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Condition: Down's Syndrome
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Total 53 results found since Jan 2013.
Neuroprotective effects of Sonic hedgehog agonist SAG in a rat model of neonatal stroke
CONCLUSIONS: These findings indicate benefit of one-time SAG treatment post insult in reducing brain injury and improving behavioral outcome after experimental neonatal stroke.IMPACT: A one-time dose of small molecule Sonic hedgehog agonist protected against neonatal stroke and improved long-term behavioral outcomes in a rat model. This study extends the use of Sonic hedgehog in treating developing brain injury, previously shown in animal models of Down syndrome and cerebellar injury. Sonic hedgehog agonist is one of the most promising therapies in treating neonatal stroke thanks to its safety profile and low dosage.PMID:3...
Source: Pediatric Research - March 3, 2021 Category: Pediatrics Authors: Vien Nguyen Manideep Chavali Amara Larpthaveesarp Srikirti Kodali Ginez Gonzalez Robin J M Franklin David H Rowitch Fernando Gonzalez Source Type: research
Heart Disease in Adults With Down Syndrome Between 1996 and 2016
Conclusion:
Adults with DS generally experience less heart disease and associated risk conditions commonly seen in the general population. Prevention and treatment guidelines for heart disease for the DS population should be adjusted after more research is conducted.
Source: Journal of the American Board of Family Medicine - November 20, 2020 Category: Primary Care Authors: Fitzpatrick, V., Rivelli, A., Bria, K., Chicoine, B. Tags: Original Research Source Type: research
Moyamoya Disease Associated with Graves ’ Disease and Down Syndrome: A Case Report and Literature Review
Moyamoya vessels (MMV) are cerebral vasculopathies characterized by the formation of net-like collateral vessels at the cerebral basal area and stenosis of the terminal internal carotid artery (ICA), proximal middle cerebral artery (MCA), and anterior cerebral artery (ACA). Moyamoya disease (MMD) is diagnosed when these MMVs occur bilaterally.1,2
Source: Journal of Stroke and Cerebrovascular Diseases - October 29, 2020 Category: Neurology Authors: Hikaru Nakamura, Kei Sato, Shota Yoshimura, Yukishige Hayashi, Tsuyoshi Izumo, Yoshiharu Tokunaga Source Type: research
Immunomagnetic Reduction Detects Plasma A β 1–42 Levels as a Potential Dominant Indicator Predicting Cognitive Decline
AbstractAlthough the concentrations of Alzheimer ’s disease (AD) biomarkers Aβ1 –40, A β1 –42 and tau protein are very low in human plasma, ultrasensitive assays such as immunomagnetic reduction (IMR) are able to precisely quantify them. Review articles have described the detailed working mechanism of IMR and revealed the feasibility of detecting early-stage AD by assaying these plasma biomarkers with IMR. In this review, we aimed to compare the significance of these plasma biomarkers in predicting cognitive decline in patients with Down syndrome, stroke, or amnestic mild cognitive impairment based on findings in t...
Source: Neurology and Therapy - October 22, 2020 Category: Neurology Source Type: research
What Types of Memory Impairments are There in Children?
Discussion
Memory is an important part of what distinguishes higher order species from others. Memory also is part of one’s self-identity. Difficulties in short-term memory can make common, everyday tasks difficult for the person experiencing the problem particularly if it recently occurred and the person’s long-term memory is intact. Difficulties with long-term memory can also have problems when language, events or even one’s own identity are affected. For some people the memory loss is temporary but for others, memory impairments are permanent and must be accepted and accommodated as part of the overall...
Source: PediatricEducation.org - March 30, 2020 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news
Automatic extraction of the intracranial volume in fetal and neonatal MR scans using convolutional neural networks
Publication date: Available online 9 November 2019Source: NeuroImage: ClinicalAuthor(s): N. Khalili, E. Turk, M.J.N.L. Benders, P. Moeskops, N.H.P. Claessens, R. de Heus, A. Franx, N. Wagenaar, J.M.P.J. Breur, M.A. Viergever, I. IšgumAbstractMR images of infants and fetuses allow non-invasive analysis of the brain. Quantitative analysis of brain development requires automatic brain tissue segmentation that is typically preceded by segmentation of the intracranial volume (ICV). Fast changes in the size and morphology of the developing brain, motion artifacts, and large variation in the field of view make ICV segmentation a...
Source: NeuroImage: Clinical - November 9, 2019 Category: Radiology Source Type: research
The reliability and validity of the Timed Up and Go as a clinical tool in individuals with and without disabilities across a lifespan: a systematic review.
Conclusions: Based on the literature assessed, the Timed Up and Go is clinically applicable and reliable across multiple populations. The Timed Up and Go has a wide variety of clinical use making it a diverse measure that should be considered when choosing an outcome an activity based outcome measure. However, there are some limitations in the validity of the utilization of the Timed Up and Go to some populations due to a lack of data and/or poor choice of comparison outcome measures when assessing validity. Additional research is needed for young to middle aged adults. IMPLICATIONS FOR REHABILITATION Outcome measures are ...
Source: Disability and Rehabilitation - October 25, 2019 Category: Rehabilitation Authors: Christopher A, Kraft E, Olenick H, Kiesling R, Doty A Tags: Disabil Rehabil Source Type: research
Benefits of curcumin in brain disorders
AbstractCurcumin is widely consumed in Asia either as turmeric directly or as one of the culinary ingredients in food recipes. The benefits of curcumin in different organ systems have been reported extensively in several neurological diseases and cancer. Curcumin has got its global recognition because of its strong antioxidant, anti ‐inflammatory, anti‐cancer, and antimicrobial activities. Additionally, it is used in diabetes and arthritis as well as in hepatic, renal, and cardiovascular diseases. Recently, there is growing attention on usage of curcumin to prevent or delay the onset of neurodegenerative diseases. This...
Source: BioFactors - June 10, 2019 Category: Biochemistry Authors: Abid Bhat,
Arehally M. Mahalakshmi,
Bipul Ray,
Sunanda Tuladhar,
Tousif A. Hediyal,
Esther Manthiannem,
Jagadeeswari Padamati,
Ramesh Chandra,
Saravana B. Chidambaram,
Meena K. Sakharkar Tags: REVIEW ARTICLE Source Type: research
Brain stem infarction in a 6-year-old boy with Down syndrome
Infarct locations in children with arterial ischemic stroke have primarily been reported to be lobar or in the basal ganglia, and those in patients with Down syndrome (DS) and antiphospholipid syndrome (APS) are typically wide and multiple. No solitary brain stem infarctions have ever been reported in children with DS until now. Here, we report a case of brain stem infarction in a 6-year-old boy with DS who had no cardiac, renal, or intestinal complications. He exhibited ataxic gait and medial longitudinal fasciculus (MLF) symptoms at first presentation.
Source: Brain and Development - March 7, 2019 Category: Neurology Authors: Toru Imagi, Tomonaga Matsushita, Miyuki Matsushita, Yukako Yae, Takaoki Yokochi, Go Kawano, Yukihiro Akita, Keizo Ohbu, Toyojiro Matsuishi Tags: Case Report Source Type: research
Multiple Cerebral Hemorrhagic Lesions Depicted by Susceptibility-Weighted Imaging in a Patient with Down Syndrome: Case Report
Our objective is to study a 53-year-old woman with Down syndrome presented with massive lobar hematoma in the left fronto-parietal lobe, and who underwent craniotomy and hematoma evacuation. Histopathological diagnosis of surgical specimen was amyloid angiopathy. Postoperative magnetic resonance studies were performed. The lesion this time showed mixed intensity on susceptibility-weighted imaging. In addition, multiple hypointense lesions were evident. An old previously unidentified hemorrhage in the right temporo-parietal lobe was accompanied by superficial cortical siderosis.
Source: Journal of Stroke and Cerebrovascular Diseases - February 20, 2019 Category: Neurology Authors: Kei Yanai, Yasuo Ishida, Hajime Nishido, Shinya Miyamoto, Kazuto Yamazaki, Katsumi Hoya Tags: Case Report Source Type: research
Down syndrome with moyamoya disease: A case series
Pawan Kumar, Inusha Panigrahi, Naveen Sankhyan, Chirag Ahuja, Prasoon K GoyadiJournal of Pediatric Neurosciences 2018 13(2):201-204
Down syndrome (DS), resulting from trisomy 21, is a common cause of mental retardation. Around 20,000 babies with DS are born every year in India. There is an increased risk of cerebral infarction in children with DS, the common causes being thromboembolism secondary to atrioventricular canal defects, right-to-left shunting, myocardial dysmotility, or cardiac valvular abnormalities. Stroke due to other causes can also occur in patients with DS, and one of these is moyamoya disease. This can b...
Source: Journal of Pediatric Neurosciences - July 5, 2018 Category: Neuroscience Authors: Pawan Kumar Inusha Panigrahi Naveen Sankhyan Chirag Ahuja Prasoon K Goyadi Source Type: research
Posterior atlantoaxial fusion using a C2 transverse foramen-penetrating screw: A technical note.
Conclusion: We introduced a novel C1-C2 transarticular screw-placement technique in which the trajectory went through the ipsilateral VA foramen due to already extent VA occlusion.
PMID: 29184713 [PubMed]
Source: Surgical Neurology International - December 2, 2017 Category: Neurosurgery Tags: Surg Neurol Int Source Type: research
Active exergames to improve cognitive functioning in neurological disabilities: a systematic review and meta-analysis.
CONCLUSIONS: Exergames are a highly-flexible tool for rehabilitation of both cognitive and motor functions in adult populations suffering from various neurological disabilities and developmental neurological disorders. Additional high-quality clinical trials with larger samples and more specific cognitive outcomes are needed to corroborate these preliminary findings.
CLINICAL REHABILITATION IMPACT: Exergames could be considered either as a supplemental treatment to conventional rehabilitation, or as strategy to extend benefits of conventional programs at home.
PMID: 29072042 [PubMed - as supplied by publisher]
Source: European Journal of Physical and Rehabilitation Medicine - October 25, 2017 Category: Rehabilitation Authors: Mura G, Carta MG, Sancassiani F, Machado S, Prosperini L Tags: Eur J Phys Rehabil Med Source Type: research
4 questions parents have about moyamoya disease
Last month, families from across the country gathered at Boston Children’s Hospital to celebrate World Moyamoya Day. The expert speakers at the Moyamoya Family Day Symposium shared the latest information about this rare but very serious condition with parents and patients alike.
Moyamoya disease occurs when the walls of the internal carotid arteries — the vessels that supply blood to important areas of the brain — become thickened and narrowed. As a result, blood flow to the brain slows, making blood clots more likely. Kids with moyamoya disease are at significantly higher risk of having a stroke, as well as other co...
Source: Thrive, Children's Hospital Boston - June 13, 2017 Category: Pediatrics Authors: Jessica Cerretani Tags: Ask the Expert Diseases & Conditions Dr. Edward Smith moyamoya Moyamoya Disease Program Source Type: news
