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Total 123144 results found since Jan 2013.
The potential role of RNA modification in skin diseases, as well as the recent advances in its detection methods and therapeutic agents
This article mainly presents the whole picture of theoretical achievements on the potential role of RNA modification in dermatology. Furthermore, this article summarizes the latest advances in clinical practice related with RNA modification, including its detection methods and drug development. Based on this comprehensive review, we aim to illustrate the current blind spots and future directions of RNA modification, which may provide new insights for researchers in this field.PMID:37722194 | DOI:10.1016/j.biopha.2023.115524
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 18, 2023 Category: Drugs & Pharmacology Authors: Yue Yu Chen Liang Xin Wang Yuling Shi Liangliang Shen Source Type: research
Role and clinical significance of immunogenic cell death biomarkers in chemoresistance and immunoregulation of head and neck squamous cell carcinoma
Biomed Pharmacother. 2023 Sep 16;167:115509. doi: 10.1016/j.biopha.2023.115509. Online ahead of print.ABSTRACTHead and neck squamous cell carcinoma (HNSCC) is one of the most common malignancies in the whole world, with little improvement in the 5-year survival rate due to the occurrence of chemoresistance. With the increasing interests in tumor immune microenvironment, immunogenic cell death (ICD)-induced chemotherapy has shown promising results in enhancing sensitivity to immune checkpoint inhibitors (ICI) and improving the efficiency of tumor immunotherapy. This review summarizes the role of key ICD biomarkers and their...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 18, 2023 Category: Drugs & Pharmacology Authors: Xuanyu Zhang Chao Shang Xue Qiao Yan Guo Source Type: research
Phenylethanoid glycosides derived from Cistanche deserticola promote neurological functions and the proliferation of neural stem cells for improving ischemic stroke
This study aims to investigate whether PhGs treatment improves the stroke and its potential mechanisms. Adult male C57BL/6 J mice were administrated PhGs once daily for 7 days after MCAO surgery. The neurological score, and catwalk were evaluated on Day 1, 3 and 7 after ischemic stroke. Furthermore, triphenyl-2,3,5-tetrazoliumchloride (TTC) and hematoxylin-eosin (H&E) staining were used for evaluating the infarct volume and neuronal restoration. The effects of PhGs on NSCs proliferation were investigated in vitro and in vivo. Western blot was used to detect the proteins of Wnt/β-catenin signaling pathway. This study f...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 18, 2023 Category: Drugs & Pharmacology Authors: Jingjing Liu Yanyan Wang Qinyuan Li Tao Liu Xu Liu Han Zhang Zhifei Fu Yifan Dai Haiyuan Yang Yu Wang Ying Wang Source Type: research
Nitric oxide in kidney transplantation
Biomed Pharmacother. 2023 Sep 16;167:115530. doi: 10.1016/j.biopha.2023.115530. Online ahead of print.ABSTRACTKidney transplantation is the treatment of choice for patients with kidney failure. Compared to dialysis therapy, it provides better quality of life and confers significant survival advantage at a relatively lower cost. However, the long-term success of this life-saving intervention is severely hampered by an inexorable clinical problem referred to as ischemia-reperfusion injury (IRI), and increases the incidence of post-transplant complications including loss of renal graft function and death of transplant recipie...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 18, 2023 Category: Drugs & Pharmacology Authors: George J Dugbartey Source Type: research
Melatonin as a therapeutic agent for alleviating endothelial dysfunction in cardiovascular diseases: Emphasis on oxidative stress
Biomed Pharmacother. 2023 Sep 16;167:115475. doi: 10.1016/j.biopha.2023.115475. Online ahead of print.ABSTRACTThe vascular endothelium is vital in maintaining cardiovascular health by regulating vascular permeability and tone, preventing thrombosis, and controlling vascular inflammation. However, when oxidative stress triggers endothelial dysfunction, it can lead to chronic cardiovascular diseases (CVDs). This happens due to oxidative stress-induced mitochondrial dysfunction, inflammatory responses, and reduced levels of nitric oxide. These factors cause damage to endothelial cells, leading to the acceleration of CVD progr...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 18, 2023 Category: Drugs & Pharmacology Authors: Xiaolu Zhang Yujia Zheng Ziyu Wang Jiali Gan Bin Yu Bin Lu Xijuan Jiang Source Type: research
BODIPY-labelled acetylcholinesterase reactivators can be encapsulated into ferritin nanovehicles for enhanced bioavailability in the CNS
Biomed Pharmacother. 2023 Sep 16;167:115490. doi: 10.1016/j.biopha.2023.115490. Online ahead of print.ABSTRACTThe BODIPY-labelled oxime reactivator was prepared and used to study its biodistribution into central nervous system. The newly synthesized oxime was found to be weak inhibitor of acetylcholinesterase and strong inhibitor of butyrylcholinesterase. Its reactivation ability for organophosphate inhibited acetylcholinesterase was found similar to a parent oxime. The BODIPY-labelled oxime was further encapsulated into recombinant human H-ferritin and evaluated in vitro and in vivo. The oxime or encapsulated oxime were f...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 18, 2023 Category: Drugs & Pharmacology Authors: Eliska Prchalova Martina Sukupova David Malinak Rudolf Andrys Ladislav Sivak Vladimir Pekarik Adam Skarka Jana Svobodova Lukas Prchal Lukas Fresser Zbynek Heger Kamil Musilek Source Type: research
Angiogenesis inhibitor-specific hypertension increases the risk of developing aortic dissection
Biomed Pharmacother. 2023 Sep 16;167:115504. doi: 10.1016/j.biopha.2023.115504. Online ahead of print.ABSTRACTAortic dissection is an adverse event of angiogenesis inhibitors; however, the association between the drugs and aortic dissection is unclear. Therefore, we investigated if and how angiogenesis inhibitors increase the onset of aortic dissection using pharmacologically-induced aortic dissection-prone model (LAB) mice, cultured endothelial cells, and real-world databases, which is a novel integrated research approach. Disproportionality analysis was performed and calculated using the reporting odds ratio as a risk si...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 18, 2023 Category: Drugs & Pharmacology Authors: Kaito Tsujinaka Yuki Izawa-Ishizawa Koji Miyata Toshihiko Yoshioka Kohei Oomine Honoka Nishi Masateru Kondo Syuto Itokazu Tatsumi Miyata Takahiro Niimura Maki Sato Fuka Aizawa Kenta Yagi Masayuki Chuma Yoshito Zamami Mitsuhiro Goda Keisuke Ishizawa Source Type: research
Discovery of YS-363 as a highly potent, selective, and orally e fficacious EGFR inhibitor
This study reports on a novel quinazoline-based compound called YS-363 that acts as a new EGFR inhibitor. YS-363 demonstrated potent inhibition against both wild-type and L858R mutant forms of EGFR with IC50 values of 0.96 nM and 0.67 nM, respectively. Additionally, YS-363 had a reversible inhibitory effect on cellular EGFR signaling, had excellent inhibitory activity on cell proliferation and migration, and induced G0/G1 cell cycle arrest and apoptosis. In xenograft models dependent on EGFR signaling, oral administration of YS-363 substantially suppressed tumor growth by inhibiting this pathway. In summary, YS-363 is a pr...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 18, 2023 Category: Drugs & Pharmacology Authors: Pengxing He Jing Jing Linna Du Xuyang Zhang Yufei Ren Han Yang Bin Yu Hongmin Liu Source Type: research
Novel Immunopharmacological Drugs for the Treatment of Allergic Diseases
Annu Rev Pharmacol Toxicol. 2023 Sep 18. doi: 10.1146/annurev-pharmtox-051623-091038. Online ahead of print.ABSTRACTThe exponential rise in the prevalence of allergic diseases since the mid-twentieth century has led to a genuine public health emergency and has also fostered major progress in research on the underlying mechanisms and potential treatments. The management of allergic diseases benefits from the biological revolution, with an array of novel immunomodulatory therapeutic and investigational tools targeting players of allergic inflammation at distinct pathophysiological steps. Prominent examples include therapeuti...
Source: Annual Review of Pharmacology and Toxicology - September 18, 2023 Category: Drugs & Pharmacology Authors: Ekaterini Tiligada Daria Gafarov Maria Zaimi Joana Vitte Francesca Levi-Schaffer Source Type: research
Deciphering Drug Targets and Actions with Single-Cell and Spatial Resolution
Annu Rev Pharmacol Toxicol. 2023 Sep 18. doi: 10.1146/annurev-pharmtox-033123-123610. Online ahead of print.ABSTRACTRecent advances in chemical, molecular, and genetic approaches have provided us with an unprecedented capacity to identify drug-target interactions across the whole proteome and genome. Meanwhile, rapid developments of single-cell and spatial omics technologies are revolutionizing our understanding of the molecular architecture of biological systems. However, a significant gap remains in how we align our understanding of drug actions, traditionally based on molecular affinities, with the in vivo cellular and ...
Source: Annual Review of Pharmacology and Toxicology - September 18, 2023 Category: Drugs & Pharmacology Authors: Zhengyuan Pang Benjamin F Cravatt Li Ye Source Type: research
Circadian Regulation of Drug Responses: Toward Sex-Specific and Personalized Chronotherapy
Annu Rev Pharmacol Toxicol. 2023 Sep 18. doi: 10.1146/annurev-pharmtox-051920-095416. Online ahead of print.ABSTRACTToday's challenge for precision medicine involves the integration of the impact of molecular clocks on drug pharmacokinetics, toxicity, and efficacy, toward personalized chronotherapy. Meaningful improvements of tolerability and/or efficacy of medications through proper administration timing have been confirmed over the past decade for immunotherapy and chemotherapy against cancer, as well as for commonly used pharmacological agents in cardiovascular, metabolic, inflammatory, and neurological conditions. Expe...
Source: Annual Review of Pharmacology and Toxicology - September 18, 2023 Category: Drugs & Pharmacology Authors: Francis A L évi Alper Okyar Eva Hadadi Pasquale F Innominato Annabelle Ballesta Source Type: research
3D Printed Personalized Colon-targeted Tablets: A Novel Approach in Ulcerative Colitis Management
Curr Drug Deliv. 2023 Sep 15. doi: 10.2174/1567201821666230915150544. Online ahead of print.ABSTRACTUlcerative colitis (UC) and Crohn's disease (CD) are two types of idiopathic inflammatory bowel disease (IBD) that are increasing in frequency and incidence worldwide, particularly in highly industrialized countries. Conventional tablets struggle to effectively deliver anti-inflammatory drugs since the inflammation is localized in different areas of the colon in each patient. The goal of 3D printing technology in pharmaceutics is to create personalized drug delivery systems (DDS) that are tailored to each individual's specif...
Source: Current Drug Delivery - September 18, 2023 Category: Drugs & Pharmacology Authors: Yachana Mishra Vijay Mishra Alaa A A Aljabali Mohamed El-Tanani Gowhar A Naikoo Nitin Charbe Sai Raghuveer Chava Murtaza M Tambuwala Source Type: research
Effect of oral versus parenteral vitamin D3 supplementation on nuclear factor- κB and platelet aggregation in type 2 diabetic patients
In conclusion, restoring normal levels of vitamin D is an important determinant to maintain normal platelet function and reduce inflammation. Nevertheless, further long-term studies are still needed.PMID:37721213 | DOI:10.1139/cjpp-2022-0359
Source: Canadian Journal of Physiology and Pharmacology - September 18, 2023 Category: Drugs & Pharmacology Authors: Esraa Habiba Samia Ali Yehia Ghanem Ola Sharaki Wafaa Hewedy Source Type: research
Prostaglandin E < sub > 2 < /sub > and myocarditis; friend or foe?
Biochem Pharmacol. 2023 Sep 16:115813. doi: 10.1016/j.bcp.2023.115813. Online ahead of print.ABSTRACTThis review article summarizes the role of prostaglandin E2 (PGE2) and its receptors (EP1-EP4) as it relates to the inflammatory cardiomyopathy, myocarditis. During the COVID-19 pandemic, the onset of myocarditis in a subset of patients prompted a debate on the use of nonsteroidal anti-inflammatory drugs (NSAIDs), like ibuprofen, which act to inhibit the actions of prostaglandins. This review aims to further understanding of the role of PGE2 in the pathogenesis or protection of the myocardium in myocarditis. Inflammatory ca...
Source: Biochemical Pharmacology - September 18, 2023 Category: Drugs & Pharmacology Authors: Timothy D Bryson Pamela Harding Source Type: research
Molecular Complex of HSIM-loaded Polymeric Nanoparticles: Potential Carriers in Osteoporosis
CONCLUSION: Bone-targeting nanoparticles incorporating functionalized simvastatin can target bone. Thus, in order to distribute simvastatin subcutaneously for the treatment of osteoporosis, the developed nanoparticles may act as a promising approach.PMID:37718521 | DOI:10.2174/1389450124666230915092910
Source: Current Drug Targets - September 18, 2023 Category: Drugs & Pharmacology Authors: Malkiet Kaur Manju Nagpal Amarjot Kaur Grewal Samrat Chauhan Chander Parkash Dora Thakur Gurjeet Singh Source Type: research
