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Total 66853 results found since Jan 2013.

Brain MRI correlations with disease burden and biomarkers in Fabry disease
ConclusionBrain MRI revealed progressive lacunar infarctions, white matter hyperintensities, and decreased brain volume in patients with Fabry disease. Brain MRI lesions were closely related to onset-age; disease duration, severity, burden; and plasma Lyso-Gb3. However, they were not associated with sex, α-galactosidase A activity, orGLA mutation type.
Source: Journal of Neurology - September 20, 2023 Category: Neurology Source Type: research

A typology of cerebral small vessel disease based on imaging markers
ConclusionThe study confirmed the existence of different SVD types with different relationships to stroke outcome. EPVS and WMH were identified as imaging features of presumably early progression. The number of microbleeds and WMH severity appear to be promising biomarkers for distinguishing clinical subgroups. Further understanding of SVD progression might require consideration of refined SVD features, e.g., for EPVS and type of lacunes.
Source: Journal of Neurology - September 20, 2023 Category: Neurology Source Type: research

Lower SBP Targets After Endovascular Therapy Do Not Meet Futility Criteria
WEDNESDAY, Sept. 20, 2023 -- For patients with acute ischemic stroke undergoing endovascular therapy, lower systolic blood pressure (SBP) targets do not meet prespecified criteria for futility, according to a study published in the Sept. 5 issue of...
Source: Drugs.com - Pharma News - September 20, 2023 Category: Pharmaceuticals Source Type: news

Result of 48-Hour Approach to Symptomatic Carotid Lesions in Patients With Stable Neurologic Examinations
Timing of treatment for symptomatic carotid disease has a controversial history with current guidelines recommending carotid surgery within 48 hours up to 2 weeks. Advocating for earlier carotid endarterectomy (CEA) after stroke (cerebrovascular accident [CVA]) or while a patient is having transient ischemic attacks (TIA) can potentially provide additional benefit to acute stroke patients resulting in improved stroke and death outcomes.
Source: Journal of Vascular Surgery - September 20, 2023 Category: Surgery Authors: Tigran Divanyan, Jeffrey Hnath, Amanda Kistler, Misak Harutyunyan, W John Byrne, Julia Kleene Tags: Carotid Artery Interventions Source Type: research

Optimal management of carotid artery disease in patients undergoing coronary artery bypass
It is well-known that patients undergoing coronary artery bypass grafting (CABG) with coexisting carotid artery disease are at increased risk for perioperative stroke and death. The prevalence of carotid disease among patients undergoing CABG is 6% to 14%,1 and the risk of stroke following CABG increases from 3% for unilateral 50% to 99% stenosis to 5% for bilateral 50% to 99% stenoses and 10% for carotid occlusion.2 The risk of stroke and death are notably higher in patients with a history of transient ischemic attack (TIA)/stroke.
Source: Journal of Vascular Surgery - September 20, 2023 Category: Surgery Authors: Christopher K. Zarins Tags: Invited commentary Source Type: research

Fibromuscular dysplasia incidentally identified with computed tomography angiography
A 78-year-old woman had presented to the emergency room with altered mental status after the inadvertent consumption of a cannabis product. A stroke workup was initiated, including computed tomography angiography, which demonstrated severe tortuosity and a beaded appearance of her bilateral internal carotid arteries (A/Cover and B). The radiographic imaging findings, including alternating areas of bulging and narrowing, were consistent with fibromuscular dysplasia (FMD; C). The patient denied any history of transient ischemic attack, cerebrovascular accident, amaurosis fugax, or chronic kidney issues.
Source: Journal of Vascular Surgery - September 20, 2023 Category: Surgery Authors: Henry Lee, Bethany Lueck, Kevin M. Casey Tags: Vascular Image Source Type: research

How to improve the description of superior mesenteric artery occlusions in acute mesenteric ischemia: A new computed tomography anatomic segmentation
Acute mesenteric ischemia (AMI) is an intestinal vascular emergency and one of the most severe ischemic syndromes. For stroke or myocardial infarction, arterial segmentations were proposed as early as 1938 and 1975, respectively. These segmentations - used on a daily basis - made it possible to harmonize practices and standardize neurovascular and coronary studies. There is no such standardization in AMI, but the vital and functional prognostic challenge is of the same order. In addition, the lack of a standardized description of superior mesenteric artery (SMA) lesions limits the interpretation and comparability of the studies.
Source: Annals of Vascular Surgery - September 20, 2023 Category: Surgery Authors: Lorenzo Garzelli, Iannis Ben Abdallah, Arnaud Tual, Alexandre Nuzzo, Jonathan Cortese Yves Panis, Olivier Corcos, Val érie Vilgrain, Yves Castier, Maxime Ronot Source Type: research

Nrf2 and Ferroptosis: A New Research Direction for Ischemic Stroke
Cell Mol Neurobiol. 2023 Sep 20. doi: 10.1007/s10571-023-01411-y. Online ahead of print.ABSTRACTIschemic stroke (IS) is one of the leading causes of death and morbidity worldwide. As a novel form of cell death, ferroptosis is an important mechanism of ischemic stroke. Nuclear factor E2-related factor 2 (Nrf2) is the primary regulator of cellular antioxidant response. In addition to alleviating ischemic stroke nerve damage by reducing oxidative stress, Nrf2 regulates genes associated with ferroptosis, suggesting that Nrf2 may inhibit ferroptosis after ischemic stroke. However, the specific pathway of Nrf2 on ferroptosis in ...
Source: Cellular and Molecular Neurobiology - September 20, 2023 Category: Cytology Authors: Xiaoman Deng Wenming Chu Hanrui Zhang Yongjun Peng Source Type: research

Neuroprotective effects of oxytocin against ischemic stroke in rats by blocking glutamate release and CREB-mediated DNA hypermethylation
Biomed Pharmacother. 2023 Sep 18;167:115520. doi: 10.1016/j.biopha.2023.115520. Online ahead of print.ABSTRACTGlutamate plays a crucial role in cognitive impairments after ischemic stroke. There is a scarcity of information about how glutamate-induced activation of cAMP-response element binding (CREB) signaling pathway regulates both the negative and positive regulators of synaptic plasticity. Recent studies have demonstrated the involvement of prominent epigenetic repressors, such as MeCP2 and DNMTs, in stroke. Neuroprotective effects of oxytocin against ischemia have been previously reported, while the underlying mechani...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 20, 2023 Category: Drugs & Pharmacology Authors: Xin-Yu Fan Guang Shi Yun-Peng Zhao Jing-Jing Yang Juan Feng Source Type: research

Protein kinase D2 confers neuroprotection by promoting AKT and CREB activation in ischemic stroke
In this study, we found that PKD2 expression and activity were significantly upregulated in the ipsilateral side of the brain after transient focal cerebral ischemia, which coincides with the upregulation of PKD2 in primary neurons in response to in vitro ischemia, implying a potential role of PKD2 in neuronal survival in ischemic stroke. Using kinase-dead PKD2 knock-in (PKD2-KI) mice, we examined whether loss of PKD2 activity affected stroke outcomes in mice subjected to 1 h of transient middle cerebral artery occlusion (tMCAO) and 24 h of reperfusion. Our data demonstrated that PKD2-KI mice exhibited larger infarction vo...
Source: Neurobiology of Disease - September 20, 2023 Category: Neurology Authors: Jaclyn A Connelly Xuejing Zhang Yuzhou Chen Yapeng Chao Yejie Shi Tija C Jacob Q Jane Wang Source Type: research

Low value of inherited thrombophilia testing among patients with stroke or transient ischemic attack: A three-year retrospective study
Inherited thrombophilia testing in the acute inpatient setting is controversial and expensive, and rarely changes clinical management. We evaluated ordering patterns and results of inpatient inherited thrombophilia testing for patients who presented with an isolated acute ischemic stroke or transient ischemic attack (TIA) without concurrent venous thromboembolism.
Source: Journal of Stroke and Cerebrovascular Diseases - September 20, 2023 Category: Neurology Authors: Shyam Majmundar, Sameep Thapa, Elan S. Miller, Rodney Bell, Robin Dharia, Diana Tzeng, Shaista Alam, Ruben Rhoades Source Type: research

A nomogram predicts early neurological deterioration after mechanical thrombectomy in patients with ischemic stroke
DiscussionOur study established and validated a nomogram to stratify the risk of END before mechanical embolectomy and identify high-risk patients, who should be more cautious when making clinical decisions.
Source: Frontiers in Neurology - September 20, 2023 Category: Neurology Source Type: research

Case report: Retrograde endovascular recanalization of vertebral artery occlusion with non-tapered stump via the deep cervical collateral
ConclusionAntegrade endovascular recanalization of VA occlusion with a non-tapered stump is a challenge. The retrograde endovascular method via the cervical collateral may be an alternative for this type of VA occlusion, which requires further exploration.
Source: Frontiers in Neurology - September 20, 2023 Category: Neurology Source Type: research

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