Association of CALM1 rs3179089 Polymorphism with Ischemic Stroke in Chinese Han Population

This study aims to evaluate the relationship betweenCALM1 rs3179089 polymorphism and ischemic stroke (IS) in Chinese Han population. A total of 550 patients with IS and 550 control subjects were recruited and genotyped using Sequenom MassArray technology. The mRNA expression ofCALM1 was measured using quantitative real-time polymerase chain reaction.CALM1 mRNA expression was significantly higher in patients with IS than that in control subjects (P = 0.006). The genomic frequency distribution was significantly different between female patients with IS and female controls (χ2 = 6.043,P = 0.047). In recessive model,CALM1 rs3179089 polymorphism was associated with the risk of IS in female patients. GG genotype significantly increased the risk of IS compared with the CC+GC genotype in females (OR 8.68,P = 0.042; adjusted OR 8.72,Padj = 0.042). Rs3179089 polymorphism was associated positively with plasmas D-Dimer of patients with IS in recessive model (βa = 3.24,P = 0.018;βb = 3.20,Padj = 0.019). Moreover, rs3179089 polymorphism was related positively to thrombin time of patients with IS in addictive (βa = 2.32,P = 0.005,βb = 2.26,Padj=0.006) and recessive model (βa = 11.19,P = 0.001,βb = 11.13,Padj = 0.001).CALM1 expression was involved in the development of IS.CALM1 rs3179089 polymorphism was associated with IS risk in Chinese females, and related to blood coagulation of IS patients.
Source: NeuroMolecular Medicine - Category: Neurology Source Type: research