascale Roland Nicaise, Nadine Ajzenberg, Andrey Strukov, Antoine Dossier, Diane Rouzaud, Thomas Papo, Karim Sacr é Tags: Letter to the Editors-in-Chief Source Type: research

AHA News: Pregnancy Complications Could Increase Woman ' s Stroke Risk at Earlier Age
THURSDAY, Feb. 2, 2023 (American Heart Association News) -- Women who have pregnancy-related health problems face an increased risk for having a stroke much earlier in life than their peers with uncomplicated pregnancies, a risk that climbs with...
Source: Drugs.com - Daily MedNews - February 2, 2023 Category: General Medicine Source Type: news