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Total 23 results found since Jan 2013.

Stroke death in patients receiving radiation for head and neck cancer in the modern era
CONCLUSIONS: While radiotherapy for head and neck cancer increases the hazard of stroke death, this is reduced in the modern era and remains a very small absolute risk.PMID:37397363 | PMC:PMC10313411 | DOI:10.3389/fonc.2023.1111764
Source: Cancer Control - July 3, 2023 Category: Cancer & Oncology Authors: Sara J Hardy Sanjukta Bandyopadhyay Hongmei Yang Annalynn Williams Abdi Gudina Michael A Cummings Hong Zhang Deepinder P Singh Yuhchyau Chen Nimish A Mohile Michelle C Janelsins Michael T Milano Source Type: research

Risk of Cardiovascular Events Among Patients With Head and Neck Cancer
This cohort study examines cardiovascular risk profiles, incident stroke, myocardial infarction, and mortality in US veterans with head and neck squamous cell carcinoma.
Source: JAMA Otolaryngology - Head and Neck Surgery - June 22, 2023 Category: ENT & OMF Source Type: research

Stroke death in patients receiving radiation for head and neck cancer in the modern era
ConclusionsWhile radiotherapy for head and neck cancer increases the hazard of stroke death, this is reduced in the modern era and remains a very small absolute risk.
Source: Frontiers in Oncology - June 15, 2023 Category: Cancer & Oncology Source Type: research

Patients With Head/Neck Cancer See Lower Stroke Risk With Initial Surgery
(MedPage Today) -- In oropharyngeal squamous cell carcinoma (OPSCC), the type of initial treatment appears to influence the likelihood of stroke in the years afterward, researchers said. A population-based study of U.S. veterans treated for OPSCC...
Source: MedPage Today Radiology - August 12, 2022 Category: Radiology Source Type: news

E-224 Bilateral external carotid artery sacrifice in massive refractory hemorrhage of the pharynx: a case report
This report suggests that bilateral ECA embolization may be safe in acute settings. In this report, the bleeding did not respond to conservative or surgical management and ECA embolization was used as a life-saving procedure in order to stop massive bleeding. Bilateral external carotid artery embolization is rarely employed because of the high risk of facial necrosis. Additionally, ECAs are also assumed to serve as potential blood reservoirs, particularly in the case of ICA occlusion where the ipsilateral ECA can significantly contribute to intracranial blood flow via collaterals. However, in this report, no complications ...
Source: Journal of NeuroInterventional Surgery - July 23, 2022 Category: Neurosurgery Authors: Esmaeil, S., Eltatawy, A., Hossein Abbasi, M., Mowla, A., Grossman, A., Prestigiacomo, C., Shirani, P. Tags: SNIS 19th annual meeting electronic poster abstracts Source Type: research

Risk of Stroke After Definitive Radiotherapy —Cause for Concern or Modest Risk?
With the rapidly increasing prevalence of oropharyngeal squamous cell carcinoma (OPSCC), largely driven by the human papillomavirus (HPV) epidemic, and with relative equipoise between radiation-based and surgery-based treatment protocols, there has been renewed interest in describing differences in functional outcomes between the 2 treatment modalities. Radiation is theoretically related to stroke risk due to carotid artery intimal injury, which could lead to the development of atherosclerosis. Both carotid artery stenosis and carotid intima-medial thickness have been shown to be associated with radiation therapy providing...
Source: JAMA Otolaryngology - Head and Neck Surgery - June 23, 2022 Category: ENT & OMF Source Type: research

Up-front Surgery and Risk of Stroke in US Veterans With Oropharyngeal Carcinoma
This cohort study evaluates the association of up-front surgery and stroke risk compared with nonsurgical treatment for oropharyngeal squamous cell carcinoma among US veterans.
Source: JAMA Otolaryngology - Head and Neck Surgery - June 23, 2022 Category: ENT & OMF Source Type: research

Janssen Announces U.S. FDA Approval of PONVORY ™ (ponesimod), an Oral Treatment for Adults with Relapsing Multiple Sclerosis Proven Superior to Aubagio® (teriflunomide) in Reducing Annual Relapses and Brain Lesions
TITUSVILLE, N.J. – (March 19, 2021) – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced that the U.S. Food and Drug Administration (FDA) approved PONVORY™ (ponesimod), a once-daily oral selective sphingosine-1-phosphate receptor 1 (S1P1) modulator, to treat adults with relapsing forms of multiple sclerosis (MS), to include clinically isolated syndrome, relapsing-remitting disease and active secondary progressive disease.1,2,3 PONVORY™ offers MS patients superior efficacy in reducing annualized relapse rates compared to an established oral therapy and a proven safety profile backed by ove...
Source: Johnson and Johnson - March 19, 2021 Category: Pharmaceuticals Tags: Innovation Source Type: news

CDKN2B-AS1: An indispensable long non-coding RNA in multiple diseases.
CONCLUSIONS: Long non-coding RNA CDKN2B-AS1 likely serves as a promising therapeutic target or prognosis biomarker in multiple human diseases. PMID: 32767927 [PubMed - as supplied by publisher]
Source: Current Pharmaceutical Design - August 4, 2020 Category: Drugs & Pharmacology Authors: Song C, Qi Y, Zhang J, Guo C, Yuan C Tags: Curr Pharm Des Source Type: research

Connecting Metainflammation and Neuroinflammation Through the PTN-MK-RPTP β/ζ Axis: Relevance in Therapeutic Development
Conclusion The expression of the components of the PTN-MK-RPTPβ/ζ axis in immune cells and in inflammatory diseases suggests important roles for this axis in inflammation. Pleiotrophin has been recently identified as a limiting factor of metainflammation, a chronic pathological state that contributes to neuroinflammation and neurodegeneration. Pleiotrophin also seems to potentiate acute neuroinflammation independently of the inflammatory stimulus while MK seems to play different -even opposite- roles in acute neuroinflammation depending on the stimulus. Which are the functions of MK and PTN in chronic neuroi...
Source: Frontiers in Pharmacology - April 11, 2019 Category: Drugs & Pharmacology Source Type: research

Long non-coding SNHG1 in cancer
ConclusionSNHG1 likely acts as a useful tumour biomarker for cancer diagnosis, prognosis and treatment.
Source: Clinica Chimica Acta - March 6, 2019 Category: Laboratory Medicine Source Type: research

Long non-coding SNHG1 in cancer.
CONCLUSION: SNHG1 likely acts as a useful tumour biomarker for cancer diagnosis, prognosis and treatment. PMID: 30849309 [PubMed - as supplied by publisher]
Source: International Journal of Clinical Chemistry - March 4, 2019 Category: Chemistry Authors: Thin K, Tu JC, Sudheesh C Tags: Clin Chim Acta Source Type: research

Association of Cancer Cell Type and Extracellular Vesicles With Coagulopathy in Patients With Lung Cancer and Stroke Brief Report
Conclusions—Our findings indicate that cancer cell type is associated with circulating EV levels and coagulopathy in patients with lung cancer and stroke.
Source: Stroke - April 23, 2018 Category: Neurology Authors: Jong-Won Chung, Yeon Hee Cho, Myung-Ju Ahn, Mi Ji Lee, Gyeong-Moon Kim, Chin-Sang Chung, Oh Young Bang Tags: Biomarkers, Mechanisms, Translational Studies, Cerebrovascular Disease/Stroke, Thrombosis Brief Reports Source Type: research

Urine Arsenic and Arsenic Metabolites in U.S. Adults and Biomarkers of Inflammation, Oxidative Stress, and Endothelial Dysfunction: A Cross-Sectional Study
Conclusion: In a cross-sectional study of U.S. adults, we observed some positive associations of uAs and toenail As concentrations with biomarkers potentially relevant to CVD pathogenesis and inflammation, and evidence of a higher capacity to metabolize inorganic As was negatively associated with a marker of oxidative stress. https://doi.org/10.1289/EHP2062 Received: 14 April 2017 Revised: 13 November 2017 Accepted: 15 November 2017 Published: 15 December 2017 Address correspondence to S.F. Farzan, 2001 N. Soto St., Los Angeles, CA, 90032. Telephone: (323)-442-5101; Email: sffarzan@usc.edu Supplemental Material is ava...
Source: EHP Research - December 16, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

The Association of Arsenic Metabolism with Cancer, Cardiovascular Disease, and Diabetes: A Systematic Review of the Epidemiological Evidence
Conclusions: Population level of iAs% and DMA%, but not MMA%, were associated with arsenic exposure levels. Overall, study findings suggest that higher MMA% was associated with an increased risk of cancer and cardiovascular disease, while lower MMA% was associated with an increased risk of diabetes and metabolic syndrome. Additional population-based studies and experimental studies are needed to further evaluate and understand the role of arsenic exposure in arsenic metabolism and the role of arsenic metabolism in disease development. https://doi.org/10.1289/EHP577 Received: 01 June 2016 Revised: 26 February 2017 Acce...
Source: EHP Research - August 2, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research