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Condition: Ischemic Stroke

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Total 66853 results found since Jan 2013.

Blood biomarker changes following therapeutic hypothermia in ischemic stroke
ConclusionAlthough the exact roles of MMP3, FABP, and IL-8 in hypothermia-treated stroke patients are not known, further exploration is needed to confirm their roles in brain ischemia.
Source: Brain and Behavior - September 18, 2023 Category: Neurology Authors: Elena Pal à, Anna Penalba, Alejandro Bustamante, Teresa García‐Berrocoso, Marcel Lamana‐Vallverdú, Christian Meisel, Andreas Meisel, H. Bart van der Worp, Malcolm R Macleod, Bernd Kallmünzer, Stefan Schwab, Joan Montaner Tags: BRIEF REPORT Source Type: research

Vasculitis associated with adenosine deaminase 2 deficiency: at the crossroads between Beh çet's disease and autoinflammation. A viewpoint
Reumatismo. 2023 Sep 18;75(3). doi: 10.4081/reumatismo.2023.1578.ABSTRACTAdenosine deaminase 2 deficiency (DADA2) is a rare monogenic vasculopathy caused by loss-of-function homozygous or compound heterozygous mutations in ADA2, formerly CECR1 (cat eye syndrome chromosome region 1) gene. The DADA2 phenotype is widely heterogeneous, and patients may present with fever, weight loss, livedo reticularis/racemosa, digital ischemia, cutaneous ulceration, peripheral neuropathy, abdominal pain, bowel perforation, and portal or nephrogenic hypertension. More specific manifestations include early-onset ischemic or hemorrhagic stroke...
Source: Reumatismo - September 18, 2023 Category: Rheumatology Authors: A Colangelo F Tromby G Cafaro R Gerli E Bartoloni C Perricone Source Type: research

Triglyceride-glucose index and the risk of stroke in American adults: findings from the atherosclerosis risk in communities study
CONCLUSIONS: The TyG index independently predict stroke progression.PMID:37723527 | DOI:10.1186/s13098-023-01161-3
Source: Atherosclerosis - September 18, 2023 Category: Cardiology Authors: Xinyi Wang Qiyu Liu Tongxin Wang Wende Tian Xuanye Chen Jie Zhang Qiuyi Li Dan Ma Lin Zhao Zhuo Chen Hao Xu Keji Chen Source Type: research

Angiography-based hemodynamic features predict recurrent ischemic events after angioplasty and stenting of intracranial vertebrobasilar atherosclerotic stenosis
CONCLUSIONS: In patients with intracranial vertebrobasilar atherosclerosis treated with PTAS, preprocedural prolonged TTP of the target vessel and shortened trans-stenotic TTP difference were associated with stroke relapse. Q-DSA-defined hemodynamic parameters provided incremental predictive value over conventional parameters for stroke recurrence.CLINICAL RELEVANCE STATEMENT: Quantitative DSA analysis enables intuitive observation and semi-quantitative evaluation of peri-therapeutic cerebral blood flow. More importantly, quantitative DSA-defined hemodynamic parameters have the potential for risk stratification of patients...
Source: Atherosclerosis - September 18, 2023 Category: Cardiology Authors: Kangmo Huang Weihe Yao Mingming Zha Shanmei Qin Yingle Li Yan Xu Rui Liu Ruidong Ye Yunfei Han Wusheng Zhu Zhongzhao Teng Juan Du Xinfeng Liu Source Type: research

Association of thyroid peroxidase antibody with the RNF213 p.R4810K variant in ischemic stroke/transient ischemic attack
CONCLUSIONS: Elevated TPO-Ab levels may be significantly associated with presence of the RNF213 p. R4810K variant in IS/TIA patients. Thus, TPO-Ab may inherently modify IS/TIA development in RNF213 p. R4810K variant carriers.PMID:37722316 | DOI:10.1016/j.atherosclerosis.2023.117281
Source: Atherosclerosis - September 18, 2023 Category: Cardiology Authors: Takeshi Yoshimoto Hiroyuki Ishiyama Yorito Hattori Kunihiro Nishimura Yoko Okada Hideaki Watanabe Yasumasa Ohyagi Yasuhisa Akaiwa Tomoyuki Miyamoto Michi Kawamoto Masahiko Ichijo Hiroyasu Inoue Noriyuki Matsukawa Toshiki Mizuno Hirofumi Matsuyama Hidekazu Source Type: research

Single-center experience of endovascular treatment for patients with progressive posterior circulation cerebral infarction exceeding 24 h
CONCLUSION: In patients with progressive posterior circulation cerebral infarction caused by vertebral basilar artery occlusion, ET is effective and safe even if the time from onset to puncture exceeds 24 h.PMID:37719319 | PMC:PMC10505061 | DOI:10.2478/abm-2023-0046
Source: Biomed Res - September 18, 2023 Category: Research Authors: Guangfeng Zhao Xiongjun He Yajie Liu Liang Zhang Kaifeng Li Source Type: research

Phenylethanoid glycosides derived from Cistanche deserticola promote neurological functions and the proliferation of neural stem cells for improving ischemic stroke
This study aims to investigate whether PhGs treatment improves the stroke and its potential mechanisms. Adult male C57BL/6 J mice were administrated PhGs once daily for 7 days after MCAO surgery. The neurological score, and catwalk were evaluated on Day 1, 3 and 7 after ischemic stroke. Furthermore, triphenyl-2,3,5-tetrazoliumchloride (TTC) and hematoxylin-eosin (H&E) staining were used for evaluating the infarct volume and neuronal restoration. The effects of PhGs on NSCs proliferation were investigated in vitro and in vivo. Western blot was used to detect the proteins of Wnt/β-catenin signaling pathway. This study f...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 18, 2023 Category: Drugs & Pharmacology Authors: Jingjing Liu Yanyan Wang Qinyuan Li Tao Liu Xu Liu Han Zhang Zhifei Fu Yifan Dai Haiyuan Yang Yu Wang Ying Wang Source Type: research

SERPINA3: A novel inflammatory biomarker associated with cerebral small vessel disease burden in ischemic stroke
CONCLUSION: In summary, among four inflammatory biomarkers that we investigated, SERPINA3 level at baseline was associated with WMH severity, which revealed a novel biomarker for CSVD and validated its relationship with inflammation and endothelial dysfunction.PMID:37721405 | DOI:10.1111/cns.14472
Source: CNS Neuroscience and Therapeutics - September 18, 2023 Category: Neuroscience Authors: Xiao Hu Zhong-Song Xiao Yi-Qing Shen Wen-Song Yang Peng Wang Pei-Zheng Li Zi-Jie Wang Ming-Jun Pu Li-Bo Zhao Peng Xie Qi Li Source Type: research

Single-center experience of endovascular treatment for patients with progressive posterior circulation cerebral infarction exceeding 24 h
CONCLUSION: In patients with progressive posterior circulation cerebral infarction caused by vertebral basilar artery occlusion, ET is effective and safe even if the time from onset to puncture exceeds 24 h.PMID:37719319 | PMC:PMC10505061 | DOI:10.2478/abm-2023-0046
Source: Biomed Res - September 18, 2023 Category: Research Authors: Guangfeng Zhao Xiongjun He Yajie Liu Liang Zhang Kaifeng Li Source Type: research

Polypharmacy and Bleeding Outcomes After Percutaneous Coronary Intervention
CONCLUSIONS: In a real-world population of patients undergoing PCI, approximately 90% were on ≥5 medications. Increasing number of medications was associated with a higher adjusted risk for major bleeding, but not ischemic events.PMID:37722886 | DOI:10.1253/circj.CJ-23-0558
Source: Circulation Journal - September 18, 2023 Category: Cardiology Authors: Ko Yamamoto Takeshi Morimoto Masahiro Natsuaki Hiroki Shiomi Neiko Ozasa Hiroki Sakamoto Yasuaki Takeji Takenori Domei Takeshi Tada Ryoji Taniguchi Takashi Uegaito Miho Yamada Teruki Takeda Hiroshi Eizawa Satoru Suwa Manabu Shirotani Toshihiro Tamura Mori Source Type: research

Case report: Heterozygous mutation in HTRA1 causing typical cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy
Conclusion: This case suggests that patients carrying a heterozygous mutation in G905A may also have typical clinical features of CARASIL, which allows us to have a more comprehensive understanding of CARASIL.
Source: Frontiers in Genetics - September 18, 2023 Category: Genetics & Stem Cells Source Type: research