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Condition: Ischemic Stroke
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Total 66853 results found since Jan 2013.
Correlation Study of Chronic Renal Insufficiency and Long-Term Prognosis of Patients with Acute Ischemic Cerebral Apoplexy After Intravenous rt-PA Thrombolysis
CONCLUSION: CKD is an independent risk factor for acute ischemic cerebral apoplexy patients with intravenous rt-PA thrombolysis.PMID:37708556
Source: Alternative Therapies in Health and Medicine - September 14, 2023 Category: Complementary Medicine Authors: Cui Zhao GuoMin Xie Source Type: research
Sun Pharma unit inks licensing pact with US-based firm to introduce drug to treat stroke
"The Phase 3 clinical trial for Tyvalzi conducted in India demonstrated statistically and clinically meaningful improvement in neurological outcomes in ischemic stroke," Sun Pharma India Business CEO Kirti Ganorkar said. Tyvalzi is a first-in-class innovative drug which can help improve the quality of life of stroke patients, he added.
Source: The Economic Times Healthcare and Biotech News - September 14, 2023 Category: Pharmaceuticals Source Type: news
Mortality risk after the first occurrence of osteoporotic vertebral compression fractures in the general population: A nationwide cohort study
This study aimed to evaluate mortality risk after the first occurrence of OVCF in the general population using a nationwide dataset from the Korean National Health Insurance System. We identified 291,203 newly diagnosed patients with OVCF and 873,609 patients without OVCF at a ratio of 1:3 matched by sex and age between 2010 and 2012. We investigated the latent characteristics of patients’ demographic information and chronic comorbidities that could affect mortality when diagnosed with OVCF. By comparing the cohort data, the hazar d ratio for subsequent mortality in patients with OVCF was calculated and adjusted based on...
Source: PLoS One - September 14, 2023 Category: Biomedical Science Authors: Hee Jung Son Source Type: research
Sleep duration and risk of stroke and coronary heart disease: a 9-year community-based prospective study of 0.5 million Chinese adults
There is uncertainty about the optimum sleep duration for risk of different subtypes of stroke and ischaemic heart disease.
Source: BMC Neurology - September 14, 2023 Category: Neurology Authors: Yiping Chen, Christiana Kartsonaki, Robert Clarke, Yu Guo, Huaidong Du, Canqing Yu, Ling Yang, Pei Pei, Rebecca Stevens, Sushila Burgess, Yujie Hua, Junshi Chen, Jun Lv, Liming Li and Zhengming Chen Tags: Research article Source Type: research
CircPTP4A2 Promotes Microglia Polarization in Cerebral Ischemic Stroke via miR-20b-5p/YTHDF1/TIMP2 Axis
AbstractActivated microglia play dual roles in ischemic stroke (IS) according to its polarization states. Herein, we investigated the function of circPTP4A2 in regulating microglia polarization in IS. IS models were established by MACO/R and OGD/R treatment. TTC staining was employed to detect cerebral infarct size. Cell vitality was measured using CCK-8 assay. CD16 and CD206 levels were examined using flow cytometry. The interactions between circPTP4A2, miR-20b-5p, and YTHDF1 were analyzed by dual-luciferase reporter gene, RIP, or RNA pull-down assays. circPTP4A2 was upregulated in IS patients. circPTP4A2 knockdown allevi...
Source: NeuroMolecular Medicine - September 14, 2023 Category: Neurology Source Type: research
Selecting stroke patients for thrombectomy: is CTA+ASPECTS enough?
Since 2014, a series of randomised controlled trails (RCTs) have demonstrated the benefit of endovascular thrombectomy (EVT) on functional outcome for the participants who had acute ischaemic stroke (AIS) with occlusion of a proximal intracranial artery in the anterior circulation. The characteristics of the people enrolled in these RCTs have been used to define recommended criteria to select patients for thrombectomy in clinical practice. The initial group of RCTs largely enrolled participants early after AIS (mostly under 6 hours) who had National Institutes of Health stroke scale scores ≥6 (range 0–42 with lowe...
Source: Journal of Neurology, Neurosurgery and Psychiatry - September 14, 2023 Category: Neurosurgery Authors: Powers, W. Tags: Editorial commentaries Source Type: research
Endovascular treatment for large-core ischaemic stroke: a meta-analysis of randomised controlled clinical trials
Conclusion
EVT appears to be effective and safe and may be considered for the treatment of large-core AIS, as assessed by ASPECTS of 2–5 or volumetric methods.
PROSPERO registration number
CRD42022334417.
Source: Journal of Neurology, Neurosurgery and Psychiatry - September 14, 2023 Category: Neurosurgery Authors: Palaiodimou, L., Sarraj, A., Safouris, A., Magoufis, G., Lemmens, R., Sandset, E. C., Turc, G., Psychogios, M., Tsivgoulis, G. Tags: Editor's choice Cerebrovascular disease Source Type: research
Clot-based time attenuation curve as a novel imaging predictor of mechanical thrombectomy functional outcome in acute ischemia stroke
ConclusionsThrombus TAC on CTP were found to be a promising new imaging biomarker to predict the outcomes of MT in AIS.Clinical relevance statementThis study revealed that clot-based time attenuation curve based on admission perfusion CT could reflect the permeability and composition of thrombus and, also, provide valuable information to predict the clinical outcomes of mechanical thrombectomy in patients with acute ischemia stroke.Key Points• Two time-attenuation curves distributions achieved strong correlations (|r|= 0.627, p < 0.001) with histopathological results.• The unimodal time-attenuation curve was ...
Source: European Radiology - September 14, 2023 Category: Radiology Source Type: research
Aspiration thrombectomy with the Penumbra System for patients with stroke and late onset to treatment: a subset analysis of the COMPLETE registry
ConclusionFor patients with AIS due to anterior circulation LVO and with late onset to treatment, aspiration thrombectomy with the Penumbra System appears to be safe and effective. The rates of good functional outcome and all-cause mortality from this study compared favorably with those rates from the medical management arms of the DAWN and DEFUSE-3 studies.Clinical trial registrationhttps://www.clinicaltrials.gov, NCT03464565.
Source: Frontiers in Neurology - September 14, 2023 Category: Neurology Source Type: research
Predictors of failure of early neurological improvement in early time window following endovascular thrombectomy: a multi-center study
ConclusionDiabetes mellitus history, pre-stroke mRS, longer last known well-to-puncture time, lack of modified thrombolysis in cerebral infarction = 3, and the number of mechanical thrombectomy passes are the predictors of FENI. Future large-scale studies are required to validate these findings.
Source: Frontiers in Neurology - September 14, 2023 Category: Neurology Source Type: research
CircPTP4A2 Promotes Microglia Polarization in Cerebral Ischemic Stroke via miR-20b-5p/YTHDF1/TIMP2 Axis
AbstractActivated microglia play dual roles in ischemic stroke (IS) according to its polarization states. Herein, we investigated the function of circPTP4A2 in regulating microglia polarization in IS. IS models were established by MACO/R and OGD/R treatment. TTC staining was employed to detect cerebral infarct size. Cell vitality was measured using CCK-8 assay. CD16 and CD206 levels were examined using flow cytometry. The interactions between circPTP4A2, miR-20b-5p, and YTHDF1 were analyzed by dual-luciferase reporter gene, RIP, or RNA pull-down assays. circPTP4A2 was upregulated in IS patients. circPTP4A2 knockdown allevi...
Source: NeuroMolecular Medicine - September 14, 2023 Category: Neurology Source Type: research
Even a Mild Head Injury Raises the Odds for Stroke
WEDNESDAY, Sept. 13, 2023 -- Any head injury — even a mild one — raises a person’s risk of later having an ischemic stroke.
Having multiple injuries increases that risk, even more so than the severity of a single traumatic brain injury (TBI),...
Source: Drugs.com - Daily MedNews - September 13, 2023 Category: General Medicine Source Type: news
High-Sensitivity C-reactive Protein and Intracranial Arterial Stenosis Predicted Recurrent Stroke and Dependence or Death in Minor Stroke or Transient Ischemic Attack
CONCLUSION: Concomitant presence of increased hsCRP levels and ICAS was associated with increased risk of stroke recurrence and dependence or death in patients with minor ischemic stroke or transient ischemic attack.PMID:37704441 | DOI:10.5551/jat.64229
Source: Journal of Atherosclerosis and Thrombosis - September 13, 2023 Category: Cardiology Authors: Jiejie Li Yuesong Pan Mengxing Wang Xia Meng Jinxi Lin Zixiao Li Hao Li Yilong Wang Xingquan Zhao Liping Liu Yongjun Wang Source Type: research
Astrocytes in functional recovery following central nervous system injuries
J Physiol. 2023 Sep 13. doi: 10.1113/JP284197. Online ahead of print.ABSTRACTAstrocytes are increasingly recognised as partaking in complex homeostatic mechanisms critical for regulating neuronal plasticity following central nervous system (CNS) insults. Ischaemic stroke and traumatic brain injury are associated with high rates of disability and mortality. Depending on the context and type of injury, reactive astrocytes respond with diverse morphological, proliferative and functional changes collectively known as astrogliosis, which results in both pathogenic and protective effects. There is a large body of research on the...
Source: The Journal of Physiology - September 13, 2023 Category: Physiology Authors: Qasim M Alhadidi Ghaith A Bahader Oiva Arvola Philip Kitchen Zahoor A Shah Mootaz M Salman Source Type: research
