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Specialty: Allergy & Immunology
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Total 72221 results found since Jan 2013.
NLRP2 in health and disease
Immunology. 2023 Sep 22. doi: 10.1111/imm.13699. Online ahead of print.ABSTRACTNLR family pyrin domain containing 2 (NLRP2) is a novel member of the Nod-like receptor (NLR) family. However, our understanding of NLRP2 has long been ambiguous. NLRP2 may have a role in the innate immune response, but its 'specific' functions remain controversial. Although NLRP2 can initiate inflammasome and promote inflammation, it can also downregulate inflammatory signals. Additionally, NLRP2 has been reported to function in the reproductive system and shows high expression in the placenta. However, the exact role of NLRP2 in the reproducti...
Source: Immunology - September 22, 2023 Category: Allergy & Immunology Authors: Tongtong Zhang Fei Xing Mingcui Qu Zhihu Yang Yafei Liu Yongchao Yao Na Xing Source Type: research
Depletion of mTOR ameliorates CD < sub > 4 < /sub > < sup > + < /sup > T cell pyroptosis by promoting autophagy activity in septic mice
In this study, a septic mouse model was developed using cecal ligation and puncture (CLP) to explore the degree of pyroptosis and autophagy of CD4+ T cells. T-cell-specific mTOR/TSC1-knockout mice were used to investigate the role of mTOR pathway in the regulation of CD4+ T cell pyroptosis. Bafilomycin, a specific autophagy inhibitor, was used to verify the regulatory effect of autophagy on pyroptosis in septic mice. We observed aggravated pyroptosis in CD4+ T cells in CLP mice accompanied by impaired autophagy activity and an overactivated mTOR signaling pathway. Depletion of mTOR relieved autophagy deficiency and reduced...
Source: International Immunopharmacology - September 22, 2023 Category: Allergy & Immunology Authors: Ran Guo Guoyu Zhao Guangxu Bai Jianwei Chen Wen Han Na Cui Hao Wang Source Type: research
The Lysosomal Calcium Channel TRPML1 Maintains Mitochondrial Fitness in NK Cells through Interorganelle Cross-Talk
In this study, we examined the role of TRPML1 (TRP cation channel, mucolipin subfamily, member 1) in regulating the homeostasis of secretory lysosomes and their cross-talk with mitochondria in human NK cells. We found that genetic deletion of TRPML1, which localizes to lysosomes in NK cells, led to mitochondrial fragmentation with evidence of collapsed mitochondrial cristae. Consequently, TRPML1-/- NK92 (NK92ML1-/-) displayed loss of mitochondrial membrane potential, increased reactive oxygen species stress, reduced ATP production, and compromised respiratory capacity. Using sensitive organelle-specific probes, we observed...
Source: Journal of Immunology - September 22, 2023 Category: Allergy & Immunology Authors: Dennis Clement Edina K Szabo Silje Zandstra Krokeide Merete Thune Wiiger Marianna Vincenti Daniel Palacios Young-Tae Chang Christian Grimm Sandip Patel Harald Stenmark Andreas Brech Rakesh Kumar Majhi Karl-Johan Malmberg Source Type: research
Mass Spectrometric Profiling of HLA-B44 Peptidomes Provides Evidence for Tapasin-Mediated Tryptophan Editing
J Immunol. 2023 Sep 22:ji2300232. doi: 10.4049/jimmunol.2300232. Online ahead of print.ABSTRACTThe extreme polymorphisms of HLA class I proteins result in structural variations in their peptide binding sites to achieve diversity in Ag presentation. External factors could independently constrict or alter HLA class I peptide repertoires. Such effects of the assembly factor tapasin were assessed for HLA-B*44:05 (Y116) and a close variant, HLA-B*44:02 (D116), which have low and high tapasin dependence, respectively, for their cell surface expression. Analyses of the HLA-B*44:05 peptidomes in the presence and absence of tapasin...
Source: Journal of Immunology - September 22, 2023 Category: Allergy & Immunology Authors: Amanpreet Kaur Avrokin Surnilla Anita J Zaitouna Michael B Mumphrey Venkatesha Basrur Irina Grigorova Marcin Cieslik Mary Carrington Alexey I Nesvizhskii Malini Raghavan Source Type: research
Methiothepin downregulates SNAP-23 and inhibits degranulation of rat basophilic leukemia cells and mouse bone marrow-derived mast cells
This article is protected by copyright. All rights reserved.PMID:37736882 | DOI:10.1002/eji.202250360
Source: European Journal of Immunology - September 22, 2023 Category: Allergy & Immunology Authors: Daisuke Kondo Ruriko Suzuki Ayako Matsumura Hitomi Meguri Masahiko Tanaka Makoto Itakura Naohide Hirashima Source Type: research
Loss of αβ but not γδ T cells in chickens causes a severe phenotype
This article is protected by copyright. All rights reserved.PMID:37735713 | DOI:10.1002/eji.202350503
Source: European Journal of Immunology - September 22, 2023 Category: Allergy & Immunology Authors: Theresa von Heyl Romina Klinger Dorothea Aumann Christian Zenner Mohanned Alhussien Antonina Schlickenrieder Kamila Lengyel Hanna-Kaisa Vikkula Teresa Mittermair Hicham Sid Benjamin Schusser Source Type: research
Musclin Mitigates the Attachment of HUVECs to THP-1 Monocytes in Hyperlipidemic Conditions through PPAR α/HO-1-Mediated Attenuation of Inflammation
This study aimed to explore the impact of musclin on inflammatory responses and the interaction between endothelial cells and monocytes under hyperlipidemic conditions. The attachment levels of THP-1 monocytes on cultured HUVECs were examined. Inflammation and the expression of cell adhesion molecules were also evaluated. To explore the molecular mechanisms of musclin, PPAR α or heme oxygenase 1 (HO-1) siRNA transfection was performed in HUVECs. The results revealed that treatment with recombinant musclin effectively suppressed the attachment of palmitate-induced HUVECs to THP-1 cells and reduced the expression of cell ad...
Source: Inflammation - September 22, 2023 Category: Allergy & Immunology Source Type: research
Fibrinogen-like protein 2 regulates macrophage glycolytic reprogramming by directly targeting PKM2 and exacerbates alcoholic liver injury
CONCLUSIONS: Taken together, Fgl2 hastens the development of alcoholic liver injury by mediating PKM2 dependent aerobic glycolysis in proinflammatory macrophages. Strategies that inhibiting proinflammatory macrophage activation by silencing Fgl2 might be a potential therapeutic intervention for alcoholic liver injury.PMID:37734200 | DOI:10.1016/j.intimp.2023.110957
Source: International Immunopharmacology - September 21, 2023 Category: Allergy & Immunology Authors: Xue Hu Xiaoyang Wan Yuting Diao Zhe Shen Zhongwei Zhang Peng Wang Danqin Hu Xiaojing Wang Weiming Yan Chaohui Yu Xiaoping Luo Hongwu Wang Qin Ning Source Type: research
Nuciferine protects against lipopolysaccharide-induced endometritis via inhibiting ferroptosis and modulating AMPK α/mTOR/HIF-1α signaling axis
Int Immunopharmacol. 2023 Sep 19;124(Pt B):110914. doi: 10.1016/j.intimp.2023.110914. Online ahead of print.ABSTRACTNuciferine (NF) is an alkaloid isolated from Nelumbo nucifera and has been reported to exhibit a wide range of pharmacological effects. However, whether NF treatment exhibits a protective effect in endometritis remains unclear. Here, the protective effects of NF on lipopolysaccharide (LPS)-induced endometritis in mice were investigated in our research. The results showed that NF significantly reversed the uterine histopathological changes, inflammatory factor levels and myeloperoxidase (MPO) activity caused b...
Source: International Immunopharmacology - September 21, 2023 Category: Allergy & Immunology Authors: Peng Jiang Linxian Zhao Ruixue Hu Zongzhen Zhai Jian Guo Kai Zhang Source Type: research
Immunomodulatory activity of dipeptidyl peptidase-4 inhibitors in immune-related diseases
This article is protected by copyright. All rights reserved.PMID:37732495 | DOI:10.1002/eji.202250302
Source: European Journal of Immunology - September 21, 2023 Category: Allergy & Immunology Authors: Marija Drakul Miodrag Čolić Source Type: research
Bilastine 0.6% preservative-free eye drops, an effective once-daily treatment to reduce signs and symptoms of allergic conjunctivitis: A pooled analysis of two randomized clinical trials
CONCLUSION: This multi-trial assessment suggests that bilastine 0.6% ophthalmic solution is efficacious for the treatment of the signs and symptoms of allergic conjunctivitis, with a rapid and prolonged duration of action, and has a favorable safety profile. The added convenience of a once-a-day dosing regimen may contribute to patient adherence and improve their quality of life.PMID:37732873 | DOI:10.18176/jiaci.0940
Source: Journal of Investigational Allergology and Clinical Immunology - September 21, 2023 Category: Allergy & Immunology Authors: P J Gomes J B Ciolino P Arranz A Gonzalo N Fern ández G Hern ández Source Type: research
Pentavalent outer membrane vesicles immunized mice sera confers passive protection against five prevalent pathotypes of diarrhoeagenic Escherichia coli in neonatal mice
Immunol Lett. 2023 Sep 19:S0165-2478(23)00158-X. doi: 10.1016/j.imlet.2023.09.009. Online ahead of print.ABSTRACTDiarrhoeagenic Escherichia coli (DEC) pathotypes are one of the major causative agents of diarrhoea induced childhood morbidity and mortality in developing countries. Licensed vaccines providing broad spectrum protection against DEC mediated infections are not available. Outer membrane vesicles (OMVs) are microvesicles released by gram-negative bacteria during the growth phase and contain multiple immunogenic proteins. Based on prevalence of infections, we have formulated a pentavalent outer-membrane vesicles (P...
Source: Immunology Letters - September 21, 2023 Category: Allergy & Immunology Authors: Soumalya Banerjee Prolay Halder Sanjib Das Suhrid Maiti Ushasi Bhaumik Moumita Dutta Goutam Chowdhury Kei Kitahara Shin-Ichi Miyoshi Asish Kumar Mukhopadhyay Shanta Dutta Hemanta Koley Source Type: research
Nervous system-related tropism of SARS-CoV-2 and autoimmunity in COVID-19 infection
This article is protected by copyright. All rights reserved.PMID:37733584 | DOI:10.1002/eji.202250230
Source: European Journal of Immunology - September 21, 2023 Category: Allergy & Immunology Authors: Robert Weissert Source Type: research
Evolution of the gasdermin family and pyroptosis
Dev Comp Immunol. 2023 Sep 19:105060. doi: 10.1016/j.dci.2023.105060. Online ahead of print.ABSTRACTGasdermins have been identified as playing a prominent role in the innate immune response as the executors of a specific type of cell death called pyroptosis. Specific proteolytic cleavage of gasdermins generates an N-terminal that oligomerizes and forms pores in the cell membrane. Although pyroptosis has been widely described in mammals, the importance of gasdermins and gasdermin-like proteins in inducing cell death in other vertebrates, in invertebrates and in other taxa including fungi and bacteria is still being determin...
Source: Developmental and Comparative Immunology - September 21, 2023 Category: Allergy & Immunology Authors: Diego Angosto-Bazarra Adriana Guijarro Pablo Pelegr ín Source Type: research
Pentraxins in invertebrates and vertebrates: From structure, function and evolution to clinical applications
Dev Comp Immunol. 2023 Sep 19:105064. doi: 10.1016/j.dci.2023.105064. Online ahead of print.ABSTRACTThe immune system is divided into two broad categories, consisting of innate and adaptive immunity. As recognition and effector factors of innate immunity and regulators of adaptive immune responses, lectins are considered to be important defense chemicals against microbial pathogens, cell trafficking, immune regulation, and prevention of autoimmunity. Pentraxins, important members of animal lectins, play a significant role in protecting the body from pathogen infection and regulating inflammatory reactions. They can recogni...
Source: Developmental and Comparative Immunology - September 21, 2023 Category: Allergy & Immunology Authors: Yuying Wang Wei Chen Shuo Ding Wenjun Wang Changliu Wang Source Type: research
