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Condition: Postnatal Depression

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Regulation of Tau Protein on the Antidepressant Effects of Ketamine in the Chronic Unpredictable Mild Stress Model
This study was carried out in accordance with the recommendations of the “Institutional Animal Care and Use Committee of China Medical University.” The protocol was approved by the “Institutional Animal Care and Use Committee of China Medical University.”Author ContributionsXWu and GW conceived and designed the experiments. YLi, RD, XR, WR, HYa, and YT performed the experiments. HYu, XZ, JY and XWa helped to analyze and interpret the data. GW drafted the manuscript. XWu, EX, YLu, and GZ provided critical revisions. All the authors reviewed and approved the final manuscript.FundingThe present stu...
Source: Frontiers in Psychiatry - April 29, 2019 Category: Psychiatry Source Type: research

Glutamate Transport and Preterm Brain Injury
Silvia Pregnolato1*, Elavazhagan Chakkarapani1, Anthony R. Isles2 and Karen Luyt1 1Department of Neonatal Neurology, Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom 2Behavioural Genetics Group, MRC Centre for Neuropsychiatric Genetics and Genomics, School of Medicine, Cardiff University, Cardiff, United Kingdom Preterm birth complications are the leading cause of child death worldwide and a top global health priority. Among the survivors, the risk of life-long disabilities is high, including cerebral palsy and impairment of movement, cognition, and beh...
Source: Frontiers in Physiology - April 23, 2019 Category: Physiology Source Type: research

Connecting Metainflammation and Neuroinflammation Through the PTN-MK-RPTP β/ζ Axis: Relevance in Therapeutic Development
Conclusion The expression of the components of the PTN-MK-RPTPβ/ζ axis in immune cells and in inflammatory diseases suggests important roles for this axis in inflammation. Pleiotrophin has been recently identified as a limiting factor of metainflammation, a chronic pathological state that contributes to neuroinflammation and neurodegeneration. Pleiotrophin also seems to potentiate acute neuroinflammation independently of the inflammatory stimulus while MK seems to play different -even opposite- roles in acute neuroinflammation depending on the stimulus. Which are the functions of MK and PTN in chronic neuroi...
Source: Frontiers in Pharmacology - April 11, 2019 Category: Drugs & Pharmacology Source Type: research

Role of TREK-1 in Health and Disease, Focus on the Central Nervous System
Conclusion and Perspectives Since their cloning 20 years ago, the physiological importance of TREK-1 channels has continued to grow (Figure 3). Today, TREK-1 channels have been shown to be important and their presence is essential in a number of physiopathological processes. Their involvement in these different processes demonstrate the necessity to design pharmacological modulators, activators or inhibitors, of these channels to correct any TREK-1-related dysfunctions. Despites a number of studies and many molecule screenings, only few putative new drugs were identified. The activators belonging to the ML and BL series ...
Source: Frontiers in Pharmacology - April 10, 2019 Category: Drugs & Pharmacology Source Type: research

How the first postpartum depression drug works
This week the Food and Drug Administration approved the first treatment specifically targeting postpartum depression, a condition that can impact women following childbirth, sometimes even starting during pregnancy. Symptoms can include sadness, loss of energy and feelings of guilt and worthlessness. Dr. David Agus joins "CBS This Morning: Saturday" to discuss how the new drug works and how a new personalized video game can help stroke victims.
Source: Health News: CBSNews.com - March 23, 2019 Category: Consumer Health News Source Type: news

AHA: Postpartum Depression May Raise Heart Risks
MONDAY, Nov. 5, 2018 (American Heart Association) -- Otherwise healthy women diagnosed with postpartum depression may be at higher risk of a heart attack, stroke or heart failure, a new study suggests. Acting on mounting evidence linking clinical...
Source: Drugs.com - Daily MedNews - November 5, 2018 Category: General Medicine Source Type: news

MRI shows kids benefit from parental conversation
MRI brain scans of young children show that conversations with adults can create...Read more on AuntMinnie.comRelated Reading: MRI shows the uniqueness of brain anatomy MRI ties high blood pressure to dementia risk MRI shows possible cause for attention woes after stroke MRI reveals effect of mild TBI on brain white matter MRI shows maternal depression meds affect babies' brains
Source: AuntMinnie.com Headlines - August 13, 2018 Category: Radiology Source Type: news

Development of a core outcome set for trials on induction of labour (COSIOL): An international multi-stakeholder Delphi study.
CONCLUSION: Trials on induction of labour should include this core outcome set to standardise reporting. This article is protected by copyright. All rights reserved. PMID: 29981523 [PubMed - as supplied by publisher]
Source: BJOG : An International Journal of Obstetrics and Gynaecology - July 7, 2018 Category: OBGYN Authors: Dos Santos F, Drymiotou S, Antequera A, Mol BW, Gale C, Devane D, Van't Hooft J, Johnson MJ, Hogg M, Thangaratinam S Tags: BJOG Source Type: research

MRI protocol syncs brain motion with cardiac rhythm
Researchers from the U.S. and Australia may be on the verge of capturing one...Read more on AuntMinnie.comRelated Reading: Novel MRI scanner fits extremity imaging like a glove MRI shows possible cause for attention woes after stroke MRI reveals effect of mild TBI on brain white matter MRI of cortical folds may help predict psychosis MRI shows maternal depression meds affect babies' brains
Source: AuntMinnie.com Headlines - May 30, 2018 Category: Radiology Source Type: news

Treatment of Depression With Duloxetine in Mitochondrial Encephalopathy, Lactic Acidosis, and Stroke-Like Episodes
We report a case in which an adult patient with MELAS and comorbid major depressive disorder demonstrated excellent response to the selective serotonin-norepinephrine reuptake inhibitor medication duloxetine.
Source: Clinical Neuropharmacology - May 1, 2018 Category: Neurology Tags: Case Reports Source Type: research

Neuroscience is the Next Oncology
by Michael D. Ehlers, MD, PhD Dr. Ehlers is with Biogen in Cambridge, Massachusetts. Innov Clin Neurosci. 2018;15(3–4):15–16 Funding: No funding was received for the preparation of this article. Disclosures: Dr. Ehlers is an employee and shareholder at Biogen Inc. in Cambridge, Massachusetts. Prominent and expensive failures in Alzheimer’s disease therapies have led to a contagious belief system in some parts of the biopharma industry that neuroscience is just too hard, too risky, and too uncertain. But, might this belief system itself be a residual bias of the past? Close inspection reveals all the signs of a coming...
Source: Innovations in Clinical Neuroscience - April 1, 2018 Category: Neuroscience Authors: ICNS Online Editor Tags: Commentary Current Issue Source Type: research

Endocrine Disruptors and Health Effects in Africa: A Call for Action
Conclusion: To address the many challenges posed by EDCs, we argue that Africans should take the lead in prioritization and evaluation of environmental hazards, including EDCs. We recommend the institution of education and training programs for chemical users, adoption of the precautionary principle, establishment of biomonitoring programs, and funding of community-based epidemiology and wildlife research programs led and funded by African institutes and private companies. https://doi.org/10.1289/EHP1774 Received: 16 February 2017 Revised: 22 May 2017 Accepted: 24 May 2017 Published: 22 August 2017 Address correspond...
Source: EHP Research - August 23, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Commentary Source Type: research

An Unusual Cause of Hyperglycemia
​BY CHRISTINE SHEELER; SEEMA ELAHI, MDA 46-year-old man presented to the ED with multiple complaints, including fatigue and dizziness for one day. His primary care physician had diagnosed him with diabetes the previous day, and had prescribed him an oral hypoglycemic as well as insulin. Neither, however, was started at the time of presentation. The patient had a medical history significant for HIV, with his most recent CD4 count above 500, and bilateral sensorineural hearing loss, which had progressively worsened since its initial onset in his 20s. His physical exam was unremarkable except for decreased hearing bilateral...
Source: The Case Files - April 13, 2017 Category: Emergency Medicine Tags: Blog Posts Source Type: research

Want to Prevent Stroke, Diabetes, Cancer? Get Moving … Now!
Worldwide, 81 per cent of school-aged children are not active enough. Photo: WHOBy Baher KamalROME, Feb 2 2017 (IPS)Tired, lazy, bored, laying down long hours watching TV or seated checking your email? Wrong. And dangerous: not enough exercise contributes to cancer, diabetes, depression and other non-communicable diseases. The warning is bold and comes from the United Nations top health organisation, which is urging people to get up and get active.And the risks of inactivity are expanding alarmingly: according to a new document by the World Health Organization (WHO), less and less people are active in many countries – wi...
Source: IPS Inter Press Service - Health - February 2, 2017 Category: Global & Universal Authors: Baher Kamal Tags: Environment Featured Global Headlines Health IPS UN: Inside the Glasshouse TerraViva United Nations Source Type: news