Neuroscience is the Next Oncology

by Michael D. Ehlers, MD, PhD Dr. Ehlers is with Biogen in Cambridge, Massachusetts. Innov Clin Neurosci. 2018;15(3–4):15–16 Funding: No funding was received for the preparation of this article. Disclosures: Dr. Ehlers is an employee and shareholder at Biogen Inc. in Cambridge, Massachusetts. Prominent and expensive failures in Alzheimer’s disease therapies have led to a contagious belief system in some parts of the biopharma industry that neuroscience is just too hard, too risky, and too uncertain. But, might this belief system itself be a residual bias of the past? Close inspection reveals all the signs of a coming era of neurotherapeutics. Regardless of therapeutic area, drug discovery and development is a long, difficult, and failure-ridden journey. Even in those areas where success blossoms—most recently in immuno-oncology­—it is easy to forget that the landscape once looked different to the casual observer. Indeed, just a few years ago many biopharmaceutical companies eschewed immuno-oncology as a marginal area with limited potential for clinical impact. Hindsight is 20-20, but a look into the rear view mirror identifies the signs and signals that foretold the advent of the new wave of immuno-oncology therapeutics. Starting with the identification of central molecular pathways for lymphocyte activation or suppression, more detailed understanding of the tumor microenvironment, the development of targeted checkpoint inhibitors, and ident...
Source: Innovations in Clinical Neuroscience - Category: Neuroscience Authors: Tags: Commentary Current Issue Source Type: research

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Source: The Lancet Respiratory Medicine - Category: Respiratory Medicine Source Type: research
Authors: Husain AM Abstract [Box: see text]. PMID: 31608668 [PubMed - as supplied by publisher]
Source: Epilepsy Currents - Category: Neurology Tags: Epilepsy Curr Source Type: research
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Source: NeuroImage: Clinical - Category: Radiology Source Type: research
Publication date: Available online 14 October 2019Source: Journal of Orthopaedic TranslationAuthor(s): Bing Chen, Bin Zi, Ling Qin, Qiaosheng PanAbstractAgeing population is now a global challenge, where physical deterioration is the common feature in elderly people. In addition, the diseases, such as spinal cord injury, stroke, and injury, could cause a partial or total loss of the ability of human locomotion. Thus, assistance is necessary for them to perform safe activities of daily living. Robotic hip exoskeletons are able to support ambulatory functions in elderly people and provide rehabilitation for the patients with...
Source: Journal of Orthopaedic Translation - Category: Orthopaedics Source Type: research
When the Trump administration dropped the drug rebate rule it introduced back in January, the decision sent shockwaves through the healthcare industry. However, almost everyone engaging in this debate is failing to see one very important thing.
Source: Healthcare News - Category: Pharmaceuticals Authors: Source Type: news
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Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
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Source: European Journal of Obstetrics and Gynecology and Reproductive Biology - Category: OBGYN Source Type: research
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Source: The Catalyst - Category: Pharmaceuticals Authors: Tags: Research and Development ALS Source Type: news
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Source: Journal of Cardiovascular Nursing - Category: Nursing Tags: ARTICLES: Heart Failure Source Type: research
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Source: Journal of Cardiovascular Nursing - Category: Nursing Tags: ARTICLES: Heart Failure Source Type: research
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