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Specialty: Allergy & Immunology
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Total 72221 results found since Jan 2013.
Do antigen-presenting CD1a, CD1b, CD1c, and CD1d molecules bind different self-lipids?
Trends Immunol. 2023 Sep 9:S1471-4906(23)00178-3. doi: 10.1016/j.it.2023.08.010. Online ahead of print.ABSTRACTHumans express four different lipid antigen-presenting molecules, CD1a, CD1b, CD1c, and CD1d, that are differentially expressed on antigen-presenting cells and which recycle through different endosomal compartments. Huang et al. now answer the question on whether the four CD1 isoforms selectively bind certain lipids.PMID:37730500 | DOI:10.1016/j.it.2023.08.010
Source: Trends in Immunology - September 20, 2023 Category: Allergy & Immunology Authors: Ildiko Van Rhijn Source Type: research
Tripartite motif containing 59 mediates protective anti-oxidative effects in intestinal injury through Nrf2 signaling
Int Immunopharmacol. 2023 Sep 18;124(Pt B):110896. doi: 10.1016/j.intimp.2023.110896. Online ahead of print.ABSTRACTElevated evidence has reported the important role of oxidative stress injury and inflammatory response in the progression of colitis. Tumor Suppressor TSBF1, TRIM59, is a ubiquitin E3 ligase and mediates immune response. However, the underlying molecular function of TRIM59 on regulation of colitis is still not understood. In the current study, we identify the TRIM59 as a critical and novel endogenous suppressor of kelch-like ECH-associated protein 1 (KEAP1), and we also determine that TRIM59 is a KEAP1-intera...
Source: International Immunopharmacology - September 20, 2023 Category: Allergy & Immunology Authors: Bing Liu Yongsheng Gao Xin Liu Qin Lian Yanliang Li Source Type: research
Dopamine Receptor 1 Impedes ILC2-Mediated Antitumor Immunity
In this study, we report that dopamine receptor 1 (DRD1) restrains ILC2 activity in the TME. DRD1 deficiency promotes ILC2 activation, which irritates eosinophil recruitment and cytotoxic CD8+ T cell expansion during ongoing malignancy. Consequently, DRD1-deficient mice exhibit delayed tumor growth and reduced tumor progression. Furthermore, fenoldopam, a selective DRD1 agonist, restrains the ILC2 response in the TME and aggravates tumor burden in mice. Taken together, our data elaborate that the DRD1 signal acts as an excitatory rheostat in regulating ILC2-dependent antitumor immunity.PMID:37728417 | DOI:10.4049/jimmunol.2300220
Source: Journal of Immunology - September 20, 2023 Category: Allergy & Immunology Authors: Xiangyang Wang Xiangyu Chen Jierong Chen Chunhui Liao Xiaofan Yang Jiasheng Zhou Shanshan Liu Shusen Ye Yuhao Zheng Linzi Huang Jiacong Zhao Lilin Ye Bihui Huang Yingjiao Cao Source Type: research
Fluid shear stress enhances dendritic cell activation
In this study, dendritic cells were activated by sustained exposure to circulatory levels of fluid shear stress using a cone-and-plate flow device and analyzed for activation markers. After 1 h of shear stress exposure, an increase in cytokine release was present in immortalized cells as well as phosphorylation of the proteins NF-κB and cFos in primary DCs. Changes in DC morphology, metabolism and proliferation were also observed. These compelling new findings point to the potential for using FSS to activate DCs for ex vivo therapeutics.PMID:37729773 | DOI:10.1016/j.imbio.2023.152744
Source: Immunobiology - September 20, 2023 Category: Allergy & Immunology Authors: Jenna A Dombroski Schyler J Rowland Abigail R Fabiano Samantha V Knoblauch Jacob M Hope Michael R King Source Type: research
The role of B-cell ferroptosis in the pathogenesis of systemic lupus erythematosus
Clin Immunol. 2023 Sep 18:109778. doi: 10.1016/j.clim.2023.109778. Online ahead of print.ABSTRACTSystemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by the dysregulation of B cell subpopulation and function. Recent studies have suggested a potential role of ferroptosis, an iron-dependent form of regulated cell death, in the pathogenesis of SLE. Here, we demonstrate that B-cell ferroptosis occurs both in lupus patients and MRL/lpr mice. Treatment with liproxstatin-1, a potent ferroptosis inhibitor, could reduce autoantibody production, improve renal damage, and alleviate lupus symptoms in vivo. ...
Source: Clinical Immunology - September 20, 2023 Category: Allergy & Immunology Authors: Qian Chen Mengmeng Xiang Zhanyan Gao Fan Lvu Zhan Sun Yilun Wang Xiangguang Shi Jinhua Xu Jie Wang Jun Liang Source Type: research
Beyond youth: Understanding CAR T cell fitness in the context of immunological aging
Semin Immunol. 2023 Sep 18;70:101840. doi: 10.1016/j.smim.2023.101840. Online ahead of print.ABSTRACTPopulation aging, a pervasive global demographic trend, is anticipated to challenge health and social systems worldwide. This phenomenon is due to medical advancements enabling longer lifespans, with 20% of the US population soon to be over 65 years old. Consequently, there will be a surge in age-related diseases. Senescence, characterized by the loss of biological maintenance and homeostasis at molecular and cellular levels, either correlates with or directly causes age-related phenotypic changes. Decline of the immune sys...
Source: Seminars in Immunology - September 20, 2023 Category: Allergy & Immunology Authors: Julia Han Noll Bruce L Levine Carl H June Joseph A Fraietta Source Type: research
Expression of concern: Matrine downregulates IL-33/ST2 expression in the central nervous system of rats with experimental autoimmune encephalomyelitis Immunology Letters, Volume 178, Pages 97 - 104, 1 October 2016
Immunol Lett. 2023 Sep 18:S0165-2478(23)00157-8. doi: 10.1016/j.imlet.2023.09.008. Online ahead of print.NO ABSTRACTPMID:37729953 | DOI:10.1016/j.imlet.2023.09.008
Source: Immunology Letters - September 20, 2023 Category: Allergy & Immunology Authors: None No Author Source Type: research
The jrs guidelines 2023 for the management of refractory asthma
Arerugi. 2023;72(8):1002-1006. doi: 10.15036/arerugi.72.1002.NO ABSTRACTPMID:37730340 | DOI:10.15036/arerugi.72.1002
Source: Arerugi - September 20, 2023 Category: Allergy & Immunology Authors: Takashi Iwanaga Source Type: research
Discovery of BbX transcription factor in the patagonian blennie: Exploring expression changes following combined bacterial and thermal stress exposure
Dev Comp Immunol. 2023 Sep 18:105056. doi: 10.1016/j.dci.2023.105056. Online ahead of print.ABSTRACTHigh-Mobility Group (HMG) proteins are involved in different processes such as transcription, replication, DNA repair, and immune response. The role of HMG proteins in the immune response of fish has been studied mainly for HMGB1, where its expression can be induced by the stimulation of viral/bacterial PAMPs and can act as a proinflammatory mediator and as a global regulator of transcription in response to temperature. However, for BbX this role remains to be discovered. In this work, we identified the BbX of E. maclovinus ...
Source: Developmental and Comparative Immunology - September 20, 2023 Category: Allergy & Immunology Authors: Danixa Mart ínez Daniela Nualart Carlos Loncoman Juan C Opazo Kattina Zabala Francisco J Morera Gonzalo A Mardones Luis Vargas-Chacoff Source Type: research
A galectin-9 involved in the microbial recognition and haemocyte autophagy in the Pacific oyster Crassostrea gigas
Dev Comp Immunol. 2023 Sep 18:105063. doi: 10.1016/j.dci.2023.105063. Online ahead of print.ABSTRACTGalectin-9 is a tandem-repeat type member of galectin family participating in various immune responses, such as cell agglutination, phagocytosis, and autophagy. In the present study, a tandem repeat galectin-9 (defined as CgGal-9) was identified from Pacific oyster Crassostrea gigas, which consisted of two conserved carbohydrate recognition domains (CRDs) joined by a linker peptide. CgGal-9 was closely clustered with CaGal-9 from C. angulata, and they were assigned into the branch of invertebrate galectin-9s in the phylogene...
Source: Developmental and Comparative Immunology - September 20, 2023 Category: Allergy & Immunology Authors: Qian Yang Jiejie Sun Wei Wu Zhen Xing Xiaoxue Yan Xiaoqian Lv Lingling Wang Linsheng Song Source Type: research
MicroRNAs in equine Endometritis: A review of pathophysiology and molecular insights for diagnostic and therapeutic strategies
Int Immunopharmacol. 2023 Sep 17;124(Pt B):110949. doi: 10.1016/j.intimp.2023.110949. Online ahead of print.ABSTRACTEndometritis plays an important role in mare infertility. Certain infectious agents interfere with the innate immune system of endometrium, causing a systemic inflammatory response that lasts for a long time and circulates via the blood or cellular degeneration, leading to endometritis due to bacterial endotoxins. Different small, non-coding RNA molecules are involved in many biological functions. For instance, microRNAs (miRNAs) are involved in the post-transcriptional regulation of gene expression. These mi...
Source: International Immunopharmacology - September 19, 2023 Category: Allergy & Immunology Authors: Sana Asif Talha Umar Zaima Umar Huma Jamil Huili Feng Peipei Zhang Saqib Umer Source Type: research
Alternative splicing variants of stimulator of interferon genes (STING) from Asian seabass (Lates calcarifer) and their immune response against red spotted grouper nervous necrosis virus (RGNNV)
Dev Comp Immunol. 2023 Sep 17:105062. doi: 10.1016/j.dci.2023.105062. Online ahead of print.ABSTRACTThe Stimulator of Interferon Genes (STING, also known as MITA/ERYS/MPYS) is an adaptor molecule that plays a crucial role in the RLR pathway and responds to DNA and RNA viruses. In the present study, we have identified two novel isoforms of STING (the canonical form named as LcSTINGa and its alternative splicing isoform named as LcSTINGb) from teleost Lates calcarifer. LcSTINGa has an ORF of 1230 bp, encoding a 409 amino acid protein, while its alternative splicing variant, LcSTINGb, features an ORF of 987 bp, encoding 328 a...
Source: Developmental and Comparative Immunology - September 19, 2023 Category: Allergy & Immunology Authors: Krishnapriya Raji Sathyan Avinash Premraj Mansi Chaudhary Rajesh Ramachandran Sajeevan Thavarool Puthiyedathu Source Type: research
Heterogeneity in RAG 1/2 Deficiency: 35 Cases From A Single Center
This study aimed to define the clinical/laboratory spectrum of RAG1/2 deficiency. We retrospectively reviewed the clinical/laboratory data of 35 patients, grouped them as severe combined immunodeficiency (SCID), Omenn Syndrome (OS), and delayed-onset combined immunodeficiency (CID) and reported nine novel mutations. Male/female ratio was 23/12. Median age of clinical manifestations was 1 months (mo) (0.5-2), 2 mo (1.25-5), and 14 mo (3.63-27), age at diagnosis was 4 mo (3-6), 4.5 mo (2.5-9.75), and 27 mo (14.5-70) in SCID (n=25;71.4%), OS (n=5;14.3%), and CID (n=5;14.3%) patients, respectively. Common clinical manifestatio...
Source: Clinical and Developmental Immunology - September 19, 2023 Category: Allergy & Immunology Authors: Betul Karaatmaca Deniz Cagdas Saliha Esenboga Baran Erman Cagman Tan Tuba Turul Ozgur Kaan Boztug Mirjam Van Der Burg Ozden Sanal Ilhan Tezcan Source Type: research
Interleukin-11 and its eminent role in tissue fibrosis: A possible therapeutic target
Clin Exp Immunol. 2023 Sep 19:uxad108. doi: 10.1093/cei/uxad108. Online ahead of print.ABSTRACTInterleukin-11 is a cytokine from the IL-6 family of cytokines that includes IL-6 and OSM. Initially described for its role in platelet generation, it is now appreciated that this cytokine has multiple functions. Recently it has been found that IL-11 is critical in fibrosis in multiple different organ systems and systemically as in the autoimmune disease systemic sclerosis. Animal models of fibrosis have determined that animals with IL-11 receptor deletions have retarded fibrosis and that in wild type animals IL-11 is found at th...
Source: Clinical and Developmental Immunology - September 19, 2023 Category: Allergy & Immunology Authors: Steven O'Reilly Source Type: research
Myelin oligodendrocyte glycoprotein antibody and N-methyl-d-aspartate receptor antibody overlapping syndrome: insights from the recent case reports
Clin Exp Immunol. 2023 Sep 19:uxad109. doi: 10.1093/cei/uxad109. Online ahead of print.ABSTRACTThe overlapping of two or more types of neural autoantibodies in one patient has increasingly been documented in recent years. The coexistence of myelin oligodendrocyte glycoprotein (MOG) and N-methyl-d-aspartate receptor (NMDAR) antibodies is most common, which leads to a unique condition known as the MOG antibody and NMDAR antibody overlapping syndrome (MNOS). Here, we have reviewed the pathogenesis, clinical manifestations, paraclinical features, and treatment of MNOS. Forty-nine patients with MNOS were included in this study....
Source: Clinical and Developmental Immunology - September 19, 2023 Category: Allergy & Immunology Authors: Bing-Qing Du Qi-Lun Lai Er-Chuang Li Meng-Ting Cai Gao-Li Fang Chun-Hong Shen Yin-Xi Zhang Mei-Ping Ding Source Type: research
