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Total 123144 results found since Jan 2013.

Micro-lightguide spectrophotometry assessment of hepatic and intestinal microcirculation in endotoxemic rats during intravenous treatment with angiotensin II
CONCLUSIONS: A dose-dependent decrease of hepatic and intestinal microcirculation during therapy with AT-II in non-septic rats was observed, which might have been influenced by a corresponding reduction in cardiac output due to elevated afterload. While hepatic microcirculation was reduced during endotoxemia, no evidence for a reduction in intestinal microcirculation facilitated by AT-II was found. In contrast, both intestinal relBF and anti-inflammatory IL-10 levels were increased during high-dose AT-II treatment.PMID:37734468 | DOI:10.1016/j.ejps.2023.106588
Source: European Journal of Pharmaceutical Sciences - September 21, 2023 Category: Drugs & Pharmacology Authors: G ötz Schmidt Laurenz Pitz Melanie Markmann Emmanuel Schneck Michael Sander Christian Koch Fabian Edinger Source Type: research

Comparison of intravenous ibuprofen pharmacokinetics between Caucasian and Chinese populations using physiologically based pharmacokinetics modeling and simulation
CONCLUSION: This study indicates that the pharmacokinetic profile and the parameters of intravenous ibuprofen are analogous in Caucasian and Chinese populations, either adults or children. In addition, this study provides effective evidence that the dosing scheme of intravenous ibuprofen in Chinese children can remain the same as the regimen that the original company (Caldolor®) provided.PMID:37734467 | DOI:10.1016/j.ejps.2023.106587
Source: European Journal of Pharmaceutical Sciences - September 21, 2023 Category: Drugs & Pharmacology Authors: Ying Jin Mengyu Zhang Xiangjie Di Xiaohui Qi Li Zheng Zhenlei Wang Source Type: research

Temporal evolution of antiretroviral therapy (2017-2021): analysis of treatment change and its economic impact
CONCLUSIONS: Optimization/simplification accounts for almost half of the reasons for TAR change, with an economic impact that, despite the inflection point of 2019, each year manages to exceed the previous one, achieving a progressive cost reduction maintained over time.PMID:37731312 | DOI:10.37201/req/047.2023
Source: Revista Espanola de Quimioterapia - September 21, 2023 Category: Drugs & Pharmacology Authors: E Herranz-Bayo H Navarro-Azn árez A Pinilla-Rello C I D íaz-Calderón-Horcada Source Type: research

Alpha-lipoic acid, apocynin or probiotics influence glutathione status and selected inflammatory parameters in C57/BL6 mice when combined with a low-fat diet
CONCLUSIONS: Supplementation of the tested compounds with LFD appears to have a positive influence on the glutathione redox status of pulmonary tissues and selected inflammatory parameters in mouse blood.PMID:37730940 | DOI:10.1007/s43440-023-00527-8
Source: Pharmacological Reports - September 21, 2023 Category: Drugs & Pharmacology Authors: Paulina Kleniewska Rafa ł Pawliczak Source Type: research

RIPTACs: A groundbreaking approach to drug discovery
Drug Discov Today. 2023 Sep 19:103774. doi: 10.1016/j.drudis.2023.103774. Online ahead of print.ABSTRACTRegulated induced proximity targeting chimeras (RIPTACs), a new class of heterobifunctional molecules, show promise in specifically targeting and eliminating cancer cells while leaving healthy cells unharmed. As a groundbreaking drug discovery approach, RIPTACs work by forming a stable complex with two proteins, one specifically found in cancer cells (target protein, TP) and the other pan-essential for cell survival (effector protein, EP), selectively disrupting the function of the EP in cancer cells and causing cell dea...
Source: Drug Discovery Today - September 21, 2023 Category: Drugs & Pharmacology Authors: Zonghui Ma Andrew A Bolinger Jia Zhou Source Type: research

Hyperoside attenuates pyrrolizidine alkaloids-induced liver injury by ameliorating TFEB-mediated mitochondrial dysfunction
In conclusion, Hyp can activate the TFEB-mediated autophagy-lysosomal pathway and mitochondrial biogenesis through inhibition of mTORC1 activity, alleviating the liver injury induced by PAs, thus suggesting the potential value of Hyp in the treatment of PA-induced hepatotoxicity.PMID:37733287 | DOI:10.1007/s12272-023-01460-3
Source: Archives of Pharmacal Research - September 21, 2023 Category: Drugs & Pharmacology Authors: Jie Xu Aizhen Xiong Xunjiang Wang Xing Yan Yilin Chen Xuanling Ye Zhengtao Wang Lili Ding Li Yang Source Type: research

Par3L, a polarity protein, promotes M1 macrophage polarization and aggravates atherosclerosis in mice via p65 and ERK activation
In this study, we investigated the roles of the polar protein Par3L in M1 macrophage polarization and atherosclerosis. To induce atherosclerosis, Apoe-/- mice were fed with an atherosclerotic Western diet for 8 or 16 weeks. We showed that Par3L expression was significantly increased in human and mouse atherosclerotic plaques. In primary mouse macrophages, oxidized low-density lipoprotein (oxLDL, 50 μg/mL) time-dependently increased Par3L expression. In Apoe-/- mice, adenovirus-mediated Par3L overexpression aggravated atherosclerotic plaque formation accompanied by increased M1 macrophages in atherosclerotic plaques and bo...
Source: Acta Pharmacologica Sinica - September 21, 2023 Category: Drugs & Pharmacology Authors: Yi-Min Huang Yu-Sen Wu Yuan-Ye Dang Yi-Ming Xu Kong-Yang Ma Xiao-Yan Dai Source Type: research

Synthetic cannabinoids in hair —Prevalence of use in abstinence control programs for driver's license regranting in Germany
Synthetic cannabinoids (SCs) have steadily increased on the drug market but are rarely analyzed in abstinence control programs for driver's license regranting. Between March 2020 and March 2021, hair samples from this collective were retrospectively screened for SCs by liquid chromatography –tandem mass spectrometry (LC–MS/MS) analysis, and those testing positive were additionally screened by liquid chromatography-high resolution time of flight mass spectrometry (LC-qTOF/MS). AbstractAlthough the use, structural variety, and prevalence of synthetic cannabinoids (SCs) have steadily increased on the drug market, they are...
Source: Drug Testing and Analysis - September 21, 2023 Category: Drugs & Pharmacology Authors: Johannes Kutzler, Aldo Eliano Polettini, Sergej Bleicher, Christoph Sauer, Wolfgang Schultis, Merja A. Neukamm, Volker Auw ärter Tags: RESEARCH ARTICLE Source Type: research

Research hotspots and trend analysis of abdominal pain in inflammatory bowel disease: A bibliometric and visualized analysis
This study provides the first bibliometric analysis of papers in this research area using visualization software and data information mining. It provides insights into this field's current status, hot spots, and trends. However, many outstanding issues in this research area still need further exploration to provide a theoretical basis for its clinical application.
Source: Frontiers in Pharmacology - September 21, 2023 Category: Drugs & Pharmacology Source Type: research

Heterogeneous vasomotor responses in segments from G öttingen Minipigs coronary, cerebral, and mesenteric artery: A comparative study
In conclusion, the vasomotor responses of isolated coronary, cerebral, and mesenteric arteries to selected agonists of endothelial, sympathetic, parasympathetic, and sensory pathways are different and the phenotypes are similar to sporadic human findings.PMID:37730143 | DOI:10.1016/j.vph.2023.107231
Source: Vascular Pharmacology - September 20, 2023 Category: Drugs & Pharmacology Authors: Anette Sams Kristian Agmund Haanes Anja Holm Spyridoula Kazantzi Lars Friis Mikkelsen Lars Edvinsson Susan Brain Majid Sheykhzade Source Type: research

Neuroprotective effects of oxytocin against ischemic stroke in rats by blocking glutamate release and CREB-mediated DNA hypermethylation
Biomed Pharmacother. 2023 Sep 18;167:115520. doi: 10.1016/j.biopha.2023.115520. Online ahead of print.ABSTRACTGlutamate plays a crucial role in cognitive impairments after ischemic stroke. There is a scarcity of information about how glutamate-induced activation of cAMP-response element binding (CREB) signaling pathway regulates both the negative and positive regulators of synaptic plasticity. Recent studies have demonstrated the involvement of prominent epigenetic repressors, such as MeCP2 and DNMTs, in stroke. Neuroprotective effects of oxytocin against ischemia have been previously reported, while the underlying mechani...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 20, 2023 Category: Drugs & Pharmacology Authors: Xin-Yu Fan Guang Shi Yun-Peng Zhao Jing-Jing Yang Juan Feng Source Type: research

The composition, pharmacological effects, related mechanisms and drug delivery of alkaloids from Corydalis yanhusuo
Biomed Pharmacother. 2023 Sep 18;167:115511. doi: 10.1016/j.biopha.2023.115511. Online ahead of print.ABSTRACTCorydalis yanhusuo W. T. Wang, also known as yanhusuo, yuanhu, yanhu and xuanhu, is one of the herb components of many Chinese Traditional Medicine prescriptions such as Jin Ling Zi San and Yuanhu-Zhitong priscription. C. yanhusuo was traditionally used to relieve pain and motivate blood and Qi circulation. Now there has been growing interest in pharmacological effects of alkaloids, the main bioactive components of C. yanhusuo. Eighty-four alkaloids isolated from C. yanhusuo are its important bioactive components a...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 20, 2023 Category: Drugs & Pharmacology Authors: Jia-Hua Feng Kang Chen Si-Yu Shen Yun-Feng Luo Xi-Hong Liu Xin Chen Wei Gao Yu-Ru Tong Source Type: research

Endothelial cell activation mediated by cold ischemia-released mitochondria is partially inhibited by defibrotide and impacts on early allograft function following liver transplantation
This study aimed to assess whether DAMPs present in the organ preservation solution (OPS) after cold ischemic storage (CIS) contribute to exacerbating the endothelial response to an inflammatory challenge and whether defibrotide treatment could counteract this effect. The activation of cultured human umbilical vein endothelial cells (HUVECs) was analyzed after challenging with end-ischemic OPS (eiOPS) obtained after CIS. Additionally, transwell assays were performed to study the ability of eiOPS to attract lymphocytes across the endothelium. The study revealed that eiOPS upregulated the expression of MCP-1 and IL-6 in HUVE...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 20, 2023 Category: Drugs & Pharmacology Authors: Francisco Villalba-L ópez David Garc ía-Bernal Sandra V Mateo Daniel Vidal-Correoso Marta Jover-Aguilar Felipe Alconchel Laura Mart ínez-Alarcón V íctor López-López Antonio R íos-Zambudio Pedro Cascales Jos é A Pons Pablo Ram írez Pablo Pelegr Source Type: research

Anti-prolactin treatment alleviates lupus conditions by regulating the JAK2-STAT3 pathway
CONCLUSIONS: In summary, these data suggest that PRL inhibition alleviates lupus-like disease in MRL/lpr mice by modulating the Jak2-Stat3 signalling cascade. More importantly, our results imply the potential of PRL inhibitors and may provide a novel therapeutic approach for lupus.PMID:37727880 | DOI:10.1111/1440-1681.13818
Source: Clinical and Experimental Pharmacology and Physiology - September 20, 2023 Category: Drugs & Pharmacology Authors: Ying Jiang Huyan Chen Jinran Lin Jiewen Pan Yanyun Shen Qiao Li Source Type: research

Translated article Consensus recommendations on the preventive treatment of migraine
CONCLUSIONS: The high degree of consensus indicates that the opinion of neurologists and hospital pharmacists on the role of anti-Calcitonin Gene-related Peptide monoclonal antibodies in the preventive treatment of migraine is very similar and allows identifying those controversies that still exist, to improve the care and follow-up of patients with migraine.PMID:37730507 | DOI:10.1016/j.farma.2023.07.002
Source: Farmacia Hospitalaria - September 20, 2023 Category: Drugs & Pharmacology Authors: Miguel Ángel Calleja-Hernández Ángel Luis Guerrero-Peral Pablo Irimia-Sieira Ic íar Martínez-López Sonia Santos-Lasaosa Maite Sarobe-Carricas Jos é María Serra López-Matencio Jos é Miguel Láinez-Andrés Source Type: research