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Cancer: Pheochromocytoma

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Total 47 results found since Jan 2013.

Synthesis and biological evaluation of aryloxyacetamide derivatives as neuroprotective agents.
Abstract A series of new aryloxyacetamide derivatives 10a-s and 14a-m are designed and synthesized. Their protective activities against the glutamate-induced cell death were investigated in differentiated rat pheochromocytoma cells (PC12 cells). Most compounds exhibited neuroprotective effects, especially for 10m, 10r, 14b and 14c, which showed potential protection of PC12 cells at three doses (0.1, 1.0, 10μM). MTT assay, Hoechst 33342/PI double staining, and high content screening (HCS) revealed that pretreatment of the cells with 10m, 10r, 14b and 14c has significantly decreased the extent of cell apoptosis in ...
Source: Bioorganic and Medicinal Chemistry Letters - March 25, 2016 Category: Chemistry Authors: Zhong Y, Xu Y, Zhang AX, Li XF, Xu ZY, Li P, Wu B Tags: Bioorg Med Chem Lett Source Type: research

Acute hypertension: a systematic review and appraisal of guidelines.
CONCLUSION: NHLBI and ESH/ESC guidelines are high quality and provide similar recommendations for management of asymptomatic acute hypertensive episodes and hypertensive emergencies. Additional research is needed to inform clinical practice guidelines for this common condition. PMID: 25598731 [PubMed]
Source: Ochsner Journal - November 18, 2015 Category: Journals (General) Tags: Ochsner J Source Type: research

Hemodynamic Stability During Pheochromocytoma Resection: Lessons Learned Over the Last Two Decades
Conclusions Postoperative outcomes following pheo resection have improved over the last two decades. Preoperative α-blockade plays a significant role in improving intraoperative hemodynamics and post-op outcomes. Increased doses of phenoxybenzamine and utilization of laparoscopic approaches have likely contributed to improved outcomes in the last decade. Intraoperative magnesium use may provide protection against hemodynamic instability and warrants further study.
Source: Annals of Surgical Oncology - November 14, 2015 Category: Cancer & Oncology Source Type: research

Predictors of Poor Outcome in Neuroleptic Malignant Syndrome: Retrospective Analysis of Nationwide Inpatient Sample (S32.006)
CONCLUSIONS: In patients admitted for neuroleptic malignant syndrome, every decade increment in age, acute kidney injury, seizures and respiratory failure were positive predictors of poor outcome. Every calendar year increase was a negative predictor of poor outcome. Study Supported by:Disclosure: Dr. Modi has nothing to disclose. Dr. Dharaiya has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Modi, S., Dharaiya, D. Tags: Movement Disorders: Tremor, Ataxia, and More Platform Blitz Source Type: research

RE-1 silencing transcription factor (REST): a regulator of neuronal development and neuronal/endocrine function
Abstract RE-1 silencing transcription factor (REST) is a transcriptional repressor that has been proposed to function as a master negative regulator of neurogenesis, as REST target genes encode neuronal receptors, ion channels, neuropeptides and synaptic proteins. During neuronal differentiation, REST expression levels are reduced, allowing expression of selected REST target genes. The analysis of neural stem/progenitor cells that are either devoid of REST or overexpress REST revealed that REST is not the master regulator that is solely responsible for the acquisition of the neuronal fate. Rather, REST provides a...
Source: Cell and Tissue Research - January 1, 2015 Category: Cytology Source Type: research

Lateralizing sensorimotor deficits in a case of pseudopheochromocytoma.
Authors: Suh J, Quinn C, Rehwinkel A Abstract Pseudopheochromocytoma is a poorly understood, rare cause of severe paroxysmal hypertension that mimics the symptomatology of pheochromocytoma in the absence of biochemical evidence of this tumor. Symptoms such as headache, nausea, sweating, and palpitations during hypertensive episodes have been described. In this paper, we describe previously unreported findings of lateralizing sensorimotor deficits in a patient with pseudopheochromocytoma. These changes presented during a hypertensive episode and were concerning for stroke but were not accompanied by acute radiologic...
Source: The Yale Journal of Biology and Medicine - December 18, 2014 Category: Universities & Medical Training Tags: Yale J Biol Med Source Type: research

Human PLacental eXpanded (PLX) mesenchymal-like adherent stromal cells confer neuroprotection to nerve growth factor (NGF)-differentiated PC12 cells exposed to ischemia by secretion of IL-6 and VEGF
Publication date: February 2015 Source:Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Volume 1853, Issue 2 Author(s): Adi Lahiani , Efrat Zahavi , Nir Netzer , Racheli Ofir , Lena Pinzur , Shani Raveh , Hadar Arien-Zakay , Ephraim Yavin , Philip Lazarovici Mesenchymal stem cells are potent candidates in stroke therapy due to their ability to secrete protective anti-inflammatory cytokines and growth factors. We investigated the neuroprotective effects of human placental mesenchymal-like adherent stromal cells (PLX) using an established ischemic model of nerve growth factor (NGF)-differentiated pheochromocy...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - December 9, 2014 Category: Molecular Biology Source Type: research

Neuroprotective effect of modified Chungsimyeolda-tang, a traditional Korean herbal formula, via autophagy induction in models of Parkinson׳s disease
This study suggests that DG is an attractive candidate drug for inducing autophagy and, therefore, may represent a promising strategy to prevent diseases associated with misfolded/aggregated proteins in various neurodegenerative disorders, including Parkinson׳s disease. Graphical abstract
Source: Journal of Ethnopharmacology - November 28, 2014 Category: Drugs & Pharmacology Source Type: research

Ultrasound-Enhanced Protective Effect of Tetramethylpyrazine against Cerebral Ischemia/Reperfusion Injury
by Chunbing Zhang, Fengmeng Teng, Juan Tu, Dong Zhang In traditional Chinese medicine, Ligusticum wallichii (Chuan Xiong) and its bioactive ingredient, tetramethylpyrazine (TMP), have been used to treat cardiovascular diseases and to relieve various neurological symptoms, such as those associated with ischemic injury. In the present study, we investigated whether ultrasound (US) exposure could enhance the protective effect of TMP against cerebral ischemia/reperfusion (I/R) injury. Glutamate-induced toxicity to pheochromocytoma (PC12) cells was used to model I/R injury. TMP was paired with US to examine whether this combin...
Source: PLoS One - November 19, 2014 Category: Biomedical Science Authors: Chunbing Zhang et al. Source Type: research

Flavonoids Isolated from Rumex aquaticus Exhibit Neuroprotective and Neurorestorative Properties by Enhancing Neurite Outgrowth and Synaptophysin.
In this study, the isolation of two flavonoids - quercetin-3-O-galactoside (1) and quercetin-3-O-arabinoside (2) - from Rumex aquaticus (western dock) and their neuroprotective effects were reported in the oxygen-glucose deprivation (OGD) model of in vitro ischemia using rat pheochromocytoma (PC12) cell line. Bioassay-guided fractionation of the ethyl-acetate extract of Rumex aquaticus L. afforded the isolation of compounds 1 and 2. The structures of compounds were established on the basis of spectroscopic analyses (UV, mass spectrometry (MS) and nuclear magnetic resonance spectroscopy (NMR). Both compounds were isolated f...
Source: CNS and Neurological Disorders Drug Targets - October 23, 2014 Category: Drugs & Pharmacology Authors: Orbán-Gyapai O, Raghavan A, Vasas A, Forgo P, Hohmann J, Shah ZA Tags: CNS Neurol Disord Drug Targets Source Type: research

Equol is neuroprotective during focal cerebral ischemia and reperfusion that involves p-Src and gp91phox.
Abstract Both of gp91(phox) (an isoform of nicotinamide adenine dinucleotide phosphate reduced oxidases) and Src (a non-receptor protein tyrosine kinase) are abundantly expressed in the brain and play a prominent role in mediating ischemic alteration in neurons. The inhibitory strategy of them is believed to be the promising treatment of stroke. The present study was designed to investigate the effect of equol (0.625-2.5 mg•kg(-1), i.g. for 3 days), a predominant active metabolite of daidzein, on neuroprotection against cerebral ischemia/reperfusion injury in rats and the underlying mechanisms. We found that equ...
Source: Current Neurovascular Research - September 7, 2014 Category: Neurology Authors: Wei YU, Wang Y, Zhou DX, Zhao LM, Li GR, Deng XL Tags: Curr Neurovasc Res Source Type: research

Beneficial Effect of Astragalosides on Stroke Condition Using PC12 Cells under Oxygen Glucose Deprivation and Reperfusion.
In this study, the direct effect of AST against oxygen and glucose deprivation (OGD) including neuronal injury and the underlying mechanisms in vitro were investigated. 5 h OGD followed by 24 h of reperfusion [adding back oxygen and glucose (OGD-R)] was used to induce in vitro ischemia reperfusion injury in differentiated rat pheochromocytoma PC12 cells. AST (1, 100, and 200 µg/mL) were added to the culture after 5 h of the OGD ischemic insult and was present during the reoxygenation phases. A key finding was that OGD-R decreased cell viability, increased lactate dehydrogenase, increased reactive oxygen species, apopt...
Source: Cellular and Molecular Neurobiology - May 8, 2014 Category: Cytology Authors: Chiu BY, Chang CP, Lin JW, Yu JS, Liu WP, Hsu YC, Lin MT Tags: Cell Mol Neurobiol Source Type: research

Takotsubo cardiomyopathy: A review.
Abstract Abstract Takotsubo cardiomyopathy can occur after acute mental or physical stress, subarachnoid hemorrhage, ischemic stroke, major head trauma, acute medical illness or acute pheochromocytoma crisis. It is characterized by transient systolic dysfunction of the apical and/or midventricular segments in patients without epicardial coronary artery disease. The condition occurs most commonly in postmenopausal women, and is characterized by transient left ventricular dysfunction. The pathophysiology of the disorder remains to be elucidated but may involve catecholamine excess and vasospasm. Future studies, perh...
Source: Acute Cardiac Care - February 22, 2014 Category: Cardiology Authors: Veillet-Chowdhury M, Hassan SF, Stergiopoulos K Tags: Acute Card Care Source Type: research

Effects of SARA on oxygen-glucose deprivation in PC12 cell line.
Abstract Ischemic stroke is a major composition of cerebrovascular disease, seriously threatening to human health in the world. Activin A (ActA), belonging to transforming growth factor-beta (TGF-β) super family, plays an important role in the hypoxic-ischemic brain injury through ActA/Smads pathway. While as an essential phosphorylation assistor in TGF-β signaling, the functions and mechanisms of smad anchor for receptor activation (SARA) in ischemic brain injury remain poorly understood. To solve this problem and explore the pathological processes of ischemic stroke, we used an Oxygen-Glucose deprivation (OGD)...
Source: Neurochemical Research - May 1, 2013 Category: Neuroscience Authors: Wang JQ, He JT, Du ZW, Li ZS, Liu YF, Mang J, Xu ZX Tags: Neurochem Res Source Type: research

Acute upper extremity arterial thrombosis and stroke in an unresected pheochromocytoma
Pheochromocytoma is a rare cause of hypertension in the general population. Only isolated reports show an association with acute obstructive arterial thrombosis. A 50-year-old chronically noncompliant woman with a known unresected pheochromocytoma presented to the emergency department with ataxia. Imaging confirmed a right-sided ischemic stroke. During her hospital stay, the patient developed signs consistent with acute right upper extremity ischemia resulting from occlusion in the distal right subclavian, axillary, and proximal brachial arteries. Emergent open thrombectomy was successfully performed. In patients with an u...
Source: Journal of Vascular Surgery - March 13, 2013 Category: Surgery Authors: Sameer Kaiser, John Chronakos, Alan M. Dietzek Tags: Case reports Source Type: research