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Specialty: Allergy & Immunology
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Total 72221 results found since Jan 2013.
The effect of artesunate to reverse CLP-induced sepsis immunosuppression mice with secondary infection is tightly related to reducing the apoptosis of T cells via decreasing the inhibiting receptors and activating MAPK/ERK pathway
Int Immunopharmacol. 2023 Sep 14;124(Pt A):110917. doi: 10.1016/j.intimp.2023.110917. Online ahead of print.ABSTRACTT cells play an important role in regulating immune system balance. Sepsis-associated immunosuppression causes apoptosis of T cells and a decrease in their number. Previously, artesunate was found to have an immunomodulatory effect on immunosuppression in model mice with cecal ligation and puncture (CLP)-induced sepsis. In the present study, mouse sepsis models of CLP and CLP with secondary infection were established and treated with artesunate in order to examine the effect of artesunate on adaptive immune r...
Source: International Immunopharmacology - September 16, 2023 Category: Allergy & Immunology Authors: Yue Yuan Ling Hua Jun Zhou Dan Liu Fumin Ouyang Xuemin Chen Shujuan Long Yasi Huang Xin Liu Jiang Zheng Hong Zhou Source Type: research
Procalcitonin is elevated in severe malaria and is a promising biomarker of severe malaria and multi-organ dysfunction: A cross-sectional study and meta-analysis
CONCLUSIONS: PCT is elevated in P. falciparum-infected patients and could be a good biomarker for diagnosis of severe malaria and multi-organ dysfunction. It can help in the management of severe disease with additional treatment options.PMID:37716164 | DOI:10.1016/j.intimp.2023.110923
Source: International Immunopharmacology - September 16, 2023 Category: Allergy & Immunology Authors: Rina Tripathy Bidyut K Das Aditya K Panda Source Type: research
PR-957 retards rheumatoid arthritis progression and inflammation by inhibiting LMP7-mediated CD4 < sup > + < /sup > T cell imbalance
CONCLUSION: PR-957 ameliorates RA progression and inflammation by repressing LMP7-mediated CD4+ T cell imbalance.PMID:37716163 | DOI:10.1016/j.intimp.2023.110860
Source: International Immunopharmacology - September 16, 2023 Category: Allergy & Immunology Authors: Qingyang Liu Jin Shen Jian Wang Jinjun Xia Jian Yin Guowei Cheng Ximing Qian Yun Jiang Xin Ge Qiubo Wang Source Type: research
Therapeutic potential of ozone water treatment in alleviating atopic dermatitis symptoms in mouse models: Exploring its bactericidal and direct anti-inflammatory properties
This study aimed to verify the bactericidal effects of ozone water at different concentrations (3 and 11 mg/L) against staphylococcal species in vitro, as well as evaluate the anti-inflammatory effects of ozone water in a mouse model of AD and pyoderma. Initially, the bactericidal properties of several concentrations of ozone water were confirmed with Staphylococcus aureus and methicillin-resistant S. pseudintermedius. Both 3 and 11 mg/L of ozone water exhibited a significant bactericidal effect against staphylococci at less than 100 times dilution. We next examined the cellular cytotoxicity and cytokine production (Interl...
Source: International Immunopharmacology - September 16, 2023 Category: Allergy & Immunology Authors: Mao Kaneki Chiharu Ohira Miyu Takahashi Naoki Iwashita Yoshiichi Takagi Masaki Nagane Jumpei Uchiyama Tomoki Fukuyama Source Type: research
Amisulpride attenuates 5-fluorouracil-induced cognitive deficits via modulating hippocampal Wnt/GSK-3 β/β-catenin signaling in Wistar rats
This study aimed at investigating the effects of chronic treatment with amisulpride (5 mg/kg/day) in the management of 5-fluorouracil (5-FU)-induced cognitive deficits in Wistar rats. Rats received 5 intraperitoneal injections of 5-FU (25 mg/kg every 3 days). 5-FU treatment induced impairments in spatial learning (reduction in object location discrimination ratio) and non-spatial learning (reduction in novel object recognition discrimination ratio). Moreover, 5-FU induced a decrease in the activity of the Wnt/GSK-3β/β-catenin pathway with a decrease in brain-derived neurotrophic factor (BDNF) level in the hippocampus. Th...
Source: International Immunopharmacology - September 16, 2023 Category: Allergy & Immunology Authors: Radwa S Raafat Mohamed Z Habib Amany A AbdElfattah Nouran K Olama Sahar M Abdelraouf Nevien Hendawy Khaled A Kamal Salwa A Nawishy Sawsan Aboul-Fotouh Source Type: research
BET proteins inhibitor JQ1 impairs GM-CSF-promoted peritoneal macrophage self-renewal and IL-4-induced alternative polarization
Int Immunopharmacol. 2023 Sep 14;124(Pt A):110942. doi: 10.1016/j.intimp.2023.110942. Online ahead of print.ABSTRACTPeritoneal macrophages (PMs), which resided in peritoneal cavity, are crucial to maintain tissue homeostasis and immunity. Macrophage self-renewal and polarization states are critical for PM population homeostasis and function. However, the underlying molecular mechanism that regulates self-renewal and polarization of PMs is still unclear and needs to be explored. Here, we demonstrated that PMs self-renewal was stimulated by granulocyte macrophage colony-stimulating factor (GM-CSF), but not by macrophage colo...
Source: International Immunopharmacology - September 16, 2023 Category: Allergy & Immunology Authors: Xue Chen Qiong Jiang Laibin Ren Hongyu Ren Haizhao Xu Jinyong Wang Pengbo Wang Shanze Chen Yuanqi Hua Sichong Ren Ning Huang Lanlan Zhang Lijia Xiao Source Type: research
Better safe than sorry: Naive T-cell dynamics in healthy ageing
Semin Immunol. 2023 Sep 14;70:101839. doi: 10.1016/j.smim.2023.101839. Online ahead of print.ABSTRACTIt is well-known that the functioning of the immune system gradually deteriorates with age, and we are increasingly confronted with its consequences as the life expectancy of the human population increases. Changes in the T-cell pool are among the most prominent features of the changing immune system during healthy ageing, and changes in the naive T-cell pool in particular are generally held responsible for its gradual deterioration. These changes in the naive T-cell pool are thought to be due to involution of the thymus. I...
Source: Seminars in Immunology - September 16, 2023 Category: Allergy & Immunology Authors: Rob J de Boer Kiki Tesselaar Jos é A M Borghans Source Type: research
Temozolomide-based sonodynamic therapy induces immunogenic cell death in glioma
CONCLUSIONS: TMZ-based SDT was capable of triggering ICD in glioma. The discovery of TMZ as a sonosensitizer have shown great promise in the treatment of GBM.PMID:37716612 | DOI:10.1016/j.clim.2023.109772
Source: Clinical Immunology - September 16, 2023 Category: Allergy & Immunology Authors: Yan Zhou Jiji Jiao Rongyan Yang Binli Wen Qiaoli Wu Lixia Xu Xiaoguang Tong Hua Yan Source Type: research
Genetic polymorphisms of rs73620203 in the transforming growth interacting factor gene associated with rheumatoid arthritis in a Chinese population
CONCLUSION: Our study provides the first evidence that rs73620203 is associated with RA susceptibility and the relationship between TGIF gene SNPs and the regulation of bone metabolism in RA patients.PMID:37716127 | DOI:10.1016/j.imbio.2023.152741
Source: Immunobiology - September 16, 2023 Category: Allergy & Immunology Authors: Huiling Tan Ruyu Ren Xuean Wang Wenchuang Hu Bin Yang Source Type: research
Transforming growth factor- β, Interleukin-23 and interleukin-1β modulate TH22 response during active multidrug-resistant tuberculosis
Immunology. 2023 Sep 16. doi: 10.1111/imm.13698. Online ahead of print.ABSTRACTWe previously reported that patients with multidrug-resistant tuberculosis (MDR-TB) showed low systemic and Mtb-induced Th22 responses associated to high sputum bacillary load and severe lung lesions suggesting that Th22 response could influence the ability of these patients to control bacillary growth and tissue damage. In MDR-TB patients, the percentage of IL-22+ cells inversely correlates with the proportion of senescent PD-1+ T cells. Herein, we aimed to evaluate the pathways involved on the regulation of systemic and Mtb-induced Th22 respon...
Source: Immunology - September 16, 2023 Category: Allergy & Immunology Authors: Bel én R Imperiale Ana Gamberale Noem í Yokobori Ana Garc ía Bruno Bartoletti Omar Aidar Beatriz L ópez Victor Cruz Pablo Gonz ález Montaner Domingo J Palmero Silvia de la Barrera Source Type: research
COVID-19 vaccine effectiveness against hospitalizations in Paraguay, May 2021-April 2022: A test-negative design
CONCLUSIONS: This study contributes to our understanding of COVID-19 VE in Latin America and to global understanding of vaccines that have not been widely used in North America and Europe. VE estimates from Paraguay can parameterize models to estimate the impact of the national COVID-19 vaccination campaign in Paraguay and similar settings.PMID:37716830 | DOI:10.1016/j.vaccine.2023.09.015
Source: Vaccine - September 16, 2023 Category: Allergy & Immunology Authors: Sandra Irala Sarah Hamid Elena Penayo Fabiana Michel Paula Couto Cynthia Vazquez Mar ía José Ortega Chavely Dom ínguez Silvia Battaglia Marta Von Horoch Romeo Montoya Guillermo Sequera Francisco Nogareda Source Type: research
Evaluation of an iELISA for detection and quantification of rabies antibodies in domestic dog sera
Vaccine. 2023 Sep 14:S0264-410X(23)01058-7. doi: 10.1016/j.vaccine.2023.09.004. Online ahead of print.ABSTRACTMany rabies endemic-countries have recognized rabies as a public health problem that can be eliminated. As a result, some countries have started implementing small-scale vaccination programs with the aim of scaling them up. Post-vaccination serological monitoring is crucial to assess the efficacy of these programs. The recommended serological tests, the rapid fluorescent focus inhibition test, and the fluorescent antibody virus neutralization (FAVN) are accurate; however, the procedures require considerable experti...
Source: Vaccine - September 16, 2023 Category: Allergy & Immunology Authors: Ahmed Lugelo Katie Hampson Lorraine M McElhinney Felix Lankester Source Type: research
Efficacy and immunogenicity of a veterinary vaccine candidate against tick-borne encephalitis in dogs
Vaccine. 2023 Sep 14:S0264-410X(23)01089-7. doi: 10.1016/j.vaccine.2023.09.019. Online ahead of print.ABSTRACTTick-borne encephalitis (TBE) is a severe neuroinfection of humans. Dogs are also commonly infected with tick-borne encephalitis virus (TBEV). These infections are usually asymptomatic, but sometimes show clinical signs similar to those seen in humans and can be fatal. To date, there is no TBEV vaccine available for use in dogs. To address this need, a TBEV vaccine candidate for dogs based on inactivated whole virus antigen was developed. The safety, immunogenicity, and efficacy of the vaccine candidate were tested...
Source: Vaccine - September 16, 2023 Category: Allergy & Immunology Authors: Jiri Salat Milan Hunady Pavel Svoboda Lucie Strelcova Petra Strakova Andrea Fortova Martin Palus Daniel Ruzek Source Type: research
Hepatic safety and efficacy of immunomodulatory drugs used in patients with autoimmune hepatitis
CONCLUSION: Among 25 AIH patients who were treated with immunomodulatory drugs for different reasons, the majority had a fovorable course, relapse was frequent in difficult-to-treat patients who received belimumab, and four with concomitant IBD had insufficient response.PMID:37716078 | DOI:10.1016/j.jaut.2023.103113
Source: Journal of Autoimmunity - September 16, 2023 Category: Allergy & Immunology Authors: Benedetta Terziroli Beretta-Piccoli Gustav Buescher George Dalekos Kalliopi Zachou Anja Geerts Nasser Semmo Mirjam Kolev Eleonora De Martin Maciej K Janik Jo ão Madaleno Milica Lalosevic Stojkovic J érôme Dumortier Thomas Vanwolleghem Ida Schregel Silj Source Type: research
Harnessing autoimmunity with dominant self-peptide: Modulating the sustainability of tissue-preferential antigen-specific Tregs by governing the binding stability via peptide flanking residues
J Autoimmun. 2023 Sep 14;140:103094. doi: 10.1016/j.jaut.2023.103094. Online ahead of print.ABSTRACTSensitization to self-peptides induces various immunological responses, from autoimmunity to tumor immunity, depending on the peptide sequence; however, the underlying mechanisms remain unclear, and thus, curative therapeutic options considering immunity balance are limited. Herein, two overlapping dominant peptides of myelin proteolipid protein, PLP136-150 and PLP139-151, which induce different forms of experimental autoimmune encephalomyelitis (EAE), monophasic and relapsing EAE, respectively, were investigated. Mice with ...
Source: Journal of Autoimmunity - September 16, 2023 Category: Allergy & Immunology Authors: Youwei Lin Shun Sakuraba Chandirasegaran Massilamany Jayagopala Reddy Yoshimasa Tanaka Sachiko Miyake Takashi Yamamura Source Type: research
