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Bilateral carotid artery dissection associated with Eagle syndrome in a drug-addicted young adult with stroke: a case report
Source: Neurological Sciences - September 15, 2022 Category: Neurology Source Type: research

Impact of Electronic Cigarette Vaping on Cerebral Ischemia: What We Know So Far
AbstractElectronic cigarettes (ECs) are battery-powered nicotine delivery devices that have rapidly gained popularity and attention globally. ECs work by heating a liquid to produce an aerosol that usually contains nicotine, flavoring compounds, and other chemicals, which are inhaled during vaping. EC aerosols are depicted to contain a lower number and overall quantity of harmful toxicants than conventional cigarettes (CCs). However, emerging research indicates that EC aerosols contain harmful ingredients including ultrafine particles, volatile organic compounds, and heavy metals. One common ingredient found in both CCs an...
Source: Translational Stroke Research - April 18, 2022 Category: Neurology Source Type: research

Epidemiology of young stroke in the ludhiana population-based stroke registry
Conclusion: Hypertension, diabetes mellitus, drug addiction, and tobacco intake were significantly associated with young stroke. Outcome was also better in younger people.
Source: Annals of Indian Academy of Neurology - February 22, 2022 Category: Neurology Authors: Monika Singla Gagandeep Singh Paramdeep Kaur Jeyaraj D Pandian Source Type: research

Neurological toll of COVID-19
AbstractThe first case of coronavirus illness was discovered in Wuhan, China, in January 2020 and quickly spread worldwide within the next couple of months. The condition was initially only linked with respiratory disorders. After the evolution of various variants of the SARS-CoV-2, the critical impact of the virus spread to multiple organs and soon, neurological disorder manifestations started to appear in the infected patients. The review is focused on the manifestation of various neurological disorders linked with both the central nervous system and peripheral nervous system. Disorders such as cytokine release syndrome,...
Source: Neurological Sciences - January 16, 2022 Category: Neurology Source Type: research

Association between neurological outcome and poststroke comorbid mood and anxiety disorders: A real ‐life experience
ConclusionsThe frequency of comorbid PSED remains high (1/5 patient) despite improved awareness of these conditions. The association between poststroke complications and the presence of PSED emphasizes the need for standardized neurological and psychological evaluations at follow-up. These results foster the need to improve the management of addictive behaviors to reduce the burden of PSED.
Source: Brain and Behavior - May 5, 2021 Category: Neurology Authors: Yolaine Rabat, Richard Houeze, Sharmila Sagnier, Stephane Olindo, Mathilde Poli, Sabrina Debruxelles, Pauline Renou, Fran çois Rouanet, Sylvie Berthoz, Igor Sibon Tags: ORIGINAL RESEARCH Source Type: research

Psychostimulant use disorder emphasizing methamphetamine and the opioid -dopamine connection: Digging out of a hypodopaminergic ditch
Approved food and drug administration (FDA) medications to treat Psychostimulant Use Disorder (PUD) are needed. Both acute and chronic neurological deficits related to the neurophysiological effects of these powerfully addictive drugs can cause stroke and alterations in mood and cognition.
Source: Journal of the Neurological Sciences - November 27, 2020 Category: Neurology Authors: Kenneth Blum, Jean Lud Cadet, Mark S. Gold Tags: Review Article Source Type: research

Sleep disorders and disrupted sleep in addiction, withdrawal and abstinence with focus on alcohol and opioids
Sleep is very important for our physical and mental health. Sleep disturbances increase risk of substance use disorders as well as risk of onset and worsening of medical and other primary psychiatric problems like diabetes, kidney disease, high blood pressure, heart disease, stroke, and depression [1,2]. Substance use disorders, particularly alcohol and opioids can cause or exacerbate sleep disturbances [3,4] leading to even greater problems with our health in addition to the consequences of substance use [1,2].
Source: Journal of the Neurological Sciences - January 29, 2020 Category: Neurology Authors: William-Bernard Reid-Varley, Caridad Ponce-Martinez, Khurshid A. Khurshid Tags: Review Article Source Type: research

Assessment of the relationship between platelet reactivity, vascular risk factors and gender in cerebral ischaemia patients.
CONCLUSIONS: There are no differences between platelet reactivity and the incidence of aspirin resistance in patients with stroke and TIA. Male gender and smoking are associated with greater reactivity of platelets and more frequent occurrence of acetylsalicylic acid resistance in patients with cerebral ischaemia. CLINICAL IMPLICATIONS: Dual antiplatelet therapy or clopidogrel treatment should be considered in smoking males with cerebral ischaemia due to the high risk of aspirin inefficiency. PMID: 31343071 [PubMed - as supplied by publisher]
Source: Neurologia i Neurochirurgia Polska - July 24, 2019 Category: Neurology Authors: Wiśniewski A, Sikora J, Filipska K, Kozera G Tags: Neurol Neurochir Pol Source Type: research

Increasing the Risk of Stroke by Opium Addiction
Stroke is among the leading causes of mortality and morbidity in the world. Besides the identified risk factor, Ischemic stroke evidence show drug use develops or exacerbates the atherosclerotic process. The current study aimed at comparing cerebrovascular ultrasounds ’ changes in addicted and nonaddicted people who developed ischemic stroke.
Source: Journal of Stroke and Cerebrovascular Diseases - April 14, 2019 Category: Neurology Authors: Seyed Mohammad Mousavi-Mirzaei, Abolfazl Talebi, Alireza Amirabadizadeh, Samaneh Nakhaee, Ghodsieh Azarkar, Omid Mehrpour Source Type: research

Association of CALM1 rs3179089 Polymorphism with Ischemic Stroke in Chinese Han Population
This study aims to evaluate the relationship betweenCALM1 rs3179089 polymorphism and ischemic stroke (IS) in Chinese Han population. A total of 550 patients with IS and 550 control subjects were recruited and genotyped using Sequenom MassArray technology. The mRNA expression ofCALM1 was measured using quantitative real-time polymerase chain reaction.CALM1 mRNA expression was significantly higher in patients with IS than that in control subjects (P = 0.006). The genomic frequency distribution was significantly different between female patients with IS and female controls (χ2 = 6.043,P = 0.047). In recessive mod...
Source: NeuroMolecular Medicine - April 30, 2018 Category: Neurology Source Type: research

Opium Addiction and Ischemic Stroke in Isfahan, Iran: A Case-Control Study
Conclusion: Our study showed OA is a risk factor for stroke. However, a follow-up study with a larger cohort is required to confirm the results.Eur Neurol 2018;79:82 –85
Source: European Neurology - December 22, 2017 Category: Neurology Source Type: research

Delayed Varenicline Administration Reduces Inflammation and Improves Forelimb Use Following Experimental Stroke
Pharmacological activation of the cholinergic anti-inflammatory pathway (CAP), specifically by activating α7 nicotinic acetylcholine receptors, has been shown to confer short-term improvements in outcome. Most studies have investigated administration within 24 hours of stroke, and few have investigated drugs approved for use in human patients. We investigated whether delayed administration of varenicli ne, a high-affinity agonist at α7 nicotinic receptors and an established therapy for nicotine addiction, decreased brain inflammation and improved functional performance in a mouse model of experimental stroke.
Source: Journal of Stroke and Cerebrovascular Diseases - August 7, 2017 Category: Neurology Authors: Siyi Chen, Laura Bennet, Ailsa L. McGregor Source Type: research

Tale of the Good and the Bad Cdk5: Remodeling of the Actin Cytoskeleton in the Brain
AbstractCdk5 kinase, a cyclin-dependent kinase family member, is a key regulator of cytoskeletal remodeling in the brain. Cdk5 is essential for brain development during embryogenesis. After birth, it is essential for numerous neuronal processes such as learning and memory formation, drug addiction, pain signaling, and long-term behavior changes, all of which rely on rapid alterations in the cytoskeleton. Cdk5 activity is deregulated in various brain disorders including Alzheimer ’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, and ischemic stroke, resulting in profound remodeling of the neuronal cytoskel...
Source: Molecular Neurobiology - May 13, 2017 Category: Neurology Source Type: research

Hospital Readmissions following Stroke: a Retrospective Study (P6.270)
Conclusions:These results suggest that early inpatient and post-hospitalization interventions to address alcohol abuse and homelessness during the index hospital admission may reduce the rate of hospital readmission within 30 days. The results have prompted interventions on the stroke service such as early inpatient social work and addiction medicine involvement and closer post-discharge follow-up for patients with risk factors of alcohol abuse and homelessness.Disclosure: Dr. Parikh has nothing to disclose. Dr. George has nothing to disclose. Dr. Liyanage-Don has nothing to disclose. Dr. Hohler has nothing to disclose. Dr...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Parikh, S., George, P., Liyanage-Don, N., Hohler, A., Denis, R., Weinberg, J. Tags: Cerebrovascular Disease Health Services Research Source Type: research

Cessation of Smoking and Alcohol Addiction Following Thalamic Hemorrhage
We describe a case of thalamic intracerebral hemorrhage leading to cessation of smoking. Case Report: A 53-year-old female presented to the emergency department with right-sided weakness and dysarthria. Initial systolic blood pressure was 220 mm Hg. Computed tomography scan showed a left thalamic hemorrhage with associated edema and hemorrhage extending into the left lateral and third ventricle. She recovered uneventfully and was discharged to inpatient rehabilitation and eventually transitioned home. Three months later in the clinic, she reported that following the stroke, she abruptly stopped smoking without any smoking...
Source: The Neurologist - November 1, 2016 Category: Neurology Tags: Case Report/Case Series Source Type: research

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