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Condition: Thrombosis
Procedure: Ultrasound

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Total 256 results found since Jan 2013.

Therapeutic application of contrast-enhanced ultrasound and low-dose urokinase for thrombolysis in a porcine model of acute peripheral arterial occlusion
In this study, we investigated the effect of additional US and microbubbles on standard low-dose intra-arterial thrombolysis in a porcine model of extensive peripheral arterial occlusion.
Source: Journal of Vascular Surgery - April 24, 2014 Category: Surgery Authors: Harm P. Ebben, Johanna H. Nederhoed, Jeroen Slikkerveer, Otto Kamp, Geert W.J.M. Tangelder, René J.P. Musters, Willem Wisselink, Kak K. Yeung Source Type: research

Amusia: Unique Presentation of Stroke (P6.261)
CONCLUSIONS:Even though music and speech are similar in principle and execution they are functions of different hemispheres of the brain. Unlike aphasia, anatomical localization of amusia has not been established but it is known that right non dominant hemisphere is concerned with musical ability. Impairment of musical ability in the presence of intact speech can be the only presenting finding in stroke. Their identification is the key to early and appropriate treatment.Study Supported by:NoneDisclosure: Dr. Ramchandani has nothing to disclose. Dr. Alsmaan has nothing to disclose. Dr. Schwarz has nothing to disclose. Dr. A...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Ramchandani, C., Alsmaan, F., Schwarz, H., Alkhoury, Z. Tags: Cerebrovascular Disease and Interventional Neurology: Case Reports Source Type: research

Right Hemispheric Acute Ischemic Stroke Secondary To Right Common Carotid Artery Free Floating Thrombus Due To Hypercoagulable State In An Otherwise Healthy 48-Year-Old Woman. (P6.263)
Conclusions: Due to the high association between malignancy and hypercoagulable state, further work up needs to be warranted in the evaluation of a patient with FFT. To our knowledge this is the first case report of symptomatic FFT treated with an oral direct factor-Xa inhibitor. Further randomized clinical trials are required to assess the best therapeutic approach of this condition.Disclosure: Dr. Orjuela has nothing to disclose. Dr. Gill has nothing to disclose. Dr. Vlahovic has nothing to disclose. Dr. Morales-Vidal has nothing to disclose.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Orjuela, K., Gill, R., Vlahovic, L., Morales-Vidal, S. Tags: Cerebrovascular Disease and Interventional Neurology: Case Reports Source Type: research

In silico Study of Low-Frequency Transcranial Ultrasound Fields in Acute Ischemic Stroke Patients
Abstract: Ultrasound in the sub-megahertz range enhances thrombolysis and may be applied transcranially to ischemic stroke patients. The consistency of transcranial insonification needs to be evaluated. Acoustic and thermal simulations based on computed-tomography (CT) scans of 20 patients were performed. An unfocused 120-kHz transducer allowed homogeneous insonification of the thrombus, and positioning based on external landmarks performed similarly to an optimized placement based on CT data. With a weakly focused 500-kHz transducer, the landmark-based positioning underperformed. The predicted inter-patient variation of i...
Source: Ultrasound in Medicine and Biology - March 17, 2014 Category: Radiology Authors: Guillaume Bouchoux, Ravishankar Shivashankar, Todd A. Abruzzo, Christy K. Holland Tags: Original Contributions Source Type: research

Internal Carotid Artery Floating Thrombus in Relapsing Polychondritis
We present a 52‐year‐old man without any known risk factors for stroke, treated with prednisone and azathioprine for relapsing polychondritis, who presented a minor left hemisphere stroke. Ultrasound of the neck vessels revealed an isoechogenic thrombus in the left internal carotid artery superimposed on a smooth moderately stenosing isoechogenic atheroma of the carotid bulb. The patient was treated with high‐dose tinzaparin and was followed with serial ultrasound. After 16 days, the thrombus demonstrated a hypoechogenic core surrounded by a hyperechogenic rim and the following day it resolved completely. Thrombus fo...
Source: Journal of Neuroimaging - February 23, 2014 Category: Radiology Authors: Theodoros Karapanayiotides, Konstantinos Kouskouras, Panagiotis Ioannidis, Eleni Polychroniadou, Nikolaos Grigoriadis, Dimitrios Karacostas Tags: Case Report Source Type: research

Towards Effective and Safe Thrombolysis and Thromboprophylaxis: Preclinical Testing of a Novel Antibody-Targeted Recombinant Plasminogen Activator Directed Against Activated Platelets.
CONCLUSIONS: Targeting of scuPA to activated GPIIb/IIIa allows effective thrombolysis and the potential novel use as a fibrinolytic agent for thromboprophylaxis without bleeding complications. PMID: 24508759 [PubMed - as supplied by publisher]
Source: Circulation Research - February 9, 2014 Category: Cardiology Authors: Wang X, Palasubramaniam J, Gkanatsas Y, Hohmann JD, Westein E, Kanojia R, Alt K, Huang D, Jia F, Ahrens I, Medcalf RL, Peter K, Hagemeyer CE Tags: Circ Res Source Type: research

Posterior transverse plication of the internal carotid artery to correct for kinking
Conclusions: Although the indications for additional shortening procedures following CEA need to be defined, in this small series, PTP as an additional shortening procedure of the ICA following CEA seems feasible and safe with no additional periprocedural risk for narrowing at the plicature or thrombosis of the endarterectomy plane. However, restenosis at the plicature may hamper the long term benefit of carotid reconstruction.
Source: Journal of Vascular Surgery - January 21, 2014 Category: Surgery Authors: Michiel H.F. Poorthuis, Eelco C. Brand, Raechel J. Toorop, Frans L. Moll, Gert Jan de Borst Tags: Clinical research studies Source Type: research

Renovascular hypertension: A report of 21 cases.
Abstract Renovascular hypertension (RVH) is among the most common forms of secondary hypertension. We studied 21 patients (eight male and 13 female) with RVH who were encountered during a period of 16 years. The average age of the patients was 34.75 years. Trans-renal Doppler ultrasound confirmed the diagnosis of renovascular stenosis (RAS) as the cause of RVH in 95% of the patients. Computed tomography angiography was performed in ten cases, which confirmed the diagnosis in all these cases. Magnetic resonance angiography was performed in only three patients. Renal scintigraphy was performed in 11 patients, with D...
Source: Saudi Journal of Kidney Diseases and Transplantation - January 1, 2014 Category: Urology & Nephrology Authors: Labidi J, Touat D, Abdelghanim K, Ajili F, Ariba YB, Abdelhafidh NB, Louzir B, Othmani S Tags: Saudi J Kidney Dis Transpl Source Type: research

No surgery without previous compression ultrasound in patients with a superficial venous thrombosis: A case of massive paradoxical embolism.
We report a case of a LLSVT complicated with a massive bilateral PE and an ischemic cerebral stroke, occurring immediately after a varicose vein surgery. Venous ultrasonography of the lower limbs must be systematically performed in case of LLSVT, in order to evaluate the presence of an associated LLDVT. A rigorous diagnostic and therapeutic approach is the only way to optimize the treatment of this disorder, and to avoid the occurrence of dramatic venous thromboembolic complications. PMID: 24365154 [PubMed - as supplied by publisher]
Source: Annales Francaises d'Anesthesie et de Reanimation - December 20, 2013 Category: Anesthesiology Authors: Reynaud Q, Catella J, Diconne E, Lafond P, Tardy B Tags: Ann Fr Anesth Reanim Source Type: research

CLOTBUST-Hands Free: Pilot Safety Study of a Novel Operator-Independent Ultrasound Device in Patients With Acute Ischemic Stroke Clinical Sciences
Conclusions— Sonothrombolysis using a novel, operator-independent device, in combination with systemic tPA, seems safe, and recanalization rates warrant evaluation in a phase III efficacy trial. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: CLOTBUST-HF NCT01240356.
Source: Stroke - November 25, 2013 Category: Neurology Authors: Barreto, A. D., Alexandrov, A. V., Shen, L., Sisson, A., Bursaw, A. W., Sahota, P., Peng, H., Ardjomand-Hessabi, M., Pandurengan, R., Rahbar, M. H., Barlinn, K., Indupuru, H., Gonzales, N. R., Savitz, S. I., Grotta, J. C. Tags: Acute Cerebral Infarction, Doppler ultrasound, Transcranial Doppler etc., Thrombolysis, Other Stroke Treatment - Medical Clinical Sciences Source Type: research

Scan could detect those on brink of heart attack
Conclusion This is a valuable study which shows the promise of using PET-CT with radioactively labelled sodium fluoride (NaF) as a way of identifying fatty deposits in the heart arteries that could be at risk of rupturing and causing a heart attack. The results confirmed that the marker used in this study (NaF) was better than the chemical marker normally used in PET-CT scans (FDG). The technique has the principal value of being a non-invasive technique compared with coronary angiography, which is the standard method used to look at blockages in heart arteries. As it does not involve surgical intervention, this could ha...
Source: NHS News Feed - November 11, 2013 Category: Consumer Health News Tags: Heart/lungs Medical practice Source Type: news

New Insights into Mechanisms of Sonothrombolysis Using Ultra-High-Speed Imaging
Abstract: Thrombotic arterial occlusion is the principal etiology for acute cardiovascular syndromes such as stroke, myocardial infarction and unstable angina. Exposing the thrombus to ultrasound and microbubbles facilitates thrombus disruption, making “sonothrombolysis” a potentially powerful therapeutic strategy for thromboembolic diseases. However, optimization of such a strategy, and hence clinical translation, is constrained by an incomplete understanding of mechanisms by which ultrasound-induced microbubble vibrations disrupt blood clots. We posit that previously reported sonothrombolytic efficacy using inertial ...
Source: Ultrasound in Medicine and Biology - October 21, 2013 Category: Radiology Authors: Xucai Chen, Jonathan E. Leeman, Jianjun Wang, John J. Pacella, Flordeliza S. Villanueva Tags: Technical Note Source Type: research

MRI-guided Sonothrombolysis of Rabbit Carotid Artery
The potential of magnetic resonance imaging–guided focused ultrasound (MRgFUS) combined with the thrombolytic drug recombinant tissue plasminogen activator (rt-PA) to dissolve clots in the carotid of a New Zealand rabbit in vivo is evaluated. A spherically focused transducer of 5-cm diameter, focusing at 10 cm and operating at 1 MHz, was used. A pulsed ultrasound protocol was used that maintains a tissue temperature increase of less than 1°C in the clot (called safe temperature). MRgFUS has the potentials to dissolve clots that are injected in the carotid of rabbits in vivo. It was found that the time needed for ope...
Source: Journal of Stroke and Cerebrovascular Diseases - October 14, 2013 Category: Neurology Authors: Christakis Damianou, Venediktos Hadjisavvas, Nicos Mylonas, Andreas Couppis, Kleanthis Ioannides Tags: Original Articles Source Type: research

Arterial Closure Devices for Treatment of Inadvertent Large-Caliber Catheter Insertion Into the Subclavian or Carotid Artery: A Case Series of Five Patients
CENTRAL VENOUS CATHETERIZATION is a common procedure in today`s medicine. Iatrogenic complications occur in up to 34% of catheter placements including 5% of arterial puncture. A variety of complications by arterial puncture have recently been described, including airway obstruction, pseudoaneurysms, arteriovenous fistulas, and even stroke caused by arterial thrombosis or embolization. Although 2-D ultrasound assisted insertion of large central venous catheters may reduce adverse events, it might not be available in an emergency setting, and the use of ultrasound guidance requires training. Depending on anatomic localizatio...
Source: Journal of Cardiothoracic and Vascular Anesthesia - September 9, 2013 Category: Anesthesiology Authors: Arno Stellmes, Nicolas Diehm, Malte Book, Jürg Schmidli, Dai-Do Do, Jan Gralla Tags: Case Reports Source Type: research

Single whole-leg compression ultrasound for exclusion of deep vein thrombosis in symptomatic ambulatory patients: a prospective observational cohort study
Conclusion Patients who have anticoagulation withheld following a negative or inconclusive whole leg CUS for suspected DVT have a low rate of adverse events at 3 months. Including the calf in ultrasound examination aided and clarified diagnosis in approximately one third of patients. Technical failure remains an issue: several factors were significantly associated with inconclusive results in our cohort and may warrant an alternative diagnostic approach Abstract 008 Table 1Measuring ED crowding Measure Operational DefinitionAbility of ambulances to offload patients.An ED is crowded when the 90th percentile time betwe...
Source: Emergency Medicine Journal - September 7, 2013 Category: Emergency Medicine Authors: Horner, D., Hogg, K., Body, R., Mackway-Jones, K. Tags: Drugs: cardiovascular system, Stroke, Venous thromboembolism, Radiology, Clinical diagnostic tests, Radiology (diagnostics) DAY 1: FOUR TOP SCORING CEM ABSTRACTS: ELGAR 2 12:00-13:00 Source Type: research