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Specialty: Drugs & Pharmacology
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Total 123144 results found since Jan 2013.
Paraptosis: a non-classical paradigm of cell death for cancer therapy
Acta Pharmacol Sin. 2023 Sep 15. doi: 10.1038/s41401-023-01159-7. Online ahead of print.ABSTRACTDue to the sustained proliferative potential of cancer cells, inducing cell death is a potential strategy for cancer therapy. Paraptosis is a mode of cell death characterized by endoplasmic reticulum (ER) and/or mitochondrial swelling and cytoplasmic vacuolization, which is less investigated. Considerable evidence shows that paraptosis can be triggered by various chemical compounds, particularly in cancer cells, thus highlighting the potential application of this non-classical mode of cell death in cancer therapy. Despite these ...
Source: Acta Pharmacologica Sinica - September 15, 2023 Category: Drugs & Pharmacology Authors: Chun-Cao Xu Yi-Fan Lin Mu-Yang Huang Xiao-Lei Zhang Pei Wang Ming-Qing Huang Jin-Jian Lu Source Type: research
Effects of wet granulation process variables on the quantitative assay model of transmission Raman spectroscopy for pharmaceutical tablets
Eur J Pharm Biopharm. 2023 Sep 13:S0939-6411(23)00242-4. doi: 10.1016/j.ejpb.2023.09.009. Online ahead of print.ABSTRACTTransmission Raman spectroscopy (TRS) is a process analytical technology tool for nondestructive analysis of drug content in tablets. Although wet granulation is the most used tablet manufacturing method, most TRS studies have focused on tablets manufactured via direct compression. The effects of upstream process parameter variations, such as granulation, on the prediction performance of TRS quantitative models are unknown. We evaluated the effects of process parameter variations during granulation on the...
Source: European Journal of Pharmaceutics and Biopharmaceutics - September 15, 2023 Category: Drugs & Pharmacology Authors: Ryo Ohashi Tatsuo Koide Toshiro Fukami Source Type: research
Design, Development and in vitro quantification of novel electrosprayed Everolimus-loaded Soluplus ®/Polyvinyl alcohol nanoparticles via stability-indicating HPLC method in cancer therapy
In conclusion, the novel developed HPLC system can be applied for the quantification of different chemotherapeutic agents and the novel electrosprayed hydrogel NP is a potential drug delivery system to increase solubility and bioavailability of RAD001 in cancer therapy.PMID:37714413 | DOI:10.1016/j.ejpb.2023.09.008
Source: European Journal of Pharmaceutics and Biopharmaceutics - September 15, 2023 Category: Drugs & Pharmacology Authors: Lynn Louis Bor Shin Chee Marion McAfee Michael J D Nugent Source Type: research
DICTrank: The largest reference list of 1318 human drugs ranked by risk of drug-induced cardiotoxicity using FDA labeling
Drug Discov Today. 2023 Sep 13:103770. doi: 10.1016/j.drudis.2023.103770. Online ahead of print.ABSTRACTDrug-induced cardiotoxicity (DICT) is a leading cause of drug trial failure and discontinuation. Current drug annotations for cardiotoxicity largely focus on individual outcomes or mechanisms. Considering the broad spectrum of adverse cardiac events, we developed Drug-Induced Cardiotoxicity Rank (DICTrank) using FDA labeling and comprehensively classified 1318 human drugs into four categories: Most-DICT-Concern (n=341), Less-DICT-Concern (n=528), No-DICT-Concern (n=343), and Ambiguous-DICT-Concern (n=106). Notably, DICTr...
Source: Drug Discovery Today - September 15, 2023 Category: Drugs & Pharmacology Authors: Yanyan Qu Ting Li Zhichao Liu Dongying Li Weida Tong Source Type: research
TDP-43 protein interactome informs about perturbed canonical pathways and may help develop personalized medicine approaches for patients with TDP-43 pathology
Drug Discov Today. 2023 Sep 13:103769. doi: 10.1016/j.drudis.2023.103769. Online ahead of print.ABSTRACTTransactive response DNA binding protein of 43 kDa (TDP-43) pathology is a common proteinopathy observed among a broad spectrum of patients with neurodegenerative disease, regardless of the mutation. This suggests that protein-protein interactions of TDP-43 with other proteins may in part be responsible for the pathology. To gain better insights, we investigated TDP-43-binding proteins in each domain and correlated these interactions with canonical pathways. These investigations revealed key cellular events that are invo...
Source: Drug Discovery Today - September 15, 2023 Category: Drugs & Pharmacology Authors: Benjamin R Helmold Kate E Pauss P Hande Ozdinler Source Type: research
Potential Benefits of Therapeutic Drug Monitoring for Beta-lactam Antibiotics in Augmented Renal Clearance Patients: A Case Report
CONCLUSION: Suboptimal administration could not only lead to treatment failure, but to the selection and growth of resistant pathogens. Implementing TDM would offer the possibility to adjust drug regimens in real time and prevent situations like these to happen.PMID:37713726 | DOI:10.1139/cjpp-2023-0109
Source: Canadian Journal of Physiology and Pharmacology - September 15, 2023 Category: Drugs & Pharmacology Authors: Ibrahim El-Haffaf Jean Laverdi ère Martin Albert Am élie Marsot David Williamson Source Type: research
Off-Label Reduced Dose Apixaban in Older Adults With Atrial Fibrillation and Associated Outcomes
CONCLUSION AND RELEVANCE: Older adults with nonvalvular AF are commonly prescribed lower-than-recommended doses of apixaban. However, no significant association was found between empiric off-label reduced dosing and stroke or bleeding outcomes.PMID:37712551 | DOI:10.1177/10600280231199137
Source: The Annals of Pharmacotherapy - September 15, 2023 Category: Drugs & Pharmacology Authors: Ashley M Campbell Elizabeth Pae Eunice Lee Timothy Jacisin Alina Price Jessica DeAngelo Source Type: research
Natural products and mitochondrial allies in colorectal cancer therapy
Biomed Pharmacother. 2023 Sep 13;167:115473. doi: 10.1016/j.biopha.2023.115473. Online ahead of print.ABSTRACTColorectal cancer (CRC) is a globally prevalent malignancy with a high potential for metastasis. Existing cancer treatments have limitations, including drug resistance and adverse effects. Researchers are striving to develop effective therapies to address these challenges. Impressively, contemporary research has discovered that many natural products derived from foods, plants, insects, and marine invertebrates can suppress the progression, metastasis, and invasion of CRC. In this review, we conducted a comprehensiv...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 15, 2023 Category: Drugs & Pharmacology Authors: Feng Wei Qing Nian Maoyuan Zhao Yueqiang Wen Yi Yang Jundong Wang Zhelin He Xiaoyan Chen Xiang Yin Jian Wang Xiao Ma Yu Chen Peimin Feng Jinhao Zeng Source Type: research
Budesonide, an anti-inflammatory drug, exacerbate clostridioides difficile colitis in mice
CONCLUSIONS: Anti-inflammatory drugs including corticosteroid therapy may worsen the incidence and severity of CDI in this mouse model. These studies may have important clinical implications for understanding the role of anti-inflammatory/ corticosteroid therapy in CDI and inflammatory bowel disease management.PMID:37713991 | DOI:10.1016/j.biopha.2023.115489
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 15, 2023 Category: Drugs & Pharmacology Authors: Qianyun Lin Zitong Li Lei Lu Hua Xu Eddie Lou Alyssa Chen Dustin Sun Wuyi Zhang Weishu Zhu Eric U Yee Pamela Suzanne Sears Xinhua Chen Ciaran P Kelly Source Type: research
Luteolin as a potential hepatoprotective drug: Molecular mechanisms and treatment strategies
This article summarizes the pharmacological effects, pharmacokinetic characteristics, and toxicity of luteolin against liver diseases, and provides prospect. The results indicate that luteolin improves liver lesions through various mechanisms, including inhibiting inflammatory factors, reducing oxidative stress, regulating lipid balance, slowing down excessive aggregation of extracellular matrix, inducing apoptosis and autophagy of liver cancer cells. Pharmacokinetics research manifested that due to metabolic effects, the bioavailability of luteolin is relatively low. It is worth noting that appropriate modification, new d...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 15, 2023 Category: Drugs & Pharmacology Authors: Chenhao Yao Shu Dai Cheng Wang Ke Fu Rui Wu Xingtao Zhao Yuxin Yao Yunxia Li Source Type: research
Antagonism of a key peptide 'T14' driving neurodegeneration: Evaluation of a next generation therapeutic
Biomed Pharmacother. 2023 Sep 13;167:115498. doi: 10.1016/j.biopha.2023.115498. Online ahead of print.ABSTRACTT14, a 14mer peptide derived from the C-terminus of acetylcholinesterase (AChE) is a signalling molecule that could drive neurodegeneration via the alpha 7 nicotinic acetylcholine receptor. Its levels increase as Alzheimer's pathology progresses; however, a cyclic variant of the compound, NBP14, can block the effects of the endogenous linear counterpart in-vitro, ex vivo, and in vivo. Here, we explore the antagonistic potential of two 6mer peptides, NBP6A and NBP6B. These are smaller linear versions of NBP14, desig...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 15, 2023 Category: Drugs & Pharmacology Authors: Sanskar Ranglani Sibah Hasan Kashif Mahfooz Jack Gordon Sara Garcia-Rates Susan Greenfield Source Type: research
Naotaifang formula attenuates OGD/R-induced inflammation and ferroptosis by regulating microglial M1/M2 polarization through BMP6/SMADs signaling pathway
CONCLUSION: Microglial M1/M2 polarization plays a pivotal role in inflammation and ferroptosis during OGD/R. The BMP6/SMADs signaling pathway is a potential therapeutical target of inflammation and ferroptosis induced by the transformation of microglia. Moreover, NTF could alleviate inflammation and ferroptosis through the BMP6/SMADs signaling pathway in OGD/R-injured microglia.PMID:37713988 | DOI:10.1016/j.biopha.2023.115465
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 15, 2023 Category: Drugs & Pharmacology Authors: Jun Liao Mengzhen Wei Jianjun Wang Jinsong Zeng Danhong Liu Qiusi Du Jinwen Ge Zhigang Mei Source Type: research
Itaconic acid and dimethyl itaconate exert antibacterial activity in carbon-enriched environments through the TCA cycle
This study enriches knowledge on the inhibition of bacteria by IA and DI in a carbon-mixed environment, suggesting an alternative method for treating bacterial infections by immune metabolites.PMID:37713987 | DOI:10.1016/j.biopha.2023.115487
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 15, 2023 Category: Drugs & Pharmacology Authors: L Y Xie Y B Xu X Q Ding S Liang D L Li A K Fu X A Zhan Source Type: research
Amazonian medicinal plants efficiently inactivate Herpes and Chikungunya viruses
This study contributes to the understanding of medicinal species native to the Brazilian Amazon, revealing their potential in combating viral infections that have plagued humanity for centuries (HSV-1) or currently lack specific therapeutic interventions (CHIKV).PMID:37713986 | DOI:10.1016/j.biopha.2023.115476
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 15, 2023 Category: Drugs & Pharmacology Authors: Catielen Paula Pavi Isabella Dai Pr á Rafael Dorighello Cadamuro Isamu Kanzaki Jhuly Wellen Ferreira Lacerda Louis Pergaud Sandjo Roberto Messias Bezerra Jorge Federico Orellana Segovia Gislaine Fongaro Izabella Tha ís Silva Source Type: research
The influence of atorvastatin, amlodipine and ethoxidol on ubiquinol and ubiquinone endogenous plasma concentrations in patients with chronic heart failure
CONCLUSION: Amlodipine is able to neutralize the negative effect of atorvastin on the redox balance of CoQ10 in patients with CHF. An additional prescription of the antioxidant ethoxidol to standard therapy for patients with CHF was substantiated. Determination of the redox state of CoQ10 in plasma can be used to diagnose and assess the degree of oxidative stress in patients with cardiovascular diseases, as well as to assess the efficacy and safety of ongoing pharmacotherapy.PMID:37711113 | DOI:10.2174/1389200224666230913133201
Source: Current Drug Metabolism - September 15, 2023 Category: Drugs & Pharmacology Authors: Vladlena I Zozina Svetlana N Kondratenko Evgenia V Shikh Liudmila M Krasnykh Evgeny S Melnikov Vladimir G Kukes Source Type: research
