Boningmycin induces AMPK-mediated endoplasmic reticulum-associated degradation of PD-L1 protein in human cancer cells

In conclusion, it is the first report demonstrating that BON decreases PD-L1 protein level through AMPK-mediated endoplasmic reticulum-associated degradation pathway. These findings will benefit the clinical transformation of BON and aid in the elucidation of molecular mechanism of BLM-related compounds.PMID:37717372 | DOI:10.1016/j.intimp.2023.110905

Source: International Immunopharmacology - September 17, 2023 Category: Allergy & Immunology Authors: Juan Zhang Jincai Wang Yue Shang Yang Chen Shuzhen Chen Qiyang He Source Type: research