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Specialty: Allergy & Immunology
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Total 72221 results found since Jan 2013.
Corrigendum to "Rapamycin regulates osteogenic differentiation through Parkin-mediated mitophagy in rheumatoid arthritis" Int. Immunopharmacol. 113(Part B) (2022) 109407
Int Immunopharmacol. 2023 Sep 15:110941. doi: 10.1016/j.intimp.2023.110941. Online ahead of print.NO ABSTRACTPMID:37718175 | DOI:10.1016/j.intimp.2023.110941
Source: International Immunopharmacology - September 17, 2023 Category: Allergy & Immunology Authors: Qiyue Chen Kai Fan Guangbao Song Xinqiong Wang Jinwei Zhang Huan Chen Xuan Qin Yao Lu Weizhong Qi Source Type: research
Boningmycin induces AMPK-mediated endoplasmic reticulum-associated degradation of PD-L1 protein in human cancer cells
In conclusion, it is the first report demonstrating that BON decreases PD-L1 protein level through AMPK-mediated endoplasmic reticulum-associated degradation pathway. These findings will benefit the clinical transformation of BON and aid in the elucidation of molecular mechanism of BLM-related compounds.PMID:37717372 | DOI:10.1016/j.intimp.2023.110905
Source: International Immunopharmacology - September 17, 2023 Category: Allergy & Immunology Authors: Juan Zhang Jincai Wang Yue Shang Yang Chen Shuzhen Chen Qiyang He Source Type: research
Chimeric CNS-targeting-peptide engineered exosomes for experimental autoimmune encephalomyelitis therapy
Int Immunopharmacol. 2023 Sep 15;124(Pt B):110835. doi: 10.1016/j.intimp.2023.110835. Online ahead of print.ABSTRACTMultiple sclerosis (MS) is an inflammatory disease of the central nervous system (CNS) that causes demyelination, neuronal damage and white matter loss, but there is still no known cure. Exosomes are 30-200 nm-sized double-layered membrane vesicles that can easily cross the blood-brain barrier (BBB). Exosomes from umbilical cord mesenchymal stem cells（UMSCs） have been found to treat experimental autoimmune encephalomyelitis (EAE) through the action of anti-inflammatory and immunomodulatory, but its clinic...
Source: International Immunopharmacology - September 17, 2023 Category: Allergy & Immunology Authors: Ying-Kai Wang Yun-Peng Zhao Ming-Zhu Ye Ling Wang Tian-Shu Lan Yue Wang Zhong-Quan Qi Source Type: research
Potential value of Interleukin-6 as a diagnostic biomarker in human MDD and the antidepressant effect of its receptor antagonist tocilizumab in lipopolysaccharide-challenged rats
Int Immunopharmacol. 2023 Sep 15;124(Pt B):110903. doi: 10.1016/j.intimp.2023.110903. Online ahead of print.ABSTRACTDepression is a common mental disease with disastrous effect on the health and wealth globally. Focusing on the role for inflammation and immune activation in the pathogenesis of depression, many tries have been taken into effect targeting at the blockage of inflammatory cytokines, among which interleukin- 6 (IL-6) and its receptor antagonist tocilizumab attracts more attention, with inconsistent findings. Moderate to severe depressive disorder (MSDD) patients were enrolled and the serum concentrations of IL-...
Source: International Immunopharmacology - September 17, 2023 Category: Allergy & Immunology Authors: Dandan Xu Yayun Xu Xinran Gao Mengyu Yan Chen Zhang Xian Wu Qingrong Xia Jinfang Ge Source Type: research
Identifying immuno-related diagnostic genes and immune infiltration signatures for periodontitis and alopecia areata
CONCLUSION: Three candidate hub IRGs (CTSS, IL2RG, and ITGAL) were identified with considerable diagnostic values. Besides, mast cells could serve as markers for AA, while plasma may indicate PD. Our research has the potential to identify shared diagnostic candidate genes and immune cells for AA and PD patients.PMID:37717318 | DOI:10.1016/j.intimp.2023.110880
Source: International Immunopharmacology - September 17, 2023 Category: Allergy & Immunology Authors: Haoyu Wang Ruoqu Wei Tanjun Deng Jie Zhang Zhengyu Shen Source Type: research
BALB/c and C57BL/6 mice differ in oxidant and antioxidant responses in innate and adaptive immune cells in an asthma model induced by cockroach allergens
Int Immunopharmacol. 2023 Sep 15;124(Pt B):110892. doi: 10.1016/j.intimp.2023.110892. Online ahead of print.ABSTRACTAsthma is a complex and heterogenous disease affected by a multitude of factors. Several phenotypes of asthma exist which are influenced by various molecular mechanisms that include presence of antioxidant and oxidant enzymes in different immune cells such as dendritic cells (DCs), alveolar macrophages (AMs), neutrophils, and T cells. Close interaction between epithelial cells and dendritic cells initiates complex pathogenesis of asthma followed by involvement of other innate and adaptive immune cells. In chr...
Source: International Immunopharmacology - September 17, 2023 Category: Allergy & Immunology Authors: Layla A Al-Kharashi Saleh A Alqarni Sheikh F Ahmad Naif O Al-Harbi Sary Alsanea Khalid E Ibrahim Mohammad M Algahtani Khalid Alhazzani Gamal A Shazly Mohammad M Al-Harbi Ahmed Nadeem Source Type: research
A novel drug combination of Tofacitinib and Iguratimod alleviates rheumatoid arthritis and secondary osteoporosis
CONCLUSION: TOF + IGU alleviated the severity of RRA in the CIA + TNF rat model, relieving joint inflammation, reducing bone erosion, and suppressing pyroptosis. The combined application of TOF and IGU may have a superimposed therapeutic effect on RRA and secondary osteoporotic bone remodeling.PMID:37717316 | DOI:10.1016/j.intimp.2023.110913
Source: International Immunopharmacology - September 17, 2023 Category: Allergy & Immunology Authors: Jie Chen Qincheng Che Yuying Kou Xing Rong Xiaojie Zhang Minqi Li Qiang Shu Source Type: research
Avian safety guardian: Luteolin restores Mycoplasma gallisepticum-induced immunocompromise to improve production performance via inhibiting the IL-17/NF-kB pathway
This study indicates Lut can serve as a safe and effective antibiotic alternative drug for preventing and treating MG-induced CRD. It also provides new evidence to explore the molecular mechanisms of MG infection.PMID:37717315 | DOI:10.1016/j.intimp.2023.110946
Source: International Immunopharmacology - September 17, 2023 Category: Allergy & Immunology Authors: Tengfei Wang Guangyang Jiang Shan Lv Yufei Xiao Changyong Fan Mengyun Zou Yingjie Wang Qiao Guo Md Ahsanul Kabir Xiuli Peng Source Type: research
Brevilin A attenuates cartilage destruction in osteoarthritis mouse model by inhibiting inflammation and ferroptosis via SIRT1/Nrf2/GPX4 signaling pathway
In conclusion, brevilin A protected mice against OA via suppressing inflammatory response and ferroptosis by regulating SIRT1/Nrf2/GPX4 signaling.PMID:37717314 | DOI:10.1016/j.intimp.2023.110924
Source: International Immunopharmacology - September 17, 2023 Category: Allergy & Immunology Authors: Qing Ruan Cuijie Wang Yunfeng Zhang Jiayang Sun Source Type: research
Quantification of camelid cytokine mRNA expression in PBMCs by microfluidic qPCR technology
Dev Comp Immunol. 2023 Sep 15:105061. doi: 10.1016/j.dci.2023.105061. Online ahead of print.ABSTRACTCamelids are economically and socially important in several parts of the world and might carry pathogens with epizootic or zoonotic potential. However, biological research in these species is limited due to lack of reagents. Here, we developed RT-qPCR assays to quantify a panel of camelid innate and adaptive immune response genes, which can be monitored in a single run. The assays were validated with PHA, PMA-ionomycin, and Poly I:C-stimulated PBMCs from alpaca, dromedary camel and llama, including normalization by multiple ...
Source: Developmental and Comparative Immunology - September 17, 2023 Category: Allergy & Immunology Authors: Jordi Rodon Nigeer Te Maria Ballester Joaquim Segal és J úlia Vergara-Alert Albert Bensaid Source Type: research
Targeting C5a is beneficial in critically ill COVID-19 patients
Immunobiology. 2023 Sep 12;228(6):152743. doi: 10.1016/j.imbio.2023.152743. Online ahead of print.NO ABSTRACTPMID:37717470 | DOI:10.1016/j.imbio.2023.152743
Source: Immunobiology - September 17, 2023 Category: Allergy & Immunology Authors: Endry H T Lim Alexander P J Vlaar Matthijs C Brouwer Diederik van de Beek Source Type: research
Active inoculation with an inactivated Coxsackievirus A2 vaccine induces neutralizing antibodies and protects mice against lethal infection
In conclusion, our findings suggest that this experimental inactivated CVA2 vaccine is a promising component of polyvalent vaccines related to HFMD in the near future.PMID:37718187 | DOI:10.1016/j.vaccine.2023.08.083
Source: Vaccine - September 17, 2023 Category: Allergy & Immunology Authors: Yuexia Wang Wangquan Ji Dong Li Tiantian Sun Peiyu Zhu Junwei Li Liang Zhang Yu Zhang Haiyan Yang Shuaiyin Chen Yuefei Jin Guangcai Duan Source Type: research
Baseline immune states (BIS) associated with vaccine responsiveness and factors that shape the BIS
Semin Immunol. 2023 Sep 15;70:101842. doi: 10.1016/j.smim.2023.101842. Online ahead of print.ABSTRACTVaccines are among the greatest inventions in medicine, leading to the elimination or control of numerous diseases, including smallpox, polio, measles, rubella, and, most recently, COVID-19. Yet, the effectiveness of vaccines varies among individuals. In fact, while some recipients mount a robust response to vaccination that protects them from the disease, others fail to respond. Multiple clinical and epidemiological factors contribute to this heterogeneity in responsiveness. Systems immunology studies fueled by advances in...
Source: Seminars in Immunology - September 17, 2023 Category: Allergy & Immunology Authors: Djamel Nehar-Belaid Mark Sokolowski Sathyabaarathi Ravichandran Jacques Banchereau Damien Chaussabel Duygu Ucar Source Type: research
cGAS-like receptors: back to the future
Trends Immunol. 2023 Sep 11:S1471-4906(23)00177-1. doi: 10.1016/j.it.2023.08.009. Online ahead of print.ABSTRACTRecent studies have characterized ancient forms of cyclic GMP-AMP (cGAMP) synthase (cGAS)-like receptors (cGLRs) in bacterial and Drosophila immunity. Using bioinformatics and biochemical screening, Li et al. recently constructed and characterized >3000 cGLRs to reveal conserved mechanisms of nucleic acid sensing across animal immunity.PMID:37718174 | DOI:10.1016/j.it.2023.08.009
Source: Trends in Immunology - September 17, 2023 Category: Allergy & Immunology Authors: Fiachra Humphries Source Type: research
The diversity of cGLR receptors: shedding new light on innate immunity
Trends Immunol. 2023 Sep 12:S1471-4906(23)00181-3. doi: 10.1016/j.it.2023.09.001. Online ahead of print.ABSTRACTThe characterization of a new group of innate pattern recognition receptors detected in >500 species across the tree of life by Li et al. reveals surprising commonalities and peculiarities shared with other innate receptors. Receptor diversity within and among species opens the way to reconsidering the costs and benefits of innate immune recognition.PMID:37718173 | DOI:10.1016/j.it.2023.09.001
Source: Trends in Immunology - September 17, 2023 Category: Allergy & Immunology Authors: C Jessica E Metcalf Alexander E Downie Source Type: research
