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Condition: Down's Syndrome
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Total 53 results found since Jan 2013.
Idiopathic pulmonary hemosiderosis and stroke secondary to protein C deficiency in a child with Down syndrome: a case report
ConclusionIdiopathic pulmonary hemosiderosis remains a severe disease, which is rarely associated with Down syndrome. The management of this disease in Down syndrome patients is difficult, especially when associated with an ischemic stroke secondary to protein C deficiency.
Source: Journal of Medical Case Reports - March 11, 2023 Category: General Medicine Source Type: research
Sex Differences in Cardiovascular Disease and Dysregulation in Down Syndrome
Am J Physiol Heart Circ Physiol. 2023 Feb 17. doi: 10.1152/ajpheart.00544.2022. Online ahead of print.ABSTRACTThis scoping review and retrospective medical record review is focused on potential sex differences in cardiovascular diseases in patients with Down syndrome. We limited our review to peer-reviewed, primary articles in the English language, in the PubMed and Web of Science databases from 1965-2021. Four categorical domains were identified and searched using additional keywords: 1) congenital heart disease, 2) baseline physiology and risk factors, 3) heart disease and hypertension, and 4) stroke and cerebrovascular ...
Source: American Journal of Physiology. Heart and Circulatory Physiology - February 17, 2023 Category: Physiology Authors: Melissa L Bates Anastasiia Vasileva Laura D M Flores Yana Pryakhina Michelle Buckman Michael H Tomasson Lara R DeRuisseau Source Type: research
Associations between chronic conditions and death in hospital among adults (aged 20+ years) during first acute care hospitalizations with a confirmed or suspected COVID-19 diagnosis in Canada
ConclusionConditions most strongly associated with in-hospital death among hospitalized adults with COVID-19 vary across the life course, and the impact of chronic conditions and comorbidity attenuate with age.
Source: PLoS One - January 4, 2023 Category: Biomedical Science Authors: Dianne Zakaria Source Type: research
Hemodynamic and cardiorespiratory responses to submaximal and maximal exercise in adults with Down syndrome
Conclusion: During submaximal exercise, we verified a compensatory response of HR, and greater VE and VO2 in the individuals with DS. In addition, we were able to observe that the DS group had a reduced SBP and MAP response to submaximal exercise. On the other hand, we found that adults with DS have lower peak hemodynamic and cardiorespiratory values, and a lower cardiac reserve. Further research is warranted to investigate the effects of these results on the general health of adults with DS and the impact of long-term exercise programs on these parameters.
Source: Frontiers in Physiology - August 19, 2022 Category: Physiology Source Type: research
Pediatric COVID-19 Cases Are Surging, Pushing Hospitals —and Health Care Workers—to Their Breaking Points
Aug. 20 was a good day in the pediatric intensive care unit at Children’s Hospital New Orleans. Carvase Perrilloux, a two-month-old baby who’d come in about a week earlier with respiratory syncytial virus and COVID-19, was finally ready to breathe without the ventilator keeping his tiny body alive. “You did it!” nurses in PPE cooed as they removed the tube from his airway and he took his first solo gasp, bare toes kicking.
Downstairs, Quintetta Edwards was preparing for her 17-year-old son, Nelson Alexis III, to be discharged after spending more than two weeks in the hospital with COVID-19—fir...
Source: TIME: Health - August 26, 2021 Category: Consumer Health News Authors: Jamie Ducharme/New Orleans, La. Tags: Uncategorized COVID-19 healthscienceclimate Source Type: news
The burden of dementia due to Down syndrome, Parkinson's disease, stroke, and traumatic brain injury: a systematic analysis for the Global Burden of Disease Study 2019 -
BACKGROUND: In light of the increasing trend in the global number of individuals affected by dementia and the lack of any available disease-modifying therapies, it is necessary to fully understand and quantify the global burden of dementia. This work aimed...
Source: SafetyLit - July 3, 2021 Category: International Medicine & Public Health Tags: Research Methods, Surveillance and Codes, Models Source Type: news
The Burden of Dementia due to Down Syndrome, Parkinson ’s Disease, Stroke, and Traumatic Brain Injury: A Systematic Analysis for the Global Burden of Disease Study 2019
Background: In light of the increasing trend in the global number of individuals affected by dementia and the lack of any available disease-modifying therapies, it is necessary to fully understand and quantify the global burden of dementia. This work aimed to estimate the proportion of dementia due to Down syndrome, Parkinson ’s disease, clinical stroke, and traumatic brain injury (TBI), globally and by world region, in order to better understand the contribution of clinical diseases to dementia prevalence.Methods: Through literature review, we obtained data on the relative risk of dementia with each condition and estima...
Source: Neuroepidemiology - June 28, 2021 Category: Epidemiology Source Type: research
Linking cortical astrocytic neogenin deficiency to the development of Moyamoya disease-like vasculopathy
Neurobiol Dis. 2021 Mar 25:105339. doi: 10.1016/j.nbd.2021.105339. Online ahead of print.ABSTRACTMoyamoya-like vasculopathy, the "puff of smoke"-like small vessels in the brain, is initially identified in patients with Moyamoya disease (MMD), a rare cerebrovascular disease, and later found in patients with various types of neurological conditions, including Down syndrome, Stroke, and vascular dementia. It is thus of interest to understand how this vasculopathy is developed. Here, we provided evidence for cortical astrocytic neogenin (NEO1) deficiency to be a risk factor for its development. NEO1, a member of deleted in col...
Source: Neurobiology of Disease - March 29, 2021 Category: Neurology Authors: Xiao Ren Ling-Ling Yao Jin-Xiu Pan Jun-Shi Zhang Lin Mei Yong-Gang Wang Wen-Cheng Xiong Source Type: research
Neuroprotective effects of Sonic hedgehog agonist SAG in a rat model of neonatal stroke
CONCLUSIONS: These findings indicate benefit of one-time SAG treatment post insult in reducing brain injury and improving behavioral outcome after experimental neonatal stroke.IMPACT: A one-time dose of small molecule Sonic hedgehog agonist protected against neonatal stroke and improved long-term behavioral outcomes in a rat model. This study extends the use of Sonic hedgehog in treating developing brain injury, previously shown in animal models of Down syndrome and cerebellar injury. Sonic hedgehog agonist is one of the most promising therapies in treating neonatal stroke thanks to its safety profile and low dosage.PMID:3...
Source: Pediatric Research - March 3, 2021 Category: Pediatrics Authors: Vien Nguyen Manideep Chavali Amara Larpthaveesarp Srikirti Kodali Ginez Gonzalez Robin J M Franklin David H Rowitch Fernando Gonzalez Source Type: research
