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Condition: Kawasaki Disease

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Total 22 results found since Jan 2013.

Cardiovascular risk in vasculitis
Best Pract Res Clin Rheumatol. 2023 Jun 9:101831. doi: 10.1016/j.berh.2023.101831. Online ahead of print.ABSTRACTThe present review summarizes the burden, risk factors, biomarkers of and therapeutic consideration for cardiovascular disease in systemic vasculitis. Ischemic heart disease (IHD) and stroke are intrinsic features of Kawasaki disease, Takayasu arteritis, Giant Cell Arteritis (GCA), and Behcet's disease. The risk of IHD and stroke is increased in anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV) and cryoglobulinemic vasculitis. Behcet's disease could present with venous thromboembolism. The risk of...
Source: Cell Research - June 11, 2023 Category: Cytology Authors: Durga Prasanna Misra Aman Sharma George A Karpouzas George D Kitas Source Type: research

Cardiovascular outcomes in children with Kawasaki disease: a population-based cohort study
CONCLUSION: KD survivors are at increased risk of post-discharge cardiovascular events but have a lower risk of death, which justifies enhanced cardiovascular disease surveillance in these patients.IMPACT: Among 4597 Kawasaki disease (KD) survivors, 79 (1.7%) experienced major adverse cardiac events (MACE) and 632 (13.8%) had composite cardiovascular events during 11-year median follow-up. KD survivors had significantly higher risks of post-discharge MACE and cardiovascular events versus non-exposed children. Only nine KD survivors (0.2%) died during follow-up, and the risk of mortality was significantly lower among KD sur...
Source: Pediatric Research - November 15, 2022 Category: Pediatrics Authors: Cal Robinson Rahul Chanchlani Anastasia Gayowsky Sandeep Brar Elizabeth Darling Catherine Demers Tapas Mondal Rulan Parekh Hsien Seow Michelle Batthish Source Type: research

What to Know About High Cholesterol in Kids
Heart disease is the leading cause of death in the U.S., but it’s not something we usually associate with kids. In many cases, however, the seeds of heart attacks and strokes may be sown in childhood. That’s because high or abnormal cholesterol levels, which are a major risk factor for heart disease and stroke, are not uncommon in kids. “People may feel that cholesterol is mostly an adult issue, which is not correct,” says Dr. Nivedita Patni, a pediatric endocrinologist at Children’s Health in Dallas and an assistant professor of pediatrics at UT Southwestern Medical Center. About 1 in 5 child...
Source: TIME: Health - July 13, 2022 Category: Consumer Health News Authors: Sandeep Ravindran Tags: Uncategorized freelance healthscienceclimate heart health Source Type: news

Neuropathology of Pediatric SARS-CoV-2 Infection in the Forensic Setting: Novel Application of Ex Vivo Imaging in Analysis of Brain Microvasculature
We report 8 such cases (4 infants aged 7–36 weeks, 4 children aged 5–15 years). Four underwent ex vivo magnetic resonance neuroimaging, to assist in identification of subtle lesions related to vascular compromise. All infants were found unresponsive (3 in unsafe sleeping conditions); all but 1 had recent rhinitis and/or influenza-like illness (ILI) in the family; 1 had history of sickle cell disease. Ex vivo neuroimaging in 1 case revealed white matter (WM) signal hyperintensity and diffuse exaggeration of perivascular spaces, corresponding microscopically to WM mineralization. Neurohistology in the remaining 3 infants...
Source: Frontiers in Neurology - May 24, 2022 Category: Neurology Source Type: research

Protective Roles of Xijiao Dihuang Tang on Coronary Artery Injury in Kawasaki Disease
ConclusionOur findings demonstrated that XJDHT mitigated coronary artery injury of KD through suppressing endothelial cell damage via PI3K/Akt-NF κB signaling.
Source: Cardiovascular Drugs and Therapy - October 19, 2021 Category: Cardiology Source Type: research

Viruses, Vol. 13, Pages 700: Long-COVID and Post-COVID Health Complications: An Up-to-Date Review on Clinical Conditions and Their Possible Molecular Mechanisms
id J Alzahrani Aristóteles Góes-Neto Vasco Azevedo Preetam Ghosh Debmalya Barh The COVID-19 pandemic has infected millions worldwide, leaving a global burden for long-term care of COVID-19 survivors. It is thus imperative to study post-COVID (i.e., short-term) and long-COVID (i.e., long-term) effects, specifically as local and systemic pathophysiological outcomes of other coronavirus-related diseases (such as Middle East Respiratory Syndrome (MERS) and Severe Acute Respiratory Syndrome (SARS)) were well-cataloged. We conducted a comprehensive review of adverse post-COVID health outcomes and potential long-COV...
Source: Viruses - April 18, 2021 Category: Virology Authors: Bruno Silva Silva Andrade S érgio Siqueira Wagner Rodrigues de Assis de Assis Soares Fernanda de Souza de Souza Rangel Naiane Oliveira Santos Andria dos Santos dos Santos Freitas Priscila Ribeiro da Ribeiro da Silveira Sandeep Tiwari Khalid J Alzahrani A Tags: Review Source Type: research

How Common are Aortic Aneurysms?
Discussion Aortic root dilatation or thoracic aortic aneurysm occurs in 6:100,000 individuals > 50 years of age. It is due to aging, hypertension, hypercholesterolemia, and smoking. Tertiary syphilis was a cause in the preantibiotic era. Pediatric aneurysms are very uncommon but the exact prevalence is different due to the various causes. Aneurysms are due to genetic disorders, congenital anomalies or post-surgical repair. In pediatric patients with sudden cardiac deaths, 5.4% are due to ruptured thoracic aortic aneurysms. Learning Point Some causes of pediatric aneurysms include: Familial thoracic aneurysm and dissect...
Source: PediatricEducation.org - February 22, 2021 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

How Does SARS-CoV-2 Affect the Central Nervous System? A Working Hypothesis
Interstitial pneumonia was the first manifestation to be recognized as caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); however, in just a few weeks, it became clear that the coronavirus disease-2019 (COVID-19) overrun tissues and more body organs than just the lungs, so much so that it could be considered a systemic pathology. Several studies reported the involvement of the conjunctiva, the gut, the heart and its pace, and vascular injuries such as thromboembolic complications and Kawasaki disease in children and toddlers were also described. More recently, it was reported that in a sample of 214 SA...
Source: Frontiers in Psychiatry - November 16, 2020 Category: Psychiatry Source Type: research

The American Heart Association's Call to Action for Reducing the Global Burden of Rheumatic Heart Disease: A Policy Statement From the American Heart Association.
Disease Committee of the Council on Lifelong Congenital Heart Disease and Heart Health in the Young; Advocacy Coordinating Committee; Council on Cardiovascular and Stroke Nursing; and Council on Clinical Cardiology Abstract Rheumatic heart disease (RHD) affects ≈40 million people and claims nearly 300 000 lives each year. The historic passing of a World Health Assembly resolution on RHD in 2018 now mandates a coordinated global response. The American Heart Association is committed to serving as a global champion and leader in RHD care and prevention. Here, we pledge support in 5 key areas: (1) professional healt...
Source: Circulation - October 19, 2020 Category: Cardiology Authors: Beaton A, Kamalembo FB, Dale J, Kado JH, Karthikeyan G, Kazi DS, Longenecker CT, Mwangi J, Okello E, Ribeiro ALP, Taubert KA, Watkins DA, Wyber R, Zimmerman M, Carapetis J, American Heart Association Young Hearts Rheumatic Fever, Endocarditis and Kawasaki Tags: Circulation Source Type: research

Age- and Sex-Associated Impacts of Body Mass Index on Stroke Type Risk: A 27-Year Prospective Cohort Study in a Low-Income Population in China
Conclusions Being overweight increased the risk of both ischemic and hemorrhagic strokes; obesity was only associated with an increased risk of IS. Additionally, the positive association between BMI and stroke risk was only observed in participants aged <65 years and the associations differed between men and women. Being overweight increased the risk of both ischemic and hemorrhagic strokes in men and being underweight increased their risk of hemorrhagic stroke. In women, being overweight increased the hemorrhagic stroke risk, whereas obesity increased their IS risks. The high prevalence of hypertension and elevat...
Source: Frontiers in Neurology - April 30, 2019 Category: Neurology Source Type: research

Neurological Involvement in Primary Systemic Vasculitis
Conclusion Neurological involvement is a common complication of PSV (Table 1), and neurologists play an important role in the identification and diagnosis of PSV patients with otherwise unexplained neurological symptoms as their chief complaint. This article summarizes the neurological manifestations of PSV and hopes to improve neuroscientists' understanding of this broad range of diseases. TABLE 1 Table 1. Common CNS and PNS involvements of primary systemic vasculitis. Author Contributions SZ conceived the article and wrote the manuscript. DY and GT reviewed and edited the manuscript. All authors ...
Source: Frontiers in Neurology - April 25, 2019 Category: Neurology Source Type: research

Evaluation of longitudinal and radial left ventricular functions on 2 ‐D and 3‐D echocardiography before and after intravenous immunoglobulin in acute Kawasaki disease
ConclusionsLVEDV decreased longitudinally during the acute phase of KD with preservation of LVESV, reducing both LVSV and LVEF. Serum BNP is a useful marker for evaluating LV function only prior to IVIG treatment.
Source: Pediatrics International - December 20, 2017 Category: Pediatrics Authors: Ikuo Hashimoto, Yu Saitou, Nao Sakata, Ko Shibata Tags: Original Article Source Type: research

Evaluation of longitudinal and radial left ventricular functions using two ‐ and three‐dimensional echocardiography before and after intravenous immunoglobulin administration in patients with acute Kawasaki disease
Conclusionsthe LVEDV decreased longitudinally during the acute phase of KD with preservation of the LVESV, reducing both the LVSV and LVEF. The serum BNP level is a useful marker for evaluating LV function only prior to IVIG administration.This article is protected by copyright. All rights reserved.
Source: Pediatrics International - August 1, 2017 Category: Pediatrics Authors: Ikuo Hashimoto, Yu Saitou, Nao Sakata, Ko Shibata Tags: Original Article Source Type: research