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Cancer: Pheochromocytoma

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Total 47 results found since Jan 2013.

MiR-29a-3p Enhances the Viability of Rat Neuronal Cells that Injured by Oxygen-Glucose Deprivation/Reoxygenation Treatment Through Targeting TNFRSF1A and Regulating NF- κB Signaling Pathway
We attempt to investigate the role of TNFRSF1A and its underlying mechanism in oxygen-glucose deprivation/reoxygenation (OGD/R)-induced injury in rat pheochromocytoma PC12 cells.
Source: Journal of Stroke and Cerebrovascular Diseases - October 14, 2020 Category: Neurology Authors: Xiao-Zeng Gao, Zhao-Xia Zhang, Guang-Liang Han Source Type: research

Screening for phaeochromocytoma in patients with acute cerebrovascular disease: Is it necessary?
CONCLUSION: We noted that CATS/METS were elevated in one-third of patients, especially in patients with high systolic blood pressure. Increase in CATS/METS should be appropriately followed up with repeat testing. Since false elevation in CATS/METS has been reported in cerebrovascular disease, screening for phaeochromocytoma is best deferred for a month. PMID: 32860372 [PubMed - as supplied by publisher]
Source: Malaysian Journal of Pathology - August 30, 2020 Category: Pathology Tags: Malays J Pathol Source Type: research

MicroRNA-18a-5p mitigates oxygen-glucose-deprivation/reoxygenation-induced injury through suppression of TLRs/NF- κB signaling by targeting TLR8 in PC12 cells.
MicroRNA-18a-5p mitigates oxygen-glucose-deprivation/reoxygenation-induced injury through suppression of TLRs/NF-κB signaling by targeting TLR8 in PC12 cells. Biosci Biotechnol Biochem. 2020 Aug 20;:1-8 Authors: Lu YY, Ma XJ, Yang YN Abstract This work aimed to assess the role of TLR8 in cerebral I/R injury and its in-depth pathogenesis. Bioinformatics analysis indicated that TLR8 was up-regulated in patients with ischemic stroke than that in healthy control, and miR-18a-5p was the upstream regulatory of TLR8. Then, the rat pheochromocytoma PC12 cells were exposed in oxygen-glucose-deprivation/reoxyg...
Source: Bioscience, Biotechnology, and Biochemistry - August 19, 2020 Category: Biochemistry Authors: Lu YY, Ma XJ, Yang YN Tags: Biosci Biotechnol Biochem Source Type: research

Synthesis of Novel Aryloxyethylamine Derivatives and Evaluation of Their in Vitro and in Vivo Neuroprotective Activities.
Abstract A series of aryloxyacetamine derivatives W1 - W37 were designed, synthesized and evaluated for their biological activity. Their structures were confirmed by 1 H-NMR, 13 C-NMR, and HR-ESI-MS. The preliminary screening of neuroprotection of compounds in vitro was detected by MTT, and the anti-ischaemic activity in vivo was tested using bilateral common carotid artery occlusion in Kunming Mice. Most of these compounds showed potent neuroprotective effects against the glutamate-induced cell death in differentiated rat pheochromocytoma cells (PC12 cells), especially for W1 , W7 , W16 , W26 , W28 , W29 and W30 ...
Source: Chemistry and Biodiversity - June 23, 2020 Category: Biochemistry Authors: Zhong Y, Gao Y, Xu Y, Qi C, Wu B Tags: Chem Biodivers Source Type: research

LncRNA ANRIL protects against oxygen and glucose deprivation (OGD)-induced injury in PC-12 cells: potential role in ischaemic stroke.
In conclusion, lncRNA ANRIL alleviated OGD-induced PC-12 cell injury as evidenced. PI3K/AKT pathway might be involved in this regulating progression. PMID: 31174432 [PubMed - in process]
Source: Artificial Cells, Nanomedicine and Biotechnology - June 10, 2019 Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research

L-NBP, a multiple growth factor activator, attenuates ischemic neuronal impairments possibly through promoting neuritogenesis
Publication date: Available online 7 January 2019Source: Neurochemistry InternationalAuthor(s): Yuming Zhao, Dongmei Liu, Jiang Li, XiaoJie Zhang, Xiaoliang WangAbstractIn China, L-3-n-butylphthalide (L-NBP) showed promising pharmacological actions in stroke treatment. Analyzing the characteristics of L-NBP might provide valuable hints for new drug design. The current study is aimed to determine the effects of L-NBP on neuritogenesis and further to elucidate the neuronal protection against stroke impairment in vitro. L-NBP was applied to rat pheochromocytoma PC12 cells and cultured rat cortical neurons under the normoxic...
Source: Neurochemistry International - January 7, 2019 Category: Neuroscience Source Type: research

Unusual Techniques for Preserving Surgical and Oncologic Safety in Hepatectomy of Advanced Adrenal Malignancy with Vena Cava and Liver Invasion
We report herein three cases of major hepatectomy with IVC invasion and discuss several surgical tips.Patients and MethodsFrom March 2011 to February 2014, we retrospectively reviewed three cases of adrenal malignancy with liver and IVC invasion. Based on the severity of the malignant tumor, each case illustrates a different method to address surgical complications and maintain oncologic safety. Case 1: A 34-year-old woman was diagnosed with adrenocortical tumor during medical examination. Tumor invaded the right lobe of the liver and very close to the IVC. Fortunately, there was little thrombosis inside the IVC; we perfor...
Source: Annals of Surgical Oncology - October 1, 2018 Category: Cancer & Oncology Source Type: research

IMM-H004, a Novel Coumarin Derivative Compound, Inhibits H2O2-Induced Neurotoxicity via Antioxidant and Antiapoptosis in PC12 Cells
IMM-H004 [7-hydroxy-5-methoxy-4-methyl-3-(4-methylpiperazin-1-yl)-coumarin] is a novel derivative of coumarin, which played neuroprotective roles in brain ischemia in rats in previous studies. Although antiapoptosis and improving synapsis structure were proved, the effects and mechanisms of IMM-H004 in brain ischemia need further study. In this paper, the effect of IMM-H004 on H2O2-induced neurotoxicity in pheochromocytoma (PC12) cells was researched. Morphological observation, MTT method and PI/Hoechst staining were used to indicate cell viability and apoptosis.
Source: Journal of Stroke and Cerebrovascular Diseases - September 19, 2018 Category: Neurology Authors: Xiu-Yun Song, Jin-Feng Hu, Dong-Hui Wu, Hai-Jie Ji, Nai-Hong Chen Source Type: research

Unusual Techniques for Preserving Surgical and Oncologic Safety in Hepatectomy of Advanced Adrenal Malignancy with Vena Cava and Liver Invasion
We report herein three cases of major hepatectomy with IVC invasion and discuss several surgical tips.Patients and MethodsFrom March 2011 to February 2014, we retrospectively reviewed three cases of adrenal malignancy with liver and IVC invasion. Based on the severity of the malignant tumor, each case illustrates a different method to address surgical complications and maintain oncologic safety. Case 1: A 34-year-old woman was diagnosed with adrenocortical tumor during medical examination. Tumor invaded the right lobe of the liver and very close to the IVC. Fortunately, there was little thrombosis inside the IVC; we perfor...
Source: Annals of Surgical Oncology - September 6, 2018 Category: Cancer & Oncology Source Type: research

Design, synthesis and neuroprotective activities of novel cinnamide derivatives containing benzylpiperazine moiety
AbstractA new series of cinnamide derivatives6a–l were synthesized by the reaction of acyl chlorides with various substituted benzylpiperazines. The structures were characterized by1H NMR,13C NMR, and HRMS. The potential neuroprotective activities of cinnamide analogs were evaluated in differentiated rat pheochromocytoma cells (PC12 cells) and in mice subjected to acute cerebral ischemia. Among the series,6a,6b, and6c, featuring a 1,3-benzodioxole moiety, showed potent neuroprotection both in vivo and in vitro. The three compounds were selected and further studied to determine their mechanism of action. MTT assay, Hoechs...
Source: Medicinal Chemistry Research - February 22, 2018 Category: Chemistry Source Type: research

An interesting presentation of pheochromocytoma
We present a case of a 41-year-old male patient who presented with cerebellar infarct and found to have aortic thrombi and later developed acute myocardial infaction during same hospitalization. To the best of our knowledge, this is the first reported case of this kind.
Source: Indian Journal of Critical Care Medicine - January 15, 2018 Category: Intensive Care Authors: Sunil Kumar Garg Pragya Garg Mehmet Urumdas Source Type: research

Perioperative Management of Pheochromocytoma Resection in a Patient With Severe Aortic Stenosis
PHEOCHROMOCYTOMA IS A rare catecholamine-secreting tumor composed of chromaffin tissue arising from the adrenal medulla. Surgical resection is a high-risk procedure and remains a clinical challenge for anesthesiologists and surgeons. There is potential for massive and sudden changes in catecholamine release resulting in significant hemodynamic effects, which in turn can lead to devastating cardiac and neurologic complications such as myocardial infarction, stroke, or death. Advances in medical management and anesthetic and surgical techniques have led to improved surgical outcomes.
Source: Journal of Cardiothoracic and Vascular Anesthesia - December 21, 2017 Category: Anesthesiology Authors: Jagroop Singh Saran, Jacob Moalem, Luke Schoeniger, Konstantine Tzimas Tags: Case Report Source Type: research

Takotsubo-Like Myocardial Dysfunction in Ischemic Stroke Clinical Sciences
This study included 23 patients (0.42%). The mean age was 70.7±13.9 years, with predominance of women (73.9%) and typical pattern of Takotsubo-like myocardial dysfunction (91.3%). They were associated with short-term poor functional outcomes, including high mortality, neurological deterioration, and functional status at discharge, compared with those without (39.1% versus 2.4%, 47.8% versus 7.4%; and median [interquartile range], 5 [5–6] versus 3 [2–4]; all P
Source: Stroke - October 23, 2016 Category: Neurology Authors: Jung, J.-M., Kim, J.-G., Kim, J. B., Cho, K.-H., Yu, S., Oh, K., Kim, Y.-H., Choi, J.-Y., Seo, W.-K. Tags: Risk Factors, Cardiomyopathy, Prognosis, Mortality/Survival, Ischemic Stroke Original Contributions Source Type: research

Is there an optimal preoperative management strategy for phaeochromocytoma/paraganglioma?
This article is protected by copyright. All rights reserved.
Source: Clinical Endocrinology - September 30, 2016 Category: Endocrinology Authors: B.G. Challis, R.T. Casey, H L Simpson, M. Gurnell Tags: Clinical Question Source Type: research